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Bruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia, CTCAE

MedGen UID:
282006
•Concept ID:
C1559093
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia, CTCAE

Professional guidelines

PubMed

Initial analysis of the synergy of programmed cell death-1 (PD-1) inhibitor and concurrent chemoradiotherapy treatment for recurrent/metastatic head and neck squamous cell carcinoma patients.
Li L, Chen L, Yan L, Guo Y, Li F, Fan M, Lan M, Lai X, Zhou J, Huang Y, Xu P, Lang J, Feng M
Radiat Oncol 2023 Jul 4;18(1):109. doi: 10.1186/s13014-023-02310-8. PMID: 37403098Free PMC Article
Individualized 131I-mIBG therapy in the management of refractory and relapsed neuroblastoma.
George SL, Falzone N, Chittenden S, Kirk SJ, Lancaster D, Vaidya SJ, Mandeville H, Saran F, Pearson AD, Du Y, Meller ST, Denis-Bacelar AM, Flux GD
Nucl Med Commun 2016 May;37(5):466-72. doi: 10.1097/MNM.0000000000000470. PMID: 26813989Free PMC Article
Toxicity profile of temozolomide in the treatment of 300 malignant glioma patients in Korea.
Bae SH, Park MJ, Lee MM, Kim TM, Lee SH, Cho SY, Kim YH, Kim YJ, Park CK, Kim CY
J Korean Med Sci 2014 Jul;29(7):980-4. Epub 2014 Jul 11 doi: 10.3346/jkms.2014.29.7.980. PMID: 25045231Free PMC Article

Recent clinical studies

Etiology

Administering [(177)Lu]Lu-PSMA-617 Prior to Radical Prostatectomy in Men with High-risk Localised Prostate Cancer (LuTectomy): A Single-centre, Single-arm, Phase 1/2 Study.
Eapen RS, Buteau JP, Jackson P, Mitchell C, Oon SF, Alghazo O, McIntosh L, Dhiantravan N, Scalzo MJ, O'Brien J, Sandhu S, Azad AA, Williams SG, Sharma G, Haskali MB, Bressel M, Chen K, Jenjitranant P, McVey A, Moon D, Lawrentschuk N, Neeson PJ, Murphy DG, Hofman MS
Eur Urol 2024 Mar;85(3):217-226. Epub 2023 Oct 26 doi: 10.1016/j.eururo.2023.08.026. PMID: 37891072
Phase II trial demonstrates the efficacy and safety of individualized, dosimetry-based (177)Lu-DOTATATE treatment of NET patients.
Sundlöv A, Gleisner KS, Tennvall J, Ljungberg M, Warfvinge CF, Holgersson K, Hallqvist A, Bernhardt P, Svensson J
Eur J Nucl Med Mol Imaging 2022 Sep;49(11):3830-3840. Epub 2022 Apr 22 doi: 10.1007/s00259-022-05786-w. PMID: 35451612Free PMC Article
The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients.
de Jong C, Chargi N, Herder GJM, van Haarlem SWA, van der Meer F, van Lindert ASR, Ten Heuvel A, Brouwer J, de Jong PA, Devriese LA, Huitema ADR, Egberts TCG, de Bree R, Deneer VHM
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1554-1564. Epub 2022 Mar 18 doi: 10.1002/jcsm.12967. PMID: 35301821Free PMC Article
Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia.
Björn N, Sigurgeirsson B, Svedberg A, Pradhananga S, Brandén E, Koyi H, Lewensohn R, de Petris L, Apellániz-Ruiz M, Rodríguez-Antona C, Lundeberg J, Gréen H
Pharmacogenomics J 2020 Apr;20(2):179-191. Epub 2019 Oct 15 doi: 10.1038/s41397-019-0099-8. PMID: 31616045
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

Diagnosis

Hematologic abnormalities in Aicardi Goutières Syndrome.
Adang LA, Gavazzi F, D'Aiello R, Isaacs D, Bronner N, Arici ZS, Flores Z, Jan A, Scher C, Sherbini O, Behrens EM, Goldbach-Mansky R, Olson TS, Lambert MP, Sullivan KE, Teachey DT, Witmer C, Vanderver A, Shults J
Mol Genet Metab 2022 Aug;136(4):324-329. Epub 2022 Jun 16 doi: 10.1016/j.ymgme.2022.06.003. PMID: 35786528Free PMC Article
The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients.
de Jong C, Chargi N, Herder GJM, van Haarlem SWA, van der Meer F, van Lindert ASR, Ten Heuvel A, Brouwer J, de Jong PA, Devriese LA, Huitema ADR, Egberts TCG, de Bree R, Deneer VHM
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1554-1564. Epub 2022 Mar 18 doi: 10.1002/jcsm.12967. PMID: 35301821Free PMC Article
Feasibility and Therapeutic Potential of Combined Peptide Receptor Radionuclide Therapy With Intensive Chemotherapy for Pediatric Patients With Relapsed or Refractory Metastatic Neuroblastoma.
Fathpour G, Jafari E, Hashemi A, Dadgar H, Shahriari M, Zareifar S, Jenabzade AR, Vali R, Ahmadzadehfar H, Assadi M
Clin Nucl Med 2021 Jul 1;46(7):540-548. doi: 10.1097/RLU.0000000000003577. PMID: 33782280
The Effect of Concurrent Stereotactic Body Radiation and Anti-PD-1 Therapy for Recurrent Metastatic Sarcoma.
Callaghan CM, Seyedin SN, Mohiuddin IH, Hawkes KL, Petronek MS, Anderson CM, Buatti JM, Milhem MM, Monga V, Allen BG
Radiat Res 2020 Aug 1;194(2):124-132. doi: 10.1667/RADE-20-00017. PMID: 32845986Free PMC Article
Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia.
Björn N, Sigurgeirsson B, Svedberg A, Pradhananga S, Brandén E, Koyi H, Lewensohn R, de Petris L, Apellániz-Ruiz M, Rodríguez-Antona C, Lundeberg J, Gréen H
Pharmacogenomics J 2020 Apr;20(2):179-191. Epub 2019 Oct 15 doi: 10.1038/s41397-019-0099-8. PMID: 31616045

Therapy

Peptide receptor radionuclide therapy (PRRT) in metastatic neuroendocrine tumors of unknown primary (CUP-NETs).
Baum RP, Wang P, Jakobsson V, Zhao T, Schuchardt C, Khong PL, Zhang J
Theranostics 2024;14(1):133-142. Epub 2024 Jan 1 doi: 10.7150/thno.88619. PMID: 38164147Free PMC Article
Administering [(177)Lu]Lu-PSMA-617 Prior to Radical Prostatectomy in Men with High-risk Localised Prostate Cancer (LuTectomy): A Single-centre, Single-arm, Phase 1/2 Study.
Eapen RS, Buteau JP, Jackson P, Mitchell C, Oon SF, Alghazo O, McIntosh L, Dhiantravan N, Scalzo MJ, O'Brien J, Sandhu S, Azad AA, Williams SG, Sharma G, Haskali MB, Bressel M, Chen K, Jenjitranant P, McVey A, Moon D, Lawrentschuk N, Neeson PJ, Murphy DG, Hofman MS
Eur Urol 2024 Mar;85(3):217-226. Epub 2023 Oct 26 doi: 10.1016/j.eururo.2023.08.026. PMID: 37891072
Pooled Safety Analysis of Single-Agent Lurbinectedin in Patients With Advanced Solid Tumours.
Leary A, Oaknin A, Trigo JM, Moreno V, Delord JP, Boni V, Braña I, Fernández C, Kahatt C, Nieto A, Cullell-Young M, Zeaiter A, Subbiah V
Eur J Cancer 2023 Oct;192:113259. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113259. PMID: 37634282
Phase 2 trial of palbociclib and ganitumab in patients with relapsed Ewing sarcoma.
Shulman DS, Merriam P, Choy E, Guenther LM, Cavanaugh KL, Kao PC, Posner A, Bhushan K, Fairchild G, Barker E, Klega K, Stegmaier K, Crompton BD, London WB, DuBois SG
Cancer Med 2023 Jul;12(14):15207-15216. Epub 2023 Jun 12 doi: 10.1002/cam4.6208. PMID: 37306107Free PMC Article
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

Prognosis

Panobinostat in combination with bortezomib and dexamethasone in multiply relapsed and refractory myeloma; UK routine care cohort.
Maouche N, Kishore B, Bhatti Z, Basu S, Karim F, Sundararaman S, Collings F, Tseu B, Leary H, Ryman N, Reddy U, Vallance GD, Kothari J, Ramasamy K
PLoS One 2022;17(7):e0270854. Epub 2022 Jul 7 doi: 10.1371/journal.pone.0270854. PMID: 35797277Free PMC Article
The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients.
de Jong C, Chargi N, Herder GJM, van Haarlem SWA, van der Meer F, van Lindert ASR, Ten Heuvel A, Brouwer J, de Jong PA, Devriese LA, Huitema ADR, Egberts TCG, de Bree R, Deneer VHM
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1554-1564. Epub 2022 Mar 18 doi: 10.1002/jcsm.12967. PMID: 35301821Free PMC Article
Early vascular toxicity after pediatric allogeneic hematopoietic stem cell transplantation.
Leimi L, Jahnukainen K, Olkinuora H, Meri S, Vettenranta K
Bone Marrow Transplant 2022 May;57(5):705-711. Epub 2022 Feb 17 doi: 10.1038/s41409-022-01607-8. PMID: 35177827Free PMC Article
Phase II study of chidamide in combination with cisplatin in patients with metastatic triple-negative breast cancer.
Meng Y, Jin J, Gong C, Miao H, Tao Z, Li T, Cao J, Wang L, Wang B, Zhang J, Hu X
Ann Palliat Med 2021 Nov;10(11):11255-11264. Epub 2021 Oct 8 doi: 10.21037/apm-21-1139. PMID: 34670391
Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia.
Björn N, Sigurgeirsson B, Svedberg A, Pradhananga S, Brandén E, Koyi H, Lewensohn R, de Petris L, Apellániz-Ruiz M, Rodríguez-Antona C, Lundeberg J, Gréen H
Pharmacogenomics J 2020 Apr;20(2):179-191. Epub 2019 Oct 15 doi: 10.1038/s41397-019-0099-8. PMID: 31616045

Clinical prediction guides

Peptide receptor radionuclide therapy (PRRT) in metastatic neuroendocrine tumors of unknown primary (CUP-NETs).
Baum RP, Wang P, Jakobsson V, Zhao T, Schuchardt C, Khong PL, Zhang J
Theranostics 2024;14(1):133-142. Epub 2024 Jan 1 doi: 10.7150/thno.88619. PMID: 38164147Free PMC Article
Safety and efficacy of peptide receptor radionuclide therapy with (177)Lu-DOTA-EB-TATE in patients with metastatic neuroendocrine tumors.
Jiang Y, Liu Q, Wang G, Sui H, Wang R, Wang J, Zhang J, Zhu Z, Chen X
Theranostics 2022;12(15):6437-6445. Epub 2022 Sep 6 doi: 10.7150/thno.77219. PMID: 36185603Free PMC Article
Influence of pretreatment with everolimus or sunitinib on the subacute hematotoxicity of (177)Lu-DOTATATE PRRT.
Medaer E, Verslype C, Van Cutsem E, Dekervel J, Clement PM, Nackaerts K, Laenen A, Gheysens O, Goffin K, Jentjens S, Van Laere K, Deroose CM
Acta Oncol 2020 Jun;59(6):644-651. Epub 2020 Feb 8 doi: 10.1080/0284186X.2020.1723161. PMID: 32036716
Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia.
Björn N, Sigurgeirsson B, Svedberg A, Pradhananga S, Brandén E, Koyi H, Lewensohn R, de Petris L, Apellániz-Ruiz M, Rodríguez-Antona C, Lundeberg J, Gréen H
Pharmacogenomics J 2020 Apr;20(2):179-191. Epub 2019 Oct 15 doi: 10.1038/s41397-019-0099-8. PMID: 31616045
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

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