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Platelet Engraftment

MedGen UID:
364198
•Concept ID:
C1882407
•
Finding

Definition

A platelet count of 20,000 to 50,000 (platelets per microliter of blood) is a sign of platelet engraftment. For patients who receive marrow or peripheral blood cells, platelet engraftment often happens at the same time or a little bit after neutrophil engraftment. For patients who receive cord blood, it may be 8 weeks or longer after transplant before platelet engraftment occurs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlatelet Engraftment

Professional guidelines

PubMed

Radiation Therapy Can Be Safely Incorporated into Pretransplantation Treatment Regimens for Patients with Multiple Myeloma.
Damron EP, Qazilbash MH, Fang PQ, Wu SY, Dabaja BS, Rondon G, Hosing C, Champlin RE, Bashir Q, Shpall EJ, Knafl MK, Lee HC, Manasanch EE, Patel K, Thomas SK, Orlowski RZ, Weber DM, Pinnix CC, Gunther JR
Transplant Cell Ther 2023 Jan;29(1):37.e1-37.e7. Epub 2022 Oct 29 doi: 10.1016/j.jtct.2022.10.020. PMID: 37753818
Treatment With the Combination of Rituximab and Intravenous γ Globulin Is Effective in Promoting Engraftment in Donor-Specific Antibody Positive Patients Receiving Myeloablative Conditioning Haploidentical Stem Cell Transplantation.
Shen Y, Zhang L, Zhang X, Zhang T, Jiang E, Feng S, He Y, Zhang R
Transplant Cell Ther 2023 Aug;29(8):514.e1-514.e6. Epub 2023 May 11 doi: 10.1016/j.jtct.2023.05.005. PMID: 37178922
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article

Recent clinical studies

Etiology

Outcomes with HLA-matched unrelated donor versus haploidentical hematopoietic cell transplantation.
Mushtaq MU, Shahzad M, Amin MK, Lutfi F, DeJarnette S, Al-Ramahi JS, Li K, Ahmed N, Bansal R, Abdelhakim H, Shune L, Abdallah AO, Abhyankar SH, McGuirk JP, Singh AK
Leuk Lymphoma 2024 Apr;65(4):493-502. Epub 2024 Jan 2 doi: 10.1080/10428194.2023.2300708. PMID: 38164945
Herombopag promotes platelet engraftment and decreases platelet transfusion after allogeneic hematopoietic stem cell transplantation.
Zheng X, Zhang H, Guo W, Cao Y, Liu X, Zhai W, Zhang X, Wang F, Wei J, Yang D, Huang Y, Pang A, Feng S, Jiang E, Han M
Eur J Haematol 2023 May;110(5):527-533. Epub 2023 Jan 20 doi: 10.1111/ejh.13925. PMID: 36599813
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Transfusion support issues in hematopoietic stem cell transplantation.
Cohn CS
Cancer Control 2015 Jan;22(1):52-9. doi: 10.1177/107327481502200108. PMID: 25504279
Neonatal and adult megakaryopoiesis.
Liu ZJ, Sola-Visner M
Curr Opin Hematol 2011 Sep;18(5):330-7. doi: 10.1097/MOH.0b013e3283497ed5. PMID: 21738028

Diagnosis

Optimizing Autologous Stem Cell Transplantation in Multiple Myeloma: The Impact of Intensive Chemomobilization.
Portuguese AJ, Yeh AC, Banerjee R, Holmberg L, Wuliji N, Green DJ, Mielcarek M, Gopal AK, Gooley T, Stevenson P, Cowan AJ
Transplant Cell Ther 2024 Aug;30(8):774.e1-774.e12. Epub 2024 May 18 doi: 10.1016/j.jtct.2024.05.016. PMID: 38768908Free PMC Article
Once-Daily Foscarnet Is Effective for Human Herpesvirus 6 Reactivation after Hematopoietic Stem Cell Transplantation.
Vittayawacharin P, E'Leimat G, Lee BJ, Griffin S, Doh J, Nam H, Blodget E, Jeyakumar D, Kongtim P, Ciurea SO
Transplant Cell Ther 2023 Jun;29(6):397.e1-397.e6. Epub 2023 Mar 4 doi: 10.1016/j.jtct.2023.02.022. PMID: 36878429
Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials.
Chhabra S, Callander N, Watts NL, Costa LJ, Thapa B, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Anderson LD Jr, Bal S, Dhakal B, Nathwani N, Shah N, Medvedova E, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Schmidt T, Orlowski RZ, Shain KH, Cowan AJ, Dholaria B, Cornell RF, Jerkins JH, Pei H, Cortoos A, Patel S, Lin TS, Usmani SZ, Richardson PG, Voorhees PM
Transplant Cell Ther 2023 Mar;29(3):174.e1-174.e10. Epub 2022 Dec 6 doi: 10.1016/j.jtct.2022.11.029. PMID: 36494017
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial.
Voorhees PM, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Costa LJ, Anderson LD Jr, Nathwani N, Shah N, Efebera YA, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Orlowski RZ, Shain KH, Cowan AJ, Murphy S, Lutska Y, Pei H, Ukropec J, Vermeulen J, de Boer C, Hoehn D, Lin TS, Richardson PG
Blood 2020 Aug 20;136(8):936-945. doi: 10.1182/blood.2020005288. PMID: 32325490Free PMC Article

Therapy

Pembrolizumab Added to Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Relapsed or Refractory Classic Hodgkin Lymphoma: A Multi-institutional Phase 2 Investigator-Initiated Nonrandomized Clinical Trial.
Bryan LJ, Casulo C, Allen PB, Smith SE, Savas H, Dillehay GL, Karmali R, Pro B, Kane KL, Bazzi LA, Chmiel JS, Palmer BA, Mehta J, Gordon LI, Winter JN
JAMA Oncol 2023 May 1;9(5):683-691. doi: 10.1001/jamaoncol.2022.7975. PMID: 36928527Free PMC Article
Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials.
Chhabra S, Callander N, Watts NL, Costa LJ, Thapa B, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Anderson LD Jr, Bal S, Dhakal B, Nathwani N, Shah N, Medvedova E, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Schmidt T, Orlowski RZ, Shain KH, Cowan AJ, Dholaria B, Cornell RF, Jerkins JH, Pei H, Cortoos A, Patel S, Lin TS, Usmani SZ, Richardson PG, Voorhees PM
Transplant Cell Ther 2023 Mar;29(3):174.e1-174.e10. Epub 2022 Dec 6 doi: 10.1016/j.jtct.2022.11.029. PMID: 36494017
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial.
Voorhees PM, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Costa LJ, Anderson LD Jr, Nathwani N, Shah N, Efebera YA, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Orlowski RZ, Shain KH, Cowan AJ, Murphy S, Lutska Y, Pei H, Ukropec J, Vermeulen J, de Boer C, Hoehn D, Lin TS, Richardson PG
Blood 2020 Aug 20;136(8):936-945. doi: 10.1182/blood.2020005288. PMID: 32325490Free PMC Article
Transfusion support issues in hematopoietic stem cell transplantation.
Cohn CS
Cancer Control 2015 Jan;22(1):52-9. doi: 10.1177/107327481502200108. PMID: 25504279

Prognosis

Once-Daily Foscarnet Is Effective for Human Herpesvirus 6 Reactivation after Hematopoietic Stem Cell Transplantation.
Vittayawacharin P, E'Leimat G, Lee BJ, Griffin S, Doh J, Nam H, Blodget E, Jeyakumar D, Kongtim P, Ciurea SO
Transplant Cell Ther 2023 Jun;29(6):397.e1-397.e6. Epub 2023 Mar 4 doi: 10.1016/j.jtct.2023.02.022. PMID: 36878429
Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials.
Chhabra S, Callander N, Watts NL, Costa LJ, Thapa B, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Anderson LD Jr, Bal S, Dhakal B, Nathwani N, Shah N, Medvedova E, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Schmidt T, Orlowski RZ, Shain KH, Cowan AJ, Dholaria B, Cornell RF, Jerkins JH, Pei H, Cortoos A, Patel S, Lin TS, Usmani SZ, Richardson PG, Voorhees PM
Transplant Cell Ther 2023 Mar;29(3):174.e1-174.e10. Epub 2022 Dec 6 doi: 10.1016/j.jtct.2022.11.029. PMID: 36494017
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Transfusion support issues in hematopoietic stem cell transplantation.
Cohn CS
Cancer Control 2015 Jan;22(1):52-9. doi: 10.1177/107327481502200108. PMID: 25504279
Peripheral blood stem cell mobilization tactics.
Rosenbeck LL, Srivastava S, Kiel PJ
Ann Pharmacother 2010 Jan;44(1):107-16. Epub 2009 Dec 8 doi: 10.1345/aph.1M289. PMID: 19996324

Clinical prediction guides

Outcomes with HLA-matched unrelated donor versus haploidentical hematopoietic cell transplantation.
Mushtaq MU, Shahzad M, Amin MK, Lutfi F, DeJarnette S, Al-Ramahi JS, Li K, Ahmed N, Bansal R, Abdelhakim H, Shune L, Abdallah AO, Abhyankar SH, McGuirk JP, Singh AK
Leuk Lymphoma 2024 Apr;65(4):493-502. Epub 2024 Jan 2 doi: 10.1080/10428194.2023.2300708. PMID: 38164945
Comparison of Haploidentical Stem Cell Transplantation with Post-Transplantation Cyclophosphamide versus Umbilical Cord Blood Transplantation in Adult Patients with Aplastic Anemia.
Onishi Y, Mori T, Yamazaki H, Hiramoto N, Zaimoku Y, Kanaya M, Matsue K, Onizuka M, Aotsuka N, Uchida N, Onodera K, Kanda J, Nakamae H, Yamamoto R, Kuriyama T, Kimura T, Ichinohe T, Atsuta Y; Adult Aplastic Anemia Working Group of the Japanese Society for Transplantation and Cellular Therapy
Transplant Cell Ther 2023 Dec;29(12):766.e1-766.e8. Epub 2023 Sep 18 doi: 10.1016/j.jtct.2023.09.009. PMID: 37730121
Pembrolizumab Added to Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Relapsed or Refractory Classic Hodgkin Lymphoma: A Multi-institutional Phase 2 Investigator-Initiated Nonrandomized Clinical Trial.
Bryan LJ, Casulo C, Allen PB, Smith SE, Savas H, Dillehay GL, Karmali R, Pro B, Kane KL, Bazzi LA, Chmiel JS, Palmer BA, Mehta J, Gordon LI, Winter JN
JAMA Oncol 2023 May 1;9(5):683-691. doi: 10.1001/jamaoncol.2022.7975. PMID: 36928527Free PMC Article
Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials.
Chhabra S, Callander N, Watts NL, Costa LJ, Thapa B, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Anderson LD Jr, Bal S, Dhakal B, Nathwani N, Shah N, Medvedova E, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Schmidt T, Orlowski RZ, Shain KH, Cowan AJ, Dholaria B, Cornell RF, Jerkins JH, Pei H, Cortoos A, Patel S, Lin TS, Usmani SZ, Richardson PG, Voorhees PM
Transplant Cell Ther 2023 Mar;29(3):174.e1-174.e10. Epub 2022 Dec 6 doi: 10.1016/j.jtct.2022.11.029. PMID: 36494017
Transfusion support issues in hematopoietic stem cell transplantation.
Cohn CS
Cancer Control 2015 Jan;22(1):52-9. doi: 10.1177/107327481502200108. PMID: 25504279

Recent systematic reviews

Effect of prior lenalidomide or daratumumab exposure on hematopoietic stem cell collection and reconstitution in multiple myeloma.
Duan H, Jiang Q, Liu L, Deng M, Lai Q, Jiang Y, Li Z, Xu B, Lin Z
Ann Hematol 2024 Oct;103(10):3839-3853. Epub 2024 Mar 6 doi: 10.1007/s00277-024-05683-2. PMID: 38448787
Clinical Outcomes of Umbilical Cord Blood Transplantation Using Ex Vivo Expansion: A Systematic Review and Meta-Analysis of Controlled Studies.
Saiyin T, Kirkham AM, Bailey AJM, Shorr R, Pineault N, Maganti HB, Allan DS
Transplant Cell Ther 2023 Feb;29(2):129.e1-129.e9. Epub 2022 Nov 15 doi: 10.1016/j.jtct.2022.11.007. PMID: 36396108
Efficacy and safety of mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis.
Li T, Luo C, Zhang J, Wei L, Sun W, Xie Q, Liu Y, Zhao Y, Xu S, Wang L
Stem Cell Res Ther 2021 Apr 20;12(1):246. doi: 10.1186/s13287-021-02304-x. PMID: 33879242Free PMC Article
Pegylated granulocyte-colony stimulating factor versus non-pegylated granulocyte-colony stimulating factor for peripheral blood stem cell mobilization: A systematic review and meta-analysis.
Kuan JW, Su AT, Leong CF
J Clin Apher 2017 Dec;32(6):517-542. Epub 2017 May 9 doi: 10.1002/jca.21550. PMID: 28485020
Bone marrow versus peripheral blood allogeneic haematopoietic stem cell transplantation for haematological malignancies in adults.
Holtick U, Albrecht M, Chemnitz JM, Theurich S, Skoetz N, Scheid C, von Bergwelt-Baildon M
Cochrane Database Syst Rev 2014 Apr 20;2014(4):CD010189. doi: 10.1002/14651858.CD010189.pub2. PMID: 24748537Free PMC Article

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