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Ovarian clear cell malignant adenofibroma

MedGen UID:
384483
•Concept ID:
C2075522
•
Neoplastic Process
Synonyms: Ovarian Clear Cell Adenocarcinofibroma; ovarian clear cell adenocarcinofibroma; Ovarian Clear Cell Malignant Adenofibroma; ovarian clear cell malignant adenofibroma
 
Monarch Initiative: MONDO:0003922

Definition

A malignant neoplasm of the ovary with an invasive epithelial component and a fibrotic stroma. The epithelial component is characterized by the presence of malignant epithelial cells with clear cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian clear cell malignant adenofibroma

Professional guidelines

PubMed

Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Recent clinical studies

Etiology

B7-H4 is Inversely Correlated With T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer.
Pagnotti GM, Atkinson RM, Romeiser J, Akalin A, Korman MB, Shroyer KR
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):515-522. doi: 10.1097/PAI.0000000000000608. PMID: 29189263
Prognostic impact of interleukin-6 expression in stage I ovarian clear cell carcinoma.
Kawabata A, Yanaihara N, Nagata C, Saito M, Noguchi D, Takenaka M, Iida Y, Takano H, Yamada K, Iwamoto M, Kiyokawa T, Okamoto A
Gynecol Oncol 2017 Sep;146(3):609-614. Epub 2017 Jun 30 doi: 10.1016/j.ygyno.2017.06.027. PMID: 28673661
Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes.
Kato H, Hatano Y, Makino H, Furui T, Morishige KI, Matsuo M
Abdom Radiol (NY) 2016 Dec;41(12):2476-2483. doi: 10.1007/s00261-016-0777-9. PMID: 27167231
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1α, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma.
Kato M, Yamamoto S, Takano M, Matsubara O, Furuya K
Int J Gynecol Pathol 2012 May;31(3):254-63. doi: 10.1097/PGP.0b013e318237d66c. PMID: 22498943

Diagnosis

Papillary Cystadenofibroma of the Epididymis: A Case Report.
Parisi X, Feinstein A, Merkulova Y, Rodriguez M, Sun Y
Int J Surg Pathol 2024 Aug;32(5):948-951. Epub 2023 Sep 16 doi: 10.1177/10668969231201412. PMID: 37715657
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Therapy

B7-H4 is Inversely Correlated With T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer.
Pagnotti GM, Atkinson RM, Romeiser J, Akalin A, Korman MB, Shroyer KR
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):515-522. doi: 10.1097/PAI.0000000000000608. PMID: 29189263
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Ovarian endometriosis associated with carcinoma and sarcoma: case report.
Boruban MC, Jaishuen A, Sirisabya N, Li Y, Zheng HG, Deavers MT, Kavanagh JJ
Eur J Gynaecol Oncol 2008;29(4):393-6. PMID: 18714578

Prognosis

Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Prognostic impact of interleukin-6 expression in stage I ovarian clear cell carcinoma.
Kawabata A, Yanaihara N, Nagata C, Saito M, Noguchi D, Takenaka M, Iida Y, Takano H, Yamada K, Iwamoto M, Kiyokawa T, Okamoto A
Gynecol Oncol 2017 Sep;146(3):609-614. Epub 2017 Jun 30 doi: 10.1016/j.ygyno.2017.06.027. PMID: 28673661
ARID1A expression in ovarian clear cell carcinoma with an adenofibromatous component.
Nishikimi K, Kiyokawa T, Tate S, Iwamoto M, Shozu M
Histopathology 2015 Dec;67(6):866-71. Epub 2015 Jun 7 doi: 10.1111/his.12721. PMID: 25913291
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Clinical prediction guides

B7-H4 is Inversely Correlated With T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer.
Pagnotti GM, Atkinson RM, Romeiser J, Akalin A, Korman MB, Shroyer KR
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):515-522. doi: 10.1097/PAI.0000000000000608. PMID: 29189263
Prognostic impact of interleukin-6 expression in stage I ovarian clear cell carcinoma.
Kawabata A, Yanaihara N, Nagata C, Saito M, Noguchi D, Takenaka M, Iida Y, Takano H, Yamada K, Iwamoto M, Kiyokawa T, Okamoto A
Gynecol Oncol 2017 Sep;146(3):609-614. Epub 2017 Jun 30 doi: 10.1016/j.ygyno.2017.06.027. PMID: 28673661
Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes.
Kato H, Hatano Y, Makino H, Furui T, Morishige KI, Matsuo M
Abdom Radiol (NY) 2016 Dec;41(12):2476-2483. doi: 10.1007/s00261-016-0777-9. PMID: 27167231
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma.
Yamamoto S, Tsuda H, Takano M, Tamai S, Matsubara O
Virchows Arch 2012 Jan;460(1):77-87. Epub 2011 Nov 26 doi: 10.1007/s00428-011-1169-8. PMID: 22120431

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