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Hereditary fallopian tube carcinoma

MedGen UID:
307556
•Concept ID:
C1512418
•
Neoplastic Process
Synonyms: Familial Fallopian Tube Carcinoma; familial fallopian tube carcinoma; familiar fallopian tube carcinoma; hereditary fallopian tube cancer; Hereditary Fallopian Tube Carcinoma; hereditary fallopian tube carcinoma
 
Monarch Initiative: MONDO:0004166

Definition

Fallopian tube carcinoma that has developed in relatives of patients that have a history of fallopian tube carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHereditary fallopian tube carcinoma

Professional guidelines

PubMed

Management of Preinvasive Lesions.
Patrono MG, Corzo C, Iniesta M, Ramirez PT
Clin Obstet Gynecol 2017 Dec;60(4):771-779. doi: 10.1097/GRF.0000000000000316. PMID: 28957950
Practice Bulletin No 182: Hereditary Breast and Ovarian Cancer Syndrome.
Obstet Gynecol 2017 Sep;130(3):e110-e126. doi: 10.1097/AOG.0000000000002296. PMID: 28832484
Practice Bulletin No. 182 Summary: Hereditary Breast and Ovarian Cancer Syndrome.
Obstet Gynecol 2017 Sep;130(3):657-659. doi: 10.1097/AOG.0000000000002285. PMID: 28832475

Recent clinical studies

Etiology

Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial.
Poveda A, Floquet A, Ledermann JA, Asher R, Penson RT, Oza AM, Korach J, Huzarski T, Pignata S, Friedlander M, Baldoni A, Park-Simon TW, Tamura K, Sonke GS, Lisyanskaya A, Kim JH, Filho EA, Milenkova T, Lowe ES, Rowe P, Vergote I, Pujade-Lauraine E; SOLO2/ENGOT-Ov21 investigators
Lancet Oncol 2021 May;22(5):620-631. Epub 2021 Mar 18 doi: 10.1016/S1470-2045(21)00073-5. PMID: 33743851
Management of Preinvasive Lesions.
Patrono MG, Corzo C, Iniesta M, Ramirez PT
Clin Obstet Gynecol 2017 Dec;60(4):771-779. doi: 10.1097/GRF.0000000000000316. PMID: 28957950
Risk-reducing salpingectomy: Let us be opportunistic.
Long Roche KC, Abu-Rustum NR, Nourmoussavi M, Zivanovic O
Cancer 2017 May 15;123(10):1714-1720. Epub 2017 Mar 23 doi: 10.1002/cncr.30528. PMID: 28334425Free PMC Article
Hereditary Ovarian Cancer and Risk Reduction.
Andrews L, Mutch DG
Best Pract Res Clin Obstet Gynaecol 2017 May;41:31-48. Epub 2017 Jan 17 doi: 10.1016/j.bpobgyn.2016.10.017. PMID: 28254144
Inherited Mutations in Women With Ovarian Carcinoma.
Norquist BM, Harrell MI, Brady MF, Walsh T, Lee MK, Gulsuner S, Bernards SS, Casadei S, Yi Q, Burger RA, Chan JK, Davidson SA, Mannel RS, DiSilvestro PA, Lankes HA, Ramirez NC, King MC, Swisher EM, Birrer MJ
JAMA Oncol 2016 Apr;2(4):482-90. doi: 10.1001/jamaoncol.2015.5495. PMID: 26720728Free PMC Article

Diagnosis

AGO-OVAR 28/ENGOT-ov57. Niraparib alone versus niraparib in combination with bevacizumab in patients with carboplatin-taxane-based chemotherapy in advanced ovarian cancer: a multicenter randomized phase III trial.
Heitz F, Marth C, Henry S, Reuss A, Cibula D, Gaba Garcia L, Colombo N, Schmalfeld B, de Gregorio N, Wimberger P, Hasenburg A, Sehouli J, Gropp-Meier M, Schouten PC, Hahnen E, Hauke J, Polleis S, Harter P
Int J Gynecol Cancer 2023 Dec 4;33(12):1966-1969. doi: 10.1136/ijgc-2023-004944. PMID: 37935524
Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial.
Poveda A, Floquet A, Ledermann JA, Asher R, Penson RT, Oza AM, Korach J, Huzarski T, Pignata S, Friedlander M, Baldoni A, Park-Simon TW, Tamura K, Sonke GS, Lisyanskaya A, Kim JH, Filho EA, Milenkova T, Lowe ES, Rowe P, Vergote I, Pujade-Lauraine E; SOLO2/ENGOT-Ov21 investigators
Lancet Oncol 2021 May;22(5):620-631. Epub 2021 Mar 18 doi: 10.1016/S1470-2045(21)00073-5. PMID: 33743851
High-grade serous carcinoma of tubo-ovarian origin: recent developments.
Singh N, McCluggage WG, Gilks CB
Histopathology 2017 Sep;71(3):339-356. Epub 2017 Jul 18 doi: 10.1111/his.13248. PMID: 28477361
Inherited Mutations in Women With Ovarian Carcinoma.
Norquist BM, Harrell MI, Brady MF, Walsh T, Lee MK, Gulsuner S, Bernards SS, Casadei S, Yi Q, Burger RA, Chan JK, Davidson SA, Mannel RS, DiSilvestro PA, Lankes HA, Ramirez NC, King MC, Swisher EM, Birrer MJ
JAMA Oncol 2016 Apr;2(4):482-90. doi: 10.1001/jamaoncol.2015.5495. PMID: 26720728Free PMC Article
Key features of extrauterine pelvic serous tumours (fallopian tube, ovary, and peritoneum).
Delair D, Soslow RA
Histopathology 2012 Sep;61(3):329-39. Epub 2012 Feb 28 doi: 10.1111/j.1365-2559.2011.04167.x. PMID: 22372521

Therapy

Genetic Basis of Breast and Ovarian Cancer: Approaches and Lessons Learnt from Three Decades of Inherited Predisposition Testing.
Barili V, Ambrosini E, Bortesi B, Minari R, De Sensi E, Cannizzaro IR, Taiani A, Michiara M, Sikokis A, Boggiani D, Tommasi C, Serra O, Bonatti F, Adorni A, Luberto A, Caggiati P, Martorana D, Uliana V, Percesepe A, Musolino A, Pellegrino B
Genes (Basel) 2024 Feb 8;15(2) doi: 10.3390/genes15020219. PMID: 38397209Free PMC Article
Beyond Sterilization: A Comprehensive Review on the Safety and Efficacy of Opportunistic Salpingectomy as a Preventative Strategy for Ovarian Cancer.
Zadabedini Masouleh T, Etchegary H, Hodgkinson K, Wilson BJ, Dawson L
Curr Oncol 2023 Nov 28;30(12):10152-10165. doi: 10.3390/curroncol30120739. PMID: 38132373Free PMC Article
AGO-OVAR 28/ENGOT-ov57. Niraparib alone versus niraparib in combination with bevacizumab in patients with carboplatin-taxane-based chemotherapy in advanced ovarian cancer: a multicenter randomized phase III trial.
Heitz F, Marth C, Henry S, Reuss A, Cibula D, Gaba Garcia L, Colombo N, Schmalfeld B, de Gregorio N, Wimberger P, Hasenburg A, Sehouli J, Gropp-Meier M, Schouten PC, Hahnen E, Hauke J, Polleis S, Harter P
Int J Gynecol Cancer 2023 Dec 4;33(12):1966-1969. doi: 10.1136/ijgc-2023-004944. PMID: 37935524
Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial.
Poveda A, Floquet A, Ledermann JA, Asher R, Penson RT, Oza AM, Korach J, Huzarski T, Pignata S, Friedlander M, Baldoni A, Park-Simon TW, Tamura K, Sonke GS, Lisyanskaya A, Kim JH, Filho EA, Milenkova T, Lowe ES, Rowe P, Vergote I, Pujade-Lauraine E; SOLO2/ENGOT-Ov21 investigators
Lancet Oncol 2021 May;22(5):620-631. Epub 2021 Mar 18 doi: 10.1016/S1470-2045(21)00073-5. PMID: 33743851
Opportunistic Salpingectomy at the Time of Urogynecologic Surgery: Why, in Whom, and How?
Catanzarite T, Eskander RN
Female Pelvic Med Reconstr Surg 2020 Jun;26(6):401-406. doi: 10.1097/SPV.0000000000000741. PMID: 31135579

Prognosis

Hereditary breast and ovarian cancer triggered by occult fallopian tube cancer: a case report.
Murakami H, Fujiwara S, Nishie R, Ueda S, Terada S, Yamada T, Ohmichi M
J Med Case Rep 2023 Aug 18;17(1):351. doi: 10.1186/s13256-023-04095-6. PMID: 37592269Free PMC Article
Clinical and pathological outcomes of risk-reducing salpingo-oophorectomy for Japanese women with hereditary breast and ovarian cancer.
Nomura H, Ikki A, Fusegi A, Omi M, Aoki Y, Netsu S, Tanigawa T, Matoda M, Okamoto S, Omatsu K, Nakajima T, Ueki A, Tonooka A, Kanao H
Int J Clin Oncol 2021 Dec;26(12):2331-2337. Epub 2021 Aug 28 doi: 10.1007/s10147-021-02020-9. PMID: 34453642
Outcomes of Incidental Fallopian Tube High-Grade Serous Carcinoma and Serous Tubal Intraepithelial Carcinoma in Women at Low Risk of Hereditary Breast and Ovarian Cancer.
Chay WY, McCluggage WG, Lee CH, Köbel M, Irving J, Millar J, Gilks CB, Tinker AV
Int J Gynecol Cancer 2016 Mar;26(3):431-6. doi: 10.1097/IGC.0000000000000639. PMID: 26807643
Inherited Mutations in Women With Ovarian Carcinoma.
Norquist BM, Harrell MI, Brady MF, Walsh T, Lee MK, Gulsuner S, Bernards SS, Casadei S, Yi Q, Burger RA, Chan JK, Davidson SA, Mannel RS, DiSilvestro PA, Lankes HA, Ramirez NC, King MC, Swisher EM, Birrer MJ
JAMA Oncol 2016 Apr;2(4):482-90. doi: 10.1001/jamaoncol.2015.5495. PMID: 26720728Free PMC Article
Key features of extrauterine pelvic serous tumours (fallopian tube, ovary, and peritoneum).
Delair D, Soslow RA
Histopathology 2012 Sep;61(3):329-39. Epub 2012 Feb 28 doi: 10.1111/j.1365-2559.2011.04167.x. PMID: 22372521

Clinical prediction guides

Clinical and pathological outcomes of risk-reducing salpingo-oophorectomy for Japanese women with hereditary breast and ovarian cancer.
Nomura H, Ikki A, Fusegi A, Omi M, Aoki Y, Netsu S, Tanigawa T, Matoda M, Okamoto S, Omatsu K, Nakajima T, Ueki A, Tonooka A, Kanao H
Int J Clin Oncol 2021 Dec;26(12):2331-2337. Epub 2021 Aug 28 doi: 10.1007/s10147-021-02020-9. PMID: 34453642
Management of Preinvasive Lesions.
Patrono MG, Corzo C, Iniesta M, Ramirez PT
Clin Obstet Gynecol 2017 Dec;60(4):771-779. doi: 10.1097/GRF.0000000000000316. PMID: 28957950
Video-assisted genetic counseling in patients with ovarian, fallopian and peritoneal carcinoma.
Watson CH, Ulm M, Blackburn P, Smiley L, Reed M, Covington R, Bokovitz L, Tillmanns T
Gynecol Oncol 2016 Oct;143(1):109-112. Epub 2016 Jul 12 doi: 10.1016/j.ygyno.2016.07.094. PMID: 27416795Free PMC Article
Inherited Mutations in Women With Ovarian Carcinoma.
Norquist BM, Harrell MI, Brady MF, Walsh T, Lee MK, Gulsuner S, Bernards SS, Casadei S, Yi Q, Burger RA, Chan JK, Davidson SA, Mannel RS, DiSilvestro PA, Lankes HA, Ramirez NC, King MC, Swisher EM, Birrer MJ
JAMA Oncol 2016 Apr;2(4):482-90. doi: 10.1001/jamaoncol.2015.5495. PMID: 26720728Free PMC Article
Loss of LKB1 and p53 synergizes to alter fallopian tube epithelial phenotype and high-grade serous tumorigenesis.
George SH, Milea A, Sowamber R, Chehade R, Tone A, Shaw PA
Oncogene 2016 Jan 7;35(1):59-68. Epub 2015 Mar 23 doi: 10.1038/onc.2015.62. PMID: 25798842

Recent systematic reviews

Patient perspectives on risk-reducing salpingectomy with delayed oophorectomy for ovarian cancer risk-reduction: A systematic review of the literature.
Perez L, Webster E, Bull L, Brewer JT, Ahsan MD, Lin J, Levi SR, Cantillo E, Chapman-Davis E, Holcomb K, Rosenberg SM, Frey MK
Gynecol Oncol 2023 Jun;173:106-113. Epub 2023 Apr 26 doi: 10.1016/j.ygyno.2023.04.006. PMID: 37116391Free PMC Article
Outcome and Prognostic Impact of Surgical Staging in Serous Tubal Intraepithelial Carcinoma: A Cohort Study and Systematic Review.
Van der Hoeven NMA, Van Wijk K, Bonfrer SE, Beltman JJ, Louwe LA, De Kroon CD, Van Asperen CJ, Gaarenstroom KN
Clin Oncol (R Coll Radiol) 2018 Aug;30(8):463-471. Epub 2018 Apr 22 doi: 10.1016/j.clon.2018.03.036. PMID: 29691126

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