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Invasive hydatidiform mole

MedGen UID:
3055
•Concept ID:
C0008493
•
Neoplastic Process
Synonyms: Chorioadenoma; Chorioadenomas; Hydatidiform Mole, Invasive; Hydatidiform Moles, Invasive; Invasive Hydatidiform Mole; Invasive Hydatidiform Moles; Invasive Mole; Invasive Moles; Mole, Invasive; Mole, Invasive Hydatidiform; Moles, Invasive; Moles, Invasive Hydatidiform
SNOMED CT: Invasive hydatidiform mole (416669000); Chorioadenoma (416669000); Chorioadenoma destruens (416669000); IM - Invasive mole (416669000); Invasive mole (416669000); Invasive mole - placenta (416669000); Invasive hydatidiform mole (18799007); Malignant hydatidiform mole (18799007); Chorioadenoma destruens (18799007); Chorioadenoma (18799007); Invasive mole (18799007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0020549
Orphanet: ORPHA99925

Definition

A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometriumand histologically characterized hyperplasia of trophoblasts, generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. Indicative signs include persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after evacuation of a hydatidiform mole. Metastases (in the lungs or vagina) may be observed. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive hydatidiform mole

Professional guidelines

PubMed

Gestational trophoblastic neoplasia: does centralization of care impact clinical management?
Mitric C, Yang K, Bhat G, Lheureux S, Laframboise S, Li X, Bouchard-Fortier G
Int J Gynecol Cancer 2023 Nov 6;33(11):1724-1732. doi: 10.1136/ijgc-2023-004526. PMID: 37723102
Gestational trophoblastic diseases - clinical guidelines for diagnosis, treatment, follow-up, and counselling.
Niemann I, Vejerslev LO, Frøding L, Blaakær J, Maroun LL, Hansen ES, Grove A, Lund H, Havsteen H, Sunde L
Dan Med J 2015 Nov;62(11):A5082. PMID: 26522484
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article

Recent clinical studies

Etiology

Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A
J Matern Fetal Neonatal Med 2018 Feb;31(3):271-277. Epub 2017 Feb 2 doi: 10.1080/14767058.2017.1281906. PMID: 28093002
Invasive mole in a perimenopausal woman: a case report and systematic review.
von Welser SF, Grube M, Ortmann O
Arch Gynecol Obstet 2015 Dec;292(6):1193-9. Epub 2015 Jun 7 doi: 10.1007/s00404-015-3777-z. PMID: 26050078
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article
Pathology of gestational trophoblastic diseases.
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885
Gestational trophoblastic neoplasms.
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Diagnosis

Cornual invasive hydatidiform mole: a rare case report and literature review.
Qian J, Xu S, Chen L
BMC Womens Health 2023 Nov 2;23(1):566. doi: 10.1186/s12905-023-02727-z. PMID: 37919704Free PMC Article
Invasive Mole After Incomplete Miscarriage.
Habek D
Z Geburtshilfe Neonatol 2022 Aug;226(4):282. Epub 2022 Mar 9 doi: 10.1055/a-1742-3767. PMID: 35263771
Invasive mole with lung metastasis after an abdominal complete hydatidiform mole treatment.
Suzuki S, Takahashi K, Obayashi S, Kitazawa M, Kuroda H, Fukasawa I
J Obstet Gynaecol Res 2021 Jan;47(1):420-424. Epub 2020 Oct 20 doi: 10.1111/jog.14537. PMID: 33078868
Pathology of gestational trophoblastic diseases.
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885
Gestational trophoblastic neoplasms.
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Therapy

Invasive mole in a perimenopausal woman: a case report and systematic review.
von Welser SF, Grube M, Ortmann O
Arch Gynecol Obstet 2015 Dec;292(6):1193-9. Epub 2015 Jun 7 doi: 10.1007/s00404-015-3777-z. PMID: 26050078
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article
Invasive mole.
Franke HR, Vermorken JB, von Kessel H, Dijkhuizen GH, Calame JJ, Stolk JG
Eur J Obstet Gynecol Reprod Biol 1986 Mar;21(3):181-5. doi: 10.1016/0028-2243(86)90034-1. PMID: 3007229
Invasive mole.
Lurain JR, Brewer JI
Semin Oncol 1982 Jun;9(2):174-80. PMID: 6289460
Gestational trophoblastic neoplasms.
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Prognosis

Invasive and metastatic hydatidiform moles in Slovakia in 1993‒2022.
McCullough L, Danihel L, Sufliarsky J, Kubickova M, Niznanska Z, Adamec A, Korbel M
Bratisl Lek Listy 2024;125(7):423-428. doi: 10.4149/BLL_2024_65. PMID: 38943503
Gut Microbial Diversity in Female Patients With Invasive Mole and Choriocarcinoma and Its Differences Versus Healthy Controls.
Liu X, Pan X, Liu H, Ma X
Front Cell Infect Microbiol 2021;11:704100. Epub 2021 Aug 26 doi: 10.3389/fcimb.2021.704100. PMID: 34513727Free PMC Article
Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A
J Matern Fetal Neonatal Med 2018 Feb;31(3):271-277. Epub 2017 Feb 2 doi: 10.1080/14767058.2017.1281906. PMID: 28093002
Pathology of gestational trophoblastic diseases.
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885
Trophoblastic tumors--prognostic factors.
Jones WB
Cancer 1981 Jul 15;48(2 Suppl):602-7. doi: 10.1002/1097-0142(19810715)48:1+<602::aid-cncr2820481326>3.0.co;2-8. PMID: 6268287

Clinical prediction guides

Gut Microbial Diversity in Female Patients With Invasive Mole and Choriocarcinoma and Its Differences Versus Healthy Controls.
Liu X, Pan X, Liu H, Ma X
Front Cell Infect Microbiol 2021;11:704100. Epub 2021 Aug 26 doi: 10.3389/fcimb.2021.704100. PMID: 34513727Free PMC Article
Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A
J Matern Fetal Neonatal Med 2018 Feb;31(3):271-277. Epub 2017 Feb 2 doi: 10.1080/14767058.2017.1281906. PMID: 28093002
Differential expression of E-cadherin, β-catenin, and Lewis x between invasive hydatidiform moles and post-molar choriocarcinomas.
Candelier JJ, Frappart L, Diatta AL, Yadaden T, Cissé ML, Afoutou JM, Picard JY, Mennesson B, Slim R, Si-Tayeb K, Coullin P
Virchows Arch 2013 Jun;462(6):653-63. Epub 2013 May 17 doi: 10.1007/s00428-013-1427-z. PMID: 23681114
New discoveries on the biology and detection of human chorionic gonadotropin.
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article
Pathology of gestational trophoblastic diseases.
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885

Recent systematic reviews

Invasive mole in a perimenopausal woman: a case report and systematic review.
von Welser SF, Grube M, Ortmann O
Arch Gynecol Obstet 2015 Dec;292(6):1193-9. Epub 2015 Jun 7 doi: 10.1007/s00404-015-3777-z. PMID: 26050078
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article

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