Vaginal carcinosarcoma

MedGen UID:: 275573
•Concept ID:: C1519918
•: Neoplastic Process

Synonyms:	malignant vaginal mixed epithelial and mesenchymal tumor; malignant vaginal mixed epithelial and mesenchymal tumour; Vaginal Carcinosarcoma; vaginal carcinosarcoma; Vaginal Malignant Mixed Mesodermal (Mullerian) Tumor; vaginal malignant mixed mesodermal (Mullerian) tumor; vaginal malignant mixed mesodermal (Mullerian) tumour; Vaginal Malignant Mixed Mesodermal (Müllerian) Tumor; vaginal malignant mixed mesodermal (Müllerian) tumor; vaginal malignant mixed mesodermal (Müllerian) tumour; vaginal malignant mixed Mullerian tumor; vaginal malignant mixed Mullerian tumour; vaginal mixed epithelial and mesenchymal tumor; vaginal mixed epithelial and mesenchymal tumour

Monarch Initiative:	MONDO:0006488

Definition

An aggressive mixed epithelial and mesenchymal neoplasm that arises from the vagina and is characterized by the presence of a malignant epithelial component and a malignant mesenchymal component. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVVaginal carcinosarcoma

Disease
- Neoplasm
  - Malignant neoplastic disease
    - Malignant mixed neoplasm
      - Carcinosarcoma
        Malignant Mixed Mesodermal (Mullerian) Tumor
        Vaginal carcinosarcoma

Professional guidelines

PubMed

Clinicopathological characteristics, treatment and outcomes in uterine carcinosarcoma and grade 3 endometrial cancer patients: a comparative study.

Zhu J, Wen H, Bi R, Wu X
J Gynecol Oncol 2016 Mar;27(2):e18. Epub 2015 Oct 12 doi: 10.3802/jgo.2016.27.e18. PMID: 26463439 Free PMC Article

Adjuvant treatment for endometrial cancer: literature review and recommendations by the Comité de l'évolution des pratiques en oncologie (CEPO).

Morneau M, Foster W, Lalancette M, Van Nguyen-Huynh T, Renaud MC, Samouëlian V, Letarte N; Comité de l'évolution des pratiques en oncologie; Comité de l'évolution des pratiques en oncologie, Almanric K, Boily G, Bouchard P, Boulanger J, Cournoyer G, Couture F, Gervais N, Goulet S, Guay MP, Kavanagh M, Lemieux J, Lespérance B, Letarte N, Morneau M, Ouellet JF, Pineau G, Rajan R, Roy I, Samson B, Sidéris L, Vincent F
Gynecol Oncol 2013 Oct;131(1):231-40. Epub 2013 Jul 19 doi: 10.1016/j.ygyno.2013.07.084. PMID: 23872191

Evaluation of prognostic factors and treatment outcomes in uterine carcinosarcoma.

Galaal K, Kew FM, Tam KF, Lopes A, Meirovitz M, Naik R, Godfrey KA, Hatem MH, Edmondson RJ
Eur J Obstet Gynecol Reprod Biol 2009 Apr;143(2):88-92. Epub 2009 Feb 7 doi: 10.1016/j.ejogrb.2008.12.014. PMID: 19201517

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Recent clinical studies

Diagnosis

Two Components of Variant Profiles in Primary Vaginal Carcinosarcoma via Next-Generation Sequencing and a Literature Review.

Kotoku R, Yanazume S, Kuroda T, Kobayashi Y, Kitazono I, Akahane T, Tanimoto A, Kobayashi H
Int J Surg Pathol 2022 May;30(3):288-294. Epub 2021 Aug 31 doi: 10.1177/10668969211037915. PMID: 34463147

Trichoblastic Carcinosarcoma Arising From the Vagina: A Case Report With Comprehensive Immunophenotypic Analysis.

Li JJX, Ng JKM, Choi PCL, Lee JHS, Yu MY
Int J Surg Pathol 2020 Jun;28(4):440-446. Epub 2019 Nov 20 doi: 10.1177/1066896919887803. PMID: 31747847

Primary carcinosarcoma of the vagina.

Shibata R, Umezawa A, Takehara K, Aoki D, Nozawa S, Hata J
Pathol Int 2003 Feb;53(2):106-10. doi: 10.1046/j.1440-1827.2003.01442.x. PMID: 12588439

See all (3)