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Adult Spinal Cord Neoplasm

MedGen UID:
384871
•Concept ID:
C2347754
•
Neoplastic Process
Synonym: Adult Spinal Cord Tumor

Professional guidelines

PubMed

Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Intradural spinal tumors in adults-update on management and outcome.
Ottenhausen M, Ntoulias G, Bodhinayake I, Ruppert FH, Schreiber S, Förschler A, Boockvar JA, Jödicke A
Neurosurg Rev 2019 Jun;42(2):371-388. Epub 2018 Feb 17 doi: 10.1007/s10143-018-0957-x. PMID: 29455369

Recent clinical studies

Etiology

Clinical Characteristics, Management, and Outcomes of Intramedullary Spinal Cord Ependymomas in Adults: A Systematic Review.
Farooqi S, Tebha SS, Qamar MA, Singh S, Alfawares Y, Ramanathan V, Haider AS, Ferini G, Sharma M, Umana GE, Aoun SG, Palmisciano P
World Neurosurg 2023 May;173:237-250.e8. Epub 2023 Feb 28 doi: 10.1016/j.wneu.2023.02.098. PMID: 36858296
Challenges in diagnosis and management of adult spinal cord gliomas.
Campello C, Tabouret E, Chinot O
Rev Neurol (Paris) 2021 May;177(5):515-523. Epub 2021 Apr 23 doi: 10.1016/j.neurol.2021.02.384. PMID: 33896651
Management, outcomes, and prognostic factors of adult primary spinal cord gliomas.
Haque W, Verma V, Barber S, Tremont IW, Brian Butler E, Teh BS
J Clin Neurosci 2021 Feb;84:8-14. Epub 2020 Dec 28 doi: 10.1016/j.jocn.2020.12.015. PMID: 33485604
Pediatric Spinal Ependymomas.
Sofuoğlu ÖE, Abdallah A
Med Sci Monit 2018 Oct 5;24:7072-7089. doi: 10.12659/MSM.910447. PMID: 30287802Free PMC Article
Spinal cord meningioma.
Levy WJ Jr, Bay J, Dohn D
J Neurosurg 1982 Dec;57(6):804-12. doi: 10.3171/jns.1982.57.6.0804. PMID: 7143063

Diagnosis

Spinal Meningiomas.
Hachem LD, Nater A, Fehlings MG
Adv Exp Med Biol 2023;1416:69-78. doi: 10.1007/978-3-031-29750-2_6. PMID: 37432620
Clinical Characteristics, Management, and Outcomes of Intramedullary Spinal Cord Ependymomas in Adults: A Systematic Review.
Farooqi S, Tebha SS, Qamar MA, Singh S, Alfawares Y, Ramanathan V, Haider AS, Ferini G, Sharma M, Umana GE, Aoun SG, Palmisciano P
World Neurosurg 2023 May;173:237-250.e8. Epub 2023 Feb 28 doi: 10.1016/j.wneu.2023.02.098. PMID: 36858296
Intramedullary spinal cord lesions in children.
Hani U, Tebha SS, Bakhshi SK, Shamim MS
J Pak Med Assoc 2021 Feb;71(2(B)):775-777. PMID: 33941981
Challenges in diagnosis and management of adult spinal cord gliomas.
Campello C, Tabouret E, Chinot O
Rev Neurol (Paris) 2021 May;177(5):515-523. Epub 2021 Apr 23 doi: 10.1016/j.neurol.2021.02.384. PMID: 33896651
Intradural spinal tumors in adults-update on management and outcome.
Ottenhausen M, Ntoulias G, Bodhinayake I, Ruppert FH, Schreiber S, Förschler A, Boockvar JA, Jödicke A
Neurosurg Rev 2019 Jun;42(2):371-388. Epub 2018 Feb 17 doi: 10.1007/s10143-018-0957-x. PMID: 29455369

Therapy

Molecular profile and clinical outcome of adult primary spinal cord glioblastoma: a systematic review.
Ezzat B, Young T, Schüpper AJ, Kalagara R, Zhang JY, Lemonick M, Bhanot P, Quinones A, Choudhri T, Germano IM
J Neurosurg Spine 2024 Oct 1;41(4):541-550. Epub 2024 Jul 26 doi: 10.3171/2024.4.SPINE231350. PMID: 39059422
Stereotactic Radiosurgery for Cranial and Spinal Hemangioblastomas: A Single-Institution Retrospective Series.
Yoo KH, Park DJ, Marianayagam NJ, Gu X, Pollom EL, Soltys SG, Chang SD, Meola A
Neurosurgery 2024 Mar 1;94(3):630-642. Epub 2023 Oct 17 doi: 10.1227/neu.0000000000002728. PMID: 37967154
A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma.
Gilbert MR, Yuan Y, Wu J, Mendoza T, Vera E, Omuro A, Lieberman F, Robins HI, Gerstner ER, Wu J, Wen PY, Mikkelsen T, Aldape K, Armstrong TS
Neuro Oncol 2021 Mar 25;23(3):468-477. doi: 10.1093/neuonc/noaa240. PMID: 33085768Free PMC Article
Clinical Features and Outcomes of Primary Spinal Cord Glioblastoma: A Single-Center Experience and Literature Review.
Yang K, Man W, Jing L, Sun Z, Liang P, Wang J, Wang G
World Neurosurg 2020 Nov;143:e157-e165. Epub 2020 Jul 18 doi: 10.1016/j.wneu.2020.07.066. PMID: 32688042
Metastatic Spinal Cord Compression: Unraveling the Diagnostic and Therapeutic Challenges.
Boussios S, Cooke D, Hayward C, Kanellos FS, Tsiouris AK, Chatziantoniou AA, Zakynthinakis-Kyriakou N, Karathanasi A
Anticancer Res 2018 Sep;38(9):4987-4997. doi: 10.21873/anticanres.12817. PMID: 30194142

Prognosis

Anaplastic gangliogliomas of the spinal cord: a scoping review of the literature.
Vlachos N, Lampros MG, Zigouris A, Voulgaris S, Alexiou GA
Neurosurg Rev 2022 Feb;45(1):295-304. Epub 2021 Jul 27 doi: 10.1007/s10143-021-01612-3. PMID: 34312775
Spinal hemangioblastoma: surgical procedures, outcomes and review of the literature.
Wang H, Zhang L, Wang H, Nan Y, Ma Q
Acta Neurol Belg 2021 Aug;121(4):973-981. Epub 2020 Jul 7 doi: 10.1007/s13760-020-01420-4. PMID: 32638270
Pediatric Spinal Ependymomas.
Sofuoğlu ÖE, Abdallah A
Med Sci Monit 2018 Oct 5;24:7072-7089. doi: 10.12659/MSM.910447. PMID: 30287802Free PMC Article
Primary Spinal Oligoastrocytoma.
Zhao H, Yuan M, Yang L, Niu J, Yuan X, Bai Y, Guo L
J Craniofac Surg 2016 May;27(3):e311-3. doi: 10.1097/SCS.0000000000002572. PMID: 27092919
Intramedullary cavernous malformations.
Chabert E, Morandi X, Carney MP, Riffaud L, Louail C, Carsin-Nicol B
J Neuroradiol 1999 Dec;26(4):262-8. PMID: 10783555

Clinical prediction guides

Stereotactic high-dose irradiation for intramedullary metastases.
Goncharov YE, Zubatkina IS, Ivanov PI
Zh Vopr Neirokhir Im N N Burdenko 2024;88(4):22-30. doi: 10.17116/neiro20248804122. PMID: 39169578
Molecular profile and clinical outcome of adult primary spinal cord glioblastoma: a systematic review.
Ezzat B, Young T, Schüpper AJ, Kalagara R, Zhang JY, Lemonick M, Bhanot P, Quinones A, Choudhri T, Germano IM
J Neurosurg Spine 2024 Oct 1;41(4):541-550. Epub 2024 Jul 26 doi: 10.3171/2024.4.SPINE231350. PMID: 39059422
Presentation and management of spinal meningioma and its association with breast carcinoma-case series and systematic review.
Wang D, Sadek AR, Vaseeharan S, Manivannan S, Walker M, Nader-Sepahi A
Br J Neurosurg 2024 Dec;38(6):1460-1465. Epub 2022 Apr 18 doi: 10.1080/02688697.2022.2061419. PMID: 35435093
Spinal Hemangioblastomas and Neuropathic Pain.
Etli MU, Sarıkaya C, Onen MR, Naderi S
World Neurosurg 2021 May;149:e780-e784. Epub 2021 Feb 1 doi: 10.1016/j.wneu.2021.01.100. PMID: 33540101
Lumbar paraganglioma.
Dillard-Cannon E, Atsina KB, Ghobrial G, Gnass E, Curtis MT, Heller J
J Clin Neurosci 2016 Aug;30:149-151. Epub 2016 Mar 28 doi: 10.1016/j.jocn.2016.01.019. PMID: 27032749

Recent systematic reviews

Molecular profile and clinical outcome of adult primary spinal cord glioblastoma: a systematic review.
Ezzat B, Young T, Schüpper AJ, Kalagara R, Zhang JY, Lemonick M, Bhanot P, Quinones A, Choudhri T, Germano IM
J Neurosurg Spine 2024 Oct 1;41(4):541-550. Epub 2024 Jul 26 doi: 10.3171/2024.4.SPINE231350. PMID: 39059422
Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis.
Hagbohm C, Ouellette R, Flanagan EP, Jonsson DI, Piehl F, Banwell B, Wickström R, Iacobaeus E, Granberg T, Ineichen BV
Eur J Neurol 2024 Jul;31(7):e16284. Epub 2024 Mar 20 doi: 10.1111/ene.16284. PMID: 38506182Free PMC Article
Autoimmune and paraneoplastic neurological disorders: A review of relevant neuroimaging findings.
Akkus S, Elkhooly M, Amatya S, Shrestha K, Sharma K, Kagzi Y, Khan E, Gupta R, Piquet AL, Jaiswal S, Wen S, Tapia M, Samant R, Sista SR, Sriwastava S
J Neurol Sci 2023 Nov 15;454:120830. Epub 2023 Oct 9 doi: 10.1016/j.jns.2023.120830. PMID: 37856996
Intramedullary Spinal Cord Metastases from Breast Cancer: A Systematic Review.
Scalia G, Costanzo R, Viola A, Bonosi L, Porzio M, Giovannini A, Graziano F, Iacopino DG, Maugeri R, Nicoletti GF, Umana GE
Anticancer Res 2023 Feb;43(2):523-535. doi: 10.21873/anticanres.16189. PMID: 36697093
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329

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