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Growth hormone-producing pituitary gland carcinoma

MedGen UID:
277331
•Concept ID:
C1334587
•
Neoplastic Process
Synonyms: Growth Hormone Producing Pituitary Gland Carcinoma; Growth hormone producing pituitary gland carcinoma; growth hormone-producing pituitary gland carcinoma; Malignant Growth Hormone Producing Neoplasm of Pituitary; malignant Growth hormone producing neoplasm of pituitary; Malignant Growth Hormone Producing Neoplasm of Pituitary Gland; malignant Growth hormone producing neoplasm of pituitary gland; Malignant Growth Hormone Producing Neoplasm of the Pituitary; malignant Growth hormone producing neoplasm of the pituitary; Malignant Growth Hormone Producing Neoplasm of the Pituitary Gland; malignant Growth hormone producing neoplasm of the pituitary gland; Malignant Growth Hormone Producing Pituitary Gland Neoplasm; malignant Growth hormone producing pituitary gland neoplasm; Malignant Growth Hormone Producing Pituitary Gland Tumor; malignant Growth hormone producing pituitary gland tumor; malignant Growth hormone producing pituitary gland tumour; Malignant Growth Hormone Producing Pituitary Neoplasm; malignant Growth hormone producing pituitary neoplasm; Malignant Growth Hormone Producing Pituitary Tumor; malignant Growth hormone producing pituitary tumor; malignant Growth hormone producing pituitary tumour; Malignant Growth Hormone Producing Tumor; malignant Growth hormone producing tumor; Malignant Growth Hormone Producing Tumor of Pituitary; malignant Growth hormone producing tumor of pituitary; Malignant Growth Hormone Producing Tumor of Pituitary Gland; malignant Growth hormone producing tumor of pituitary gland; Malignant Growth Hormone Producing Tumor of the Pituitary; malignant Growth hormone producing tumor of the pituitary; Malignant Growth Hormone Producing Tumor of the Pituitary Gland; malignant Growth hormone producing tumor of the pituitary gland; malignant Growth hormone producing tumour; malignant Growth hormone producing tumour of pituitary; malignant Growth hormone producing tumour of pituitary gland; malignant Growth hormone producing tumour of the pituitary; malignant Growth hormone producing tumour of the pituitary gland; Malignant Growth Hormone Secreting Neoplasm of Pituitary; malignant Growth hormone secreting neoplasm of pituitary; Malignant Growth Hormone Secreting Neoplasm of Pituitary Gland; malignant Growth hormone secreting neoplasm of pituitary gland; Malignant Growth Hormone Secreting Neoplasm of the Pituitary; malignant Growth hormone secreting neoplasm of the pituitary; Malignant Growth Hormone Secreting Neoplasm of the Pituitary Gland; malignant Growth hormone secreting neoplasm of the pituitary gland; Malignant Growth Hormone Secreting Pituitary Gland Neoplasm; malignant Growth hormone secreting pituitary gland neoplasm; Malignant Growth Hormone Secreting Pituitary Gland Tumor; malignant Growth hormone secreting pituitary gland tumor; malignant Growth hormone secreting pituitary gland tumour; Malignant Growth Hormone Secreting Pituitary Neoplasm; malignant Growth hormone secreting pituitary neoplasm; Malignant Growth Hormone Secreting Pituitary Tumor; malignant Growth hormone secreting pituitary tumor; malignant Growth hormone secreting pituitary tumour; Malignant Growth Hormone Secreting Tumor of Pituitary; malignant Growth hormone secreting tumor of pituitary; Malignant Growth Hormone Secreting Tumor of Pituitary Gland; malignant Growth hormone secreting tumor of pituitary gland; Malignant Growth Hormone Secreting Tumor of the Pituitary; malignant Growth hormone secreting tumor of the pituitary; Malignant Growth Hormone Secreting Tumor of the Pituitary Gland; malignant Growth hormone secreting tumor of the pituitary gland; malignant Growth hormone secreting tumour of pituitary; malignant Growth hormone secreting tumour of pituitary gland; malignant Growth hormone secreting tumour of the pituitary; malignant Growth hormone secreting tumour of the pituitary gland; Malignant Pituitary Gland Somatotrophinoma; malignant pituitary gland Somatotrophinoma; malignant pituitary gland somatotropinoma; Malignant Pituitary Somatotrophinoma; malignant pituitary Somatotrophinoma; malignant pituitary somatotropinoma; Malignant Somatotrophinoma of Pituitary; malignant Somatotrophinoma of pituitary; Malignant Somatotrophinoma of Pituitary Gland; malignant Somatotrophinoma of pituitary gland; Malignant Somatotrophinoma of the Pituitary Gland; malignant Somatotrophinoma of the pituitary gland; malignant somatotropinoma; malignant somatotropinoma of pituitary; malignant somatotropinoma of pituitary gland; malignant somatotropinoma of the pituitary; malignant somatotropinoma of the pituitary gland; Metastatic Growth Hormone-Producing PitNET; Metastatic Somatotroph Pituitary Neuroendocrine Tumor
 
Monarch Initiative: MONDO:0003828

Definition

Growth hormone-producing pituitary neuroendocrine tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrowth hormone-producing pituitary gland carcinoma

Recent clinical studies

Etiology

Acromegaly caused by growth hormone-releasing hormone-producing tumors: long-term observational studies in three patients.
Biermasz NR, Smit JW, Pereira AM, Frölich M, Romijn JA, Roelfsema F
Pituitary 2007;10(3):237-49. doi: 10.1007/s11102-007-0045-7. PMID: 17541749Free PMC Article

Diagnosis

A Case of Pituitary Carcinoma Initially Diagnosed as an Ectopic Growth Hormone Producing Pituitary Adenoma with a High Ki-67 Labeling Index.
Endo T, Ogawa Y, Watanabe M, Tominaga T
J Neurol Surg A Cent Eur Neurosurg 2018 Jan;79(1):90-95. Epub 2017 Jun 6 doi: 10.1055/s-0037-1600515. PMID: 28586933
No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Mäkinen MJ, Birkenkamp-Demtröder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA
Endocr Relat Cancer 2007 Sep;14(3):901-6. doi: 10.1677/ERC-07-0025. PMID: 17914118
Acromegaly caused by growth hormone-releasing hormone-producing tumors: long-term observational studies in three patients.
Biermasz NR, Smit JW, Pereira AM, Frölich M, Romijn JA, Roelfsema F
Pituitary 2007;10(3):237-49. doi: 10.1007/s11102-007-0045-7. PMID: 17541749Free PMC Article
The differential diagnosis of lesions involving the sella turcica.
Kovacs K, Horvath E
Endocr Pathol 2001 Winter;12(4):389-95. doi: 10.1385/ep:12:4:389. PMID: 11914472
Gamma irradiation effects on human growth hormone producing pituitary adenoma tissue. An analysis of morphology and hormone secretion in an in vitro model system.
Anniko M, Arndt J, Rähn T, Werner S
Acta Otolaryngol 1982 May-Jun;93(5-6):485-500. doi: 10.3109/00016488209130908. PMID: 7102306

Prognosis

The differential diagnosis of lesions involving the sella turcica.
Kovacs K, Horvath E
Endocr Pathol 2001 Winter;12(4):389-95. doi: 10.1385/ep:12:4:389. PMID: 11914472

Clinical prediction guides

No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Mäkinen MJ, Birkenkamp-Demtröder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA
Endocr Relat Cancer 2007 Sep;14(3):901-6. doi: 10.1677/ERC-07-0025. PMID: 17914118
Acromegaly caused by growth hormone-releasing hormone-producing tumors: long-term observational studies in three patients.
Biermasz NR, Smit JW, Pereira AM, Frölich M, Romijn JA, Roelfsema F
Pituitary 2007;10(3):237-49. doi: 10.1007/s11102-007-0045-7. PMID: 17541749Free PMC Article
A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly.
Sanno N, Teramoto A, Osamura RY, Genka S, Katakami H, Jin L, Lloyd RV, Kovacs K
J Clin Endocrinol Metab 1997 Aug;82(8):2731-7. doi: 10.1210/jcem.82.8.4175. PMID: 9253362
Gamma irradiation effects on human growth hormone producing pituitary adenoma tissue. An analysis of morphology and hormone secretion in an in vitro model system.
Anniko M, Arndt J, Rähn T, Werner S
Acta Otolaryngol 1982 May-Jun;93(5-6):485-500. doi: 10.3109/00016488209130908. PMID: 7102306

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