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Leukocytes, CTCAE

MedGen UID:
326363
•Concept ID:
C1560219
•
Finding

Professional guidelines

PubMed

Efficacy of programmed cell death 1 inhibitor maintenance therapy after combined treatment with programmed cell death 1 inhibitors and anti-CD19-chimeric antigen receptor T cells in patients with relapsed/refractory diffuse large B-cell lymphoma and high tumor burden.
Mu J, Deng H, Lyu C, Yuan J, Li Q, Wang J, Jiang Y, Deng Q, Shen J
Hematol Oncol 2023 Apr;41(2):275-284. Epub 2022 Mar 1 doi: 10.1002/hon.2981. PMID: 35195933
Immunological consequences of cladribine treatment in multiple sclerosis: A real-world study.
Rolfes L, Pfeuffer S, Huntemann N, Schmidt M, Su C, Skuljec J, Aslan D, Hackert J, Kleinschnitz K, Hagenacker T, Pawlitzki M, Ruck T, Kleinschnitz C, Meuth SG, Pul R
Mult Scler Relat Disord 2022 Aug;64:103931. Epub 2022 May 29 doi: 10.1016/j.msard.2022.103931. PMID: 35690010
Concomitant chemotherapy and radiation for the treatment of advanced-stage endometrial cancer.
Wilkinson-Ryan I, Binder PS, Pourabolghasem S, Al-Hammadi N, Fuh K, Hagemann A, Thaker P, Schwarz J, Grigsby P, Mutch D, Powell M
Gynecol Oncol 2014 Jul;134(1):24-8. Epub 2014 May 10 doi: 10.1016/j.ygyno.2014.05.002. PMID: 24823648

Recent clinical studies

Etiology

Incidence and severity of immune-related hepatitis after dual checkpoint therapy is linked to younger age independent of herpes virus immunity.
Zhang Z, Rafei-Shamsabadi D, Lehr S, Buettner N, Diehl R, Huzly D, Pinato DJ, Thimme R, Meiss F, Bengsch B
J Transl Med 2022 Dec 12;20(1):582. doi: 10.1186/s12967-022-03755-3. PMID: 36503532Free PMC Article
Human leucocyte antigen genotype association with the development of immune-related adverse events in patients with non-small cell lung cancer treated with single agent immunotherapy.
Abed A, Law N, Calapre L, Lo J, Bhat V, Bowyer S, Millward M, Gray ES
Eur J Cancer 2022 Sep;172:98-106. Epub 2022 Jun 24 doi: 10.1016/j.ejca.2022.05.021. PMID: 35759816
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Meulendijks D, Henricks LM, Jacobs BAW, Aliev A, Deenen MJ, de Vries N, Rosing H, van Werkhoven E, de Boer A, Beijnen JH, Mandigers CMPW, Soesan M, Cats A, Schellens JHM
Br J Cancer 2017 May 23;116(11):1415-1424. Epub 2017 Apr 20 doi: 10.1038/bjc.2017.94. PMID: 28427087Free PMC Article
Use of LDH and autoimmune side effects to predict response to ipilimumab treatment.
Dick J, Lang N, Slynko A, Kopp-Schneider A, Schulz C, Dimitrakopoulou-Strauss A, Enk AH, Hassel JC
Immunotherapy 2016 Sep;8(9):1033-44. doi: 10.2217/imt-2016-0083. PMID: 27485076
Inflammatory adverse events are associated with disease-free survival after vaccine therapy among patients with melanoma.
Hu Y, Smolkin ME, White EJ, Petroni GR, Neese PY, Slingluff CL Jr
Ann Surg Oncol 2014 Nov;21(12):3978-84. Epub 2014 May 20 doi: 10.1245/s10434-014-3794-3. PMID: 24841355Free PMC Article

Diagnosis

Timed adoptive T cell transfer during chemotherapy in patients with recurrent platinum-sensitive epithelial ovarian cancer.
Verdegaal EME, Santegoets SJ, Welters MJP, de Bruin L, Visser M, van der Minne CE, de Kok PM, Loof NM, Boekestijn S, Roozen I, Westra IM, Meij P, Van der Burg SH, Kroep JR
J Immunother Cancer 2023 Nov;11(11) doi: 10.1136/jitc-2023-007697. PMID: 37949617Free PMC Article
First in man study: Bcl-Xl_42-CAF(®)09b vaccines in patients with locally advanced prostate cancer.
Mørk SK, Kongsted P, Westergaard MCW, Albieri B, Granhøj JS, Donia M, Martinenaite E, Holmström MO, Madsen K, Kverneland AH, Kjeldsen JW, Holmstroem RB, Lorentzen CL, Nørgaard N, Andreasen LV, Wood GK, Christensen D, Klausen MS, Hadrup SR, Thor Straten P, Andersen MH, Svane IM
Front Immunol 2023;14:1122977. Epub 2023 Mar 14 doi: 10.3389/fimmu.2023.1122977. PMID: 36999039Free PMC Article
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Meulendijks D, Henricks LM, Jacobs BAW, Aliev A, Deenen MJ, de Vries N, Rosing H, van Werkhoven E, de Boer A, Beijnen JH, Mandigers CMPW, Soesan M, Cats A, Schellens JHM
Br J Cancer 2017 May 23;116(11):1415-1424. Epub 2017 Apr 20 doi: 10.1038/bjc.2017.94. PMID: 28427087Free PMC Article
Use of LDH and autoimmune side effects to predict response to ipilimumab treatment.
Dick J, Lang N, Slynko A, Kopp-Schneider A, Schulz C, Dimitrakopoulou-Strauss A, Enk AH, Hassel JC
Immunotherapy 2016 Sep;8(9):1033-44. doi: 10.2217/imt-2016-0083. PMID: 27485076
Inflammatory adverse events are associated with disease-free survival after vaccine therapy among patients with melanoma.
Hu Y, Smolkin ME, White EJ, Petroni GR, Neese PY, Slingluff CL Jr
Ann Surg Oncol 2014 Nov;21(12):3978-84. Epub 2014 May 20 doi: 10.1245/s10434-014-3794-3. PMID: 24841355Free PMC Article

Therapy

Intradermal Naked DNA Vaccination by DNA Tattooing for Mounting Tumor-Specific Immunity in Stage IV Melanoma Patients: A Phase I Clinical Trial.
Geukes Foppen MH, Rohaan MW, Borgers JSW, Philips D, Vyth-Dreese F, Beijnen JH, Nuijen B, van den Berg JH, Haanen JBAG
Oncol Res Treat 2024;47(7-8):351-359. Epub 2024 Apr 5 doi: 10.1159/000537896. PMID: 38583422Free PMC Article
First-in-human study with intratumoral administration of a CD40 agonistic antibody, ADC-1013, in advanced solid malignancies.
Irenaeus SMM, Nielsen D, Ellmark P, Yachnin J, Deronic A, Nilsson A, Norlén P, Veitonmäki N, Wennersten CS, Ullenhag GJ
Int J Cancer 2019 Sep 1;145(5):1189-1199. Epub 2019 Mar 8 doi: 10.1002/ijc.32141. PMID: 30664811
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Meulendijks D, Henricks LM, Jacobs BAW, Aliev A, Deenen MJ, de Vries N, Rosing H, van Werkhoven E, de Boer A, Beijnen JH, Mandigers CMPW, Soesan M, Cats A, Schellens JHM
Br J Cancer 2017 May 23;116(11):1415-1424. Epub 2017 Apr 20 doi: 10.1038/bjc.2017.94. PMID: 28427087Free PMC Article
Inflammatory adverse events are associated with disease-free survival after vaccine therapy among patients with melanoma.
Hu Y, Smolkin ME, White EJ, Petroni GR, Neese PY, Slingluff CL Jr
Ann Surg Oncol 2014 Nov;21(12):3978-84. Epub 2014 May 20 doi: 10.1245/s10434-014-3794-3. PMID: 24841355Free PMC Article
The relationship between treatment time of gemcitabine and development of hematologic toxicity in cancer patients.
Iwata K, Aizawa K, Sakai S, Jingami S, Fukunaga E, Yoshida M, Hamada A, Saito H
Biol Pharm Bull 2011;34(11):1765-8. doi: 10.1248/bpb.34.1765. PMID: 22040893

Prognosis

Incidence and severity of immune-related hepatitis after dual checkpoint therapy is linked to younger age independent of herpes virus immunity.
Zhang Z, Rafei-Shamsabadi D, Lehr S, Buettner N, Diehl R, Huzly D, Pinato DJ, Thimme R, Meiss F, Bengsch B
J Transl Med 2022 Dec 12;20(1):582. doi: 10.1186/s12967-022-03755-3. PMID: 36503532Free PMC Article
Human leucocyte antigen genotype association with the development of immune-related adverse events in patients with non-small cell lung cancer treated with single agent immunotherapy.
Abed A, Law N, Calapre L, Lo J, Bhat V, Bowyer S, Millward M, Gray ES
Eur J Cancer 2022 Sep;172:98-106. Epub 2022 Jun 24 doi: 10.1016/j.ejca.2022.05.021. PMID: 35759816
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Meulendijks D, Henricks LM, Jacobs BAW, Aliev A, Deenen MJ, de Vries N, Rosing H, van Werkhoven E, de Boer A, Beijnen JH, Mandigers CMPW, Soesan M, Cats A, Schellens JHM
Br J Cancer 2017 May 23;116(11):1415-1424. Epub 2017 Apr 20 doi: 10.1038/bjc.2017.94. PMID: 28427087Free PMC Article
Use of LDH and autoimmune side effects to predict response to ipilimumab treatment.
Dick J, Lang N, Slynko A, Kopp-Schneider A, Schulz C, Dimitrakopoulou-Strauss A, Enk AH, Hassel JC
Immunotherapy 2016 Sep;8(9):1033-44. doi: 10.2217/imt-2016-0083. PMID: 27485076
Inflammatory adverse events are associated with disease-free survival after vaccine therapy among patients with melanoma.
Hu Y, Smolkin ME, White EJ, Petroni GR, Neese PY, Slingluff CL Jr
Ann Surg Oncol 2014 Nov;21(12):3978-84. Epub 2014 May 20 doi: 10.1245/s10434-014-3794-3. PMID: 24841355Free PMC Article

Clinical prediction guides

Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients.
Ahmadvand M, Barough MS, Barkhordar M, Faridfar A, Ghaderi A, Jalaeikhoo H, Rajaienejad M, Majidzadeh K, Ghavamzadeh A, Sarrami-Forooshani R
BMC Cancer 2023 Nov 10;23(1):1090. doi: 10.1186/s12885-023-11610-x. PMID: 37950209Free PMC Article
Patient-reported outcomes in CD30-directed CAR-T cells against relapsed/refractory CD30+ lymphomas.
Tschernia NP, Heiling H, Deal AM, Cheng C, Babinec C, Gonzalez M, Morrison JK, Dittus C, Dotti G, Beaven AW, Serody JS, Wood WA, Savoldo B, Grover NS
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2023-006959. PMID: 37527906Free PMC Article
Incidence and severity of immune-related hepatitis after dual checkpoint therapy is linked to younger age independent of herpes virus immunity.
Zhang Z, Rafei-Shamsabadi D, Lehr S, Buettner N, Diehl R, Huzly D, Pinato DJ, Thimme R, Meiss F, Bengsch B
J Transl Med 2022 Dec 12;20(1):582. doi: 10.1186/s12967-022-03755-3. PMID: 36503532Free PMC Article
Immunological consequences of cladribine treatment in multiple sclerosis: A real-world study.
Rolfes L, Pfeuffer S, Huntemann N, Schmidt M, Su C, Skuljec J, Aslan D, Hackert J, Kleinschnitz K, Hagenacker T, Pawlitzki M, Ruck T, Kleinschnitz C, Meuth SG, Pul R
Mult Scler Relat Disord 2022 Aug;64:103931. Epub 2022 May 29 doi: 10.1016/j.msard.2022.103931. PMID: 35690010
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Meulendijks D, Henricks LM, Jacobs BAW, Aliev A, Deenen MJ, de Vries N, Rosing H, van Werkhoven E, de Boer A, Beijnen JH, Mandigers CMPW, Soesan M, Cats A, Schellens JHM
Br J Cancer 2017 May 23;116(11):1415-1424. Epub 2017 Apr 20 doi: 10.1038/bjc.2017.94. PMID: 28427087Free PMC Article

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