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Pyothorax-Associated Lymphoma

MedGen UID:
313646
•Concept ID:
C1709781
•
Neoplastic Process
Synonym: Pleural Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

Definition

An aggressive diffuse large B-cell lymphoma arising in the pleural cavity of patients with a history of long standing pyothorax. Patients present with chest and back pain, fever, productive cough, dyspnea, and hemoptysis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPyothorax-Associated Lymphoma

Professional guidelines

PubMed

The management of pyothorax-associated lymphoma using 18F-FDG PET/CT.
Ito K, Shida Y, Kubota K, Morooka M, Aruga T, Itami J, Matsuda H
Ann Nucl Med 2010 Nov;24(9):649-54. Epub 2010 Aug 26 doi: 10.1007/s12149-010-0408-4. PMID: 20740330

Recent clinical studies

Etiology

Pyothorax-associated lymphoma: imaging findings.
Ueda T, Andreas C, Itami J, Miyakawa K, Fujimoto H, Ito H, Roos JE
AJR Am J Roentgenol 2010 Jan;194(1):76-84. doi: 10.2214/AJR.09.2603. PMID: 20028908
Cell origin of pyothorax-associated lymphoma: a lymphoma strongly associated with Epstein-Barr virus infection.
Takakuwa T, Tresnasari K, Rahadiani N, Miwa H, Daibata M, Aozasa K
Leukemia 2008 Mar;22(3):620-7. Epub 2007 Dec 13 doi: 10.1038/sj.leu.2405059. PMID: 18079737
Body cavity lymphoma.
Ascoli V, Lo-Coco F
Curr Opin Pulm Med 2002 Jul;8(4):317-22. doi: 10.1097/00063198-200207000-00013. PMID: 12055396
Treatment for pyothorax-associated lymphoma.
Aruga T, Itami J, Nakajima K, Shibata K, Nojo T, Aruga M, Inagaki K, Morita T, Ito H, Nomura T, Mikami A, Nemoto K, Yasuda S, Uno T, Hara R, Isobe K, Machida N
Radiother Oncol 2000 Jul;56(1):59-63. doi: 10.1016/s0167-8140(00)00169-9. PMID: 10869756
Pyothorax-associated lymphoma.
Aozasa K
Int J Hematol 1996 Dec;65(1):9-16. doi: 10.1016/s0925-5710(96)00532-4. PMID: 8990621

Diagnosis

Case 322: Pyothorax-associated Lymphoma.
Hu JY, Lee KH, Yun G
Radiology 2024 Feb;310(2):e223090. doi: 10.1148/radiol.223090. PMID: 38411510
Primary diffuse large B-cell lymphoma as a chest-wall mass: A case report.
Zhang Q, Ju Y, Qu T, Wang T, Liu X
Medicine (Baltimore) 2018 Nov;97(47):e13291. doi: 10.1097/MD.0000000000013291. PMID: 30461640Free PMC Article
Pyothorax-associated lymphoma: imaging findings.
Ueda T, Andreas C, Itami J, Miyakawa K, Fujimoto H, Ito H, Roos JE
AJR Am J Roentgenol 2010 Jan;194(1):76-84. doi: 10.2214/AJR.09.2603. PMID: 20028908
Pyothorax-associated lymphoma: an unusual case with both T- and B-cell genotypes.
Nakamichi I, Takakuwa T, Tanio Y, Iuchi K, Aozasa K
Virchows Arch 2005 Nov;447(5):888-91. Epub 2005 Jul 14 doi: 10.1007/s00428-005-0034-z. PMID: 16021507
Pyothorax-associated lymphoma.
Yasukawa M, Hamada M, Ohshima K
Br J Haematol 2002 Nov;119(2):293. doi: 10.1046/j.1365-2141.2002.03752.x. PMID: 12406060

Therapy

Primary Effusion Lymphoma-like Lymphoma in a Patient with Neurofibromatosis Type 1.
Oki M, Nanao T, Shinoda T, Tsuda A, Yasuda A, Seki T, Ozawa H, Nakamura N, Takagi A
Tokai J Exp Clin Med 2016 Sep 20;41(3):123-9. PMID: 27628603
Pyothorax-associated lymphoma: imaging findings.
Ueda T, Andreas C, Itami J, Miyakawa K, Fujimoto H, Ito H, Roos JE
AJR Am J Roentgenol 2010 Jan;194(1):76-84. doi: 10.2214/AJR.09.2603. PMID: 20028908
DNA sequences of the immunoglobulin heavy chain variable region gene in pyothorax-associated lymphoma.
Miwa H, Takakuwa T, Nakatsuka S, Tomita Y, Iuchi K, Aozasa K
Oncology 2002;62(3):241-50. doi: 10.1159/000059572. PMID: 12065872
Expression profile of human herpesvirus 8 (HHV-8) in pyothorax associated lymphoma and in effusion lymphoma.
O'Donovan M, Silva I, Uhlmann V, Bermingham N, Luttich K, Martin C, Sheils O, Killalea A, Kenny C, Pileri S, O'Leary JJ
Mol Pathol 2001 Apr;54(2):80-5. doi: 10.1136/mp.54.2.80. PMID: 11322168Free PMC Article
Pyothorax-associated lymphoma.
Aozasa K
Int J Hematol 1996 Dec;65(1):9-16. doi: 10.1016/s0925-5710(96)00532-4. PMID: 8990621

Prognosis

Primary Effusion Lymphoma-like Lymphoma in a Patient with Neurofibromatosis Type 1.
Oki M, Nanao T, Shinoda T, Tsuda A, Yasuda A, Seki T, Ozawa H, Nakamura N, Takagi A
Tokai J Exp Clin Med 2016 Sep 20;41(3):123-9. PMID: 27628603
Acute or chronic life-threatening diseases associated with Epstein-Barr virus infection.
Okano M, Gross TG
Am J Med Sci 2012 Jun;343(6):483-9. doi: 10.1097/MAJ.0b013e318236e02d. PMID: 22104426
Pyothorax-associated lymphoma: an unusual case with both T- and B-cell genotypes.
Nakamichi I, Takakuwa T, Tanio Y, Iuchi K, Aozasa K
Virchows Arch 2005 Nov;447(5):888-91. Epub 2005 Jul 14 doi: 10.1007/s00428-005-0034-z. PMID: 16021507
Pyothorax-associated lymphoma (PAL): a western case with marked angiocentricity and review of the literature.
Androulaki A, Drakos E, Hatzianastassiou D, Vgenopoulou S, Gazouli M, Korkolopoulou P, Patsouris E, Dosios T
Histopathology 2004 Jan;44(1):69-76. doi: 10.1111/j.1365-2559.2004.01737.x. PMID: 14717672
Mechanism for the development of pyothorax-associated lymphoma.
Kanno H, Aozasa K
Pathol Int 1998 Sep;48(9):653-64. doi: 10.1111/j.1440-1827.1998.tb03966.x. PMID: 9778104

Clinical prediction guides

Primary Effusion Lymphoma-like Lymphoma in a Patient with Neurofibromatosis Type 1.
Oki M, Nanao T, Shinoda T, Tsuda A, Yasuda A, Seki T, Ozawa H, Nakamura N, Takagi A
Tokai J Exp Clin Med 2016 Sep 20;41(3):123-9. PMID: 27628603
The management of pyothorax-associated lymphoma using 18F-FDG PET/CT.
Ito K, Shida Y, Kubota K, Morooka M, Aruga T, Itami J, Matsuda H
Ann Nucl Med 2010 Nov;24(9):649-54. Epub 2010 Aug 26 doi: 10.1007/s12149-010-0408-4. PMID: 20740330
Diffuse large B-cell lymphomas with plasmablastic differentiation.
Teruya-Feldstein J
Curr Oncol Rep 2005 Sep;7(5):357-63. doi: 10.1007/s11912-005-0062-5. PMID: 16091196
Expression of Epstein-Barr virus latent infection genes and oncogenes in lymphoma cell lines derived from pyothorax-associated lymphoma.
Kanno H, Yasunaga Y, Ohsawa M, Taniwaki M, Iuchi K, Naka N, Torikai K, Shimoyama M, Aozasa K
Int J Cancer 1996 Jul 3;67(1):86-94. doi: 10.1002/(SICI)1097-0215(19960703)67:1<86::AID-IJC15>3.0.CO;2-A. PMID: 8690530
Pyothorax-associated lymphoma: development of Epstein-Barr virus-associated lymphoma within the inflammatory cavity.
Fukayama M, Hayashi Y, Ooba T, Funata N, Ibuka T, Koike M, Hebisawa A, Kurasawa A, Fukayama M, Nakahiro K
Pathol Int 1995 Nov;45(11):825-31. doi: 10.1111/j.1440-1827.1995.tb03402.x. PMID: 8581145

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