U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 2 Tumor Pain, CTCAE

MedGen UID:
281636
•Concept ID:
C1557608
•
Finding

Definition

Moderate pain; limiting instrumental ADL [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Tumor Pain, CTCAE

Professional guidelines

PubMed

Late adverse events in patients with pelvic cancer after oncologic treatment-intervention and treatment effect.
Iselius S, Knutsen A, Mikiver R, Uppugunduri S
Support Care Cancer 2023 Apr 13;31(5):263. doi: 10.1007/s00520-023-07733-3. PMID: 37055633Free PMC Article
Analysis of tolerance and security of chemo hyperthermia with Mitomycin C for the treatment of non-muscle invasive bladder cancer.
León-Mata J, Domínguez JL, Redorta JP, Sousa González D, Alvarez Casal M, Sousa Escandón A, Piñeiro Vázquez E
Arch Esp Urol 2018 May;71(4):426-437. PMID: 29745932
RTOG, CTCAE and WHO criteria for acute radiation dermatitis correlate with cutaneous blood flow measurements.
Huang CJ, Hou MF, Luo KH, Wei SY, Huang MY, Su SJ, Kuo HY, Yuan SS, Chen GS, Hu SC, Chuang HY
Breast 2015 Jun;24(3):230-6. Epub 2015 Mar 14 doi: 10.1016/j.breast.2015.01.008. PMID: 25777626

Recent clinical studies

Etiology

Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients.
Ahmadvand M, Barough MS, Barkhordar M, Faridfar A, Ghaderi A, Jalaeikhoo H, Rajaienejad M, Majidzadeh K, Ghavamzadeh A, Sarrami-Forooshani R
BMC Cancer 2023 Nov 10;23(1):1090. doi: 10.1186/s12885-023-11610-x. PMID: 37950209Free PMC Article
A randomized trial to evaluate the preventive effect of lafutidine on chemotherapy-induced peripheral neuropathy in patients treated with carboplatin and paclitaxel for lung cancer.
Cho K, Saikawa H, Hashimoto T, Katagiri H, Owada Y, Yakuwa K, Fujimura I, Utsumi Y, Akiyama M, Nagashima H, Takahashi F, Maemondo M
Ann Palliat Med 2023 Nov;12(6):1136-1145. Epub 2023 Sep 18 doi: 10.21037/apm-23-90. PMID: 37731302
Complications of Percutaneous Radiofrequency Ablation of Spinal Osseous Metastases: An 8-Year Single-Center Experience.
Tomasian A, Marlow J, Hillen TJ, Jennings JW
AJR Am J Roentgenol 2021 Jun;216(6):1607-1613. Epub 2021 Mar 31 doi: 10.2214/AJR.20.23494. PMID: 33787296
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180
Analysis of tolerance and security of chemo hyperthermia with Mitomycin C for the treatment of non-muscle invasive bladder cancer.
León-Mata J, Domínguez JL, Redorta JP, Sousa González D, Alvarez Casal M, Sousa Escandón A, Piñeiro Vázquez E
Arch Esp Urol 2018 May;71(4):426-437. PMID: 29745932

Diagnosis

Impact of Pain on Symptom Burden in Chemotherapy-Induced Peripheral Neurotoxicity.
Mahfouz FM, Li T, Timmins HC, Horvath LG, Harrison M, Grimison P, Marx G, Goldstein D, Park SB
J Natl Compr Canc Netw 2024 Feb 15;22(2):108-116. doi: 10.6004/jnccn.2023.7083. PMID: 38364373
Activated osteoarthritis following immune checkpoint inhibitor treatment: an observational study.
Reid P, Liew DF, Akruwala R, Bass AR, Chan KK
J Immunother Cancer 2021 Sep;9(9) doi: 10.1136/jitc-2021-003260. PMID: 34526389Free PMC Article
Ultrasound has limited diagnostic utility in children with acute lymphoblastic leukemia developing pancreatitis.
Richardson R, Morin CE, Wheeler CA, Guo Y, Li Y, Jeha S, Inaba H, Pui CH, Karol SE, McCarville MB
Pediatr Blood Cancer 2021 Jan;68(1):e28730. Epub 2020 Oct 27 doi: 10.1002/pbc.28730. PMID: 33111506Free PMC Article
Hypofractionated sequential radiotherapy boost: a promising strategy in inoperable locally advanced pancreatic cancer patients.
Mattiucci GC, Boldrini L, Nardangeli A, D'Aviero A, Buwenge M, Cellini F, Deodato F, Dinapoli N, Frascino V, Macchia G, Morganti AG, Valentini V
J Cancer Res Clin Oncol 2021 Mar;147(3):661-667. Epub 2020 Oct 1 doi: 10.1007/s00432-020-03411-7. PMID: 33001271
Acupuncture for Bortezomib-Induced Peripheral Neuropathy: Not Just for Pain.
Zhi WI, Ingram E, Li SQ, Chen P, Piulson L, Bao T
Integr Cancer Ther 2018 Dec;17(4):1079-1086. Epub 2018 Jul 20 doi: 10.1177/1534735418788667. PMID: 30027756Free PMC Article

Therapy

Impact of Pain on Symptom Burden in Chemotherapy-Induced Peripheral Neurotoxicity.
Mahfouz FM, Li T, Timmins HC, Horvath LG, Harrison M, Grimison P, Marx G, Goldstein D, Park SB
J Natl Compr Canc Netw 2024 Feb 15;22(2):108-116. doi: 10.6004/jnccn.2023.7083. PMID: 38364373
Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients.
Ahmadvand M, Barough MS, Barkhordar M, Faridfar A, Ghaderi A, Jalaeikhoo H, Rajaienejad M, Majidzadeh K, Ghavamzadeh A, Sarrami-Forooshani R
BMC Cancer 2023 Nov 10;23(1):1090. doi: 10.1186/s12885-023-11610-x. PMID: 37950209Free PMC Article
Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180
Analysis of tolerance and security of chemo hyperthermia with Mitomycin C for the treatment of non-muscle invasive bladder cancer.
León-Mata J, Domínguez JL, Redorta JP, Sousa González D, Alvarez Casal M, Sousa Escandón A, Piñeiro Vázquez E
Arch Esp Urol 2018 May;71(4):426-437. PMID: 29745932

Prognosis

Ultrasound has limited diagnostic utility in children with acute lymphoblastic leukemia developing pancreatitis.
Richardson R, Morin CE, Wheeler CA, Guo Y, Li Y, Jeha S, Inaba H, Pui CH, Karol SE, McCarville MB
Pediatr Blood Cancer 2021 Jan;68(1):e28730. Epub 2020 Oct 27 doi: 10.1002/pbc.28730. PMID: 33111506Free PMC Article
Hypofractionated sequential radiotherapy boost: a promising strategy in inoperable locally advanced pancreatic cancer patients.
Mattiucci GC, Boldrini L, Nardangeli A, D'Aviero A, Buwenge M, Cellini F, Deodato F, Dinapoli N, Frascino V, Macchia G, Morganti AG, Valentini V
J Cancer Res Clin Oncol 2021 Mar;147(3):661-667. Epub 2020 Oct 1 doi: 10.1007/s00432-020-03411-7. PMID: 33001271
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
Adverse Health Outcomes and Associations with Self-Reported General Health in Childhood Lymphoma Survivors.
Johannsdottir IMR, Hamre H, Fosså SD, Loge JH, Drolsum L, Lund MB, Nordsletten L, Kiserud C
J Adolesc Young Adult Oncol 2017 Sep;6(3):470-476. Epub 2017 Aug 24 doi: 10.1089/jayao.2017.0018. PMID: 28837384
Percutaneous cryoablation for inoperable malignant lung tumors: midterm results.
Chou HP, Chen CK, Shen SH, Sheu MH, Wu MH, Wu YC, Chang CY
Cryobiology 2015 Feb;70(1):60-5. Epub 2014 Dec 23 doi: 10.1016/j.cryobiol.2014.12.004. PMID: 25541142

Clinical prediction guides

Impact of Pain on Symptom Burden in Chemotherapy-Induced Peripheral Neurotoxicity.
Mahfouz FM, Li T, Timmins HC, Horvath LG, Harrison M, Grimison P, Marx G, Goldstein D, Park SB
J Natl Compr Canc Netw 2024 Feb 15;22(2):108-116. doi: 10.6004/jnccn.2023.7083. PMID: 38364373
Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients.
Ahmadvand M, Barough MS, Barkhordar M, Faridfar A, Ghaderi A, Jalaeikhoo H, Rajaienejad M, Majidzadeh K, Ghavamzadeh A, Sarrami-Forooshani R
BMC Cancer 2023 Nov 10;23(1):1090. doi: 10.1186/s12885-023-11610-x. PMID: 37950209Free PMC Article
Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
Activated osteoarthritis following immune checkpoint inhibitor treatment: an observational study.
Reid P, Liew DF, Akruwala R, Bass AR, Chan KK
J Immunother Cancer 2021 Sep;9(9) doi: 10.1136/jitc-2021-003260. PMID: 34526389Free PMC Article
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

Recent systematic reviews

Efficacy and safety of magnetic resonance-guided focused ultrasound for the treatment of painful bone metastases: a systematic review and meta-analysis.
Baal JD, Chen WC, Baal U, Wagle S, Baal JH, Link TM, Bucknor MD
Skeletal Radiol 2021 Dec;50(12):2459-2469. Epub 2021 May 21 doi: 10.1007/s00256-021-03822-8. PMID: 34018007Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...