U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Loss of Chromosome 18

MedGen UID:
309324
Concept ID:
C1517967
Cell or Molecular Dysfunction
Synonym: del(18)

Definition

A cytogenetic abnormality that refers to loss of all or part of chromosome 18. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 18

Professional guidelines

PubMed

Pekarsky Y, Balatti V, Croce CM
Cell Death Differ 2018 Jan;25(1):21-26. Epub 2017 Oct 6 doi: 10.1038/cdd.2017.159. PMID: 28984869Free PMC Article
Davis C, Cuckle H, Yaron Y
Prenat Diagn 2014 Nov;34(11):1044-8. Epub 2014 Jun 11 doi: 10.1002/pd.4420. PMID: 24861197
Freedman A
Am J Hematol 2014 Apr;89(4):429-36. doi: 10.1002/ajh.23674. PMID: 24687887

Recent clinical studies

Etiology

Lawlor RT, Mafficini A, Sciammarella C, Cantù C, Rusev BC, Piredda ML, Antonello D, Grimaldi S, Bonizzato G, Sperandio N, Marchegiani G, Malleo G, Pea A, Salvia R, Mombello A, Mazzoleni G, Nottegar A, Hanspeter E, Riva G, Tomezzoli A, Bencivenga M, de Manzoni G, Pedron S, Paolino G, Mattiolo P, Brosens LA, Silvestris N, Fassan M, Cooke SL, Beer PA, Milella M, Adsay VN, Cheng L, Scarpa A, Luchini C
Hum Pathol 2021 Dec;118:30-41. Epub 2021 Sep 22 doi: 10.1016/j.humpath.2021.09.006. PMID: 34562502
Malki A, ElRuz RA, Gupta I, Allouch A, Vranic S, Al Moustafa AE
Int J Mol Sci 2020 Dec 24;22(1) doi: 10.3390/ijms22010130. PMID: 33374459Free PMC Article
Nilsson O
Neuroendocrinology 2013;97(1):7-18. Epub 2012 Nov 2 doi: 10.1159/000343232. PMID: 22986706
Cereda A, Carey JC
Orphanet J Rare Dis 2012 Oct 23;7:81. doi: 10.1186/1750-1172-7-81. PMID: 23088440Free PMC Article
Dotan E, Cohen SJ
Semin Oncol 2011 Aug;38(4):511-20. doi: 10.1053/j.seminoncol.2011.05.005. PMID: 21810510Free PMC Article

Diagnosis

Simbolo M, Vicentini C, Mafficini A, Fassan M, Pedron S, Corbo V, Mastracci L, Rusev B, Pedrazzani C, Landoni L, Grillo F, Cingarlini S, Rindi G, Luchini C, Scarpa A, Lawlor RT
Virchows Arch 2018 Dec;473(6):709-717. Epub 2018 Sep 16 doi: 10.1007/s00428-018-2450-x. PMID: 30219970Free PMC Article
Cody JD, Sebold C, Heard P, Carter E, Soileau B, Hasi-Zogaj M, Hill A, Rupert D, Perry B, O'Donnell L, Gelfond J, Lancaster J, Fox PT, Hale DE
Am J Med Genet C Semin Med Genet 2015 Sep;169(3):265-80. Epub 2015 Aug 3 doi: 10.1002/ajmg.c.31446. PMID: 26235940
Cereda A, Carey JC
Orphanet J Rare Dis 2012 Oct 23;7:81. doi: 10.1186/1750-1172-7-81. PMID: 23088440Free PMC Article
Dotan E, Cohen SJ
Semin Oncol 2011 Aug;38(4):511-20. doi: 10.1053/j.seminoncol.2011.05.005. PMID: 21810510Free PMC Article
George B, Kopetz S
Curr Oncol Rep 2011 Jun;13(3):206-15. doi: 10.1007/s11912-011-0162-3. PMID: 21373987

Therapy

Lawlor RT, Mafficini A, Sciammarella C, Cantù C, Rusev BC, Piredda ML, Antonello D, Grimaldi S, Bonizzato G, Sperandio N, Marchegiani G, Malleo G, Pea A, Salvia R, Mombello A, Mazzoleni G, Nottegar A, Hanspeter E, Riva G, Tomezzoli A, Bencivenga M, de Manzoni G, Pedron S, Paolino G, Mattiolo P, Brosens LA, Silvestris N, Fassan M, Cooke SL, Beer PA, Milella M, Adsay VN, Cheng L, Scarpa A, Luchini C
Hum Pathol 2021 Dec;118:30-41. Epub 2021 Sep 22 doi: 10.1016/j.humpath.2021.09.006. PMID: 34562502
Hugen N, Simmer F, Mekenkamp LJ, Koopman M, van den Broek E, de Wilt JH, Punt CJ, Ylstra B, Meijer GA, Nagtegaal ID
Oncotarget 2015 Sep 22;6(28):25715-25. doi: 10.18632/oncotarget.4706. PMID: 26329972Free PMC Article
Dotan E, Cohen SJ
Semin Oncol 2011 Aug;38(4):511-20. doi: 10.1053/j.seminoncol.2011.05.005. PMID: 21810510Free PMC Article
Waterston AM, Cassidy J
Drugs 2005;65(14):1935-47. doi: 10.2165/00003495-200565140-00003. PMID: 16162019
Cascinu S, Georgoulias V, Kerr D, Maughan T, Labianca R, Ychou M
Ann Oncol 2003;14 Suppl 2:ii25-9. doi: 10.1093/annonc/mdg725. PMID: 12810454

Prognosis

Cody JD, Sebold C, Heard P, Carter E, Soileau B, Hasi-Zogaj M, Hill A, Rupert D, Perry B, O'Donnell L, Gelfond J, Lancaster J, Fox PT, Hale DE
Am J Med Genet C Semin Med Genet 2015 Sep;169(3):265-80. Epub 2015 Aug 3 doi: 10.1002/ajmg.c.31446. PMID: 26235940
Giovannetti E, Wang Q, Avan A, Funel N, Lagerweij T, Lee JH, Caretti V, van der Velde A, Boggi U, Wang Y, Vasile E, Peters GJ, Wurdinger T, Giaccone G
J Natl Cancer Inst 2014 Jan;106(1):djt346. Epub 2013 Dec 3 doi: 10.1093/jnci/djt346. PMID: 24301457Free PMC Article
Cereda A, Carey JC
Orphanet J Rare Dis 2012 Oct 23;7:81. doi: 10.1186/1750-1172-7-81. PMID: 23088440Free PMC Article
Dotan E, Cohen SJ
Semin Oncol 2011 Aug;38(4):511-20. doi: 10.1053/j.seminoncol.2011.05.005. PMID: 21810510Free PMC Article
George B, Kopetz S
Curr Oncol Rep 2011 Jun;13(3):206-15. doi: 10.1007/s11912-011-0162-3. PMID: 21373987

Clinical prediction guides

Du N, Bao W, Zhang K, Lu X, Crew R, Wang X, Liu G, Wang F
BMC Cancer 2019 May 2;19(1):412. doi: 10.1186/s12885-019-5625-1. PMID: 31046733Free PMC Article
Druliner BR, Ruan X, Sicotte H, O'Brien D, Liu H, Kocher JA, Boardman L
Mol Carcinog 2018 Jan;57(1):114-124. Epub 2017 Oct 18 doi: 10.1002/mc.22738. PMID: 28926134Free PMC Article
George B, Kopetz S
Curr Oncol Rep 2011 Jun;13(3):206-15. doi: 10.1007/s11912-011-0162-3. PMID: 21373987
Collodel G, Giannerini V, Antonio Pascarelli N, Federico MG, Comodo F, Moretti E
Andrologia 2009 Dec;41(6):352-60. doi: 10.1111/j.1439-0272.2009.00936.x. PMID: 19891633
Stewart TL
Obstet Gynecol Clin North Am 2004 Mar;31(1):21-33. doi: 10.1016/S0889-8545(03)00126-8. PMID: 15062445

Recent systematic reviews

Saadeh-Jackson S, King K, Al Saif H, Jackson-Cook C, Schleede J, Couser NL
J Pediatr Ophthalmol Strabismus 2021 Nov-Dec;58(6):e44-e48. Epub 2021 Nov 1 doi: 10.3928/01913913-20210826-01. PMID: 34851787
Davis C, Cuckle H, Yaron Y
Prenat Diagn 2014 Nov;34(11):1044-8. Epub 2014 Jun 11 doi: 10.1002/pd.4420. PMID: 24861197
Popat S, Houlston RS
Eur J Cancer 2005 Sep;41(14):2060-70. doi: 10.1016/j.ejca.2005.04.039. PMID: 16125380

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...