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Grade 2 Pancreatitis, CTCAE

MedGen UID:
291733
•Concept ID:
C1556678
•
Finding

Definition

Enzyme elevation; radiologic findings only [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Pancreatitis, CTCAE

Professional guidelines

PubMed

Incorporating Yttrium-90 trans-arterial radioembolization (TARE) in the treatment of metastatic pancreatic adenocarcioma: a single center experience.
Kim AY, Unger K, Wang H, Pishvaian MJ
BMC Cancer 2016 Jul 18;16:492. doi: 10.1186/s12885-016-2552-2. PMID: 27430276Free PMC Article
A retrospective study of capecitabine/temozolomide (CAPTEM) regimen in the treatment of metastatic pancreatic neuroendocrine tumors (pNETs) after failing previous therapy.
Saif MW, Kaley K, Brennan M, Garcon MC, Rodriguez G, Rodriguez T
JOP 2013 Sep 10;14(5):498-501. doi: 10.6092/1590-8577/1589. PMID: 24018594
Unresectable locally advanced pancreatic cancer: a multimodal treatment using neoadjuvant chemoradiotherapy (gemcitabine plus stereotactic radiosurgery) and subsequent surgical exploration.
Polistina F, Costantin G, Casamassima F, Francescon P, Guglielmi R, Panizzoni G, Febbraro A, Ambrosino G
Ann Surg Oncol 2010 Aug;17(8):2092-101. Epub 2010 Mar 12 doi: 10.1245/s10434-010-1019-y. PMID: 20224860

Recent clinical studies

Etiology

Cytoreduction and Hyperthermic Intraperitoneal Paclitaxel and Cisplatin for Gastric Cancer with Peritoneal Metastasis.
Buckarma E, Thiels CA, Jin Z, Grotz TE
Ann Surg Oncol 2024 Jan;31(1):622-629. Epub 2023 Oct 26 doi: 10.1245/s10434-023-14379-2. PMID: 37880514
Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
Hypofractionated sequential radiotherapy boost: a promising strategy in inoperable locally advanced pancreatic cancer patients.
Mattiucci GC, Boldrini L, Nardangeli A, D'Aviero A, Buwenge M, Cellini F, Deodato F, Dinapoli N, Frascino V, Macchia G, Morganti AG, Valentini V
J Cancer Res Clin Oncol 2021 Mar;147(3):661-667. Epub 2020 Oct 1 doi: 10.1007/s00432-020-03411-7. PMID: 33001271
Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens.
Denton CC, Rawlins YA, Oberley MJ, Bhojwani D, Orgel E
Pediatr Blood Cancer 2018 Mar;65(3) Epub 2017 Dec 8 doi: 10.1002/pbc.26891. PMID: 29218844Free PMC Article
Dose-Volume Histogram Analysis of Stereotactic Body Radiotherapy Treatment of Pancreatic Cancer: A Focus on Duodenal Dose Constraints.
Goldsmith C, Price P, Cross T, Loughlin S, Cowley I, Plowman N
Semin Radiat Oncol 2016 Apr;26(2):149-56. Epub 2015 Dec 24 doi: 10.1016/j.semradonc.2015.12.002. PMID: 27000512

Diagnosis

Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
Docetaxel monotherapy induces necrotic acute pancreatitis.
Ben Abdallah I, Berrazega Y, Rachdi H, Mejri N, Neji H, Daoud N, Boussen H
J Oncol Pharm Pract 2022 Sep;28(6):1446-1449. Epub 2022 Jan 24 doi: 10.1177/10781552221075541. PMID: 35068260
Hypofractionated sequential radiotherapy boost: a promising strategy in inoperable locally advanced pancreatic cancer patients.
Mattiucci GC, Boldrini L, Nardangeli A, D'Aviero A, Buwenge M, Cellini F, Deodato F, Dinapoli N, Frascino V, Macchia G, Morganti AG, Valentini V
J Cancer Res Clin Oncol 2021 Mar;147(3):661-667. Epub 2020 Oct 1 doi: 10.1007/s00432-020-03411-7. PMID: 33001271
Stereotactic Body Radiotherapy for Elderly Patients With Medically Inoperable Pancreatic Cancer.
Yechieli RL, Robbins JR, Mahan M, Siddiqui F, Ajlouni M
Am J Clin Oncol 2017 Feb;40(1):22-26. doi: 10.1097/COC.0000000000000090. PMID: 24879474
Phase II trial of epidermal growth factor ointment for patients with Erlotinib-related skin effects.
Hwang IG, Kang JH, Oh SY, Lee S, Kim SH, Song KH, Son C, Park MJ, Kang MH, Kim HG, Lee J, Park YS, Sun JM, Kim HJ, Kim CK, Yi SY, Jang JS, Park K, Kim HJ
Support Care Cancer 2016 Jan;24(1):301-309. Epub 2015 Jun 4 doi: 10.1007/s00520-015-2783-9. PMID: 26041481

Therapy

Cytoreduction and Hyperthermic Intraperitoneal Paclitaxel and Cisplatin for Gastric Cancer with Peritoneal Metastasis.
Buckarma E, Thiels CA, Jin Z, Grotz TE
Ann Surg Oncol 2024 Jan;31(1):622-629. Epub 2023 Oct 26 doi: 10.1245/s10434-023-14379-2. PMID: 37880514
Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis.
Holmstroem RB, Nielsen OH, Jacobsen S, Riis LB, Theile S, Bjerrum JT, Vilmann P, Johansen JS, Boisen MK, Eefsen RHL, Marie Svane I, Nielsen DL, Chen IM
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005111. PMID: 36096534Free PMC Article
Hypofractionated sequential radiotherapy boost: a promising strategy in inoperable locally advanced pancreatic cancer patients.
Mattiucci GC, Boldrini L, Nardangeli A, D'Aviero A, Buwenge M, Cellini F, Deodato F, Dinapoli N, Frascino V, Macchia G, Morganti AG, Valentini V
J Cancer Res Clin Oncol 2021 Mar;147(3):661-667. Epub 2020 Oct 1 doi: 10.1007/s00432-020-03411-7. PMID: 33001271
Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens.
Denton CC, Rawlins YA, Oberley MJ, Bhojwani D, Orgel E
Pediatr Blood Cancer 2018 Mar;65(3) Epub 2017 Dec 8 doi: 10.1002/pbc.26891. PMID: 29218844Free PMC Article

Prognosis

Cytoreduction and Hyperthermic Intraperitoneal Paclitaxel and Cisplatin for Gastric Cancer with Peritoneal Metastasis.
Buckarma E, Thiels CA, Jin Z, Grotz TE
Ann Surg Oncol 2024 Jan;31(1):622-629. Epub 2023 Oct 26 doi: 10.1245/s10434-023-14379-2. PMID: 37880514
Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
Combined use of 177Lu-DOTATATE and metronomic capecitabine (Lu-X) in FDG-positive gastro-entero-pancreatic neuroendocrine tumors.
Nicolini S, Bodei L, Bongiovanni A, Sansovini M, Grassi I, Ibrahim T, Monti M, Caroli P, Sarnelli A, Diano D, Di Iorio V, Grana CM, Cittanti C, Pieri F, Severi S, Paganelli G
Eur J Nucl Med Mol Imaging 2021 Sep;48(10):3260-3267. Epub 2021 Feb 18 doi: 10.1007/s00259-021-05236-z. PMID: 33604690Free PMC Article
Hypofractionated sequential radiotherapy boost: a promising strategy in inoperable locally advanced pancreatic cancer patients.
Mattiucci GC, Boldrini L, Nardangeli A, D'Aviero A, Buwenge M, Cellini F, Deodato F, Dinapoli N, Frascino V, Macchia G, Morganti AG, Valentini V
J Cancer Res Clin Oncol 2021 Mar;147(3):661-667. Epub 2020 Oct 1 doi: 10.1007/s00432-020-03411-7. PMID: 33001271
Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens.
Denton CC, Rawlins YA, Oberley MJ, Bhojwani D, Orgel E
Pediatr Blood Cancer 2018 Mar;65(3) Epub 2017 Dec 8 doi: 10.1002/pbc.26891. PMID: 29218844Free PMC Article

Clinical prediction guides

Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial.
Corti F, Brizzi MP, Amoroso V, Giuffrida D, Panzuto F, Campana D, Prinzi N, Milione M, Cascella T, Spreafico C, Randon G, Oldani S, Leporati R, Scotto G, Pulice I, Stocchetti BL, Porcu L, Coppa J, Di Bartolomeo M, de Braud F, Pusceddu S
BMC Cancer 2023 Sep 26;23(1):908. doi: 10.1186/s12885-023-11287-2. PMID: 37752423Free PMC Article
Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens.
Denton CC, Rawlins YA, Oberley MJ, Bhojwani D, Orgel E
Pediatr Blood Cancer 2018 Mar;65(3) Epub 2017 Dec 8 doi: 10.1002/pbc.26891. PMID: 29218844Free PMC Article
Stereotactic Body Radiotherapy for Elderly Patients With Medically Inoperable Pancreatic Cancer.
Yechieli RL, Robbins JR, Mahan M, Siddiqui F, Ajlouni M
Am J Clin Oncol 2017 Feb;40(1):22-26. doi: 10.1097/COC.0000000000000090. PMID: 24879474

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