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Salivary gland adenosquamous carcinoma

MedGen UID:
277627
•Concept ID:
C1335894
•
Neoplastic Process
Synonyms: saliva-secreting gland adenosquamous carcinoma; Salivary Gland Adenosquamous Carcinoma; salivary gland adenosquamous carcinoma
 
Monarch Initiative: MONDO:0006401

Definition

A rare, aggressive carcinoma that arises from the salivary glands. It is characterized by the presence of a squamous and a glandular epithelial component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary gland adenosquamous carcinoma

Professional guidelines

PubMed

Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases.
Alos L, Castillo M, Nadal A, Caballero M, Mallofre C, Palacin A, Cardesa A
Histopathology 2004 Jun;44(6):570-9. doi: 10.1111/j.1365-2559.2004.01881.x. PMID: 15186272
Induction of cyclin-dependent kinase inhibitor, p21WAF1, by treatment with 3,4-dihydro-6-[4-(3,4)-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinoline (vesnarinone) in a human salivary cancer cell line with mutant p53 gene.
Sato M, Kawamata H, Harada K, Nakashiro K, Ikeda Y, Gohda H, Yoshida H, Nishida T, Ono K, Kinoshita M, Adachi M
Cancer Lett 1997 Jan 30;112(2):181-9. doi: 10.1016/s0304-3835(96)04581-8. PMID: 9066726

Recent clinical studies

Etiology

Mucoepidermoid Carcinoma of the Uterine Cervix-Single-Center Study Over a 10-Year Period.
Yordanov A, Karamanliev M, Tantchev L, Konsoulova A, Strashilov S, Vasileva-Slaveva M
Medicina (Kaunas) 2020 Jan 18;56(1) doi: 10.3390/medicina56010037. PMID: 31963763Free PMC Article
"Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features.
Saeki K, Ohishi Y, Matsuda R, Mochidome N, Miyasaka Y, Yamamoto H, Koga Y, Maehara Y, Nakamura M, Oda Y
Am J Surg Pathol 2018 Nov;42(11):1419-1428. doi: 10.1097/PAS.0000000000001135. PMID: 30138216
Ciliated Adenosquamous Carcinoma: Expanding the Phenotypic Diversity of Human Papillomavirus-Associated Tumors.
Radkay-Gonzalez L, Faquin W, McHugh JB, Lewis JS Jr, Tuluc M, Seethala RR
Head Neck Pathol 2016 Jun;10(2):167-75. Epub 2015 Sep 28 doi: 10.1007/s12105-015-0653-x. PMID: 26411881Free PMC Article
Mucoepidermoid carcinoma: a five-decade journey.
Chenevert J, Barnes LE, Chiosea SI
Virchows Arch 2011 Feb;458(2):133-40. Epub 2011 Jan 18 doi: 10.1007/s00428-011-1040-y. PMID: 21243374
Salivary gland-like tumours of the breast: surgical and molecular pathology.
Pia-Foschini M, Reis-Filho JS, Eusebi V, Lakhani SR
J Clin Pathol 2003 Jul;56(7):497-506. doi: 10.1136/jcp.56.7.497. PMID: 12835294Free PMC Article

Diagnosis

Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
ALK Rearrangements Characterize 2 Distinct Types of Salivary Gland Carcinomas: Clinicopathologic and Molecular Analysis of 4 Cases and Literature Review.
Agaimy A, Baněčková M, Ihrler S, Mueller SK, Franchi A, Hartmann A, Stoehr R, Skálová A
Am J Surg Pathol 2021 Sep 1;45(9):1166-1178. doi: 10.1097/PAS.0000000000001698. PMID: 33871952
Mucoepidermoid Carcinoma of the Uterine Cervix-Single-Center Study Over a 10-Year Period.
Yordanov A, Karamanliev M, Tantchev L, Konsoulova A, Strashilov S, Vasileva-Slaveva M
Medicina (Kaunas) 2020 Jan 18;56(1) doi: 10.3390/medicina56010037. PMID: 31963763Free PMC Article
Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression.
Williams L, Thompson LD, Seethala RR, Weinreb I, Assaad AM, Tuluc M, Ud Din N, Purgina B, Lai C, Griffith CC, Chiosea SI
Am J Surg Pathol 2015 May;39(5):705-13. doi: 10.1097/PAS.0000000000000413. PMID: 25871467
What the EWSR1-ATF1 fusion has taught us about hyalinizing clear cell carcinoma.
Tanguay J, Weinreb I
Head Neck Pathol 2013 Mar;7(1):28-34. Epub 2013 Mar 5 doi: 10.1007/s12105-013-0427-2. PMID: 23459838Free PMC Article

Therapy

A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results.
Chao KS, Deasy JO, Markman J, Haynie J, Perez CA, Purdy JA, Low DA
Int J Radiat Oncol Biol Phys 2001 Mar 15;49(4):907-16. doi: 10.1016/s0360-3016(00)01441-3. PMID: 11240231

Prognosis

Metastatic mucoepidermoid carcinoma to the pleura: a case report.
Mashiana S, Duarte EM
J Med Case Rep 2022 Feb 16;16(1):69. doi: 10.1186/s13256-022-03285-y. PMID: 35168684Free PMC Article
Mucoepidermoid Carcinoma of the Uterine Cervix-Single-Center Study Over a 10-Year Period.
Yordanov A, Karamanliev M, Tantchev L, Konsoulova A, Strashilov S, Vasileva-Slaveva M
Medicina (Kaunas) 2020 Jan 18;56(1) doi: 10.3390/medicina56010037. PMID: 31963763Free PMC Article
Mucoepidermoid carcinoma of the skin: a distinct entity from adenosquamous carcinoma: a case study with a review of the literature.
Riedlinger WF, Hurley MY, Dehner LP, Lind AC
Am J Surg Pathol 2005 Jan;29(1):131-5. doi: 10.1097/01.pas.0000147397.08853.6f. PMID: 15613868
Adenosquamous carcinoma of the mouth: a rare variant of squamous cell carcinoma.
Scully C, Porter SR, Speight PM, Eveson JW, Gale D
Int J Oral Maxillofac Surg 1999 Apr;28(2):125-8. PMID: 10102394
Adenosquamous carcinoma of the esophagus. A case report.
Bombí JA, Riverola A, Bordas JM, Cardesa A
Pathol Res Pract 1991 May;187(4):514-9; discussion 519-21. doi: 10.1016/S0344-0338(11)80016-6. PMID: 1876532

Clinical prediction guides

Don't SUMP it! Utility of PLAG1 immunocytochemistry in basaloid SUMP subcategory.
Sanchez-Avila M, Tjendra Y, Zuo Y, Ruiz-Cordero R, Garcia-Buitrago M, Jorda M, Gomez-Fernandez C, Velez Torres JM
Cancer Cytopathol 2024 Jan;132(1):60-68. Epub 2023 Sep 13 doi: 10.1002/cncy.22762. PMID: 37702124
Mucoepidermoid Carcinoma of the Uterine Cervix-Single-Center Study Over a 10-Year Period.
Yordanov A, Karamanliev M, Tantchev L, Konsoulova A, Strashilov S, Vasileva-Slaveva M
Medicina (Kaunas) 2020 Jan 18;56(1) doi: 10.3390/medicina56010037. PMID: 31963763Free PMC Article
Evaluation of real-time qualitative sonoelastography of focal lesions in the parotid and submandibular glands: applications and limitations.
Bhatia KS, Rasalkar DD, Lee YP, Wong KT, King AD, Yuen HY, Ahuja AT
Eur Radiol 2010 Aug;20(8):1958-64. Epub 2010 Apr 21 doi: 10.1007/s00330-010-1756-0. PMID: 20407904
Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma.
Achcar Rde O, Nikiforova MN, Dacic S, Nicholson AG, Yousem SA
Hum Pathol 2009 Jun;40(6):854-60. Epub 2009 Mar 9 doi: 10.1016/j.humpath.2008.11.007. PMID: 19269006
Immunohistochemical localization of keratin, vimentin and myosin in salivary gland tumors.
Matsushima R, Nakayama I, Shimizu M
Acta Pathol Jpn 1988 Apr;38(4):445-54. doi: 10.1111/j.1440-1827.1988.tb02318.x. PMID: 2456668

Recent systematic reviews

Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article

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