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Poorly Differentiated Angiosarcoma

MedGen UID:
277523
•Concept ID:
C1335441
•
Neoplastic Process

Definition

An angiosarcoma characterized by the presence of significant cytologic atypia, necrosis and high mitotic activity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoorly Differentiated Angiosarcoma

Professional guidelines

PubMed

Myeloid sarcoma: a poorly recognised but important differential diagnosis of epithelioid angiosarcoma.
Wong DD, Amanuel R, Chua YJ, Hendry S, Robbins P, Cheah CY, Amanuel B
Pathology 2023 Aug;55(5):734-738. Epub 2023 Feb 22 doi: 10.1016/j.pathol.2022.12.353. PMID: 36931918
Angiosarcomas: histology, immunohistochemistry and molecular insights with implications for differential diagnosis.
Machado I, Giner F, Lavernia J, Cruz J, Traves V, Requena C, Llombart B, López-Guerrero JA, Llombart-Bosch A
Histol Histopathol 2021 Jan;36(1):3-18. Epub 2020 Sep 4 doi: 10.14670/HH-18-246. PMID: 32885407
Treatment Approaches and Outcomes for Primary Mediastinal Sarcoma: Analysis of 976 Patients.
Engelhardt KE, DeCamp MM, Yang AD, Bilimoria KY, Odell DD
Ann Thorac Surg 2018 Aug;106(2):333-339. Epub 2018 May 2 doi: 10.1016/j.athoracsur.2018.03.068. PMID: 29729268Free PMC Article

Recent clinical studies

Diagnosis

Primary angiosarcoma of the vulva: report of a case misdiagnosed as a benign tumor.
Stolnicu S, Podoleanu C, Orban I, Stan O, Szabo B
Pol J Pathol 2021;72(2):167-169. doi: 10.5114/pjp.2021.109519. PMID: 34706524
Radiogenic angiosarcoma of the breast: case report and systematic review of the literature.
Dogan A, Kern P, Schultheis B, Häusler G, Rezniczek GA, Tempfer CB
BMC Cancer 2018 Apr 24;18(1):463. doi: 10.1186/s12885-018-4369-7. PMID: 29690864Free PMC Article
Primary High-Grade Poorly Differentiated Angiosarcoma of an Intra-parotid Lymph Node.
Ducharne-Asuaje E, Dorion D, Lamarre L, Coindre JM, Geha S
Head Neck Pathol 2016 Jun;10(2):225-8. Epub 2015 May 1 doi: 10.1007/s12105-015-0631-3. PMID: 25930154Free PMC Article
Fatal poorly differentiated angiosarcoma of the scalp.
Terada T
Int J Clin Exp Pathol 2010 May 10;3(5):541-4. PMID: 20606736Free PMC Article
Cutaneous angiosarcoma of the face.
Cannavò SP, Lentini M, Magliolo E, Guarneri C
J Eur Acad Dermatol Venereol 2003 Sep;17(5):594-5. doi: 10.1046/j.1468-3083.2003.00809.x. PMID: 12941106

Therapy

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature.
Dogan A, Kern P, Schultheis B, Häusler G, Rezniczek GA, Tempfer CB
BMC Cancer 2018 Apr 24;18(1):463. doi: 10.1186/s12885-018-4369-7. PMID: 29690864Free PMC Article
Fatal poorly differentiated angiosarcoma of the scalp.
Terada T
Int J Clin Exp Pathol 2010 May 10;3(5):541-4. PMID: 20606736Free PMC Article
Cutaneous angiosarcoma of the face.
Cannavò SP, Lentini M, Magliolo E, Guarneri C
J Eur Acad Dermatol Venereol 2003 Sep;17(5):594-5. doi: 10.1046/j.1468-3083.2003.00809.x. PMID: 12941106
Chemotherapy for angiosarcoma of the breast: case report of 30-year survival and analysis of the literature.
Silverman LR, Deligdisch L, Mandeli J, Greenspan EM
Cancer Invest 1994;12(2):145-55. doi: 10.3109/07357909409024870. PMID: 8131091

Prognosis

Primary angiosarcoma of the vulva: report of a case misdiagnosed as a benign tumor.
Stolnicu S, Podoleanu C, Orban I, Stan O, Szabo B
Pol J Pathol 2021;72(2):167-169. doi: 10.5114/pjp.2021.109519. PMID: 34706524
Radiogenic angiosarcoma of the breast: case report and systematic review of the literature.
Dogan A, Kern P, Schultheis B, Häusler G, Rezniczek GA, Tempfer CB
BMC Cancer 2018 Apr 24;18(1):463. doi: 10.1186/s12885-018-4369-7. PMID: 29690864Free PMC Article
Fatal poorly differentiated angiosarcoma of the scalp.
Terada T
Int J Clin Exp Pathol 2010 May 10;3(5):541-4. PMID: 20606736Free PMC Article
Angiosarcoma arising in a chronically lymphoedematous leg.
Sinclair SA, Sviland L, Natarajan S
Br J Dermatol 1998 Apr;138(4):692-4. doi: 10.1046/j.1365-2133.1998.02188.x. PMID: 9640382
Chemotherapy for angiosarcoma of the breast: case report of 30-year survival and analysis of the literature.
Silverman LR, Deligdisch L, Mandeli J, Greenspan EM
Cancer Invest 1994;12(2):145-55. doi: 10.3109/07357909409024870. PMID: 8131091

Clinical prediction guides

Angiosarcomas of the breast developing post radiotherapy.
Parham DM, Fisher C
Histopathology 1997 Aug;31(2):189-95. doi: 10.1046/j.1365-2559.1997.5880824.x. PMID: 9279573

Recent systematic reviews

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature.
Dogan A, Kern P, Schultheis B, Häusler G, Rezniczek GA, Tempfer CB
BMC Cancer 2018 Apr 24;18(1):463. doi: 10.1186/s12885-018-4369-7. PMID: 29690864Free PMC Article

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