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Insulin-dependent but ketosis-resistant diabetes

MedGen UID:
334070
•Concept ID:
C1842404
•
Finding
HPO: HP:0008205

Definition

Ketosis-resistant diabetes is a synonym for type II diabetes. This term thus refers to a form of type II diabetes in which patients are dependent on insulin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInsulin-dependent but ketosis-resistant diabetes

Conditions with this feature

Tropical pancreatitis
MedGen UID:
334069
•Concept ID:
C1842402
•
Disease or Syndrome
Tropical calcific pancreatitis (TCP) is a type of chronic pancreatitis unique to tropical regions. Large intraductal calculi are present, and evidence of pancreatic calcification is seen on imaging studies (summary by Mahurkar et al., 2006).
See: Condition Record
Tropical pancreatitis

Professional guidelines

PubMed

The Evaluation and Management of Pediatric Diabetic Ketoacidosis: A Comprehensive Review.
Bonadio W
Clin Pediatr (Phila) 2023 Jun;62(6):551-564. Epub 2022 Nov 25 doi: 10.1177/00099228221139982. PMID: 36433643
Insulin Management for Type 2 Diabetes During Ramadan: A Narrative Review for Clinicians.
Kieu A, Iles A
Curr Diabetes Rev 2023;19(3):e170522204910. doi: 10.2174/1573399818666220517124752. PMID: 35585815
GIP analogues and the treatment of obesity-diabetes.
Bailey CJ
Peptides 2020 Mar;125:170202. Epub 2019 Nov 19 doi: 10.1016/j.peptides.2019.170202. PMID: 31756366

Recent clinical studies

Etiology

Insulin-dependent diabetes mellitus in older adults: Current status and future prospects.
Ikegami H, Hiromine Y, Noso S
Geriatr Gerontol Int 2022 Aug;22(8):549-553. Epub 2022 Jun 16 doi: 10.1111/ggi.14414. PMID: 35711119Free PMC Article
Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective.
Zaccardi F, Webb DR, Yates T, Davies MJ
Postgrad Med J 2016 Feb;92(1084):63-9. Epub 2015 Nov 30 doi: 10.1136/postgradmedj-2015-133281. PMID: 26621825
Maturity-onset diabetes of the young (MODY): an update.
Anık A, Çatlı G, Abacı A, Böber E
J Pediatr Endocrinol Metab 2015 Mar;28(3-4):251-63. doi: 10.1515/jpem-2014-0384. PMID: 25581748
Classification of diabetes.
Maraschin Jde F
Adv Exp Med Biol 2012;771:12-9. doi: 10.1007/978-1-4614-5441-0_2. PMID: 23393666
Metformin--an update.
Bailey CJ
Gen Pharmacol 1993 Nov;24(6):1299-309. doi: 10.1016/0306-3623(93)90411-p. PMID: 8112499

Diagnosis

Atypical diabetes: a diagnostic challenge.
Sjöholm Å
BMJ Open Diabetes Res Care 2020 Aug;8(1) doi: 10.1136/bmjdrc-2020-001470. PMID: 32771985Free PMC Article
What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters.
Gilor C, Niessen SJ, Furrow E, DiBartola SP
J Vet Intern Med 2016 Jul;30(4):927-40. doi: 10.1111/jvim.14357. PMID: 27461721Free PMC Article
Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective.
Zaccardi F, Webb DR, Yates T, Davies MJ
Postgrad Med J 2016 Feb;92(1084):63-9. Epub 2015 Nov 30 doi: 10.1136/postgradmedj-2015-133281. PMID: 26621825
Maturity-onset diabetes of the young (MODY): an update.
Anık A, Çatlı G, Abacı A, Böber E
J Pediatr Endocrinol Metab 2015 Mar;28(3-4):251-63. doi: 10.1515/jpem-2014-0384. PMID: 25581748
Diabetic neuropathy.
Dyck PJ, Windebank A, Yasuda H, Service FJ, Rizza R, Zimmerman B
Adv Exp Med Biol 1985;189:305-20. doi: 10.1007/978-1-4757-1850-8_17. PMID: 4036717

Therapy

Insulin-dependent diabetes mellitus in older adults: Current status and future prospects.
Ikegami H, Hiromine Y, Noso S
Geriatr Gerontol Int 2022 Aug;22(8):549-553. Epub 2022 Jun 16 doi: 10.1111/ggi.14414. PMID: 35711119Free PMC Article
Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin.
Furmli S, Elmasry R, Ramos M, Fung J
BMJ Case Rep 2018 Oct 9;2018 doi: 10.1136/bcr-2017-221854. PMID: 30301822Free PMC Article
Effect of an Intensive Lifestyle Intervention on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial.
Johansen MY, MacDonald CS, Hansen KB, Karstoft K, Christensen R, Pedersen M, Hansen LS, Zacho M, Wedell-Neergaard AS, Nielsen ST, Iepsen UW, Langberg H, Vaag AA, Pedersen BK, Ried-Larsen M
JAMA 2017 Aug 15;318(7):637-646. doi: 10.1001/jama.2017.10169. PMID: 28810024Free PMC Article
Maturity-onset diabetes of the young (MODY): an update.
Anık A, Çatlı G, Abacı A, Böber E
J Pediatr Endocrinol Metab 2015 Mar;28(3-4):251-63. doi: 10.1515/jpem-2014-0384. PMID: 25581748
Rosiglitazone.
Balfour JA, Plosker GL
Drugs 1999 Jun;57(6):921-30; discussion 931-2. doi: 10.2165/00003495-199957060-00007. PMID: 10400405

Prognosis

Insulin-dependent diabetes mellitus in older adults: Current status and future prospects.
Ikegami H, Hiromine Y, Noso S
Geriatr Gerontol Int 2022 Aug;22(8):549-553. Epub 2022 Jun 16 doi: 10.1111/ggi.14414. PMID: 35711119Free PMC Article
Insulin-dependent diabetes and serious trauma.
Liou DZ, Singer MB, Barmparas G, Harada MY, Mirocha J, Bukur M, Salim A, Ley EJ
Eur J Trauma Emerg Surg 2016 Aug;42(4):491-496. Epub 2015 Aug 8 doi: 10.1007/s00068-015-0561-5. PMID: 26253885
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction.
Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M
N Engl J Med 1998 Jul 23;339(4):229-34. doi: 10.1056/NEJM199807233390404. PMID: 9673301
Preventing non-insulin-dependent diabetes.
Knowler WC, Narayan KM, Hanson RL, Nelson RG, Bennett PH, Tuomilehto J, Scherstén B, Pettitt DJ
Diabetes 1995 May;44(5):483-8. doi: 10.2337/diab.44.5.483. PMID: 7729603
Epidemiology, obesity, and non-insulin-dependent diabetes mellitus.
Barrett-Connor E
Epidemiol Rev 1989;11:172-81. doi: 10.1093/oxfordjournals.epirev.a036035. PMID: 2680554

Clinical prediction guides

Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective.
Zaccardi F, Webb DR, Yates T, Davies MJ
Postgrad Med J 2016 Feb;92(1084):63-9. Epub 2015 Nov 30 doi: 10.1136/postgradmedj-2015-133281. PMID: 26621825
Insulin-dependent diabetes and serious trauma.
Liou DZ, Singer MB, Barmparas G, Harada MY, Mirocha J, Bukur M, Salim A, Ley EJ
Eur J Trauma Emerg Surg 2016 Aug;42(4):491-496. Epub 2015 Aug 8 doi: 10.1007/s00068-015-0561-5. PMID: 26253885
Non-insulin-dependent diabetes mellitus.
Hales CN
Br Med Bull 1997 Jan;53(1):109-22. doi: 10.1093/oxfordjournals.bmb.a011594. PMID: 9158288
Preventing non-insulin-dependent diabetes.
Knowler WC, Narayan KM, Hanson RL, Nelson RG, Bennett PH, Tuomilehto J, Scherstén B, Pettitt DJ
Diabetes 1995 May;44(5):483-8. doi: 10.2337/diab.44.5.483. PMID: 7729603
Diabetic neuropathy.
Dyck PJ, Windebank A, Yasuda H, Service FJ, Rizza R, Zimmerman B
Adv Exp Med Biol 1985;189:305-20. doi: 10.1007/978-1-4757-1850-8_17. PMID: 4036717

Recent systematic reviews

Effectiveness of Combined Aerobic and Resistance Exercise on Cognition, Metabolic Health, Physical Function, and Health-related Quality of Life in Middle-aged and Older Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.
Zhang J, Tam WWS, Hounsri K, Kusuyama J, Wu VX
Arch Phys Med Rehabil 2024 Aug;105(8):1585-1599. Epub 2023 Oct 22 doi: 10.1016/j.apmr.2023.10.005. PMID: 37875170
Diabetes mellitus and adverse outcomes after carotid endarterectomy: A systematic review and meta-analysis.
Li F, Zhang R, Di X, Niu S, Rong Z, Liu C, Ni L
Chin Med J (Engl) 2023 Jun 20;136(12):1401-1409. Epub 2023 May 22 doi: 10.1097/CM9.0000000000002730. PMID: 37334731Free PMC Article
Health Related Quality of Life Measurements for Diabetes: A Systematic Review.
Oluchi SE, Manaf RA, Ismail S, Kadir Shahar H, Mahmud A, Udeani TK
Int J Environ Res Public Health 2021 Sep 1;18(17) doi: 10.3390/ijerph18179245. PMID: 34501838Free PMC Article
Metabolic Effects of Endoscopic Duodenal Mucosal Resurfacing: a Systematic Review and Meta-analysis.
de Oliveira GHP, de Moura DTH, Funari MP, McCarty TR, Ribeiro IB, Bernardo WM, Sagae VMT, Freitas JR Jr, Souza GMV, de Moura EGH
Obes Surg 2021 Mar;31(3):1304-1312. Epub 2021 Jan 8 doi: 10.1007/s11695-020-05170-3. PMID: 33417100
Do patients with diabetes have an increased risk of impaired fracture healing? A systematic review and meta-analysis.
Ding ZC, Zeng WN, Rong X, Liang ZM, Zhou ZK
ANZ J Surg 2020 Jul;90(7-8):1259-1264. Epub 2020 Apr 7 doi: 10.1111/ans.15878. PMID: 32255244

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