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Cutaneous B Lymphoblastic Leukemia/Lymphoma

MedGen UID:
313082
•Concept ID:
C1707589
•
Neoplastic Process
Synonyms: Cutaneous B-Lymphoblastic Leukemia/Lymphoma; Cutaneous Precursor B-Lymphoblastic Lymphoma/Leukemia

Definition

B-lymphoblastic leukemia/lymphoma that arises from the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous B Lymphoblastic Leukemia/Lymphoma

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Lymphoma-associated skin cancer: incidence, natural history, and clinical management.
Brewer JD, Habermann TM, Shanafelt TD
Int J Dermatol 2014 Mar;53(3):267-74. Epub 2013 Dec 10 doi: 10.1111/ijd.12208. PMID: 24320558
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma).
Dearden CE, Johnson R, Pettengell R, Devereux S, Cwynarski K, Whittaker S, McMillan A; British Committee for Standards in Haematology
Br J Haematol 2011 May;153(4):451-85. Epub 2011 Apr 11 doi: 10.1111/j.1365-2141.2011.08651.x. PMID: 21480860

Recent clinical studies

Etiology

Broadening the horizon: potential applications of CAR-T cells beyond current indications.
Karsten H, Matrisch L, Cichutek S, Fiedler W, Alsdorf W, Block A
Front Immunol 2023;14:1285406. Epub 2023 Nov 27 doi: 10.3389/fimmu.2023.1285406. PMID: 38090582Free PMC Article
UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial.
Benjamin R, Jain N, Maus MV, Boissel N, Graham C, Jozwik A, Yallop D, Konopleva M, Frigault MJ, Teshima T, Kato K, Boucaud F, Balandraud S, Gianella-Borradori A, Binlich F, Marchiq I, Dupouy S, Almena-Carrasco M, Pannaux M, Fouliard S, Brissot E, Mohty M; CALM Study Group
Lancet Haematol 2022 Nov;9(11):e833-e843. Epub 2022 Oct 10 doi: 10.1016/S2352-3026(22)00245-9. PMID: 36228643
Skin lesions in chronic lymphocytic leukemia.
Robak E, Robak T
Leuk Lymphoma 2007 May;48(5):855-65. doi: 10.1080/10428190601137336. PMID: 17487727
Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas.
Drexler HG, Gignac SM, von Wasielewski R, Werner M, Dirks WG
Leukemia 2000 Sep;14(9):1533-59. doi: 10.1038/sj.leu.2401878. PMID: 10994999
Clinicopathologic features of cutaneous squamous cell carcinomas of the head and neck in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.
Frierson HF Jr, Deutsch BD, Levine PA
Hum Pathol 1988 Dec;19(12):1397-402. doi: 10.1016/s0046-8177(88)80232-6. PMID: 3056829

Diagnosis

Follicular lymphoma and marginal zone lymphoma: how many diseases?
Laurent C, Cook JR, Yoshino T, Quintanilla-Martinez L, Jaffe ES
Virchows Arch 2023 Jan;482(1):149-162. Epub 2022 Nov 17 doi: 10.1007/s00428-022-03432-2. PMID: 36394631Free PMC Article
Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates.
Hristov AC, Comfere NI, Vidal CI, Sundram U
J Cutan Pathol 2020 Nov;47(11):1103-1110. Epub 2020 Sep 14 doi: 10.1111/cup.13858. PMID: 32870521
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Cutaneous B-Cell Lymphoblastic Lymphoma.
Amarasekera D, Connolly D, Gochoco A, Yang S, Grosso D, Flomenberg N, Shi W, Alpdogan SO, Duffy R, Sahu J
Am J Dermatopathol 2019 Aug;41(8):596-601. doi: 10.1097/DAD.0000000000001347. PMID: 31335415
Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas.
Drexler HG, Gignac SM, von Wasielewski R, Werner M, Dirks WG
Leukemia 2000 Sep;14(9):1533-59. doi: 10.1038/sj.leu.2401878. PMID: 10994999

Therapy

UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial.
Benjamin R, Jain N, Maus MV, Boissel N, Graham C, Jozwik A, Yallop D, Konopleva M, Frigault MJ, Teshima T, Kato K, Boucaud F, Balandraud S, Gianella-Borradori A, Binlich F, Marchiq I, Dupouy S, Almena-Carrasco M, Pannaux M, Fouliard S, Brissot E, Mohty M; CALM Study Group
Lancet Haematol 2022 Nov;9(11):e833-e843. Epub 2022 Oct 10 doi: 10.1016/S2352-3026(22)00245-9. PMID: 36228643
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Cutaneous B-Cell Lymphoblastic Lymphoma.
Amarasekera D, Connolly D, Gochoco A, Yang S, Grosso D, Flomenberg N, Shi W, Alpdogan SO, Duffy R, Sahu J
Am J Dermatopathol 2019 Aug;41(8):596-601. doi: 10.1097/DAD.0000000000001347. PMID: 31335415
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Cutaneous Adverse Events of Targeted Therapies for Hematolymphoid Malignancies.
Ransohoff JD, Kwong BY
Clin Lymphoma Myeloma Leuk 2017 Dec;17(12):834-851. Epub 2017 Jul 14 doi: 10.1016/j.clml.2017.07.005. PMID: 28918995

Prognosis

Broadening the horizon: potential applications of CAR-T cells beyond current indications.
Karsten H, Matrisch L, Cichutek S, Fiedler W, Alsdorf W, Block A
Front Immunol 2023;14:1285406. Epub 2023 Nov 27 doi: 10.3389/fimmu.2023.1285406. PMID: 38090582Free PMC Article
UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial.
Benjamin R, Jain N, Maus MV, Boissel N, Graham C, Jozwik A, Yallop D, Konopleva M, Frigault MJ, Teshima T, Kato K, Boucaud F, Balandraud S, Gianella-Borradori A, Binlich F, Marchiq I, Dupouy S, Almena-Carrasco M, Pannaux M, Fouliard S, Brissot E, Mohty M; CALM Study Group
Lancet Haematol 2022 Nov;9(11):e833-e843. Epub 2022 Oct 10 doi: 10.1016/S2352-3026(22)00245-9. PMID: 36228643
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Skin lesions in chronic lymphocytic leukemia.
Robak E, Robak T
Leuk Lymphoma 2007 May;48(5):855-65. doi: 10.1080/10428190601137336. PMID: 17487727

Clinical prediction guides

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Nationwide Statistical Analysis of Lymphoid Malignancies in Korea.
Lee H, Park HJ, Park EH, Ju HY, Oh CM, Kong HJ, Jung KW, Park BK, Lee E, Eom HS, Won YJ
Cancer Res Treat 2018 Jan;50(1):222-238. Epub 2017 Mar 30 doi: 10.4143/crt.2017.093. PMID: 28361523Free PMC Article
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma).
Dearden CE, Johnson R, Pettengell R, Devereux S, Cwynarski K, Whittaker S, McMillan A; British Committee for Standards in Haematology
Br J Haematol 2011 May;153(4):451-85. Epub 2011 Apr 11 doi: 10.1111/j.1365-2141.2011.08651.x. PMID: 21480860
Skin lesions in chronic lymphocytic leukemia.
Robak E, Robak T
Leuk Lymphoma 2007 May;48(5):855-65. doi: 10.1080/10428190601137336. PMID: 17487727

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