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Migraine without aura, susceptibility to, 4

MedGen UID:
336040
•Concept ID:
C1843773
•
Finding
Synonym: Migraine without aura 4
 
Monarch Initiative: MONDO:0011847
OMIM®: 607501

Definition

An inherited susceptibility or predisposition to developing migraines without aura. [from MONDO]

Clinical features

From HPO
Nausea
MedGen UID:
10196
•Concept ID:
C0027497
•
Sign or Symptom
A sensation of unease in the stomach together with an urge to vomit.
See: Feature record | Search on this feature
Vomiting
MedGen UID:
12124
•Concept ID:
C0042963
•
Sign or Symptom
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
See: Feature record | Search on this feature
Photophobia
MedGen UID:
43220
•Concept ID:
C0085636
•
Sign or Symptom
Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
See: Feature record | Search on this feature
Hyperreflexia
MedGen UID:
57738
•Concept ID:
C0151889
•
Finding
Hyperreflexia is the presence of hyperactive stretch reflexes of the muscles.
See: Feature record | Search on this feature
Migraine without aura
MedGen UID:
137899
•Concept ID:
C0338480
•
Disease or Syndrome
Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria
See: Feature record | Search on this feature
Phonophobia
MedGen UID:
155864
•Concept ID:
C0751466
•
Mental or Behavioral Dysfunction
An abnormally heightened sensitivity to loud sounds.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura.
Esserlind AL, Kirchmann M, Hauge AW, Le H, Olesen J
Eur J Neurol 2012 Apr;19(4):603-9. Epub 2011 Nov 22 doi: 10.1111/j.1468-1331.2011.03588.x. PMID: 22103325
Diagnostic criteria for CADASIL in the International Classification of Headache Disorders (ICHD-II): are they appropriate?
Sacco S, Degan D, Carolei A
J Headache Pain 2010 Jun;11(3):181-6. Epub 2010 Mar 12 doi: 10.1007/s10194-010-0203-6. PMID: 20224942Free PMC Article
Migraine and MTHFR C677T genotype in a population-based sample.
Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H, Frants RR, van den Maagdenberg AM, van Buchem M, Ferrari MD, Launer LJ
Ann Neurol 2006 Feb;59(2):372-5. doi: 10.1002/ana.20755. PMID: 16365871

Recent clinical studies

Etiology

Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine.
Sun X, Chen B, Qi Y, Wei M, Chen W, Wu X, Wang Q, Li J, Lei X, Luo G
J Headache Pain 2024 Jul 22;25(1):117. doi: 10.1186/s10194-024-01828-w. PMID: 39039470Free PMC Article
Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis.
Zhang W, Cheng Z, Fu F, Zhan Z
Neuroimage Clin 2023;37:103312. Epub 2023 Jan 3 doi: 10.1016/j.nicl.2023.103312. PMID: 36610309Free PMC Article
Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.
Schürks M, Rist PM, Zee RY, Chasman DI, Kurth T
Cephalalgia 2011 Oct;31(13):1381-404. doi: 10.1177/0333102411419022. PMID: 22001640Free PMC Article
MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis.
Schürks M, Rist PM, Kurth T
Headache 2010 Apr;50(4):588-99. Epub 2009 Nov 17 doi: 10.1111/j.1526-4610.2009.01570.x. PMID: 19925624Free PMC Article
The genetics of chronic headaches.
Montagna P, Cevoli S, Marzocchi N, Pierangeli G, Pini LA, Cortelli P, Mochi M
Neurol Sci 2003 May;24 Suppl 2:S51-6. doi: 10.1007/s100720300041. PMID: 12811592

Diagnosis

Transient Neurologic Dysfunction in Migraine.
Foroozan R, Cutrer FM
Neurol Clin 2019 Nov;37(4):673-694. Epub 2019 Aug 28 doi: 10.1016/j.ncl.2019.06.002. PMID: 31563226
An Update: Pathophysiology of Migraine.
Goadsby PJ, Holland PR
Neurol Clin 2019 Nov;37(4):651-671. doi: 10.1016/j.ncl.2019.07.008. PMID: 31563225
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.
Zhao H, Eising E, de Vries B, Vijfhuizen LS; International Headache Genetics Consortium, Anttila V, Winsvold BS, Kurth T, Stefansson H, Kallela M, Malik R, Stam AH, Ikram MA, Ligthart L, Freilinger T, Alexander M, Müller-Myhsok B, Schreiber S, Meitinger T, Aromas A, Eriksson JG, Boomsma DI, van Duijn CM, Zwart JA, Quaye L, Kubisch C, Dichgans M, Wessman M, Stefansson K, Chasman DI, Palotie A, Martin NG, Montgomery GW, Ferrari MD, Terwindt GM, van den Maagdenberg AM, Nyholt DR
Cephalalgia 2016 Jun;36(7):648-57. Epub 2015 Dec 8 doi: 10.1177/0333102415591497. PMID: 26660531Free PMC Article
Vision and migraine.
Vincent MB
Headache 2015 Apr;55(4):595-9. Epub 2015 Mar 11 doi: 10.1111/head.12531. PMID: 25758366
The genetics of migraine.
Ducros A, Tournier-Lasserve E, Bousser MG
Lancet Neurol 2002 Sep;1(5):285-93. doi: 10.1016/s1474-4422(02)00134-5. PMID: 12849426

Therapy

Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine.
Sun X, Chen B, Qi Y, Wei M, Chen W, Wu X, Wang Q, Li J, Lei X, Luo G
J Headache Pain 2024 Jul 22;25(1):117. doi: 10.1186/s10194-024-01828-w. PMID: 39039470Free PMC Article
Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis.
Zhang W, Cheng Z, Fu F, Zhan Z
Neuroimage Clin 2023;37:103312. Epub 2023 Jan 3 doi: 10.1016/j.nicl.2023.103312. PMID: 36610309Free PMC Article
Cerebrospinal Fluid and Plasma Amine Profiles in Interictal Migraine.
Onderwater GLJ, van Dongen RM, Harms AC, Zielman R, van Oosterhout WPJ, van Klinken JB, Goeman JJ, Terwindt GM, van den Maagdenberg AMJM, Hankemeier T, Ferrari MD
Ann Neurol 2023 Apr;93(4):715-728. Epub 2023 Jan 30 doi: 10.1002/ana.26576. PMID: 36511835
Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis.
Siokas V, Liampas I, Aloizou AM, Papasavva M, Bakirtzis C, Lavdas E, Liakos P, Drakoulis N, Bogdanos DP, Dardiotis E
Medicina (Kaunas) 2022 Mar 29;58(4) doi: 10.3390/medicina58040491. PMID: 35454329Free PMC Article
Glutathione S-transferase polymorphisms: susceptibility to migraine without aura.
Kusumi M, Ishizaki K, Kowa H, Adachi Y, Takeshima T, Sakai F, Nakashima K
Eur Neurol 2003;49(4):218-22. doi: 10.1159/000070187. PMID: 12736537

Prognosis

Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine.
Sun X, Chen B, Qi Y, Wei M, Chen W, Wu X, Wang Q, Li J, Lei X, Luo G
J Headache Pain 2024 Jul 22;25(1):117. doi: 10.1186/s10194-024-01828-w. PMID: 39039470Free PMC Article
Susceptible genes of restless legs syndrome in migraine.
Fuh JL, Chung MY, Yao SC, Chen PK, Liao YC, Hsu CL, Wang PJ, Wang YF, Chen SP, Fann CS, Kao LS, Wang SJ
Cephalalgia 2016 Oct;36(11):1028-1037. Epub 2016 Jul 19 doi: 10.1177/0333102415620907. PMID: 26643377
Vision and migraine.
Vincent MB
Headache 2015 Apr;55(4):595-9. Epub 2015 Mar 11 doi: 10.1111/head.12531. PMID: 25758366
Migraine without aura: a population-based twin study.
Gervil M, Ulrich V, Kyvik KO, Olesen J, Russell MB
Ann Neurol 1999 Oct;46(4):606-11. doi: 10.1002/1531-8249(199910)46:4<606::aid-ana8>3.0.co;2-o. PMID: 10514097
Is the comorbidity of epilepsy and migraine due to a shared genetic susceptibility?
Ottman R, Lipton RB
Neurology 1996 Oct;47(4):918-24. doi: 10.1212/wnl.47.4.918. PMID: 8857719Free PMC Article

Clinical prediction guides

Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine.
Sun X, Chen B, Qi Y, Wei M, Chen W, Wu X, Wang Q, Li J, Lei X, Luo G
J Headache Pain 2024 Jul 22;25(1):117. doi: 10.1186/s10194-024-01828-w. PMID: 39039470Free PMC Article
Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis.
Zhang W, Cheng Z, Fu F, Zhan Z
Neuroimage Clin 2023;37:103312. Epub 2023 Jan 3 doi: 10.1016/j.nicl.2023.103312. PMID: 36610309Free PMC Article
Clinical characteristics of menstrually related and non-menstrual migraine.
Güven B, Güven H, Çomoğlu S
Acta Neurol Belg 2017 Sep;117(3):671-676. Epub 2017 May 30 doi: 10.1007/s13760-017-0802-y. PMID: 28560689
Vision and migraine.
Vincent MB
Headache 2015 Apr;55(4):595-9. Epub 2015 Mar 11 doi: 10.1111/head.12531. PMID: 25758366
Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.
Schürks M, Rist PM, Zee RY, Chasman DI, Kurth T
Cephalalgia 2011 Oct;31(13):1381-404. doi: 10.1177/0333102411419022. PMID: 22001640Free PMC Article

Recent systematic reviews

Current Update on Categorization of Migraine Subtypes on the Basis of Genetic Variation: a Systematic Review.
Goel K, Chhetri A, Ludhiadch A, Munshi A
Mol Neurobiol 2024 Jul;61(7):4804-4833. Epub 2023 Dec 22 doi: 10.1007/s12035-023-03837-3. PMID: 38135854
Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis.
Zhang W, Cheng Z, Fu F, Zhan Z
Neuroimage Clin 2023;37:103312. Epub 2023 Jan 3 doi: 10.1016/j.nicl.2023.103312. PMID: 36610309Free PMC Article
Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis.
Lee HH, Chen CC, Ong JR, Lin YF, Lee FP, Hu CJ, Wang YH
Headache 2020 Jan;60(1):71-80. Epub 2019 Sep 26 doi: 10.1111/head.13670. PMID: 31557325
Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.
Schürks M, Rist PM, Zee RY, Chasman DI, Kurth T
Cephalalgia 2011 Oct;31(13):1381-404. doi: 10.1177/0333102411419022. PMID: 22001640Free PMC Article
MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis.
Schürks M, Rist PM, Kurth T
Headache 2010 Apr;50(4):588-99. Epub 2009 Nov 17 doi: 10.1111/j.1526-4610.2009.01570.x. PMID: 19925624Free PMC Article

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