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Migraine with or without aura, susceptibility to, 5

MedGen UID:
334831
Concept ID:
C1843771
Finding
Synonym: Migraine with or without aura 5
 
Monarch Initiative: MONDO:0011850
OMIM®: 607508

Definition

For a phenotypic description and discussion of genetic heterogeneity of migraine headaches, see MGR1 (157300). [from OMIM]

Clinical features

From HPO
Nausea
MedGen UID:
10196
Concept ID:
C0027497
Sign or Symptom
A sensation of unease in the stomach together with an urge to vomit.
Vomiting
MedGen UID:
12124
Concept ID:
C0042963
Sign or Symptom
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
Photophobia
MedGen UID:
43220
Concept ID:
C0085636
Sign or Symptom
Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
Migraine with aura
MedGen UID:
57822
Concept ID:
C0154723
Disease or Syndrome
A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.
Migraine without aura
MedGen UID:
137899
Concept ID:
C0338480
Disease or Syndrome
Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria
Phonophobia
MedGen UID:
155864
Concept ID:
C0751466
Mental or Behavioral Dysfunction
An abnormally heightened sensitivity to loud sounds.

Professional guidelines

PubMed

Khan J, Asoom LIA, Sunni AA, Rafique N, Latif R, Saif SA, Almandil NB, Almohazey D, AbdulAzeez S, Borgio JF
Biomed Pharmacother 2021 Jul;139:111557. Epub 2021 May 17 doi: 10.1016/j.biopha.2021.111557. PMID: 34243621
Ailani J, Burch RC, Robbins MS; Board of Directors of the American Headache Society
Headache 2021 Jul;61(7):1021-1039. Epub 2021 Jun 23 doi: 10.1111/head.14153. PMID: 34160823
Charles A
Lancet Neurol 2018 Feb;17(2):174-182. Epub 2017 Dec 8 doi: 10.1016/S1474-4422(17)30435-0. PMID: 29229375

Curated

UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

Recent clinical studies

Etiology

Grangeon L, Lange KS, Waliszewska-Prosół M, Onan D, Marschollek K, Wiels W, Mikulenka P, Farham F, Gollion C, Ducros A; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2023 Feb 20;24(1):12. doi: 10.1186/s10194-023-01547-8. PMID: 36800925Free PMC Article
Pavelic AR, Wöber C, Riederer F, Zebenholzer K
Cells 2022 Dec 29;12(1) doi: 10.3390/cells12010143. PMID: 36611935Free PMC Article
Wells RE, Beuthin J, Granetzke L
Curr Pain Headache Rep 2019 Feb 21;23(2):10. doi: 10.1007/s11916-019-0750-8. PMID: 30790138Free PMC Article
Cameron C, Kelly S, Hsieh SC, Murphy M, Chen L, Kotb A, Peterson J, Coyle D, Skidmore B, Gomes T, Clifford T, Wells G
Headache 2015 Jul-Aug;55 Suppl 4:221-35. Epub 2015 Jul 14 doi: 10.1111/head.12601. PMID: 26178694
Schwedt TJ
BMJ 2014 Mar 24;348:g1416. doi: 10.1136/bmj.g1416. PMID: 24662044

Diagnosis

Villar-Martinez MD, Goadsby PJ
Cells 2022 Sep 5;11(17) doi: 10.3390/cells11172767. PMID: 36078174Free PMC Article
Aguilar-Shea AL, Membrilla Md JA, Diaz-de-Teran J
Aten Primaria 2022 Feb;54(2):102208. Epub 2021 Nov 16 doi: 10.1016/j.aprim.2021.102208. PMID: 34798397Free PMC Article
Ha H, Gonzalez A
Am Fam Physician 2019 Jan 1;99(1):17-24. PMID: 30600979
Dodick DW
Lancet 2018 Mar 31;391(10127):1315-1330. Epub 2018 Mar 6 doi: 10.1016/S0140-6736(18)30478-1. PMID: 29523342
Silberstein SD
Lancet 2004 Jan 31;363(9406):381-91. doi: 10.1016/S0140-6736(04)15440-8. PMID: 15070571

Therapy

Hugger SS, Do TP, Ashina H, Goicochea MT, Jenkins B, Sacco S, Lee MJ, Brennan KC, Amin FM, Steiner TJ, Ashina M
Lancet Neurol 2023 Oct;22(10):934-945. Epub 2023 Sep 14 doi: 10.1016/S1474-4422(23)00206-5. PMID: 37717587
Haghdoost F, Puledda F, Garcia-Azorin D, Huessler EM, Messina R, Pozo-Rosich P
Cephalalgia 2023 Apr;43(4):3331024231159366. doi: 10.1177/03331024231159366. PMID: 36855951
Vuralli D, Ayata C, Bolay H
J Headache Pain 2018 Nov 15;19(1):109. doi: 10.1186/s10194-018-0933-4. PMID: 30442090Free PMC Article
Puledda F, Shields K
Neurotherapeutics 2018 Apr;15(2):336-345. doi: 10.1007/s13311-018-0623-6. PMID: 29616493Free PMC Article
Maasumi K, Tepper SJ, Kriegler JS
Headache 2017 Feb;57(2):194-208. Epub 2016 Dec 2 doi: 10.1111/head.12978. PMID: 27910087

Prognosis

Cen J, Wang Q, Cheng L, Gao Q, Wang H, Sun F
J Headache Pain 2024 Jun 7;25(1):96. doi: 10.1186/s10194-024-01798-z. PMID: 38844846Free PMC Article
Chiang CC, Chen SP
Handb Clin Neurol 2024;199:465-474. doi: 10.1016/B978-0-12-823357-3.00021-5. PMID: 38307663
Safiri S, Pourfathi H, Eagan A, Mansournia MA, Khodayari MT, Sullman MJM, Kaufman J, Collins G, Dai H, Bragazzi NL, Kolahi AA
Pain 2022 Feb 1;163(2):e293-e309. doi: 10.1097/j.pain.0000000000002275. PMID: 34001771
Krause DN, Warfvinge K, Haanes KA, Edvinsson L
Nat Rev Neurol 2021 Oct;17(10):621-633. Epub 2021 Sep 20 doi: 10.1038/s41582-021-00544-2. PMID: 34545218
Kelman L
Cephalalgia 2007 May;27(5):394-402. Epub 2007 Mar 30 doi: 10.1111/j.1468-2982.2007.01303.x. PMID: 17403039

Clinical prediction guides

Vanood A, Rangel IC, Starling AJ
Neurol Clin 2023 May;41(2):231-247. doi: 10.1016/j.ncl.2023.01.002. PMID: 37030955
Bae JY, Sung HK, Kwon NY, Go HY, Kim TJ, Shin SM, Lee S
Medicina (Kaunas) 2021 Dec 28;58(1) doi: 10.3390/medicina58010044. PMID: 35056352Free PMC Article
Vilela P
Eur J Radiol 2017 Nov;96:133-144. Epub 2017 May 5 doi: 10.1016/j.ejrad.2017.05.008. PMID: 28551302
von Brevern M, Lempert T
Handb Clin Neurol 2016;137:301-16. doi: 10.1016/B978-0-444-63437-5.00022-4. PMID: 27638080
Honaker J, Samy RN
Curr Opin Otolaryngol Head Neck Surg 2008 Oct;16(5):412-5. doi: 10.1097/MOO.0b013e32830a4a02. PMID: 18797281

Recent systematic reviews

Shaterian N, Shaterian N, Ghanaatpisheh A, Abbasi F, Daniali S, Jahromi MJ, Sanie MS, Abdoli A
Pain Res Manag 2022;2022:3284446. Epub 2022 Mar 31 doi: 10.1155/2022/3284446. PMID: 35401888Free PMC Article
VanderPluym JH, Halker Singh RB, Urtecho M, Morrow AS, Nayfeh T, Torres Roldan VD, Farah MH, Hasan B, Saadi S, Shah S, Abd-Rabu R, Daraz L, Prokop LJ, Murad MH, Wang Z
JAMA 2021 Jun 15;325(23):2357-2369. doi: 10.1001/jama.2021.7939. PMID: 34128998Free PMC Article
Tiseo C, Vacca A, Felbush A, Filimonova T, Gai A, Glazyrina T, Hubalek IA, Marchenko Y, Overeem LH, Piroso S, Tkachev A, Martelletti P, Sacco S; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2020 Oct 27;21(1):126. doi: 10.1186/s10194-020-01192-5. PMID: 33109076Free PMC Article
Hindiyeh NA, Zhang N, Farrar M, Banerjee P, Lombard L, Aurora SK
Headache 2020 Jul;60(7):1300-1316. Epub 2020 May 25 doi: 10.1111/head.13836. PMID: 32449944Free PMC Article
Chaibi A, Tuchin PJ, Russell MB
J Headache Pain 2011 Apr;12(2):127-33. Epub 2011 Feb 5 doi: 10.1007/s10194-011-0296-6. PMID: 21298314Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

    Consumer resources

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