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Scirrhous adenocarcinoma

MedGen UID:
2873
•Concept ID:
C0007135
•
Neoplastic Process
Synonyms: Adenocarcinoma, Scirrhous; Adenocarcinomas, Scirrhous; Carcinoma, Scirrhous; Carcinomas, Scirrhous; Scirrhous Adenocarcinoma; Scirrhous Adenocarcinomas; Scirrhous Carcinoma; Scirrhous Carcinomas
SNOMED CT: Scirrhous adenocarcinoma (4584002); Scirrhous carcinoma (4584002); Carcinoma with productive fibrosis (4584002)
 
Monarch Initiative: MONDO:0005953

Definition

An infiltrating adenocarcinoma characterized by the presence of desmoplastic stromal reaction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVScirrhous adenocarcinoma

Professional guidelines

PubMed

The Genomic Signatures of Linitis Plastica Signal the Entrance into a New Era: Novel Approaches for Diagnosis and Treatment.
Christodoulidis G, Koumarelas KE, Kouliou MN, Samara M, Thodou E, Zacharoulis D
Int J Mol Sci 2023 Sep 28;24(19) doi: 10.3390/ijms241914680. PMID: 37834127Free PMC Article
Survival following operative management of gastric linitis plastica compared with non-operative management.
Thompson RJ, Ranaghan L, Kennedy R, Clements W, Carey PD, Kennedy JA
Ann R Coll Surg Engl 2017 Mar;99(3):228-232. Epub 2016 Nov 4 doi: 10.1308/rcsann.2016.0337. PMID: 27809576Free PMC Article
Familial gastric and pancreatic cancers: Diagnosis and screening.
Raymond VM, Stoffel EM
Am Soc Clin Oncol Educ Book 2013 doi: 10.14694/EdBook_AM.2013.33.e44. PMID: 23714452

Recent clinical studies

Etiology

Neoadjuvant chemotherapy for gastric cancer in Japan: a standing position by comparing with adjuvant chemotherapy.
Yoshikawa T, Rino Y, Yukawa N, Oshima T, Tsuburaya A, Masuda M
Surg Today 2014 Jan;44(1):11-21. Epub 2013 Mar 19 doi: 10.1007/s00595-013-0529-1. PMID: 23508452
Retrospective analysis of prognosis for scirrhous-type gastric cancer: one institution's experience.
Nakamura R, Saikawa Y, Wada N, Yoshida M, Kubota T, Kumai K, Kitajima M
Int J Clin Oncol 2007 Aug;12(4):291-4. Epub 2007 Aug 20 doi: 10.1007/s10147-007-0683-9. PMID: 17701009
Mach bands in mammography.
Gordenne WH, Malchair FL
Radiology 1988 Oct;169(1):55-8. doi: 10.1148/radiology.169.1.2843941. PMID: 2843941
Aspiration of breast cysts.
Dohrmann PJ, Hughes ES, McDermott FT, Price AB
Aust N Z J Surg 1982 Dec;52(6):605-7. doi: 10.1111/j.1445-2197.1982.tb06123.x. PMID: 6299260
Pregnancy and breast cancer.
Hubay CA, Barry FM, Marr CC
Surg Clin North Am 1978 Aug;58(4):819-31. doi: 10.1016/s0039-6109(16)41594-x. PMID: 210528

Diagnosis

Neoadjuvant chemotherapy for gastric cancer in Japan: a standing position by comparing with adjuvant chemotherapy.
Yoshikawa T, Rino Y, Yukawa N, Oshima T, Tsuburaya A, Masuda M
Surg Today 2014 Jan;44(1):11-21. Epub 2013 Mar 19 doi: 10.1007/s00595-013-0529-1. PMID: 23508452
Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma.
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S
Mod Pathol 2013 Jun;26(6):782-91. Epub 2013 Jan 25 doi: 10.1038/modpathol.2012.243. PMID: 23348905
Recent results of therapy for scirrhous gastric cancer.
Ikeguchi M, Miyake T, Matsunaga T, Yamamoto M, Fukumoto Y, Yamada Y, Fukuda K, Saito H, Tatebe S, Tsujitani S
Surg Today 2009;39(4):290-4. Epub 2009 Mar 25 doi: 10.1007/s00595-008-3860-1. PMID: 19319634
Pregnancy and breast cancer.
Hubay CA, Barry FM, Marr CC
Surg Clin North Am 1978 Aug;58(4):819-31. doi: 10.1016/s0039-6109(16)41594-x. PMID: 210528
Ultrasound mammography.
Baum G
Radiology 1977 Jan;122(1):199-205. doi: 10.1148/122.1.199. PMID: 186842

Therapy

Is FGFR2 a Suitable Target to Treat Scirrhous-Type Gastric Cancer?
Yasui W
Ann Surg Oncol 2019 Apr;26(4):926-927. Epub 2019 Jan 8 doi: 10.1245/s10434-018-07146-1. PMID: 30623340
Neoadjuvant chemotherapy for gastric cancer in Japan: a standing position by comparing with adjuvant chemotherapy.
Yoshikawa T, Rino Y, Yukawa N, Oshima T, Tsuburaya A, Masuda M
Surg Today 2014 Jan;44(1):11-21. Epub 2013 Mar 19 doi: 10.1007/s00595-013-0529-1. PMID: 23508452
RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility.
Matsuoka T, Yashiro M, Kato Y, Shinto O, Kashiwagi S, Hirakawa K
Clin Exp Metastasis 2011 Oct;28(7):627-36. Epub 2011 Jun 12 doi: 10.1007/s10585-011-9396-6. PMID: 21667311
Recent results of therapy for scirrhous gastric cancer.
Ikeguchi M, Miyake T, Matsunaga T, Yamamoto M, Fukumoto Y, Yamada Y, Fukuda K, Saito H, Tatebe S, Tsujitani S
Surg Today 2009;39(4):290-4. Epub 2009 Mar 25 doi: 10.1007/s00595-008-3860-1. PMID: 19319634
Aspiration of breast cysts.
Dohrmann PJ, Hughes ES, McDermott FT, Price AB
Aust N Z J Surg 1982 Dec;52(6):605-7. doi: 10.1111/j.1445-2197.1982.tb06123.x. PMID: 6299260

Prognosis

Is FGFR2 a Suitable Target to Treat Scirrhous-Type Gastric Cancer?
Yasui W
Ann Surg Oncol 2019 Apr;26(4):926-927. Epub 2019 Jan 8 doi: 10.1245/s10434-018-07146-1. PMID: 30623340
Neoadjuvant chemotherapy for gastric cancer in Japan: a standing position by comparing with adjuvant chemotherapy.
Yoshikawa T, Rino Y, Yukawa N, Oshima T, Tsuburaya A, Masuda M
Surg Today 2014 Jan;44(1):11-21. Epub 2013 Mar 19 doi: 10.1007/s00595-013-0529-1. PMID: 23508452
Clinicopathologic characteristics and long-term prognosis of scirrhous hepatocellular carcinoma.
Lee JH, Choi MS, Gwak GY, Lee JH, Koh KC, Paik SW, Yoo BC, Choi D, Park CK
Dig Dis Sci 2012 Jun;57(6):1698-707. Epub 2012 Feb 11 doi: 10.1007/s10620-012-2075-x. PMID: 22327241
Recent results of therapy for scirrhous gastric cancer.
Ikeguchi M, Miyake T, Matsunaga T, Yamamoto M, Fukumoto Y, Yamada Y, Fukuda K, Saito H, Tatebe S, Tsujitani S
Surg Today 2009;39(4):290-4. Epub 2009 Mar 25 doi: 10.1007/s00595-008-3860-1. PMID: 19319634
Pregnancy and breast cancer.
Hubay CA, Barry FM, Marr CC
Surg Clin North Am 1978 Aug;58(4):819-31. doi: 10.1016/s0039-6109(16)41594-x. PMID: 210528

Clinical prediction guides

Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer.
Sera T, Sakuma T, Maruo K, Tsujio G, Yamamoto Y, Sugimoto A, Kushiyama S, Togano S, Kuroda K, Kasashima H, Ohira M, Maeda K
Anticancer Res 2022 Nov;42(11):5195-5203. doi: 10.21873/anticanres.16026. PMID: 36288877
Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma.
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S
Mod Pathol 2013 Jun;26(6):782-91. Epub 2013 Jan 25 doi: 10.1038/modpathol.2012.243. PMID: 23348905
Clinical implications of metastases to the ovary.
Fujiwara K, Ohishi Y, Koike H, Sawada S, Moriya T, Kohno I
Gynecol Oncol 1995 Oct;59(1):124-8. doi: 10.1006/gyno.1995.1278. PMID: 7557597
Vitamin C and cancer: an overview.
Cameron E
Int J Vitam Nutr Res Suppl 1982;23:115-27. PMID: 6180998
Pregnancy and breast cancer.
Hubay CA, Barry FM, Marr CC
Surg Clin North Am 1978 Aug;58(4):819-31. doi: 10.1016/s0039-6109(16)41594-x. PMID: 210528

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