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Ovarian yolk sac tumor, glandular pattern

MedGen UID:
309520
•Concept ID:
C1518747
•
Neoplastic Process
Synonyms: glandular pattern ovarian yolk sac tumor; glandular pattern ovarian yolk sac tumour; Ovarian Yolk Sac Tumor, Glandular Pattern; ovarian yolk sac tumor, glandular pattern; ovarian yolk Sac tumor, glandular pattern
 
Monarch Initiative: MONDO:0003905

Definition

A yolk sac tumor that arises from the ovary and is characterized by the presence of extensive differentiation into endodermal type glandular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian yolk sac tumor, glandular pattern

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
Primary Endometrial Yolk Sac Tumor With Endodermal-Intestinal Differentiation Masquerading as Metastatic Colorectal Adenocarcinoma.
Damato S, Haldar K, McCluggage WG
Int J Gynecol Pathol 2016 Jul;35(4):316-20. doi: 10.1097/PGP.0000000000000236. PMID: 26598980
New and unusual aspects of ovarian germ cell tumors.
Young RH
Am J Surg Pathol 1993 Dec;17(12):1210-24. doi: 10.1097/00000478-199312000-00002. PMID: 7694512
Pediatric malignant ovarian tumors: a 43-year review.
Gribbon M, Ein SH, Mancer K
J Pediatr Surg 1992 Apr;27(4):480-4. doi: 10.1016/0022-3468(92)90343-6. PMID: 1326038

Diagnosis

FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal-type.
Ricci C, Ambrosi F, Franceschini T, Giunchi F, Di Filippo G, Franchini E, Massari F, Mollica V, Tateo V, Bianchi FM, Colecchia M, Acosta AM, Fiorentino M
Histopathology 2023 Sep;83(3):465-476. Epub 2023 Jun 14 doi: 10.1111/his.14968. PMID: 37317674
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
Primary Endometrial Yolk Sac Tumor With Endodermal-Intestinal Differentiation Masquerading as Metastatic Colorectal Adenocarcinoma.
Damato S, Haldar K, McCluggage WG
Int J Gynecol Pathol 2016 Jul;35(4):316-20. doi: 10.1097/PGP.0000000000000236. PMID: 26598980
The yolk sac tumor: reflections on a remarkable neoplasm and two of the many intrigued by it-Gunnar Teilum and Aleksander Talerman-and the bond it formed between them.
Young RH
Int J Surg Pathol 2014 Dec;22(8):677-87. Epub 2014 Nov 12 doi: 10.1177/1066896914558265. PMID: 25395492
New and unusual aspects of ovarian germ cell tumors.
Young RH
Am J Surg Pathol 1993 Dec;17(12):1210-24. doi: 10.1097/00000478-199312000-00002. PMID: 7694512

Therapy

Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors.
Nogales FF, Buriticá C, Regauer S, González T
Am J Surg Pathol 2005 Sep;29(9):1247-51. doi: 10.1097/01.pas.0000161533.39478.a7. PMID: 16096416
Fine-needle aspiration cytology of an endometrioid-like variant of yolk sac tumor.
Strong JW, Worsham GF, Baker AS, Hawk JC 3rd, Austin RM
Diagn Cytopathol 1992;8(6):600-4. doi: 10.1002/dc.2840080613. PMID: 1281767

Prognosis

A case of ovarian endometrioid adenocarcinoma with yolk sac tumor in a 35-year-old woman.
Hong DG, Chong GO, Seong WJ, Lee YS, Cho YL, Park JY, Chae JM, Park IS
Eur J Gynaecol Oncol 2010;31(4):471-4. PMID: 20882900
Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors.
Nogales FF, Buriticá C, Regauer S, González T
Am J Surg Pathol 2005 Sep;29(9):1247-51. doi: 10.1097/01.pas.0000161533.39478.a7. PMID: 16096416
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children's Cancer Group.
Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP
Am J Surg Pathol 1998 Sep;22(9):1115-24. doi: 10.1097/00000478-199809000-00011. PMID: 9737245
Pediatric malignant ovarian tumors: a 43-year review.
Gribbon M, Ein SH, Mancer K
J Pediatr Surg 1992 Apr;27(4):480-4. doi: 10.1016/0022-3468(92)90343-6. PMID: 1326038

Clinical prediction guides

Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children's Cancer Group.
Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP
Am J Surg Pathol 1998 Sep;22(9):1115-24. doi: 10.1097/00000478-199809000-00011. PMID: 9737245
Pediatric malignant ovarian tumors: a 43-year review.
Gribbon M, Ein SH, Mancer K
J Pediatr Surg 1992 Apr;27(4):480-4. doi: 10.1016/0022-3468(92)90343-6. PMID: 1326038

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