U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Small intestinal vasoactive intestinal peptide producing tumor

MedGen UID:
277655
•Concept ID:
C1336009
•
Neoplastic Process
Synonyms: Small Intestinal Vasoactive Intestinal Peptide Producing Tumor; small intestinal vasoactive intestinal peptide producing tumor; small intestinal VIP producing tumor; small intestinal VIP producing tumour; Small Intestinal VIP-Producing NET; small intestinal VIP-producing NET; Small Intestinal VIP-Producing Neuroendocrine Tumor; small intestinal VIP-producing neuroendocrine tumor; small intestinal VIP-producing neuroendocrine tumour; Small Intestinal VIPoma; small intestinal VIPoma
 
Monarch Initiative: MONDO:0003621

Definition

A neuroendocrine tumor that arises from the small intestine and produces vasoactive intestinal peptide. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall intestinal vasoactive intestinal peptide producing tumor

Professional guidelines

PubMed

Symptomatic and Radiological Response to 177Lu-DOTATATE for the Treatment of Functioning Pancreatic Neuroendocrine Tumors.
Zandee WT, Brabander T, Blažević A, Kam BLR, Teunissen JJM, Feelders RA, Hofland J, de Herder WW
J Clin Endocrinol Metab 2019 Apr 1;104(4):1336-1344. doi: 10.1210/jc.2018-01991. PMID: 30566620
Nuclear medicine in the detection and management of pancreatic islet-cell tumours.
Virgolini I, Traub-Weidinger T, Decristoforo C
Best Pract Res Clin Endocrinol Metab 2005 Jun;19(2):213-27. doi: 10.1016/j.beem.2004.09.001. PMID: 15763696
Morphologic patterns and diagnostic criteria of VIP-producing endocrine tumors. A histologic, histochemical, ultrastructural, and biochemical study of 32 cases.
Capella C, Polak JM, Buffa R, Tapia FJ, Heitz P, Usellini L, Bloom SR, Solcia E
Cancer 1983 Nov 15;52(10):1860-74. doi: 10.1002/1097-0142(19831115)52:10<1860::aid-cncr2820521017>3.0.co;2-f. PMID: 6627205

Recent clinical studies

Etiology

Symptomatic and Radiological Response to 177Lu-DOTATATE for the Treatment of Functioning Pancreatic Neuroendocrine Tumors.
Zandee WT, Brabander T, Blažević A, Kam BLR, Teunissen JJM, Feelders RA, Hofland J, de Herder WW
J Clin Endocrinol Metab 2019 Apr 1;104(4):1336-1344. doi: 10.1210/jc.2018-01991. PMID: 30566620
Results of Duodenopancreatic Reoperations in Multiple Endocrine Neoplasia Type 1.
Albers MB, Manoharan J, Bollmann C, Chlosta MP, Holzer K, Bartsch DK
World J Surg 2019 Feb;43(2):552-558. doi: 10.1007/s00268-018-4809-1. PMID: 30288555
Surgical experience with pancreatic and peripancreatic neuroendocrine tumors: review of 125 patients.
Phan GQ, Yeo CJ, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL
J Gastrointest Surg 1998 Sep-Oct;2(5):472-82. PMID: 9843608

Diagnosis

Life-threatening diarrhea in neuroendocrine tumors: two case reports.
Gordon E, Chan DL, Arena J, Bernard E, Carr-Boyd E, Clarke SJ, Itchins M, Learoyd D, Sandanayake N, Pavlakis N
J Med Case Rep 2021 Oct 27;15(1):542. doi: 10.1186/s13256-021-03096-7. PMID: 34706762Free PMC Article
Intractable and dramatic diarrhea in liver transplantation recipient with vasoactive intestinal peptide-producing tumor after split liver transplantation: a case report.
Haiqing W, Jiayin Y, Jian Y, Lunan Y
Transplant Proc 2015 Jan-Feb;47(1):171-3. Epub 2015 Jan 14 doi: 10.1016/j.transproceed.2014.07.078. PMID: 25596962
A 45-year-old female with hypokalemic rhabdomyolysis due to VIP-producing composite pheochromocytoma.
Ende K, Henkel B, Brodhun M, Salomon C, Lauten P, Conrad E, Seifert M, Stier A, Scharf JG
Z Gastroenterol 2012 Jun;50(6):589-94. Epub 2012 Jun 1 doi: 10.1055/s-0031-1299111. PMID: 22660994
In vitro identification of vasoactive intestinal peptide receptors in human tumors: implications for tumor imaging.
Reubi JC
J Nucl Med 1995 Oct;36(10):1846-53. PMID: 7562054
Hormone-producing gastrointestinal tumors contain a high density of somatostatin receptors.
Reubi JC, Häcki WH, Lamberts SW
J Clin Endocrinol Metab 1987 Dec;65(6):1127-34. doi: 10.1210/jcem-65-6-1127. PMID: 2824549

Therapy

Symptomatic and Radiological Response to 177Lu-DOTATATE for the Treatment of Functioning Pancreatic Neuroendocrine Tumors.
Zandee WT, Brabander T, Blažević A, Kam BLR, Teunissen JJM, Feelders RA, Hofland J, de Herder WW
J Clin Endocrinol Metab 2019 Apr 1;104(4):1336-1344. doi: 10.1210/jc.2018-01991. PMID: 30566620
Intractable and dramatic diarrhea in liver transplantation recipient with vasoactive intestinal peptide-producing tumor after split liver transplantation: a case report.
Haiqing W, Jiayin Y, Jian Y, Lunan Y
Transplant Proc 2015 Jan-Feb;47(1):171-3. Epub 2015 Jan 14 doi: 10.1016/j.transproceed.2014.07.078. PMID: 25596962
Nuclear medicine in the detection and management of pancreatic islet-cell tumours.
Virgolini I, Traub-Weidinger T, Decristoforo C
Best Pract Res Clin Endocrinol Metab 2005 Jun;19(2):213-27. doi: 10.1016/j.beem.2004.09.001. PMID: 15763696
Do elevated plasma vasoactive intestinal polypeptide (VIP) levels cause small intestinal motor disturbances in humans?
Keller J, Mueller-Wolf JC, Ahmadi-Simab K, Fibbe C, Rosien U, Layer P
Dig Dis Sci 2005 Feb;50(2):276-82. doi: 10.1007/s10620-005-1595-z. PMID: 15745085
Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison syndrome.
Pratz KW, Ma C, Aubry MC, Vrtiska TJ, Erlichman C
Mayo Clin Proc 2005 Jan;80(1):116-20. doi: 10.1016/S0025-6196(11)62968-6. PMID: 15667039

Prognosis

Life-threatening diarrhea in neuroendocrine tumors: two case reports.
Gordon E, Chan DL, Arena J, Bernard E, Carr-Boyd E, Clarke SJ, Itchins M, Learoyd D, Sandanayake N, Pavlakis N
J Med Case Rep 2021 Oct 27;15(1):542. doi: 10.1186/s13256-021-03096-7. PMID: 34706762Free PMC Article
Long-term survival after diagnosis of hepatic metastatic VIPoma: report of two cases with disparate courses and review of therapeutic options.
Nguyen HN, Backes B, Lammert F, Wildberger J, Winograd R, Busch N, Rieband H, Matern S
Dig Dis Sci 1999 Jun;44(6):1148-55. doi: 10.1023/a:1026672022917. PMID: 10389687
Surgical experience with pancreatic and peripancreatic neuroendocrine tumors: review of 125 patients.
Phan GQ, Yeo CJ, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL
J Gastrointest Surg 1998 Sep-Oct;2(5):472-82. PMID: 9843608
In vitro identification of vasoactive intestinal peptide receptors in human tumors: implications for tumor imaging.
Reubi JC
J Nucl Med 1995 Oct;36(10):1846-53. PMID: 7562054
Hormone-producing gastrointestinal tumors contain a high density of somatostatin receptors.
Reubi JC, Häcki WH, Lamberts SW
J Clin Endocrinol Metab 1987 Dec;65(6):1127-34. doi: 10.1210/jcem-65-6-1127. PMID: 2824549

Clinical prediction guides

Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone.
Chey WY, Frankel WL, Roy S, Datta S, Sen CK, Dillhoff M, Muscarella P, Soergel KH, Tompkins RK, Chang TM, Bradley EL 3rd, Ellison EC
Ann Surg 2017 Aug;266(2):346-352. doi: 10.1097/SLA.0000000000001938. PMID: 27501174Free PMC Article
Surgical experience with pancreatic and peripancreatic neuroendocrine tumors: review of 125 patients.
Phan GQ, Yeo CJ, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL
J Gastrointest Surg 1998 Sep-Oct;2(5):472-82. PMID: 9843608
In vitro identification of vasoactive intestinal peptide receptors in human tumors: implications for tumor imaging.
Reubi JC
J Nucl Med 1995 Oct;36(10):1846-53. PMID: 7562054
Cross-competition between vasoactive intestinal peptide and somatostatin for binding to tumor cell membrane receptors.
Virgolini I, Yang Q, Li S, Angelberger P, Neuhold N, Niederle B, Scheithauer W, Valent P
Cancer Res 1994 Feb 1;54(3):690-700. PMID: 7905785
Effect of somatostatin on diarrhea and on small intestinal water and electrolyte transport in a patient with pancreatic cholera.
Ruskoné A, René E, Chayvialle JA, Bonin N, Pignal F, Kremer M, Bonfils S, Rambaud JC
Dig Dis Sci 1982 May;27(5):459-66. doi: 10.1007/BF01295657. PMID: 6122550

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...