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Dysphagia, CTCAE

MedGen UID:
327206
•Concept ID:
C1560331
•
Finding

Definition

A disorder characterized by difficulty in swallowing. [from NCI]

Professional guidelines

PubMed

Raster-scanned carbon ion therapy for malignant salivary gland tumors: acute toxicity and initial treatment response.
Jensen AD, Nikoghosyan AV, Ecker S, Ellerbrock M, Debus J, Herfarth KK, Münter MW
Radiat Oncol 2011 Nov 2;6:149. doi: 10.1186/1748-717X-6-149. PMID: 22046954Free PMC Article
Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system.
Palazzi M, Tomatis S, Orlandi E, Guzzo M, Sangalli C, Potepan P, Fantini S, Bergamini C, Gavazzi C, Licitra L, Scaramellini G, Cantu' G, Olmi P
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):330-7. Epub 2007 Sep 19 doi: 10.1016/j.ijrobp.2007.06.022. PMID: 17881148

Recent clinical studies

Etiology

Radiation-induced long-term dysphagia in survivors of head and neck cancer and association with dose-volume parameters.
Huynh TM, Dale E, Falk RS, Hellebust TP, Astrup GL, Malinen E, Edin NFJ, Bjordal K, Herlofson BB, Kiserud CE, Helland Å, Amdal CD
Radiother Oncol 2024 Jan;190:110044. Epub 2023 Dec 5 doi: 10.1016/j.radonc.2023.110044. PMID: 38061420
Toxicities and clinical outcome of adjuvant dysphagia optimized versus standard intensity-modulated radiotherapy for post-operative oral cavity cancers: A prospective comparative study.
Patni A, Rastogi M, Gandhi AK, Mishra VK, Srivastava AK, Sharma V, Agarwal A, Khurana R, Hadi R, Sapru S, Mishra SP
Head Neck 2023 Dec;45(12):3119-3128. Epub 2023 Oct 10 doi: 10.1002/hed.27541. PMID: 37814926
Patient-Reported Outcomes During and After Treatment for Locally Advanced Rectal Cancer in the PROSPECT Trial (Alliance N1048).
Basch E, Dueck AC, Mitchell SA, Mamon H, Weiser M, Saltz L, Gollub M, Rogak L, Ginos B, Mazza GL, Colgrove B, Chang G, Minasian L, Denicoff A, Thanarajasingam G, Musher B, George T, Venook A, Farma J, O'Reilly E, Meyerhardt JA, Shi Q, Schrag D
J Clin Oncol 2023 Jul 20;41(21):3724-3734. Epub 2023 Jun 4 doi: 10.1200/JCO.23.00903. PMID: 37270691Free PMC Article
Dose-volume toxicity modeling for de-intensified chemo-radiation therapy for HPV-positive oropharynx cancer.
Mavroidis P, Price A, Fried D, Kostich M, Amdur R, Mendenhall W, Liu C, Das S, Marks LB, Chera B
Radiother Oncol 2017 Aug;124(2):240-247. Epub 2017 Jul 13 doi: 10.1016/j.radonc.2017.06.020. PMID: 28712533
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718

Diagnosis

Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
Clinician-observed and patient-reported toxicities and their association with poor tolerance to therapy in older patients with head and neck or lung cancer treated with curative radiotherapy.
Moon DH, Chera BS, Deal AM, Wang Y, Muss HB, VanderWalde NA
J Geriatr Oncol 2019 Jan;10(1):42-47. Epub 2018 Jun 11 doi: 10.1016/j.jgo.2018.05.016. PMID: 29903673
Grading Dysphagia as a Toxicity of Head and Neck Cancer: Differences in Severity Classification Based on MBS DIGEST and Clinical CTCAE Grades.
Goepfert RP, Lewin JS, Barrow MP, Warneke CL, Fuller CD, Lai SY, Weber RS, Hutcheson KA
Dysphagia 2018 Apr;33(2):185-191. Epub 2017 Aug 23 doi: 10.1007/s00455-017-9843-x. PMID: 28836005Free PMC Article
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841
Aspiration pneumonia after chemo-intensity-modulated radiation therapy of oropharyngeal carcinoma and its clinical and dysphagia-related predictors.
Hunter KU, Lee OE, Lyden TH, Haxer MJ, Feng FY, Schipper M, Worden F, Prince ME, McLean SA, Wolf GT, Bradford CR, Chepeha DB, Eisbruch A
Head Neck 2014 Jan;36(1):120-5. Epub 2013 Jun 1 doi: 10.1002/hed.23275. PMID: 23729173Free PMC Article

Therapy

Toxicities and clinical outcome of adjuvant dysphagia optimized versus standard intensity-modulated radiotherapy for post-operative oral cavity cancers: A prospective comparative study.
Patni A, Rastogi M, Gandhi AK, Mishra VK, Srivastava AK, Sharma V, Agarwal A, Khurana R, Hadi R, Sapru S, Mishra SP
Head Neck 2023 Dec;45(12):3119-3128. Epub 2023 Oct 10 doi: 10.1002/hed.27541. PMID: 37814926
Patient-Reported Outcomes During and After Treatment for Locally Advanced Rectal Cancer in the PROSPECT Trial (Alliance N1048).
Basch E, Dueck AC, Mitchell SA, Mamon H, Weiser M, Saltz L, Gollub M, Rogak L, Ginos B, Mazza GL, Colgrove B, Chang G, Minasian L, Denicoff A, Thanarajasingam G, Musher B, George T, Venook A, Farma J, O'Reilly E, Meyerhardt JA, Shi Q, Schrag D
J Clin Oncol 2023 Jul 20;41(21):3724-3734. Epub 2023 Jun 4 doi: 10.1200/JCO.23.00903. PMID: 37270691Free PMC Article
Grading Dysphagia as a Toxicity of Head and Neck Cancer: Differences in Severity Classification Based on MBS DIGEST and Clinical CTCAE Grades.
Goepfert RP, Lewin JS, Barrow MP, Warneke CL, Fuller CD, Lai SY, Weber RS, Hutcheson KA
Dysphagia 2018 Apr;33(2):185-191. Epub 2017 Aug 23 doi: 10.1007/s00455-017-9843-x. PMID: 28836005Free PMC Article
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718
Aspiration pneumonia after chemo-intensity-modulated radiation therapy of oropharyngeal carcinoma and its clinical and dysphagia-related predictors.
Hunter KU, Lee OE, Lyden TH, Haxer MJ, Feng FY, Schipper M, Worden F, Prince ME, McLean SA, Wolf GT, Bradford CR, Chepeha DB, Eisbruch A
Head Neck 2014 Jan;36(1):120-5. Epub 2013 Jun 1 doi: 10.1002/hed.23275. PMID: 23729173Free PMC Article

Prognosis

Radiation-induced long-term dysphagia in survivors of head and neck cancer and association with dose-volume parameters.
Huynh TM, Dale E, Falk RS, Hellebust TP, Astrup GL, Malinen E, Edin NFJ, Bjordal K, Herlofson BB, Kiserud CE, Helland Å, Amdal CD
Radiother Oncol 2024 Jan;190:110044. Epub 2023 Dec 5 doi: 10.1016/j.radonc.2023.110044. PMID: 38061420
Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
The efficacy and safety of definitive concurrent chemoradiotherapy for non-operable esophageal cancer.
Dreyfuss AD, Barsky AR, Wileyto EP, Eads JR, Kucharczuk JC, Williams NN, Karasic TB, Metz JM, Ben-Josef E, Plastaras JP, Wojcieszynski AP
Cancer Med 2021 Feb;10(4):1275-1288. Epub 2021 Jan 20 doi: 10.1002/cam4.3724. PMID: 33474812Free PMC Article
Dose-volume toxicity modeling for de-intensified chemo-radiation therapy for HPV-positive oropharynx cancer.
Mavroidis P, Price A, Fried D, Kostich M, Amdur R, Mendenhall W, Liu C, Das S, Marks LB, Chera B
Radiother Oncol 2017 Aug;124(2):240-247. Epub 2017 Jul 13 doi: 10.1016/j.radonc.2017.06.020. PMID: 28712533
Aspiration pneumonia after chemo-intensity-modulated radiation therapy of oropharyngeal carcinoma and its clinical and dysphagia-related predictors.
Hunter KU, Lee OE, Lyden TH, Haxer MJ, Feng FY, Schipper M, Worden F, Prince ME, McLean SA, Wolf GT, Bradford CR, Chepeha DB, Eisbruch A
Head Neck 2014 Jan;36(1):120-5. Epub 2013 Jun 1 doi: 10.1002/hed.23275. PMID: 23729173Free PMC Article

Clinical prediction guides

Radiation-induced long-term dysphagia in survivors of head and neck cancer and association with dose-volume parameters.
Huynh TM, Dale E, Falk RS, Hellebust TP, Astrup GL, Malinen E, Edin NFJ, Bjordal K, Herlofson BB, Kiserud CE, Helland Å, Amdal CD
Radiother Oncol 2024 Jan;190:110044. Epub 2023 Dec 5 doi: 10.1016/j.radonc.2023.110044. PMID: 38061420
Toxicities and clinical outcome of adjuvant dysphagia optimized versus standard intensity-modulated radiotherapy for post-operative oral cavity cancers: A prospective comparative study.
Patni A, Rastogi M, Gandhi AK, Mishra VK, Srivastava AK, Sharma V, Agarwal A, Khurana R, Hadi R, Sapru S, Mishra SP
Head Neck 2023 Dec;45(12):3119-3128. Epub 2023 Oct 10 doi: 10.1002/hed.27541. PMID: 37814926
Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
Patient-reported outcome during radiotherapy for head and neck cancer: the use of different PRO questionnaires.
Steen-Olsen EB, Stormoen DR, Kristensen CA, Vogelius IR, Holländer-Mieritz C, Pappot H
Eur Arch Otorhinolaryngol 2022 Aug;279(8):4199-4206. Epub 2022 Mar 31 doi: 10.1007/s00405-022-07364-0. PMID: 35357578
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718

Recent systematic reviews

Dysphagia optimized radiotherapy to reduce swallowing dysfunction severity in patients undergoing treatment for head and neck cancer: A systematized scoping review.
Hutchison AR, Cartmill B, Wall LR, Ward EC
Head Neck 2019 Jun;41(6):2024-2033. Epub 2019 Feb 5 doi: 10.1002/hed.25688. PMID: 30723986

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