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Muscular atrophy, malignant neurogenic

MedGen UID:
322469
•Concept ID:
C1834689
•
Disease or Syndrome
Synonym: Muscular Atrophy, Malignant Neurogenic
 
Monarch Initiative: MONDO:0008027
OMIM®: 158650

Clinical features

From HPO
Muscular atrophy
MedGen UID:
892680
•Concept ID:
C0541794
•
Pathologic Function
The presence of skeletal muscular atrophy (which is also known as amyotrophy).
See: Feature record | Search on this feature
Respiratory paralysis
MedGen UID:
19748
•Concept ID:
C0035232
•
Finding
Inability to move the muscles of respiration.
See: Feature record | Search on this feature
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Recent clinical studies

Etiology

Skeletal muscle involvement in systemic amyloidosis is often overlooked.
Xu J, Zhou X, Wang Y, Liu W, Shan Y, Zhang D, Lv H, Zhao D, Dai T, Zhao Y, Li W, Liu F, Yan C
Neuropathol Appl Neurobiol 2024 Aug;50(4):e12996. doi: 10.1111/nan.12996. PMID: 38982616
Quantitative EMG of facial muscles in myasthenia patients with MuSK antibodies.
Farrugia ME, Kennett RP, Hilton-Jones D, Newsom-Davis J, Vincent A
Clin Neurophysiol 2007 Feb;118(2):269-77. Epub 2006 Dec 8 doi: 10.1016/j.clinph.2006.10.004. PMID: 17157556
Type-selective muscular degeneration promotes infiltrative growth of intramuscular lipoma.
Mori K, Chano T, Matsumoto K, Ishizawa M, Matsusue Y, Okabe H
BMC Musculoskelet Disord 2004 Jun 18;5:20. doi: 10.1186/1471-2474-5-20. PMID: 15202946Free PMC Article
Skeletal muscular atrophy in malignant tumour diseases: neurogenic or unspecific?
Schmitt HP
Acta Neuropathol 1979 Nov;48(2):149-52. doi: 10.1007/BF00691157. PMID: 506697
Neurogenic muscle involvement in myasthenia gravis. A clinical and histopathological study.
Oosterhuis H, Bethlem J
J Neurol Neurosurg Psychiatry 1973 Apr;36(2):244-54. doi: 10.1136/jnnp.36.2.244. PMID: 4708458Free PMC Article

Diagnosis

7T for clinical imaging of benign peripheral nerve tumors: preliminary results.
Amrami KK, Chebrolu VV, Felmlee JP, Frick MA, Powell GM, Marek T, Howe BM, Fagan AJ, Kollasch PD, Spinner RJ
Acta Neurochir (Wien) 2023 Nov;165(11):3549-3558. Epub 2023 Jul 19 doi: 10.1007/s00701-023-05724-1. PMID: 37464202
Is paravertebral muscles edema a consequence of neurogenic changes in MuSK-positive myasthenia gravis?
Bardakov SN, Tsargush VA, Carlier PG, Duc TM, Emelin AY, Polushin AY, Emelyantsev AA, Belskikh AN, Berezhnaya EN, Lapin SV, Moshnikova AN, Deev RV
Acta Myol 2022;41(4):178-187. Epub 2022 Dec 31 doi: 10.36185/2532-1900-082. PMID: 36793652Free PMC Article
Delayed postirradiation camptocormia.
Kelly L, Perju-Dumbrava LD, Thyagarajan D, Lee YC
BMJ Case Rep 2013 Aug 19;2013 doi: 10.1136/bcr-2013-200083. PMID: 23960150Free PMC Article
Quantitative EMG of facial muscles in myasthenia patients with MuSK antibodies.
Farrugia ME, Kennett RP, Hilton-Jones D, Newsom-Davis J, Vincent A
Clin Neurophysiol 2007 Feb;118(2):269-77. Epub 2006 Dec 8 doi: 10.1016/j.clinph.2006.10.004. PMID: 17157556
Neurogenic muscle involvement in myasthenia gravis. A clinical and histopathological study.
Oosterhuis H, Bethlem J
J Neurol Neurosurg Psychiatry 1973 Apr;36(2):244-54. doi: 10.1136/jnnp.36.2.244. PMID: 4708458Free PMC Article

Therapy

Neurogenic muscle atrophy in myasthenia gravis.
Brownell B, Oppenheimer DR, Spalding JM
J Neurol Neurosurg Psychiatry 1972 Jun;35(3):311-22. doi: 10.1136/jnnp.35.3.311. PMID: 4338443Free PMC Article

Prognosis

Is paravertebral muscles edema a consequence of neurogenic changes in MuSK-positive myasthenia gravis?
Bardakov SN, Tsargush VA, Carlier PG, Duc TM, Emelin AY, Polushin AY, Emelyantsev AA, Belskikh AN, Berezhnaya EN, Lapin SV, Moshnikova AN, Deev RV
Acta Myol 2022;41(4):178-187. Epub 2022 Dec 31 doi: 10.36185/2532-1900-082. PMID: 36793652Free PMC Article
Neuropathology in classical and variant ataxia-telangiectasia.
Verhagen MM, Martin JJ, van Deuren M, Ceuterick-de Groote C, Weemaes CM, Kremer BH, Taylor MA, Willemsen MA, Lammens M
Neuropathology 2012 Jun;32(3):234-44. Epub 2011 Oct 24 doi: 10.1111/j.1440-1789.2011.01263.x. PMID: 22017321
Quantitative EMG of facial muscles in myasthenia patients with MuSK antibodies.
Farrugia ME, Kennett RP, Hilton-Jones D, Newsom-Davis J, Vincent A
Clin Neurophysiol 2007 Feb;118(2):269-77. Epub 2006 Dec 8 doi: 10.1016/j.clinph.2006.10.004. PMID: 17157556
Lumbosacral perineural cysts as a cause for neurogenic muscular hypertrophy.
Amoiridis G, Wöhrle J, Heye N, Przuntek H
Electromyogr Clin Neurophysiol 1997 Aug;37(5):273-5. PMID: 9298339
Radioimmunoassay of serum myoglobin in neuromuscular diseases.
Askmark H, Osterman PO, Roxin LE, Venge P
J Neurol Neurosurg Psychiatry 1981 Jan;44(1):68-72. doi: 10.1136/jnnp.44.1.68. PMID: 7205308Free PMC Article

Clinical prediction guides

Skeletal muscle involvement in systemic amyloidosis is often overlooked.
Xu J, Zhou X, Wang Y, Liu W, Shan Y, Zhang D, Lv H, Zhao D, Dai T, Zhao Y, Li W, Liu F, Yan C
Neuropathol Appl Neurobiol 2024 Aug;50(4):e12996. doi: 10.1111/nan.12996. PMID: 38982616
Muscle histopathology in myasthenia gravis with antibodies against MuSK and AChR.
Martignago S, Fanin M, Albertini E, Pegoraro E, Angelini C
Neuropathol Appl Neurobiol 2009 Feb;35(1):103-10. doi: 10.1111/j.1365-2990.2008.00965.x. PMID: 19187062
A study of sternocleidomastoid muscular atrophy after modified neck dissection.
Ohtawa T, Katagiri M, Harada T
Surg Today 1998;28(1):46-58. doi: 10.1007/BF02483608. PMID: 9505317
Skeletal muscular atrophy in malignant tumour diseases: neurogenic or unspecific?
Schmitt HP
Acta Neuropathol 1979 Nov;48(2):149-52. doi: 10.1007/BF00691157. PMID: 506697
Neurogenic muscle involvement in myasthenia gravis. A clinical and histopathological study.
Oosterhuis H, Bethlem J
J Neurol Neurosurg Psychiatry 1973 Apr;36(2):244-54. doi: 10.1136/jnnp.36.2.244. PMID: 4708458Free PMC Article

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