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Goiter, multinodular 2(MNG2)

MedGen UID:
337370
•Concept ID:
C1846033
•
Disease or Syndrome
Synonym: MNG2
 
Monarch Initiative: MONDO:0010290
OMIM®: 300273

Definition

Multinodular goiter is a common disorder characterized by nodular enlargement of the thyroid gland. It occurs with a female:male ratio of 5:1 (summary by Capon et al., 2000). For additional phenotypic information and a discussion of genetic heterogeneity of multinodular goiter, see MNG1 (138800). [from OMIM]

Clinical features

From HPO
Euthyroid multinodular goiter
MedGen UID:
335327
•Concept ID:
C1846034
•
Disease or Syndrome
See: Feature record | Search on this feature

Recent clinical studies

Etiology

Immunohistochemical evaluation of midkine and nuclear factor-kappa B as diagnostic biomarkers for papillary thyroid cancer and synchronous metastasis.
Zhang Y, Meng Z, Zhang M, Tan J, Tian W, He X, Fu Q, Xu K, He Q, Zhu M, Li X, Zhang G, He Y, Jia Q, Zhang J, Wang S, Song X
Life Sci 2014 Nov 18;118(1):39-45. Epub 2014 Oct 2 doi: 10.1016/j.lfs.2014.09.025. PMID: 25283079

Diagnosis

Lu-177 labelled peptide treatment for radioiodine refractory differentiated thyroid carcinoma.
Elboğa U, Özkaya M, Sayiner ZA, Çelen YZ
BMJ Case Rep 2016 Mar 8;2016 doi: 10.1136/bcr-2015-213627. PMID: 26957032Free PMC Article
Immunohistochemical evaluation of midkine and nuclear factor-kappa B as diagnostic biomarkers for papillary thyroid cancer and synchronous metastasis.
Zhang Y, Meng Z, Zhang M, Tan J, Tian W, He X, Fu Q, Xu K, He Q, Zhu M, Li X, Zhang G, He Y, Jia Q, Zhang J, Wang S, Song X
Life Sci 2014 Nov 18;118(1):39-45. Epub 2014 Oct 2 doi: 10.1016/j.lfs.2014.09.025. PMID: 25283079

Therapy

Lu-177 labelled peptide treatment for radioiodine refractory differentiated thyroid carcinoma.
Elboğa U, Özkaya M, Sayiner ZA, Çelen YZ
BMJ Case Rep 2016 Mar 8;2016 doi: 10.1136/bcr-2015-213627. PMID: 26957032Free PMC Article

Prognosis

Lu-177 labelled peptide treatment for radioiodine refractory differentiated thyroid carcinoma.
Elboğa U, Özkaya M, Sayiner ZA, Çelen YZ
BMJ Case Rep 2016 Mar 8;2016 doi: 10.1136/bcr-2015-213627. PMID: 26957032Free PMC Article
Immunohistochemical evaluation of midkine and nuclear factor-kappa B as diagnostic biomarkers for papillary thyroid cancer and synchronous metastasis.
Zhang Y, Meng Z, Zhang M, Tan J, Tian W, He X, Fu Q, Xu K, He Q, Zhu M, Li X, Zhang G, He Y, Jia Q, Zhang J, Wang S, Song X
Life Sci 2014 Nov 18;118(1):39-45. Epub 2014 Oct 2 doi: 10.1016/j.lfs.2014.09.025. PMID: 25283079

Clinical prediction guides

Immunohistochemical evaluation of midkine and nuclear factor-kappa B as diagnostic biomarkers for papillary thyroid cancer and synchronous metastasis.
Zhang Y, Meng Z, Zhang M, Tan J, Tian W, He X, Fu Q, Xu K, He Q, Zhu M, Li X, Zhang G, He Y, Jia Q, Zhang J, Wang S, Song X
Life Sci 2014 Nov 18;118(1):39-45. Epub 2014 Oct 2 doi: 10.1016/j.lfs.2014.09.025. PMID: 25283079

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