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Granulocytes Increased in Bone Marrow

MedGen UID:
307520
•Concept ID:
C1512271
•
Finding

Definition

An indication that the number of granulocytes in a bone marrow sample have increased when compared to a normal baseline or a previous sample measurement. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranulocytes Increased in Bone Marrow

Professional guidelines

PubMed

Evidence in support of the bone marrow as the primary lesion in axial spondyloarthritis.
Maksymowych WP
Curr Opin Rheumatol 2023 Jul 1;35(4):213-218. Epub 2023 Apr 27 doi: 10.1097/BOR.0000000000000945. PMID: 37115850
Neonatal neutropenia: what diagnostic evaluation is needed and when is treatment recommended?
Del Vecchio A, Christensen RD
Early Hum Dev 2012 May;88 Suppl 2:S19-24. doi: 10.1016/S0378-3782(12)70007-5. PMID: 22633505
Lithium in the treatment of neutropenia.
Petrini M, Azzarà A
Curr Opin Hematol 2012 Jan;19(1):52-7. doi: 10.1097/MOH.0b013e32834da93b. PMID: 22123660

Recent clinical studies

Therapy

Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy.
Scala S, Ferrua F, Basso-Ricci L, Dionisio F, Omrani M, Quaranta P, Jofra Hernandez R, Del Core L, Benedicenti F, Monti I, Giannelli S, Fraschetta F, Darin S, Albertazzi E, Galimberti S, Montini E, Calabria A, Cicalese MP, Aiuti A
Nat Commun 2023 May 27;14(1):3068. doi: 10.1038/s41467-023-38448-y. PMID: 37244942Free PMC Article
Neutrophil hitchhiking for drug delivery to the bone marrow.
Luo Z, Lu Y, Shi Y, Jiang M, Shan X, Li X, Zhang J, Qin B, Liu X, Guo X, Huang J, Liu Y, Wang S, Li Q, Luo L, You J
Nat Nanotechnol 2023 Jun;18(6):647-656. Epub 2023 Apr 20 doi: 10.1038/s41565-023-01374-7. PMID: 37081080
Granulocyte transfusion therapy.
Marfin AA, Price TH
J Intensive Care Med 2015 Feb;30(2):79-88. Epub 2013 Aug 5 doi: 10.1177/0885066613498045. PMID: 23920161
Eosinophilia in mast cell disease.
Kovalszki A, Weller PF
Immunol Allergy Clin North Am 2014 May;34(2):357-64. Epub 2014 Mar 13 doi: 10.1016/j.iac.2014.01.013. PMID: 24745679Free PMC Article
Hepatitis C and neutropenia.
Sheehan VA, Weir A, Waters B
Curr Opin Hematol 2014 Jan;21(1):58-63. doi: 10.1097/MOH.0000000000000006. PMID: 24257097

Prognosis

Eosinophils as potential biomarkers in respiratory viral infections.
Macchia I, La Sorsa V, Urbani F, Moretti S, Antonucci C, Afferni C, Schiavoni G
Front Immunol 2023;14:1170035. Epub 2023 Jul 6 doi: 10.3389/fimmu.2023.1170035. PMID: 37483591Free PMC Article
Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Severe congenital neutropenias.
Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K
Nat Rev Dis Primers 2017 Jun 8;3:17032. doi: 10.1038/nrdp.2017.32. PMID: 28593997Free PMC Article
Neutrophil left shift and white blood cell count as markers of bacterial infection.
Honda T, Uehara T, Matsumoto G, Arai S, Sugano M
Clin Chim Acta 2016 Jun 1;457:46-53. Epub 2016 Mar 28 doi: 10.1016/j.cca.2016.03.017. PMID: 27034055
Preleukemias.
Nowell PC
Hum Pathol 1981 Jun;12(6):522-30. doi: 10.1016/s0046-8177(81)80066-4. PMID: 7275093

Clinical prediction guides

Immature granulocytes: Innovative biomarker for SARS‑CoV‑2 infection.
Georgakopoulou VE, Makrodimitri S, Triantafyllou M, Samara S, Voutsinas PM, Anastasopoulou A, Papageorgiou CV, Spandidos DA, Gkoufa A, Papalexis P, Xenou E, Chelidonis G, Sklapani P, Trakas N, Sipsas NV
Mol Med Rep 2022 Jul;26(1) Epub 2022 May 13 doi: 10.3892/mmr.2022.12733. PMID: 35551416Free PMC Article
Hemophagocytic histiocytosis in severe SARS-CoV-2 infection: A bone marrow study.
Dandu H, Yadav G, Malhotra HS, Pandey S, Sachu R, Dubey K
Int J Lab Hematol 2021 Dec;43(6):1291-1301. Epub 2021 Jun 4 doi: 10.1111/ijlh.13619. PMID: 34086418Free PMC Article
ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions.
Germic N, Hosseini A, Stojkov D, Oberson K, Claus M, Benarafa C, Calzavarini S, Angelillo-Scherrer A, Arnold IC, Müller A, Riether C, Yousefi S, Simon HU
Blood 2021 May 27;137(21):2958-2969. doi: 10.1182/blood.2020010208. PMID: 33598715Free PMC Article
Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration.
Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Masson GS, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M
Nat Neurosci 2018 Sep;21(9):1209-1217. Epub 2018 Aug 27 doi: 10.1038/s41593-018-0213-2. PMID: 30150661Free PMC Article
Preleukemias.
Nowell PC
Hum Pathol 1981 Jun;12(6):522-30. doi: 10.1016/s0046-8177(81)80066-4. PMID: 7275093

Recent systematic reviews

Effectiveness of Acupuncture for Relieving Chemotherapy-Induced Bone Marrow Suppression: A Systematic Review with a Meta-analysis and Trial Sequential Analysis.
Shih YW, Wang MH, Monsen KA, Chang CW, Rias YA, Tsai HT
J Integr Complement Med 2023 Oct;29(10):621-636. Epub 2023 May 10 doi: 10.1089/jicm.2022.0735. PMID: 37163212
Comparison of bone marrow versus peripheral blood allogeneic hematopoietic stem cell transplantation for hematological malignancies in adults - a systematic review and meta-analysis.
Holtick U, Albrecht M, Chemnitz JM, Theurich S, Shimabukuro-Vornhagen A, Skoetz N, Scheid C, von Bergwelt-Baildon M
Crit Rev Oncol Hematol 2015 May;94(2):179-88. Epub 2014 Dec 18 doi: 10.1016/j.critrevonc.2014.12.007. PMID: 25604498
Granulocyte-colony stimulating factors as adjunctive therapy for diabetic foot infections.
Cruciani M, Lipsky BA, Mengoli C, de Lalla F
Cochrane Database Syst Rev 2013 Aug 17;(8):CD006810. doi: 10.1002/14651858.CD006810.pub3. PMID: 23955465
Local intramuscular transplantation of autologous mononuclear cells for critical lower limb ischaemia.
Moazzami K, Majdzadeh R, Nedjat S
Cochrane Database Syst Rev 2011 Dec 7;(12):CD008347. doi: 10.1002/14651858.CD008347.pub2. PMID: 22161427
Granulocyte-colony stimulating factors as adjunctive therapy for diabetic foot infections.
Cruciani M, Lipsky BA, Mengoli C, de Lalla F
Cochrane Database Syst Rev 2009 Jul 8;(3):CD006810. doi: 10.1002/14651858.CD006810.pub2. PMID: 19588405

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