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Vaginal Basaloid Squamous Cell Carcinoma

MedGen UID:
275572
•Concept ID:
C1519916
•
Neoplastic Process
Synonym: Vaginal Basaloid Carcinoma

Definition

A squamous cell carcinoma that arises from the vagina and is characterized by the presence of nests of malignant basaloid squamous cells with scant amounts of cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Basaloid Squamous Cell Carcinoma

Recent clinical studies

Etiology

Tumor lesions of penis and scrotum according to WHO classification 2022.
Michalová K, Beniač P, Kacerovská D
Cesk Patol 2022 Fall;67(4):192-197. PMID: 36513504
Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma?
Day T, Otton G, Jaaback K, Weigner J, Scurry J
J Low Genit Tract Dis 2018 Apr;22(2):159-165. doi: 10.1097/LGT.0000000000000384. PMID: 29470358Free PMC Article
Premalignant lesions of the lower female genital tract: cervix, vagina and vulva.
McCluggage WG
Pathology 2013 Apr;45(3):214-28. doi: 10.1097/PAT.0b013e32835f21b1. PMID: 23442737
Malignant mullerian mixed tumors of the uterine cervix: a report of nine cases of a neoplasm with morphology often different from its counterpart in the corpus.
Clement PB, Zubovits JT, Young RH, Scully RE
Int J Gynecol Pathol 1998 Jul;17(3):211-22. PMID: 9656116
Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses.
Kurman RJ, Toki T, Schiffman MH
Am J Surg Pathol 1993 Feb;17(2):133-45. doi: 10.1097/00000478-199302000-00005. PMID: 8380681

Diagnosis

Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis.
Munkhdelger J, Shimooka T, Koyama Y, Ikeda S, Mikami Y, Fukuoka J, Hori T, Bychkov A
Int J Surg Pathol 2021 Oct;29(7):770-774. Epub 2021 Apr 1 doi: 10.1177/1066896921997132. PMID: 33792431
Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma?
Day T, Otton G, Jaaback K, Weigner J, Scurry J
J Low Genit Tract Dis 2018 Apr;22(2):159-165. doi: 10.1097/LGT.0000000000000384. PMID: 29470358Free PMC Article
Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16(INK4A) overexpression and clinicopathological correlations.
Fuste V, del Pino M, Perez A, Garcia A, Torne A, Pahisa J, Ordi J
Histopathology 2010 Dec;57(6):907-16. doi: 10.1111/j.1365-2559.2010.03727.x. PMID: 21166704
Pure basaloid squamous cell carcinoma of the uterine cervix: a case report.
Kwon YS, Kim YM, Choi GW, Kim YT, Nam JH
J Korean Med Sci 2009 Jun;24(3):542-5. Epub 2009 Jun 18 doi: 10.3346/jkms.2009.24.3.542. PMID: 19543425Free PMC Article
Malignant mullerian mixed tumors of the uterine cervix: a report of nine cases of a neoplasm with morphology often different from its counterpart in the corpus.
Clement PB, Zubovits JT, Young RH, Scully RE
Int J Gynecol Pathol 1998 Jul;17(3):211-22. PMID: 9656116

Therapy

Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis.
Munkhdelger J, Shimooka T, Koyama Y, Ikeda S, Mikami Y, Fukuoka J, Hori T, Bychkov A
Int J Surg Pathol 2021 Oct;29(7):770-774. Epub 2021 Apr 1 doi: 10.1177/1066896921997132. PMID: 33792431
Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma?
Day T, Otton G, Jaaback K, Weigner J, Scurry J
J Low Genit Tract Dis 2018 Apr;22(2):159-165. doi: 10.1097/LGT.0000000000000384. PMID: 29470358Free PMC Article
Huge right ventricular mass lesion associated with genital malignant tumor: a case report.
Higashi M, Hodatsu A, Uchiyama K, Tada H, Mori M, Ohira M, Hayashi K, Kawashiri MA
J Med Case Rep 2017 Oct 3;11(1):282. doi: 10.1186/s13256-017-1439-4. PMID: 28969678Free PMC Article
Usual vulval intraepithelial neoplasia in HIV-positive women - a case series.
Toby M, Conway K, Sethi G, Lewis F
Int J STD AIDS 2016 Dec;27(14):1253-1256. Epub 2015 Oct 14 doi: 10.1177/0956462415611513. PMID: 26472432
Papillary squamous cell carcinoma of the uterine cervix, high-risk human papilloma virus infection and p16(INK4a) expression: a case report.
Eleutério J Jr, Giraldo PC, Cavalcante DI, Gonçalves AK, Eleutério RM, Giraldo HP
Acta Cytol 2009 Mar-Apr;53(2):188-90. doi: 10.1159/000325122. PMID: 19365973

Prognosis

Malignant mullerian mixed tumors of the uterine cervix: a report of nine cases of a neoplasm with morphology often different from its counterpart in the corpus.
Clement PB, Zubovits JT, Young RH, Scully RE
Int J Gynecol Pathol 1998 Jul;17(3):211-22. PMID: 9656116
Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses.
Kurman RJ, Toki T, Schiffman MH
Am J Surg Pathol 1993 Feb;17(2):133-45. doi: 10.1097/00000478-199302000-00005. PMID: 8380681

Clinical prediction guides

A case of a vaginal Brenner tumor without a gland mimicking a borderline tumor: unusual morphology and diagnostic pitfalls.
Zhang Q, Tian C, Wang K, Xin Q, Shen Y, Zhang CS, Ma Z
J Int Med Res 2020 Aug;48(8):300060520946536. doi: 10.1177/0300060520946536. PMID: 32809866Free PMC Article
Large contribution of human papillomavirus in vaginal neoplastic lesions: a worldwide study in 597 samples.
Alemany L, Saunier M, Tinoco L, Quirós B, Alvarado-Cabrero I, Alejo M, Joura EA, Maldonado P, Klaustermeier J, Salmerón J, Bergeron C, Petry KU, Guimerà N, Clavero O, Murillo R, Clavel C, Wain V, Geraets DT, Jach R, Cross P, Carrilho C, Molina C, Shin HR, Mandys V, Nowakowski AM, Vidal A, Lombardi L, Kitchener H, Sica AR, Magaña-León C, Pawlita M, Quint W, Bravo IG, Muñoz N, de Sanjosé S, Bosch FX; HPV VVAP study group
Eur J Cancer 2014 Nov;50(16):2846-54. Epub 2014 Aug 21 doi: 10.1016/j.ejca.2014.07.018. PMID: 25155250
A case of usual (basaloid)-type vulvar intraepithelial neoplasia that failed to respond to imiquimod cream: clinical implications.
Shiozaki T, Tabata T, Toriyabe K, Motohashi T, Kondo E, Tanida K, Okugawa T, Sagawa N
Int J Clin Oncol 2011 Oct;16(5):610-2. Epub 2011 Jan 21 doi: 10.1007/s10147-010-0180-4. PMID: 21249413
Thin-layer (liquid-based) cytologic findings of papillary squamotransitional cell carcinoma of the cervix. Review of cases over a 4-year period with emphasis on potential diagnostic pitfalls.
Ng WK
Acta Cytol 2003 Mar-Apr;47(2):141-8. doi: 10.1159/000326494. PMID: 12685179
Basaloid squamous cell carcinoma of the vagina metastasizing to the lung. A case report.
Li H, Heller DS, Sama J, Bolanowski PJ, Anderson J
J Reprod Med 2000 Oct;45(10):841-3. PMID: 11077635

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