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Periorbital hyperpigmentation

MedGen UID:
337037
Concept ID:
C1844606
Finding
Synonyms: Dark circles around the eyes; Dark circles under the eyes; Darkening around the eyes; Idiopathic cutaneous hyperchromia at the orbital region; Infraorbital pigmentation; Periorbital melanosis; Pigmentation around the eyes
 
HPO: HP:0001106

Definition

Increased pigmentation of the skin in the region surrounding the orbit of the eye. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Periorbital hyperpigmentation

Conditions with this feature

Hypohidrotic X-linked ectodermal dysplasia
MedGen UID:
57890
Concept ID:
C0162359
Disease or Syndrome
Hypohidrotic ectodermal dysplasia (HED) is characterized by hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth). The cardinal features of classic HED become obvious during childhood. The scalp hair is thin, lightly pigmented, and slow growing. Sweating, although present, is greatly deficient, leading to episodes of hyperthermia until the affected individual or family acquires experience with environmental modifications to control temperature. Only a few abnormally formed teeth erupt, at a later-than-average age. Physical growth and psychomotor development are otherwise within normal limits. Mild HED is characterized by mild manifestations of any or all the characteristic features.
Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive
MedGen UID:
854356
Concept ID:
C3887494
Disease or Syndrome
Hypohidrotic ectodermal dysplasia (HED) is characterized by hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth). The cardinal features of classic HED become obvious during childhood. The scalp hair is thin, lightly pigmented, and slow growing. Sweating, although present, is greatly deficient, leading to episodes of hyperthermia until the affected individual or family acquires experience with environmental modifications to control temperature. Only a few abnormally formed teeth erupt, at a later-than-average age. Physical growth and psychomotor development are otherwise within normal limits. Mild HED is characterized by mild manifestations of any or all the characteristic features.

Professional guidelines

PubMed

Samaan CB, Cartee TV
Clin Plast Surg 2023 Jul;50(3):399-409. doi: 10.1016/j.cps.2022.12.005. PMID: 37169406
Samaan CB, Cartee TV
Facial Plast Surg Clin North Am 2022 Aug;30(3):309-319. doi: 10.1016/j.fsc.2022.03.005. PMID: 35934433
Sawant O, Khan T
Dermatol Ther 2020 Jul;33(4):e13717. Epub 2020 Jul 2 doi: 10.1111/dth.13717. PMID: 32472659

Recent clinical studies

Etiology

Evans AG, Ivanic MG, Botros MA, Pope RW, Halle BR, Glassman GE, Genova R, Al Kassis S
Arch Dermatol Res 2021 Nov;313(9):711-727. Epub 2021 Jan 12 doi: 10.1007/s00403-020-02173-z. PMID: 33433716
Sawant O, Khan T
Dermatol Ther 2020 Jul;33(4):e13717. Epub 2020 Jul 2 doi: 10.1111/dth.13717. PMID: 32472659
Dayal S, Sangal B, Sahu P
J Cosmet Dermatol 2020 Sep;19(9):2342-2348. Epub 2020 Jan 16 doi: 10.1111/jocd.13292. PMID: 31944519
Fatin AM, Mathana Sundram TK, Tan SSE, Seghayat MS, Lee CK, Rehman N, Tan CK
Skin Res Technol 2020 Jul;26(4):564-570. Epub 2020 Jan 8 doi: 10.1111/srt.12831. PMID: 31916334
Ellabban NF, Eyada M, Nada H, Kamel N
J Cosmet Dermatol 2019 Dec;18(6):1680-1685. Epub 2019 Apr 25 doi: 10.1111/jocd.12964. PMID: 31021041

Diagnosis

Syder NC, Quarshie C, Elbuluk N
Dermatol Clin 2023 Jul;41(3):393-405. Epub 2023 Apr 14 doi: 10.1016/j.det.2023.02.005. PMID: 37236709
Sawant O, Khan T
Dermatol Ther 2020 Jul;33(4):e13717. Epub 2020 Jul 2 doi: 10.1111/dth.13717. PMID: 32472659
Ellabban NF, Eyada M, Nada H, Kamel N
J Cosmet Dermatol 2019 Dec;18(6):1680-1685. Epub 2019 Apr 25 doi: 10.1111/jocd.12964. PMID: 31021041
Boruah D, Manu V, Malik A, Chatterjee M, Vasudevan B, Srinivas V
Indian J Dermatol Venereol Leprol 2015 Nov-Dec;81(6):588-93. doi: 10.4103/0378-6323.168327. PMID: 26515837
Hacker SM
Postgrad Med 1996 Jun;99(6):177-86. PMID: 8668630

Therapy

Samaan CB, Cartee TV
Facial Plast Surg Clin North Am 2022 Aug;30(3):309-319. doi: 10.1016/j.fsc.2022.03.005. PMID: 35934433
Ahramiyanpour N, Shafie'ei M, Sarvipour N, Amiri R, Akbari Z
J Cosmet Dermatol 2022 May;21(5):1874-1894. Epub 2022 Feb 14 doi: 10.1111/jocd.14834. PMID: 35124882
Roohaninasab M, Sadeghzadeh-Bazargan A, Goodarzi A
Lasers Med Sci 2021 Dec;36(9):1781-1789. Epub 2021 Jan 21 doi: 10.1007/s10103-020-03241-6. PMID: 33474663
Evans AG, Ivanic MG, Botros MA, Pope RW, Halle BR, Glassman GE, Genova R, Al Kassis S
Arch Dermatol Res 2021 Nov;313(9):711-727. Epub 2021 Jan 12 doi: 10.1007/s00403-020-02173-z. PMID: 33433716
Michelle L, Pouldar Foulad D, Ekelem C, Saedi N, Mesinkovska NA
Dermatol Surg 2021 Jan 1;47(1):70-74. doi: 10.1097/DSS.0000000000002484. PMID: 32740208

Prognosis

Croley JA, Reese V, Wagner RF Jr
JAMA Dermatol 2017 Jun 1;153(6):559-564. doi: 10.1001/jamadermatol.2016.5979. PMID: 28384669Free PMC Article
Manuskiatti W, Fitzpatrick RE, Goldman MP
Dermatol Surg 2000 Feb;26(2):114-20. doi: 10.1046/j.1524-4725.2000.98159.x. PMID: 10691938

Clinical prediction guides

Ahramiyanpour N, Shafie'ei M, Sarvipour N, Amiri R, Akbari Z
J Cosmet Dermatol 2022 May;21(5):1874-1894. Epub 2022 Feb 14 doi: 10.1111/jocd.14834. PMID: 35124882
Nilforoushzadeh MA, Heidari-Kharaji M, Alavi S, Zolghadr S, Mahmoudbeyk M, Nikkhah N
Lasers Med Sci 2021 Dec;36(9):1927-1934. Epub 2021 Feb 27 doi: 10.1007/s10103-021-03274-5. PMID: 33638096
Roohaninasab M, Sadeghzadeh-Bazargan A, Goodarzi A
Lasers Med Sci 2021 Dec;36(9):1781-1789. Epub 2021 Jan 21 doi: 10.1007/s10103-020-03241-6. PMID: 33474663
Evans AG, Ivanic MG, Botros MA, Pope RW, Halle BR, Glassman GE, Genova R, Al Kassis S
Arch Dermatol Res 2021 Nov;313(9):711-727. Epub 2021 Jan 12 doi: 10.1007/s00403-020-02173-z. PMID: 33433716
Fatin AM, Mathana Sundram TK, Tan SSE, Seghayat MS, Lee CK, Rehman N, Tan CK
Skin Res Technol 2020 Jul;26(4):564-570. Epub 2020 Jan 8 doi: 10.1111/srt.12831. PMID: 31916334

Recent systematic reviews

Montolío-Marzo S, Montolío-Marzo E, Martínez-Gil C, Rodríguez-Iranzo G, Arias-García E, Pérez-López M
Arch Soc Esp Oftalmol (Engl Ed) 2024 Jan;99(1):23-32. Epub 2023 Sep 1 doi: 10.1016/j.oftale.2023.08.010. PMID: 37661041
Ahramiyanpour N, Shafie'ei M, Sarvipour N, Amiri R, Akbari Z
J Cosmet Dermatol 2022 May;21(5):1874-1894. Epub 2022 Feb 14 doi: 10.1111/jocd.14834. PMID: 35124882
Roohaninasab M, Sadeghzadeh-Bazargan A, Goodarzi A
Lasers Med Sci 2021 Dec;36(9):1781-1789. Epub 2021 Jan 21 doi: 10.1007/s10103-020-03241-6. PMID: 33474663
Evans AG, Ivanic MG, Botros MA, Pope RW, Halle BR, Glassman GE, Genova R, Al Kassis S
Arch Dermatol Res 2021 Nov;313(9):711-727. Epub 2021 Jan 12 doi: 10.1007/s00403-020-02173-z. PMID: 33433716
Michelle L, Pouldar Foulad D, Ekelem C, Saedi N, Mesinkovska NA
Dermatol Surg 2021 Jan 1;47(1):70-74. doi: 10.1097/DSS.0000000000002484. PMID: 32740208

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