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Signet ring basal cell carcinoma

MedGen UID:
276814
•Concept ID:
C1519320
•
Neoplastic Process
Synonyms: signet ring basal cell carcinoma; Signet Ring Cell Basal Cell Carcinoma; signet Ring cell basal cell carcinoma; Skin Signet Ring Cell Basal Cell Carcinoma; skin signet Ring cell basal cell carcinoma; skin signet ring cell basal cell carcinoma; Skin Signet-Ring Cell Basal Cell Carcinoma
 
Monarch Initiative: MONDO:0002958

Definition

A rare type of basal cell carcinoma. It is characterized by the presence of mucin containing signet ring cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSignet ring basal cell carcinoma

Professional guidelines

PubMed

Metastatic Pleomorphic Lobular Carcinoma of the Breast to the Urinary Bladder: A Report of 10 Cases and Assessment of TRPS1 in the Differential Diagnosis With Plasmacytoid Urothelial Carcinoma.
Zhang GN, Susnik B, Paulsen EJ, Lyons LL, Delma KS, Jorda M, Epstein JI, Kryvenko ON
Arch Pathol Lab Med 2024 Oct 1;148(10):1110-1118. doi: 10.5858/arpa.2023-0379-OA. PMID: 38217332
Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations.
Fine SW
Adv Anat Pathol 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92. PMID: 22692283

Recent clinical studies

Etiology

Clinical, endoscopic and histological profile of colorectal cancers seen on colonoscopy in Kano, North-Western Nigeria.
Musa Y, Mohammed MF, Muhammad NO, Yusuf I, Abdulrahim AO, Samaila AA, Borodo MM
Niger Postgrad Med J 2021 Jan-Mar;28(1):22-26. doi: 10.4103/npmj.npmj_288_20. PMID: 33642320
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
A clinicopathologic study of esophageal 860 benign and malignant lesions in 910 cases of consecutive esophageal biopsies.
Terada T
Int J Clin Exp Pathol 2013;6(2):191-8. Epub 2013 Jan 15 PMID: 23330004Free PMC Article
Histological variants of prostatic carcinoma and their significance.
Humphrey PA
Histopathology 2012 Jan;60(1):59-74. doi: 10.1111/j.1365-2559.2011.04039.x. PMID: 22212078
A cytologic perspective on meibomian gland carcinoma.
Garbyal RS, Gupta P, Kumar M, Bohra A, Chaube A
Acta Cytol 2007 Mar-Apr;51(2):171-7. doi: 10.1159/000325711. PMID: 17425198

Diagnosis

Adenoid basal cell carcinoma: a rare facet of basal cell carcinoma.
Saxena K, Manohar V, Bhakhar V, Bahl S
BMJ Case Rep 2016 Apr 19;2016:10.1136/bcr-2015-214166. doi: 10.1136/bcr-2015-214166. PMID: 27095806Free PMC Article
Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations.
Fine SW
Adv Anat Pathol 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92. PMID: 22692283
Histological variants of prostatic carcinoma and their significance.
Humphrey PA
Histopathology 2012 Jan;60(1):59-74. doi: 10.1111/j.1365-2559.2011.04039.x. PMID: 22212078
Signet ring cell basal cell carcinoma.
White GM, Barr RJ, Liao SY
Am J Dermatopathol 1991 Jun;13(3):288-92. doi: 10.1097/00000372-199106000-00012. PMID: 1714249
Signet-ring clear-cell basal cell carcinoma.
Cohen RE, Zaim MT
J Cutan Pathol 1988 Jun;15(3):183-7. doi: 10.1111/j.1600-0560.1988.tb00540.x. PMID: 2456318

Therapy

Clinically occult cutaneous metastases.
Resnik KS, DiLeonardo M, Gibbons G
J Am Acad Dermatol 2006 Dec;55(6):1044-7. doi: 10.1016/j.jaad.2006.05.011. PMID: 17110220

Prognosis

Morphology, immunohistochemistry characteristics, and clinical presentation of microcystic urothelial carcinoma: a series of 10 cases.
Su W, Sui W, Cheng X, Zong Y, Qin Y, Cui F
Diagn Pathol 2023 Aug 19;18(1):94. doi: 10.1186/s13000-023-01381-1. PMID: 37598154Free PMC Article
Adenoid basal cell carcinoma: a rare facet of basal cell carcinoma.
Saxena K, Manohar V, Bhakhar V, Bahl S
BMJ Case Rep 2016 Apr 19;2016:10.1136/bcr-2015-214166. doi: 10.1136/bcr-2015-214166. PMID: 27095806Free PMC Article
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach.
Ohtawa Y, Naomoto Y, Shirakawa Y, Takaoka M, Murata T, Sonoda R, Sakurama K, Yamatsuji T, Gunduz M, Tsujigiwa H, Nagatsuka H, Terada N, Itano S, Horiki S, Yanagihara K, Nakajima M, Tanaka N
Hum Pathol 2006 Sep;37(9):1145-52. Epub 2006 Jul 7 doi: 10.1016/j.humpath.2006.04.005. PMID: 16938519
Expression of mismatch repair enzymes, hMLH1 and hMSH2 is not associated with microsatellite instability and P53 protein accumulation in basal cell carcinoma.
Saetta AA, Aroni K, Stamatelli A, Lazaris AC, Patsouris E
Arch Dermatol Res 2005 Sep;297(3):99-107. Epub 2005 Sep 29 doi: 10.1007/s00403-005-0580-x. PMID: 16012876

Clinical prediction guides

Adenoid basal cell carcinoma: a rare facet of basal cell carcinoma.
Saxena K, Manohar V, Bhakhar V, Bahl S
BMJ Case Rep 2016 Apr 19;2016:10.1136/bcr-2015-214166. doi: 10.1136/bcr-2015-214166. PMID: 27095806Free PMC Article
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations.
Fine SW
Adv Anat Pathol 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92. PMID: 22692283
Expression of mismatch repair enzymes, hMLH1 and hMSH2 is not associated with microsatellite instability and P53 protein accumulation in basal cell carcinoma.
Saetta AA, Aroni K, Stamatelli A, Lazaris AC, Patsouris E
Arch Dermatol Res 2005 Sep;297(3):99-107. Epub 2005 Sep 29 doi: 10.1007/s00403-005-0580-x. PMID: 16012876
Expression of bcl-2 and p53 oncoproteins in schistosomiasis-associated transitional and squamous cell carcinoma of urinary bladder.
Chaudhary KS, Lu QL, Abel PD, Khandan-Nia N, Shoma AM, el Baz M, Stamp GW, Lalani EN
Br J Urol 1997 Jan;79(1):78-84. doi: 10.1046/j.1464-410x.1997.30717.x. PMID: 9043502

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