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Vulvar leiomyosarcoma

MedGen UID:
378348
•Concept ID:
C2168304
•
Neoplastic Process
Synonyms: leiomyosarcoma of mammalian vulva; mammalian vulva leiomyosarcoma; Vulvar Leiomyosarcoma; vulvar leiomyosarcoma
 
Monarch Initiative: MONDO:0003372

Definition

An aggressive malignant smooth muscle neoplasm, arising from the vulva. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar leiomyosarcoma

Professional guidelines

PubMed

Criteria for Risk Stratification of Vulvar and Vaginal Smooth Muscle Tumors: An Evaluation of 71 Cases Comparing Proposed Classification Systems.
Sayeed S, Xing D, Jenkins SM, Weisman PS, Buehler D, Warmke L, Uram-Tuculescu C, Bakkum-Gamez JN, Howitt BE, Cortese C, Park KJ, Schoolmeester JK
Am J Surg Pathol 2018 Jan;42(1):84-94. doi: 10.1097/PAS.0000000000000920. PMID: 28786880Free PMC Article
Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1.
Chokoeva AA, Tchernev G, Cardoso JC, Patterson JW, Dechev I, Valkanov S, Zanardelli M, Lotti T, Wollina U
Int J Immunopathol Pharmacol 2015 Jun;28(2):168-77. Epub 2015 Mar 26 doi: 10.1177/0394632015576029. PMID: 25816394
Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2.
Chokoeva AA, Tchernev G, Cardoso JC, Patterson JW, Dechev I, Valkanov S, Zanardelli M, Lotti T, Wollina U
Int J Immunopathol Pharmacol 2015 Jun;28(2):178-86. Epub 2015 Mar 26 doi: 10.1177/0394632015575977. PMID: 25816393

Recent clinical studies

Etiology

MMPs and angiogenesis affect the metastatic potential of a human vulvar leiomyosarcoma cell line.
Alias C, Rocchi L, Ribatti D, Caraffi S, D'Angelo A, Perris R, Mangieri D
J Cell Mol Med 2015 Sep;19(9):2098-107. Epub 2015 May 22 doi: 10.1111/jcmm.12565. PMID: 26010680Free PMC Article

Diagnosis

Chemo-surgical approach in vulvar leiomyosarcoma: A case report.
Capalbo G, Logoteta A, Gallo R, Cuccu I, Gentile G, Arienzo F, Musella A, Pernazza A, Perniola G, Di Donato V, Manganaro L, Bogani G, Palaia I
Tumori 2022 Dec;108(6):NP26-NP29. Epub 2022 Oct 14 doi: 10.1177/03008916221130379. PMID: 36239461
Epithelioid leiomyosarcoma of the vulva: report of a rare case and literature review.
Lan H, Chai W, Gong F, Jia G
J Int Med Res 2022 Apr;50(4):3000605221090473. doi: 10.1177/03000605221090473. PMID: 35410510Free PMC Article
Vulvar leiomyosarcoma in Bartholin's gland area: a case report and literature review.
González-Bugatto F, Añón-Requena MJ, López-Guerrero MA, Báez-Perea JM, Bartha JL, Hervías-Vivancos B
Arch Gynecol Obstet 2009 Feb;279(2):171-4. Epub 2008 Apr 24 doi: 10.1007/s00404-008-0652-1. PMID: 18437406
Primary vulvar nocardiosis.
Gallo A, Bettoni G, Trezzi G, Lalinga V, Frigerio L
Obstet Gynecol 2006 Sep;108(3 Pt 2):728-30. doi: 10.1097/01.AOG.0000188068.10174.90. PMID: 17018480
Leiomyosarcoma of the vulva: report of a case.
Tawfik O, Huntrakoon M, Collins J, Owiety T, Seoud MA, Weed J Jr
Gynecol Oncol 1994 Aug;54(2):242-9. doi: 10.1006/gyno.1994.1202. PMID: 8063255

Therapy

Primary vulvar nocardiosis.
Gallo A, Bettoni G, Trezzi G, Lalinga V, Frigerio L
Obstet Gynecol 2006 Sep;108(3 Pt 2):728-30. doi: 10.1097/01.AOG.0000188068.10174.90. PMID: 17018480

Prognosis

Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin.
Olsen CE, Sellevold S, Theodossiou T, Patzke S, Berg K
Photodiagnosis Photodyn Ther 2017 Dec;20:35-47. Epub 2017 Aug 23 doi: 10.1016/j.pdpdt.2017.08.010. PMID: 28838761
MMPs and angiogenesis affect the metastatic potential of a human vulvar leiomyosarcoma cell line.
Alias C, Rocchi L, Ribatti D, Caraffi S, D'Angelo A, Perris R, Mangieri D
J Cell Mol Med 2015 Sep;19(9):2098-107. Epub 2015 May 22 doi: 10.1111/jcmm.12565. PMID: 26010680Free PMC Article
Vulvar leiomyosarcoma: a case report in a Nigerian woman.
Otoide V, Okobia M, Aligbe J, Okonofua F
Surg Technol Int 2002 Sep;10:71-3. PMID: 12384866
Leiomyosarcoma of the vulva. A case report.
Lösch A, Joura EA, Stani J, Breitenecker G, Lahodny J
J Reprod Med 2001 Jun;46(6):609-12. PMID: 11441690

Clinical prediction guides

Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin.
Olsen CE, Sellevold S, Theodossiou T, Patzke S, Berg K
Photodiagnosis Photodyn Ther 2017 Dec;20:35-47. Epub 2017 Aug 23 doi: 10.1016/j.pdpdt.2017.08.010. PMID: 28838761
MMPs and angiogenesis affect the metastatic potential of a human vulvar leiomyosarcoma cell line.
Alias C, Rocchi L, Ribatti D, Caraffi S, D'Angelo A, Perris R, Mangieri D
J Cell Mol Med 2015 Sep;19(9):2098-107. Epub 2015 May 22 doi: 10.1111/jcmm.12565. PMID: 26010680Free PMC Article

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