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Pyogenic granuloma

MedGen UID:
39085
•Concept ID:
C0085653
•
Neoplastic Process
Synonyms: Lobular capillary hemangioma; PG
SNOMED CT: PG - Pyogenic granuloma (39629007); Capillary hemangioma of granulation tissue type (17372009); Lobular capillary hemangioma (17372009); Granuloma pyogenicum (17372009); Pyogenic granuloma (17372009); Granuloma telangiectaticum (17372009); Pyogenic granuloma (200722003)
 
Monarch Initiative: MONDO:0022096

Definition

A friable, benign vascular neoplasm with lobular capillary architecture that presents as a raised red skin growth. [from NCI]

Professional guidelines

PubMed

Management of Bleeding Pyogenic Granulomas in Acute Care Settings.
Gaw CE, Treat JR, Friedlaender EY, Del Pizzo J
J Emerg Med 2022 Sep;63(3):339-347. Epub 2022 Oct 6 doi: 10.1016/j.jemermed.2022.04.031. PMID: 36210284
S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Pyogenic granuloma-treatment by shave-excision and/or pulsed-dye laser.
Sud AR, Tan ST
J Plast Reconstr Aesthet Surg 2010 Aug;63(8):1364-8. Epub 2009 Jul 21 doi: 10.1016/j.bjps.2009.06.031. PMID: 19625228

Recent clinical studies

Etiology

Physiology of pregnancy and oral local anesthesia considerations.
Zhou X, Zhong Y, Pan Z, Zhang J, Pan J
PeerJ 2023;11:e15585. Epub 2023 Jun 29 doi: 10.7717/peerj.15585. PMID: 37404472Free PMC Article
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Oral health during pregnancy.
Silk H, Douglass AB, Douglass JM, Silk L
Am Fam Physician 2008 Apr 15;77(8):1139-44. PMID: 18481562

Diagnosis

Pyogenic Granuloma.
Komakech D, Ssenkumba B
N Engl J Med 2022 Nov 24;387(21):1979. doi: 10.1056/NEJMicm2204602. PMID: 36416770
Tracheal Lobular Capillary Hemangioma.
Luo J, He YQ
Am J Respir Crit Care Med 2022 Oct 15;206(8):1035-1036. doi: 10.1164/rccm.202202-0297IM. PMID: 35776058
Oral pyogenic granuloma: An 18-year retrospective clinicopathological and immunohistochemical study.
Ribeiro JL, Moraes RM, Carvalho BFC, Nascimento AO, Milhan NVM, Anbinder AL
J Cutan Pathol 2021 Jul;48(7):863-869. Epub 2021 Feb 15 doi: 10.1111/cup.13970. PMID: 33486806
Congenital Vascular Tumors.
Goss JA, Greene AK
Otolaryngol Clin North Am 2018 Feb;51(1):89-97. doi: 10.1016/j.otc.2017.09.008. PMID: 29217070
Oral pyogenic granuloma: a review.
Jafarzadeh H, Sanatkhani M, Mohtasham N
J Oral Sci 2006 Dec;48(4):167-75. doi: 10.2334/josnusd.48.167. PMID: 17220613

Therapy

Physiology of pregnancy and oral local anesthesia considerations.
Zhou X, Zhong Y, Pan Z, Zhang J, Pan J
PeerJ 2023;11:e15585. Epub 2023 Jun 29 doi: 10.7717/peerj.15585. PMID: 37404472Free PMC Article
Management of Bleeding Pyogenic Granulomas in Acute Care Settings.
Gaw CE, Treat JR, Friedlaender EY, Del Pizzo J
J Emerg Med 2022 Sep;63(3):339-347. Epub 2022 Oct 6 doi: 10.1016/j.jemermed.2022.04.031. PMID: 36210284
Topical beta-blockers in dermatologic therapy.
Filoni A, Ambrogio F, De Marco A, Pacifico A, Bonamonte D
Dermatol Ther 2021 Jul;34(4):e15016. Epub 2021 Jun 21 doi: 10.1111/dth.15016. PMID: 34075667Free PMC Article
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Oral pyogenic granuloma: a review.
Jafarzadeh H, Sanatkhani M, Mohtasham N
J Oral Sci 2006 Dec;48(4):167-75. doi: 10.2334/josnusd.48.167. PMID: 17220613

Prognosis

Primary cutaneous extraskeletal osteosarcoma: a series of 16 cases.
Habeeb O, Weigelt MA, Goldblum JR, Ko JS, Habermehl G, Rubin BP, Billings SD
Pathology 2023 Apr;55(3):315-323. Epub 2022 Nov 30 doi: 10.1016/j.pathol.2022.10.002. PMID: 36567163
Pediatric melanoma update.
Mccormack L, Hawryluk EB
G Ital Dermatol Venereol 2018 Oct;153(5):707-715. Epub 2018 Feb 26 doi: 10.23736/S0392-0488.18.05924-2. PMID: 29485257
Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590
Kaposi sarcoma.
Radu O, Pantanowitz L
Arch Pathol Lab Med 2013 Feb;137(2):289-94. doi: 10.5858/arpa.2012-0101-RS. PMID: 23368874
Tumors of the cornea and conjunctiva.
Spraul CW, Grossniklaus HE
Curr Opin Ophthalmol 1996 Aug;7(4):28-34. doi: 10.1097/00055735-199608000-00006. PMID: 10163636

Clinical prediction guides

Human Orf: An Under-recognized Entity.
Santiago L, Oliveira D, Cardoso JC, Figueired A
Acta Dermatovenerol Croat 2019 Dec;27(4):280-281. PMID: 31969245
World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review.
Hong CHL, Dean DR, Hull K, Hu SJ, Sim YF, Nadeau C, Gonçalves S, Lodi G, Hodgson TA
Oral Dis 2019 Jun;25 Suppl 1:193-203. doi: 10.1111/odi.13112. PMID: 31034120
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Systemic alterations and their oral manifestations in pregnant women.
Silva de Araujo Figueiredo C, Gonçalves Carvalho Rosalem C, Costa Cantanhede AL, Abreu Fonseca Thomaz ÉB, Fontoura Nogueira da Cruz MC
J Obstet Gynaecol Res 2017 Jan;43(1):16-22. doi: 10.1111/jog.13150. PMID: 28074549
Skin metastasis: a pathologist's perspective.
Hussein MR
J Cutan Pathol 2010 Sep;37(9):e1-20. Epub 2009 Nov 17 doi: 10.1111/j.1600-0560.2009.01469.x. PMID: 19922483

Recent systematic reviews

Acitretin-induced periungual pyogenic granulomas and review.
Thomas M, Shon W, Truong AK
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754369. PMID: 34391333
Beta-Blockers for Pyogenic Granuloma: A Systematic Review of Case Reports, Case Series, and Clinical Trials.
Dany M
J Drugs Dermatol 2019 Oct 1;18(10):1006-1010. PMID: 31584779
Therapeutic approaches to pyogenic granuloma: an updated review.
Plachouri KM, Georgiou S
Int J Dermatol 2019 Jun;58(6):642-648. Epub 2018 Oct 21 doi: 10.1111/ijd.14268. PMID: 30345507
Reactive oral lesions associated with dental implants. A systematic review.
Atarbashi-Moghadam F, Atarbashi-Moghadam S, Namdari M, Shahrabi-Farahani S
J Investig Clin Dent 2018 Nov;9(4):e12342. Epub 2018 May 11 doi: 10.1111/jicd.12342. PMID: 29752778
Conjunctival autograft for pterygium.
Clearfield E, Muthappan V, Wang X, Kuo IC
Cochrane Database Syst Rev 2016 Feb 11;2(2):CD011349. doi: 10.1002/14651858.CD011349.pub2. PMID: 26867004Free PMC Article

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