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Grade 3 Oral Pain, CTCAE

MedGen UID:
291942
•Concept ID:
C1557524
•
Finding

Definition

Severe pain; limiting self care ADL [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Oral Pain, CTCAE

Recent clinical studies

Etiology

Risk factors for oral mucositis during chemotherapy treatment for solid tumors: a retrospective STROBE-guided study.
Martins JO, Borges MM, Malta CE, Carlos AC, Crispim AA, Moura JF, Fernandes-Lima IJ, Silva PG
Med Oral Patol Oral Cir Bucal 2022 Jul 1;27(4):e319-e329. doi: 10.4317/medoral.25253. PMID: 35717621Free PMC Article
Evaluation of the efficacy of the anti-ulcer oral mucosal protective agent RADoralex® in the prevention and treatment of radiation-induced oral mucosal reactions induced during treatment of nasopharyngeal carcinoma.
Yin J, Xie J, Lin J, Weng C, Lu S, Xu P, Zhang S, Luo C, Huang Y, Li L, Lang J, Feng M
Cancer Biol Ther 2022 Dec 31;23(1):27-33. Epub 2022 Jan 6 doi: 10.1080/15384047.2021.2013704. PMID: 34989325Free PMC Article
Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1.
Forner LE, Dieleman FJ, Shaw RJ, Kanatas A, Butterworth CJ, Kjeller G, Alsner J, Overgaard J, Hillerup S, Hyldegaard O, Arnell P, von Buchwald C, Kaanders JHAM, Smeele LE, Specht L, Johansen J, Witjes MJH, Merkx MAW, Jansen EC
Radiother Oncol 2022 Jan;166:137-144. Epub 2021 Nov 26 doi: 10.1016/j.radonc.2021.11.021. PMID: 34843843
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180
A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer.
Wong KH, Kuciejewska A, Sharabiani MTA, Ng-Cheng-Hin B, Hoy S, Hurley T, Rydon J, Grove L, Santos A, Ryugenji M, Bhide SA, Nutting CM, Harrington KJ, Newbold KL
Radiother Oncol 2017 Feb;122(2):207-211. Epub 2016 Jul 5 doi: 10.1016/j.radonc.2016.06.015. PMID: 27393218Free PMC Article

Diagnosis

Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy.
Nielsen SW, Hasselsteen SD, Dominiak HSH, Labudovic D, Reiter L, Dalton SO, Herrstedt J
Support Care Cancer 2022 Nov;30(11):9441-9451. Epub 2022 Aug 6 doi: 10.1007/s00520-022-07312-y. PMID: 35933415
A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma.
Chung CH, Rudek MA, Kang H, Marur S, John P, Tsottles N, Bonerigo S, Veasey A, Kiess A, Quon H, Cmelak A, Murphy BA, Gilbert J
Oral Oncol 2016 Feb;53:54-9. Epub 2015 Dec 17 doi: 10.1016/j.oraloncology.2015.11.020. PMID: 26705063Free PMC Article

Therapy

Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy.
Nielsen SW, Hasselsteen SD, Dominiak HSH, Labudovic D, Reiter L, Dalton SO, Herrstedt J
Support Care Cancer 2022 Nov;30(11):9441-9451. Epub 2022 Aug 6 doi: 10.1007/s00520-022-07312-y. PMID: 35933415
Evaluation of the efficacy of the anti-ulcer oral mucosal protective agent RADoralex® in the prevention and treatment of radiation-induced oral mucosal reactions induced during treatment of nasopharyngeal carcinoma.
Yin J, Xie J, Lin J, Weng C, Lu S, Xu P, Zhang S, Luo C, Huang Y, Li L, Lang J, Feng M
Cancer Biol Ther 2022 Dec 31;23(1):27-33. Epub 2022 Jan 6 doi: 10.1080/15384047.2021.2013704. PMID: 34989325Free PMC Article
Proton therapy for non-squamous cell carcinoma of the head and neck: planning comparison and toxicity.
Iwata H, Toshito T, Hayashi K, Yamada M, Omachi C, Nakajima K, Hattori Y, Hashimoto S, Kuroda Y, Okumura Y, Mizoe JE, Ogino H, Shibamoto Y
J Radiat Res 2019 Oct 23;60(5):612-621. doi: 10.1093/jrr/rrz036. PMID: 31147697Free PMC Article
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

Clinical prediction guides

Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy.
Nielsen SW, Hasselsteen SD, Dominiak HSH, Labudovic D, Reiter L, Dalton SO, Herrstedt J
Support Care Cancer 2022 Nov;30(11):9441-9451. Epub 2022 Aug 6 doi: 10.1007/s00520-022-07312-y. PMID: 35933415
Evaluation of the efficacy of the anti-ulcer oral mucosal protective agent RADoralex® in the prevention and treatment of radiation-induced oral mucosal reactions induced during treatment of nasopharyngeal carcinoma.
Yin J, Xie J, Lin J, Weng C, Lu S, Xu P, Zhang S, Luo C, Huang Y, Li L, Lang J, Feng M
Cancer Biol Ther 2022 Dec 31;23(1):27-33. Epub 2022 Jan 6 doi: 10.1080/15384047.2021.2013704. PMID: 34989325Free PMC Article
Patterns of oral mucositis in advanced oral squamous cell carcinoma patients managed with prophylactic photobiomodulation therapy-insights for future protocol development.
de Pauli Paglioni M, Faria KM, Palmier NR, Prado-Ribeiro AC, E Dias RB, da Graça Pinto H, Treister NS, Epstein JB, Migliorati CA, Santos-Silva AR, Brandão TB
Lasers Med Sci 2021 Mar;36(2):429-436. Epub 2020 Jul 5 doi: 10.1007/s10103-020-03091-2. PMID: 32627112
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

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