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Vaginal glandular neoplasm

MedGen UID:
275574
•Concept ID:
C1519921
•
Neoplastic Process
Synonyms: vagina glandular cell neoplasm; Vaginal Glandular Neoplasm; vaginal glandular neoplasm; Vaginal Glandular Tumor; vaginal glandular tumor; vaginal glandular tumour
 
Monarch Initiative: MONDO:0001704

Definition

A benign or malignant neoplasm that arises from the vagina and is characterized by the presence of neoplastic glandular epithelial cells. Representative examples include adenoma, endometrioid adenocarcinoma, and clear cell adenocarcinoma. [from NCI]

Professional guidelines

PubMed

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Updates in the treatment of vaginal cancer.
Jhingran A
Int J Gynecol Cancer 2022 Mar;32(3):344-351. doi: 10.1136/ijgc-2021-002517. PMID: 35256422Free PMC Article
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Recent clinical studies

Etiology

Prolapsing vaginal fibroepithelial polyp.
Leffelman A, Valaitis S
BMJ Case Rep 2022 Dec 22;15(12) doi: 10.1136/bcr-2022-250967. PMID: 36549754Free PMC Article
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
Cervical cancer.
Shepherd JH
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):293-309. Epub 2012 Feb 19 doi: 10.1016/j.bpobgyn.2011.12.004. PMID: 22353492
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777

Diagnosis

Prolapsing vaginal fibroepithelial polyp.
Leffelman A, Valaitis S
BMJ Case Rep 2022 Dec 22;15(12) doi: 10.1136/bcr-2022-250967. PMID: 36549754Free PMC Article
Squamous and Glandular Lesions of the Vulva and Vagina: What's New and What Remains Unanswered?
Wei KX, Hoang LN
Surg Pathol Clin 2022 Jun;15(2):389-405. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.011. PMID: 35715167
Updates in the treatment of vaginal cancer.
Jhingran A
Int J Gynecol Cancer 2022 Mar;32(3):344-351. doi: 10.1136/ijgc-2021-002517. PMID: 35256422Free PMC Article
Genital diseases in the mature woman.
Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777

Therapy

PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer.
van den Heerik ASVM, Horeweg N, Nout RA, Lutgens LCHW, van der Steen-Banasik EM, Westerveld GH, van den Berg HA, Slot A, Koppe FLA, Kommoss S, Mens JWM, Nowee ME, Bijmolt S, Cibula D, Stam TC, Jurgenliemk-Schulz IM, Snyers A, Hamann M, Zwanenburg AG, Coen VLMA, Vandecasteele K, Gillham C, Chargari C, Verhoeven-Adema KW, Putter H, van den Hout WB, Wortman BG, Nijman HW, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2020 Dec;30(12):2002-2007. Epub 2020 Oct 12 doi: 10.1136/ijgc-2020-001929. PMID: 33046573Free PMC Article
Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Management of vaginal intraepithelial neoplasia.
Gurumurthy M, Cruickshank ME
J Low Genit Tract Dis 2012 Jul;16(3):306-12. doi: 10.1097/LGT.0b013e31823da7fb. PMID: 22460272
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777
The DES story.
Gunning JE
Obstet Gynecol Surv 1976 Nov;31(11):827-33. doi: 10.1097/00006254-197611000-00026. PMID: 980278

Prognosis

The vaginal microbiome is associated with endometrial cancer grade and histology.
Hakimjavadi H, George SH, Taub M, Dodds LV, Sanchez-Covarrubias AP, Huang M, Pearson JM, Slomovitz BM, Kobetz EN, Gharaibeh R, Sowamber R, Pinto A, Chamala S, Schlumbrecht MP
Cancer Res Commun 2022 Jun;2(6):447-455. Epub 2022 Jun 16 doi: 10.1158/2767-9764.CRC-22-0075. PMID: 35928983Free PMC Article
Genital diseases in the mature woman.
Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777
Subsets of vulvodynia.
McKay M
J Reprod Med 1988 Aug;33(8):695-8. PMID: 3050074

Clinical prediction guides

Lateral Pelvic Sidewall Nodes.
Kelly ME, Heriot AG
Dis Colon Rectum 2023 Mar 1;66(3):355-357. Epub 2023 Jan 4 doi: 10.1097/DCR.0000000000002706. PMID: 36728599
Microbiota unbalance in relation to high-risk human papillomavirus cervical infection.
Gomez Cherey JF, Payalef SN, Fleider L, Reyes AP, Maldonado VA, Losada MO, Chen X, Cardinal LH, Wang Y, Tatti SA, Perazzi BE
Int J Gynecol Cancer 2023 Apr 3;33(4):482-488. doi: 10.1136/ijgc-2022-003760. PMID: 36604120
The vaginal microbiome is associated with endometrial cancer grade and histology.
Hakimjavadi H, George SH, Taub M, Dodds LV, Sanchez-Covarrubias AP, Huang M, Pearson JM, Slomovitz BM, Kobetz EN, Gharaibeh R, Sowamber R, Pinto A, Chamala S, Schlumbrecht MP
Cancer Res Commun 2022 Jun;2(6):447-455. Epub 2022 Jun 16 doi: 10.1158/2767-9764.CRC-22-0075. PMID: 35928983Free PMC Article
Endocervical Cytology: Inter- and Intra-Observer Variability in Conventional Pap Smears.
Pulkkinen J, Huhtala H, Krogerus LA, Hollmén S, Laurila M, Kholová I
Acta Cytol 2022;66(3):206-215. Epub 2022 Feb 28 doi: 10.1159/000522212. PMID: 35226896
Incidental vaginal müllerianosis.
Val-Bernal JF, Mayorga M
Pathol Res Pract 2016 Jun;212(6):568-72. Epub 2016 Feb 26 doi: 10.1016/j.prp.2016.02.023. PMID: 26970930

Recent systematic reviews

The prognostic significance of HPV, p16, and p53 protein expression in vaginal cancer: A systematic review.
Rasmussen CL, Bertoli HK, Sand FL, Kjaer AK, Thomsen LT, Kjaer SK
Acta Obstet Gynecol Scand 2021 Dec;100(12):2144-2156. Epub 2021 Sep 21 doi: 10.1111/aogs.14260. PMID: 34546565
Imiquimod for vaginal intraepithelial neoplasia 2-3: A systematic review and meta-analysis.
Inayama Y, Yamanishi Y, Nakatani E, Aratake J, Sasagasako N, Yamada K, Gou R, Kawamura A, Yamanishi M, Kosaka K
Gynecol Oncol 2021 Jan;160(1):140-147. Epub 2020 Oct 1 doi: 10.1016/j.ygyno.2020.09.031. PMID: 33010966
Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen.
Romero SA, Young K, Hickey M, Su HI
Cochrane Database Syst Rev 2020 Dec 21;12(12):CD007245. doi: 10.1002/14651858.CD007245.pub4. PMID: 33348436Free PMC Article
Surgical, oncological, and obstetrical outcomes after abdominal radical trachelectomy - a systematic literature review.
Pareja R, Rendón GJ, Sanz-Lomana CM, Monzón O, Ramirez PT
Gynecol Oncol 2013 Oct;131(1):77-82. Epub 2013 Jun 14 doi: 10.1016/j.ygyno.2013.06.010. PMID: 23769758
Atypical glandular cells and cervical cancer: systematic review.
Marques JP, Costa LB, Pinto AP, Lima AF, Duarte ME, Barbosa AP, Medeiros PL
Rev Assoc Med Bras (1992) 2011 Mar-Apr;57(2):234-8. doi: 10.1590/s0104-42302011000200024. PMID: 21537713

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