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Severe Sepsis

MedGen UID:
318553
•Concept ID:
C1719672
•
Disease or Syndrome
Synonym: Sepsis, Severe

Definition

Clinical syndrome defined by the presence of both infection and a systemic inflammatory response that progresses to multi-organ failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSevere Sepsis

Professional guidelines

PubMed

International Consensus Criteria for Pediatric Sepsis and Septic Shock.
Schlapbach LJ, Watson RS, Sorce LR, Argent AC, Menon K, Hall MW, Akech S, Albers DJ, Alpern ER, Balamuth F, Bembea M, Biban P, Carrol ED, Chiotos K, Chisti MJ, DeWitt PE, Evans I, Flauzino de Oliveira C, Horvat CM, Inwald D, Ishimine P, Jaramillo-Bustamante JC, Levin M, Lodha R, Martin B, Nadel S, Nakagawa S, Peters MJ, Randolph AG, Ranjit S, Rebull MN, Russell S, Scott HF, de Souza DC, Tissieres P, Weiss SL, Wiens MO, Wynn JL, Kissoon N, Zimmerman JJ, Sanchez-Pinto LN, Bennett TD; Society of Critical Care Medicine Pediatric Sepsis Definition Task Force
JAMA 2024 Feb 27;331(8):665-674. doi: 10.1001/jama.2024.0179. PMID: 38245889Free PMC Article
EASL Clinical Practice Guidelines on acute-on-chronic liver failure.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Aug;79(2):461-491. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.04.021. PMID: 37364789
Sepsis: pathophysiology and clinical management.
Gotts JE, Matthay MA
BMJ 2016 May 23;353:i1585. doi: 10.1136/bmj.i1585. PMID: 27217054

Recent clinical studies

Etiology

Ulinastatin and/or thymosin α1 for severe sepsis: A systematic review and meta-analysis.
Feng Z, Shi Q, Fan Y, Wang Q, Yin W
J Trauma Acute Care Surg 2016 Feb;80(2):335-40. doi: 10.1097/TA.0000000000000909. PMID: 26517783
Systemic inflammatory response syndrome criteria in defining severe sepsis.
Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R
N Engl J Med 2015 Apr 23;372(17):1629-38. Epub 2015 Mar 17 doi: 10.1056/NEJMoa1415236. PMID: 25776936
Interplay between sepsis and chronic health.
Yende S, Iwashyna TJ, Angus DC
Trends Mol Med 2014 Apr;20(4):234-8. Epub 2014 Mar 14 doi: 10.1016/j.molmed.2014.02.005. PMID: 24636941Free PMC Article
Epidemiology of severe sepsis.
Mayr FB, Yende S, Angus DC
Virulence 2014 Jan 1;5(1):4-11. Epub 2013 Dec 11 doi: 10.4161/viru.27372. PMID: 24335434Free PMC Article
Severe sepsis and septic shock: review of the literature and emergency department management guidelines.
Nguyen HB, Rivers EP, Abrahamian FM, Moran GJ, Abraham E, Trzeciak S, Huang DT, Osborn T, Stevens D, Talan DA; Emergency Department Sepsis Education Program and Strategies to Improve Survival (ED-SEPSIS) Working Group
Ann Emerg Med 2006 Jul;48(1):28-54. Epub 2006 May 2 doi: 10.1016/j.annemergmed.2006.02.015. PMID: 16781920

Diagnosis

The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis.
Sterling SA, Miller WR, Pryor J, Puskarich MA, Jones AE
Crit Care Med 2015 Sep;43(9):1907-15. doi: 10.1097/CCM.0000000000001142. PMID: 26121073Free PMC Article
Telemedicine and the patient with sepsis.
Badawi O, Hassan E
Crit Care Clin 2015 Apr;31(2):291-304. Epub 2015 Jan 17 doi: 10.1016/j.ccc.2014.12.007. PMID: 25814455
Systemic inflammatory response syndrome criteria in defining severe sepsis.
Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R
N Engl J Med 2015 Apr 23;372(17):1629-38. Epub 2015 Mar 17 doi: 10.1056/NEJMoa1415236. PMID: 25776936
Severe sepsis and septic shock: management and performance improvement.
Schorr CA, Zanotti S, Dellinger RP
Virulence 2014 Jan 1;5(1):190-9. Epub 2013 Dec 11 doi: 10.4161/viru.27409. PMID: 24335487Free PMC Article
International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics.
Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis
Pediatr Crit Care Med 2005 Jan;6(1):2-8. doi: 10.1097/01.PCC.0000149131.72248.E6. PMID: 15636651

Therapy

Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS
Lancet Respir Med 2023 Nov;11(11):965-974. Epub 2023 Aug 23 doi: 10.1016/S2213-2600(23)00237-0. PMID: 37633303Free PMC Article
Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies.
Papageorgiou C, Jourdi G, Adjambri E, Walborn A, Patel P, Fareed J, Elalamy I, Hoppensteadt D, Gerotziafas GT
Clin Appl Thromb Hemost 2018 Dec;24(9_suppl):8S-28S. Epub 2018 Oct 8 doi: 10.1177/1076029618806424. PMID: 30296833Free PMC Article
Severe Sepsis and Septic Shock Trials (ProCESS, ARISE, ProMISe): What is Optimal Resuscitation?
Osborn TM
Crit Care Clin 2017 Apr;33(2):323-344. doi: 10.1016/j.ccc.2016.12.004. PMID: 28284298
Sepsis: pathophysiology and clinical management.
Gotts JE, Matthay MA
BMJ 2016 May 23;353:i1585. doi: 10.1136/bmj.i1585. PMID: 27217054
International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics.
Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis
Pediatr Crit Care Med 2005 Jan;6(1):2-8. doi: 10.1097/01.PCC.0000149131.72248.E6. PMID: 15636651

Prognosis

Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis.
Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, Allegranzi B, Reinhart K
Intensive Care Med 2020 Aug;46(8):1552-1562. Epub 2020 Jun 22 doi: 10.1007/s00134-020-06151-x. PMID: 32572531Free PMC Article
The global burden of paediatric and neonatal sepsis: a systematic review.
Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N
Lancet Respir Med 2018 Mar;6(3):223-230. doi: 10.1016/S2213-2600(18)30063-8. PMID: 29508706
Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014.
Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, Jernigan JA, Martin GS, Septimus E, Warren DK, Karcz A, Chan C, Menchaca JT, Wang R, Gruber S, Klompas M; CDC Prevention Epicenter Program
JAMA 2017 Oct 3;318(13):1241-1249. doi: 10.1001/jama.2017.13836. PMID: 28903154Free PMC Article
Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations.
Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K; International Forum of Acute Care Trialists
Am J Respir Crit Care Med 2016 Feb 1;193(3):259-72. doi: 10.1164/rccm.201504-0781OC. PMID: 26414292
Severe sepsis and septic shock.
Angus DC, van der Poll T
N Engl J Med 2013 Aug 29;369(9):840-51. doi: 10.1056/NEJMra1208623. PMID: 23984731

Clinical prediction guides

Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker.
Crouser ED, Parrillo JE, Seymour C, Angus DC, Bicking K, Tejidor L, Magari R, Careaga D, Williams J, Closser DR, Samoszuk M, Herren L, Robart E, Chaves F
Chest 2017 Sep;152(3):518-526. Epub 2017 Jun 15 doi: 10.1016/j.chest.2017.05.039. PMID: 28625579Free PMC Article
Maternal Sepsis and Septic Shock.
Chebbo A, Tan S, Kassis C, Tamura L, Carlson RW
Crit Care Clin 2016 Jan;32(1):119-35. Epub 2015 Oct 19 doi: 10.1016/j.ccc.2015.08.010. PMID: 26600449
Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome.
Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D, Coppo P, Hejblum G
Arthritis Rheumatol 2014 Sep;66(9):2613-20. doi: 10.1002/art.38690. PMID: 24782338
A bedside scoring system ("Candida score") for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization.
León C, Ruiz-Santana S, Saavedra P, Almirante B, Nolla-Salas J, Alvarez-Lerma F, Garnacho-Montero J, León MA; EPCAN Study Group
Crit Care Med 2006 Mar;34(3):730-7. doi: 10.1097/01.CCM.0000202208.37364.7D. PMID: 16505659
Defining severe community-acquired pneumonia.
Neuhaus T, Ewig S
Med Clin North Am 2001 Nov;85(6):1413-25. doi: 10.1016/s0025-7125(05)70388-6. PMID: 11680110

Recent systematic reviews

Frequency and mortality of sepsis and septic shock in China: a systematic review and meta-analysis.
Liu YC, Yao Y, Yu MM, Gao YL, Qi AL, Jiang TY, Chen ZS, Shou ST, Chai YF
BMC Infect Dis 2022 Jun 21;22(1):564. doi: 10.1186/s12879-022-07543-8. PMID: 35729526Free PMC Article
Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.
Menon K, Schlapbach LJ, Akech S, Argent A, Biban P, Carrol ED, Chiotos K, Jobayer Chisti M, Evans IVR, Inwald DP, Ishimine P, Kissoon N, Lodha R, Nadel S, Oliveira CF, Peters M, Sadeghirad B, Scott HF, de Souza DC, Tissieres P, Watson RS, Wiens MO, Wynn JL, Zimmerman JJ, Sorce LR; Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine
Crit Care Med 2022 Jan 1;50(1):21-36. doi: 10.1097/CCM.0000000000005294. PMID: 34612847Free PMC Article
Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis.
Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, Allegranzi B, Reinhart K
Intensive Care Med 2020 Aug;46(8):1552-1562. Epub 2020 Jun 22 doi: 10.1007/s00134-020-06151-x. PMID: 32572531Free PMC Article
Machine learning for the prediction of sepsis: a systematic review and meta-analysis of diagnostic test accuracy.
Fleuren LM, Klausch TLT, Zwager CL, Schoonmade LJ, Guo T, Roggeveen LF, Swart EL, Girbes ARJ, Thoral P, Ercole A, Hoogendoorn M, Elbers PWG
Intensive Care Med 2020 Mar;46(3):383-400. Epub 2020 Jan 21 doi: 10.1007/s00134-019-05872-y. PMID: 31965266Free PMC Article
The global burden of paediatric and neonatal sepsis: a systematic review.
Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N
Lancet Respir Med 2018 Mar;6(3):223-230. doi: 10.1016/S2213-2600(18)30063-8. PMID: 29508706

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