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Perioral erythema

MedGen UID:
340873
Concept ID:
C1855458
Finding
Synonym: Erythema, perioral
 
HPO: HP:0033194

Definition

Erythema (Redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin) localized to the region surrounding the mouth. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPerioral erythema

Conditions with this feature

Acroerythrokeratoderma
MedGen UID:
7522
Concept ID:
C0025221
Congenital Abnormality
Mal de Meleda (MDM) is a rare autosomal recessive skin disorder characterized by transgressive palmoplantar keratoderma (PPK), keratotic skin lesions, perioral erythema, brachydactyly, and nail abnormalities (summary by Fischer et al., 2001). The PPK in MDM is often accompanied by hyperhidrosis, maceration, fetid odor, and painful fissures (Ward et al., 2003). Some patients exhibiting similar but less severe features of MDM, with milder hyperkeratosis and no nail dystrophy, lichenoid plaques, pachydermia, or distant keratosis, were previously designated as having 'Gamborg Nielsen (Norrbotten) PPK' (see NOMENCLATURE).
Hereditary acrodermatitis enteropathica
MedGen UID:
66355
Concept ID:
C0221036
Disease or Syndrome
Acrodermatitis enteropathica of the zinc deficiency type (AEZ) is characterized by intermittent simultaneous occurrence of diarrhea and dermatitis with failure to thrive. Alopecia of the scalp, eyebrows, and eyelashes is a usual feature. The skin lesions are bullous. Noteworthy is the cure by diodoquin, or diiodohydroxyquinoline (Dillaha et al., 1953; Bloom and Sobel, 1955). Rodin and Goldman (1969) described autopsy findings, including pancreatic islet hyperplasia, absence of the thymus and of germinal centers, and plasmocytosis of lymph nodes and spleen.
Inflammatory skin and bowel disease, neonatal, 1
MedGen UID:
482131
Concept ID:
C3280501
Disease or Syndrome
Any neonatal inflammatory skin and bowel disease in which the cause of the disease is a mutation in the ADAM17 gene.
IFAP syndrome 2
MedGen UID:
1763502
Concept ID:
C5436607
Disease or Syndrome
Follicular ichthyosis, atrichia, and photophobia syndrome-2 (IFAP2) is characterized by ichthyosis follicularis or follicular hyperkeratosis, sparse to no body hair, and photophobia with corneal lesions. Ultrastructural hair analysis shows trichorrhexis nodosa (Wang et al., 2020). For a discussion of genetic heterogeneity of IFAP syndrome, see IFAP1 (308205).

Professional guidelines

PubMed

Gold AH, Pozner J, Weiss R
Aesthet Surg J 2016 Oct;36(9):1058-67. Epub 2016 Jul 29 doi: 10.1093/asj/sjw086. PMID: 27474769
Holcomb JD, Kent KJ, Rousso DE
Arch Facial Plast Surg 2009 May-Jun;11(3):184-93. doi: 10.1001/archfacial.2009.29. PMID: 19451453
Mengesha YM, Bennett ML
Am J Clin Dermatol 2002;3(6):389-400. doi: 10.2165/00128071-200203060-00003. PMID: 12113648

Recent clinical studies

Etiology

Alvarado-Julio A, Chumacero-Palma K, Buenahora MR, Parra-Izquierdo V, Monsalve M, Torres AM, Chila-Moreno L, Flórez-Sarmiento C, Ramos-Casallas A, De Avila J, Bello-Gualtero JM, Jaimes D, Beltrán-Ostos A, Chalem-Choueka P, Pacheco-Tena C, Bautista-Molano W, Romero-Sánchez C
BMC Oral Health 2022 Nov 9;22(1):477. doi: 10.1186/s12903-022-02497-4. PMID: 36348398Free PMC Article
McCartan BE, Healy CM, McCreary CE, Flint SR, Rogers S, Toner ME
Oral Dis 2011 Oct;17(7):696-704. Epub 2011 Jul 13 doi: 10.1111/j.1601-0825.2011.01826.x. PMID: 21749579
Stănescu L, Georgescu CV, Georgescu AC, Georgescu I, Călin G
Rom J Morphol Embryol 2007;48(4):443-7. PMID: 18060199
Ragno V, Giampietro PG, Bruno G, Businco L
Eur J Pediatr 1993 Sep;152(9):760-2. doi: 10.1007/BF01953996. PMID: 8223811

Diagnosis

Alvarado-Julio A, Chumacero-Palma K, Buenahora MR, Parra-Izquierdo V, Monsalve M, Torres AM, Chila-Moreno L, Flórez-Sarmiento C, Ramos-Casallas A, De Avila J, Bello-Gualtero JM, Jaimes D, Beltrán-Ostos A, Chalem-Choueka P, Pacheco-Tena C, Bautista-Molano W, Romero-Sánchez C
BMC Oral Health 2022 Nov 9;22(1):477. doi: 10.1186/s12903-022-02497-4. PMID: 36348398Free PMC Article
Pereira MS, Munerato MC
Clin Med Res 2016 Mar;14(1):46-52. Epub 2016 Feb 10 doi: 10.3121/cmr.2015.1307. PMID: 26864508Free PMC Article

Therapy

Bouadjar B, Benmazouzia S, Prud'homme JF, Cure S, Fischer J
Arch Dermatol 2000 Oct;136(10):1247-52. doi: 10.1001/archderm.136.10.1247. PMID: 11030771
Ficarra G, Cicchi P, Amorosi A, Piluso S
Oral Surg Oral Med Oral Pathol 1993 Feb;75(2):220-4. doi: 10.1016/0030-4220(93)90097-n. PMID: 8426722
Ragno V, Giampietro PG, Bruno G, Businco L
Eur J Pediatr 1993 Sep;152(9):760-2. doi: 10.1007/BF01953996. PMID: 8223811
Beacham BE, Kurgansky D, Gould WM
J Am Acad Dermatol 1990 Jun;22(6 Pt 1):1029-32. doi: 10.1016/0190-9622(90)70146-9. PMID: 2164535

Prognosis

Shah K, Nasir A, Irfanullah, Shahzad S, Khan S, Ahmad W
Clin Exp Dermatol 2016 Aug;41(6):675-679. Epub 2016 Jul 5 doi: 10.1111/ced.12864. PMID: 29226984

Clinical prediction guides

Shah K, Nasir A, Irfanullah, Shahzad S, Khan S, Ahmad W
Clin Exp Dermatol 2016 Aug;41(6):675-679. Epub 2016 Jul 5 doi: 10.1111/ced.12864. PMID: 29226984
Bouadjar B, Benmazouzia S, Prud'homme JF, Cure S, Fischer J
Arch Dermatol 2000 Oct;136(10):1247-52. doi: 10.1001/archderm.136.10.1247. PMID: 11030771
Fischer J, Bouadjar B, Heilig R, Fizames C, Prud'homme JF, Weissenbach J
Eur J Hum Genet 1998 Nov-Dec;6(6):542-7. doi: 10.1038/sj.ejhg.5200254. PMID: 9887370

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