U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Immune suppression(IS)

MedGen UID:
326692
•Concept ID:
C1840264
•
Disease or Syndrome
Synonyms: IS; STREPTOCOCCAL CELL WALL ANTIGEN, SUPPRESSION OF IMMUNE RESPONSE TO
 
OMIM®: 146850

Clinical features

From HPO
Abnormality of the immune system
MedGen UID:
867388
•Concept ID:
C4021753
•
Pathologic Function
An abnormality of the immune system.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Management of Crohn Disease: A Review.
Cushing K, Higgins PDR
JAMA 2021 Jan 5;325(1):69-80. doi: 10.1001/jama.2020.18936. PMID: 33399844Free PMC Article
Mechanisms and treatment of organ failure in sepsis.
Lelubre C, Vincent JL
Nat Rev Nephrol 2018 Jul;14(7):417-427. doi: 10.1038/s41581-018-0005-7. PMID: 29691495

Recent clinical studies

Etiology

Histone lactylation: from tumor lactate metabolism to epigenetic regulation.
Yu X, Yang J, Xu J, Pan H, Wang W, Yu X, Shi S
Int J Biol Sci 2024;20(5):1833-1854. Epub 2024 Mar 3 doi: 10.7150/ijbs.91492. PMID: 38481814Free PMC Article
The choice of new treatments in autoimmune hemolytic anemia: how to pick from the basket?
Berentsen S, Fattizzo B, Barcellini W
Front Immunol 2023;14:1180509. Epub 2023 Apr 24 doi: 10.3389/fimmu.2023.1180509. PMID: 37168855Free PMC Article
Immunotherapy for hepatocellular carcinoma: Recent advances and future targets.
Yu SJ
Pharmacol Ther 2023 Apr;244:108387. Epub 2023 Mar 21 doi: 10.1016/j.pharmthera.2023.108387. PMID: 36948423
Immunopathophysiology of human sepsis.
Wiersinga WJ, van der Poll T
EBioMedicine 2022 Dec;86:104363. Epub 2022 Dec 2 doi: 10.1016/j.ebiom.2022.104363. PMID: 36470832Free PMC Article
Immunosuppressive Agents and Infectious Risk in Transplantation: Managing the "Net State of Immunosuppression".
Roberts MB, Fishman JA
Clin Infect Dis 2021 Oct 5;73(7):e1302-e1317. doi: 10.1093/cid/ciaa1189. PMID: 32803228Free PMC Article

Diagnosis

Metabolic programming and immune suppression in the tumor microenvironment.
Arner EN, Rathmell JC
Cancer Cell 2023 Mar 13;41(3):421-433. Epub 2023 Feb 16 doi: 10.1016/j.ccell.2023.01.009. PMID: 36801000Free PMC Article
Strongyloides stercoralis.
Czeresnia JM, Weiss LM
Lung 2022 Apr;200(2):141-148. Epub 2022 Apr 9 doi: 10.1007/s00408-022-00528-z. PMID: 35396957Free PMC Article
Systemic sclerosis.
Denton CP, Khanna D
Lancet 2017 Oct 7;390(10103):1685-1699. Epub 2017 Apr 13 doi: 10.1016/S0140-6736(17)30933-9. PMID: 28413064
Infection in Organ Transplantation.
Fishman JA
Am J Transplant 2017 Apr;17(4):856-879. Epub 2017 Mar 10 doi: 10.1111/ajt.14208. PMID: 28117944
Familial Hemophagocytic Lymphohistiocytosis.
Degar B
Hematol Oncol Clin North Am 2015 Oct;29(5):903-13. Epub 2015 Aug 25 doi: 10.1016/j.hoc.2015.06.008. PMID: 26461150

Therapy

Mild Crohn's Disease: Definition and Management.
Claytor J, Kumar P, Ananthakrishnan AN, Colombel JF, Agrawal M, Ungaro RC
Curr Gastroenterol Rep 2023 Mar;25(3):45-51. Epub 2023 Feb 8 doi: 10.1007/s11894-023-00863-y. PMID: 36753033
Immunopathophysiology of human sepsis.
Wiersinga WJ, van der Poll T
EBioMedicine 2022 Dec;86:104363. Epub 2022 Dec 2 doi: 10.1016/j.ebiom.2022.104363. PMID: 36470832Free PMC Article
Future Projections in Thyroid Eye Disease.
Barbesino G, Salvi M, Freitag SK
J Clin Endocrinol Metab 2022 Aug 8;107(Suppl_1):S47-S56. doi: 10.1210/clinem/dgac252. PMID: 36346684Free PMC Article
Recent advances in the mechanisms and treatment of immune thrombocytopenia.
Provan D, Semple JW
EBioMedicine 2022 Feb;76:103820. Epub 2022 Jan 21 doi: 10.1016/j.ebiom.2022.103820. PMID: 35074629Free PMC Article
Challenges and Opportunities for Pancreatic Cancer Immunotherapy.
Bear AS, Vonderheide RH, O'Hara MH
Cancer Cell 2020 Dec 14;38(6):788-802. Epub 2020 Sep 17 doi: 10.1016/j.ccell.2020.08.004. PMID: 32946773Free PMC Article

Prognosis

CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up.
Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, Aigner M, Rothe T, Minopoulou I, Tur C, Knitza J, Kharboutli S, Kretschmann S, Vasova I, Spoerl S, Reimann H, Munoz L, Gerlach RG, Schäfer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Krönke G, Mackensen A, Schett G
N Engl J Med 2024 Feb 22;390(8):687-700. doi: 10.1056/NEJMoa2308917. PMID: 38381673
Single-cell and spatial transcriptomics reveal POSTN(+) cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer.
Chen C, Guo Q, Liu Y, Hou Q, Liao M, Guo Y, Zang Y, Wang F, Liu H, Luan X, Liang Y, Guan Z, Li Y, Liu H, Dong X, Zhang X, Liu J, Xu Q
Clin Transl Med 2023 Dec;13(12):e1515. doi: 10.1002/ctm2.1515. PMID: 38115703Free PMC Article
Sepsis-Induced Immunosuppression.
Torres LK, Pickkers P, van der Poll T
Annu Rev Physiol 2022 Feb 10;84:157-181. Epub 2021 Oct 27 doi: 10.1146/annurev-physiol-061121-040214. PMID: 34705481
Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer.
Mehta AK, Kadel S, Townsend MG, Oliwa M, Guerriero JL
Front Immunol 2021;12:643771. Epub 2021 Apr 23 doi: 10.3389/fimmu.2021.643771. PMID: 33968034Free PMC Article
Familial Hemophagocytic Lymphohistiocytosis.
Degar B
Hematol Oncol Clin North Am 2015 Oct;29(5):903-13. Epub 2015 Aug 25 doi: 10.1016/j.hoc.2015.06.008. PMID: 26461150

Clinical prediction guides

CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up.
Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, Aigner M, Rothe T, Minopoulou I, Tur C, Knitza J, Kharboutli S, Kretschmann S, Vasova I, Spoerl S, Reimann H, Munoz L, Gerlach RG, Schäfer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Krönke G, Mackensen A, Schett G
N Engl J Med 2024 Feb 22;390(8):687-700. doi: 10.1056/NEJMoa2308917. PMID: 38381673
Sepsis-Induced Immunosuppression.
Torres LK, Pickkers P, van der Poll T
Annu Rev Physiol 2022 Feb 10;84:157-181. Epub 2021 Oct 27 doi: 10.1146/annurev-physiol-061121-040214. PMID: 34705481
The TIM3/Gal9 signaling pathway: An emerging target for cancer immunotherapy.
Kandel S, Adhikary P, Li G, Cheng K
Cancer Lett 2021 Jul 10;510:67-78. Epub 2021 Apr 22 doi: 10.1016/j.canlet.2021.04.011. PMID: 33895262Free PMC Article
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression.
Fousek K, Horn LA, Palena C
Pharmacol Ther 2021 Mar;219:107692. Epub 2020 Sep 24 doi: 10.1016/j.pharmthera.2020.107692. PMID: 32980444Free PMC Article
PI3Kγ is a molecular switch that controls immune suppression.
Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA
Nature 2016 Nov 17;539(7629):437-442. Epub 2016 Sep 19 doi: 10.1038/nature19834. PMID: 27642729Free PMC Article

Recent systematic reviews

Targeting PI3K-gamma in myeloid driven tumour immune suppression: a systematic review and meta-analysis of the preclinical literature.
Xu H, Russell SN, Steiner K, O'Neill E, Jones KI
Cancer Immunol Immunother 2024 Aug 6;73(10):204. doi: 10.1007/s00262-024-03779-2. PMID: 39105848Free PMC Article
IDH mutation, glioma immunogenicity, and therapeutic challenge of primary mismatch repair deficient IDH-mutant astrocytoma PMMRDIA: a systematic review.
Ahmad O, Ahmad T, Pfister SM
Mol Oncol 2024 Dec;18(12):2822-2841. Epub 2024 Feb 9 doi: 10.1002/1878-0261.13598. PMID: 38339779Free PMC Article
Pregnancy and COVID-19: high or low risk of vertical transmission.
Al-Kuraishy HM, Al-Gareeb AI, Albezrah NKA, Bahaa HA, El-Bouseary MM, Alexiou A, Al-Ziyadi SH, Batiha GE
Clin Exp Med 2023 Aug;23(4):957-967. Epub 2022 Oct 17 doi: 10.1007/s10238-022-00907-z. PMID: 36251144Free PMC Article
Rhino-orbital-cerebral-mucormycosis in COVID-19: A systematic review.
Bhattacharyya A, Sarma P, Sharma DJ, Das KK, Kaur H, Prajapat M, Kumar S, Bansal S, Prakash A, Avti P, Thota P, Reddy DH, Gautam BS, Medhi B
Indian J Pharmacol 2021 Jul-Aug;53(4):317-327. doi: 10.4103/ijp.ijp_419_21. PMID: 34414911Free PMC Article
Corticosteroids for periorbital and orbital cellulitis.
Kornelsen E, Mahant S, Parkin P, Ren LY, Reginald YA, Shah SS, Gill PJ
Cochrane Database Syst Rev 2021 Apr 28;4(4):CD013535. doi: 10.1002/14651858.CD013535.pub2. PMID: 33908631Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...