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Nasopharyngeal Papillary Adenocarcinoma

MedGen UID:
354457
•Concept ID:
C1711278
•
Neoplastic Process

Definition

A rare, low-grade exophytic adenocarcinoma with papillary growth that arises from the epithelium of the nasopharynx. If it is completely removed, the prognosis is excellent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal Papillary Adenocarcinoma

Professional guidelines

PubMed

Spreading patterns, prognostic factors and treatment outcomes of nasopharyngeal papillary adenocarcinoma and salivary gland-type carcinomas.
Liu LZ, Zhang YM, Chen Y, Li L
Clin Otolaryngol 2016 Apr;41(2):160-8. Epub 2016 Feb 4 doi: 10.1111/coa.12492. PMID: 26118586

Recent clinical studies

Etiology

Spreading patterns, prognostic factors and treatment outcomes of nasopharyngeal papillary adenocarcinoma and salivary gland-type carcinomas.
Liu LZ, Zhang YM, Chen Y, Li L
Clin Otolaryngol 2016 Apr;41(2):160-8. Epub 2016 Feb 4 doi: 10.1111/coa.12492. PMID: 26118586
Nasopharyngeal papillary adenocarcinoma. A clinicopathologic study of a low-grade carcinoma.
Wenig BM, Hyams VJ, Heffner DK
Am J Surg Pathol 1988 Dec;12(12):946-53. PMID: 2462370

Diagnosis

Primary nasopharyngeal papillary adenocarcinoma: A CARE-compliant case report.
Shen CH, Chang SL, Chang ST
Medicine (Baltimore) 2021 Nov 5;100(44):e27729. doi: 10.1097/MD.0000000000027729. PMID: 34871272Free PMC Article
Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Wang L, Min Q, Jiang J, Shao Y, Cao Y, Yan D
J Coll Physicians Surg Pak 2019 Nov;29(11):1114-1115. doi: 10.29271/jcpsp.2019.11.1114. PMID: 31659975
Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Huang F, Xiang X, Hong B, Min J, Li J
Am J Clin Pathol 2019 Oct 7;152(5):582-589. doi: 10.1093/ajcp/aqz082. PMID: 31287861
Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Baumann KB, Betz SJ
Head Neck Pathol 2019 Dec;13(4):661-663. Epub 2018 Jul 11 doi: 10.1007/s12105-018-0947-x. PMID: 29995295Free PMC Article
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case report and literature review.
Oishi N, Kondo T, Nakazawa T, Mochizuki K, Kasai K, Inoue T, Yamamoto T, Watanabe H, Hatsushika K, Masuyama K, Katoh R
Pathol Res Pract 2014 Dec;210(12):1142-5. Epub 2014 May 9 doi: 10.1016/j.prp.2014.04.020. PMID: 24893893

Therapy

Endoscopic Low-Temperature Plasma Radiofrequency Ablation for Primary Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Zhong QY, Sun Q, Liu ZH
Ear Nose Throat J 2021 Aug;100(7):563-564. Epub 2019 Oct 17 doi: 10.1177/0145561319880976. PMID: 31619076
Photodynamic therapy with topical 5-aminolevulinic acid as a post-operative adjuvant therapy for an incompletely resected primary nasopharyngeal papillary adenocarcinoma: a case report.
Wang CP, Chang YL, Chen CT, Yang TH, Lou PJ
Lasers Surg Med 2006 Jun;38(5):435-8. doi: 10.1002/lsm.20291. PMID: 16470845

Prognosis

Immunohistochemical characteristics of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report and review.
Guo H, Zhang Z, Huang C, Qiu J, Qu X
Medicine (Baltimore) 2023 Jan 27;102(4):e32655. doi: 10.1097/MD.0000000000032655. PMID: 36705380Free PMC Article
Genetic profile identification and clinicopathologic characteristics analysis of the thyroid-like low-grade nasopharyngeal papillary adenocarcinoma.
Wang T, Liu X, Yu W, Gao L, Deng W, He Q, Liao F, Chu L
Pathol Res Pract 2022 Aug;236:153980. Epub 2022 Jun 16 doi: 10.1016/j.prp.2022.153980. PMID: 35759937
Primary nasopharyngeal papillary adenocarcinoma: A CARE-compliant case report.
Shen CH, Chang SL, Chang ST
Medicine (Baltimore) 2021 Nov 5;100(44):e27729. doi: 10.1097/MD.0000000000027729. PMID: 34871272Free PMC Article
Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Baumann KB, Betz SJ
Head Neck Pathol 2019 Dec;13(4):661-663. Epub 2018 Jul 11 doi: 10.1007/s12105-018-0947-x. PMID: 29995295Free PMC Article
Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report and literature review.
Zhang WL, Ma S, Havrilla L, Cai L, Yu CQ, Shen S, Xu HT, Wang L, Yu JH, Lin XY, Wang E, Yang LH
Medicine (Baltimore) 2017 Nov;96(47):e8851. doi: 10.1097/MD.0000000000008851. PMID: 29381996Free PMC Article

Clinical prediction guides

Nasopharyngeal papillary adenocarcinoma harboring a fusion of ROS1 with GOPC: A case report.
Wang J, Luo S, Li Y, Zheng H
Medicine (Baltimore) 2021 Jan 22;100(3):e24377. doi: 10.1097/MD.0000000000024377. PMID: 33546077Free PMC Article
Clinicopathologic Characteristics of Thyroid-like Low-grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report.
Li L, Zhou F, Lin F, Han C
Appl Immunohistochem Mol Morphol 2019 Sep;27(8):e81-e84. doi: 10.1097/PAI.0000000000000545. PMID: 29494399
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with squamous differentiation: a novel histological finding.
Oide T, Kadosono O, Matsushima J, Wu D, Nagashima H, Saigusa H, Masunaga A, Nakatani Y, Hiroshima K
Hum Pathol 2017 Dec;70:43-48. Epub 2017 Jun 7 doi: 10.1016/j.humpath.2017.05.020. PMID: 28601658
Spreading patterns, prognostic factors and treatment outcomes of nasopharyngeal papillary adenocarcinoma and salivary gland-type carcinomas.
Liu LZ, Zhang YM, Chen Y, Li L
Clin Otolaryngol 2016 Apr;41(2):160-8. Epub 2016 Feb 4 doi: 10.1111/coa.12492. PMID: 26118586
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case report and literature review.
Oishi N, Kondo T, Nakazawa T, Mochizuki K, Kasai K, Inoue T, Yamamoto T, Watanabe H, Hatsushika K, Masuyama K, Katoh R
Pathol Res Pract 2014 Dec;210(12):1142-5. Epub 2014 May 9 doi: 10.1016/j.prp.2014.04.020. PMID: 24893893

Recent systematic reviews

Radiological features of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case series and systematic review.
Baba A, Matsushima S, Kessoku H, Omura K, Kurokawa R, Fukasawa N, Takeshita Y, Yamauchi H, Ogino N, Kayama R, Uchihara K, Yoshimatsu L, Ojiri H
Neuroradiology 2024 Feb;66(2):249-259. Epub 2023 Dec 16 doi: 10.1007/s00234-023-03254-2. PMID: 38103083

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