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Breast Tubular Adenoma

MedGen UID:
362754
•Concept ID:
C1879899
•
Neoplastic Process
Synonym: Tubular adenoma of breast
SNOMED CT: Tubular adenoma of breast (721597007)

Definition

A benign, well circumscribed neoplasm that arises from the breast. It is composed entirely of tubular structures that contain epithelial and myoepithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Tubular Adenoma

Professional guidelines

PubMed

Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment.
Kurian AW, Hare EE, Mills MA, Kingham KE, McPherson L, Whittemore AS, McGuire V, Ladabaum U, Kobayashi Y, Lincoln SE, Cargill M, Ford JM
J Clin Oncol 2014 Jul 1;32(19):2001-9. Epub 2014 Apr 14 doi: 10.1200/JCO.2013.53.6607. PMID: 24733792Free PMC Article
Differential diagnosis between sclerosing adenosis and tubular carcinoma of the breast under transmission and scanning electron microscope.
Baltatzis GE, Voloudakis GE, Arnogiannakis N, Misitzis J, Voloudakis-Baltatzis IE
Ultrastruct Pathol 2011 Oct;35(5):226-9. doi: 10.3109/01913123.2011.603460. PMID: 21910568
Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma.
Olgac S, Hutchinson B, Tickoo SK, Reuter VE
Mod Pathol 2006 Feb;19(2):218-24. doi: 10.1038/modpathol.3800520. PMID: 16424894

Recent clinical studies

Etiology

A rare case of syringocystadenocarcinoma papilliferum of the breast: An institutional retrospective case review and brief literature review.
McBride JD, Billings SD, Komforti MK
J Cutan Pathol 2021 Nov;48(11):1387-1391. Epub 2021 Jun 16 doi: 10.1111/cup.14080. PMID: 34089523
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Florid papillomatosis of the nipple: a rare presentation and review of the literature.
Salemis NS
Breast Dis 2015;35(2):153-6. doi: 10.3233/BD-150397. PMID: 25585841
Sonographic features of histopathologically benign solid breast lesions that have been classified as BI-RADS 4 on sonography.
Taskin F, Koseoglu K, Ozbas S, Erkus M, Karaman C
J Clin Ultrasound 2012 Jun;40(5):261-5. Epub 2012 Apr 17 doi: 10.1002/jcu.21923. PMID: 22508447
Acromegaly and cancer.
Jenkins PJ
Horm Res 2004;62 Suppl 1:108-15. doi: 10.1159/000080768. PMID: 15761242

Diagnosis

A rare case of syringocystadenocarcinoma papilliferum of the breast: An institutional retrospective case review and brief literature review.
McBride JD, Billings SD, Komforti MK
J Cutan Pathol 2021 Nov;48(11):1387-1391. Epub 2021 Jun 16 doi: 10.1111/cup.14080. PMID: 34089523
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
sQuiz your knowledge: Nipple ulceration.
Pinheiro RR, Campos S, Fernandes C
Eur J Dermatol 2017 Jun 1;27(3):339-340. doi: 10.1684/ejd.2017.3057. PMID: 28677585
Florid papillomatosis of the nipple: a rare presentation and review of the literature.
Salemis NS
Breast Dis 2015;35(2):153-6. doi: 10.3233/BD-150397. PMID: 25585841
Tubular adenomas of the breast: imaging findings with histologic correlation.
Soo MS, Dash N, Bentley R, Lee LH, Nathan G
AJR Am J Roentgenol 2000 Mar;174(3):757-61. doi: 10.2214/ajr.174.3.1740757. PMID: 10701621

Therapy

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Feminizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Schmidt RL, Murugan P, Greene DN
Arch Pathol Lab Med 2022 Jan 2;146(2):252-261. doi: 10.5858/arpa.2020-0704-RA. PMID: 33983412
BCDnet: Parallel heterogeneous eight-class classification model of breast pathology.
He Q, Cheng G, Ju H
PLoS One 2021;16(7):e0253764. Epub 2021 Jul 12 doi: 10.1371/journal.pone.0253764. PMID: 34252112Free PMC Article
Colon metastases as first clinical manifestation of lobular breast carcinoma with no subsequent evidence of breast disease.
Abu Zaanona MI, Gulati A, Rowland K
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-236225. PMID: 33257365Free PMC Article
Risk of colorectal adenomas in women with prior breast cancer.
Shukla A, Shukla S, Osowo A, Mashtare T, Bhutani MS, Guha S
Dig Dis Sci 2012 Dec;57(12):3240-5. Epub 2012 Oct 12 doi: 10.1007/s10620-012-2432-9. PMID: 23065089
Invasive ductal carcinoma associated with tubular adenoma of the breast.
Domoto H, Tsuda H, Miyakawa K, Shinoda A, Nanasawa T
Pathol Int 2002 Mar;52(3):244-8. doi: 10.1046/j.1440-1827.2002.01338.x. PMID: 11972869

Prognosis

Tubular Adenoma of the Breast: Radiologic-Pathologic Correlation.
Joo GJ, Carter GJ, Berg WA
J Breast Imaging 2023 Nov 30;5(6):703-711. doi: 10.1093/jbi/wbad066. PMID: 38141235
Pediatric breast masses: an argument for observation.
McLaughlin CM, Gonzalez-Hernandez J, Bennett M, Piper HG
J Surg Res 2018 Aug;228:247-252. Epub 2018 Apr 12 doi: 10.1016/j.jss.2018.03.056. PMID: 29907218
Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway.
Volckmar AL, Leichsenring J, Flechtenmacher C, Pfarr N, Siebolts U, Kirchner M, Budczies J, Bockmayr M, Ridinger K, Lorenz K, Herpel E, Noske A, Weichert W, Klauschen F, Schirmacher P, Penzel R, Endris V, Stenzinger A
Genes Chromosomes Cancer 2017 Jan;56(1):11-17. Epub 2016 Aug 9 doi: 10.1002/gcc.22396. PMID: 27438523
Florid papillomatosis of the nipple: a rare presentation and review of the literature.
Salemis NS
Breast Dis 2015;35(2):153-6. doi: 10.3233/BD-150397. PMID: 25585841
Sonographic features of histopathologically benign solid breast lesions that have been classified as BI-RADS 4 on sonography.
Taskin F, Koseoglu K, Ozbas S, Erkus M, Karaman C
J Clin Ultrasound 2012 Jun;40(5):261-5. Epub 2012 Apr 17 doi: 10.1002/jcu.21923. PMID: 22508447

Clinical prediction guides

Convolution Neural Network for Breast Cancer Detection and Classification Using Deep Learning.
Abunasser BS, Al-Hiealy MRJ, Zaqout IS, Abu-Naser SS
Asian Pac J Cancer Prev 2023 Feb 1;24(2):531-544. doi: 10.31557/APJCP.2023.24.2.531. PMID: 36853302Free PMC Article
Pediatric breast masses: an argument for observation.
McLaughlin CM, Gonzalez-Hernandez J, Bennett M, Piper HG
J Surg Res 2018 Aug;228:247-252. Epub 2018 Apr 12 doi: 10.1016/j.jss.2018.03.056. PMID: 29907218
Surgical breast lesions in adolescent patients and a review of the literature.
Sönmez K, Türkyilmaz Z, Karabulut R, Demiroğullari B, Ozen IO, Moralioğlu S, Başaklar AC, Kale N
Acta Chir Belg 2006 Jul-Aug;106(4):400-4. doi: 10.1080/00015458.2006.11679915. PMID: 17017692
Ductal adenoma of the breast. An immunohistochemical study of five cases.
Guarino M, Reale D, Squillaci S, Micoli G
Pathol Res Pract 1993 Jun;189(5):515-20. doi: 10.1016/S0344-0338(11)80358-4. PMID: 8378175
Adenomas of the breast and ectopic breast under lactational influences.
O'Hara MF, Page DL
Hum Pathol 1985 Jul;16(7):707-12. doi: 10.1016/s0046-8177(85)80156-8. PMID: 4007846

Recent systematic reviews

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Feminizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Schmidt RL, Murugan P, Greene DN
Arch Pathol Lab Med 2022 Jan 2;146(2):252-261. doi: 10.5858/arpa.2020-0704-RA. PMID: 33983412

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