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Benign carotid body paraganglioma

MedGen UID:
396868
•Concept ID:
C2698359
•
Neoplastic Process
Synonyms: Benign Carotid Body Paraganglioma; benign carotid body paraganglioma; Benign Chemodectoma; benign chemodectoma; carotid body paraganglioma, benign; chemodectoma, benign; Non-Metastatic Carotid Body Paraganglioma
 
Monarch Initiative: MONDO:0006104

Definition

A paraganglioma that arises from and is confined to the carotid body. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign carotid body paraganglioma

Professional guidelines

PubMed

Current management of carotid body tumors.
Ozawa H
Auris Nasus Larynx 2024 Jun;51(3):501-506. Epub 2024 Mar 23 doi: 10.1016/j.anl.2024.01.007. PMID: 38522353
Treatment of relapses of benign latero-cervical pathology: a narrative literature review.
Meliante PG, Colizza A, Ralli M, Minni A, Angeletti D, Cambria F, de Vincentiis M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl 1):S76-S83. doi: 10.14639/0392-100X-suppl.1-43-2023-10. PMID: 37698104Free PMC Article
Treatment of Head and Neck Paragangliomas.
Hu K, Persky MS
Cancer Control 2016 Jul;23(3):228-41. doi: 10.1177/107327481602300306. PMID: 27556663

Recent clinical studies

Etiology

Current management of carotid body tumors.
Ozawa H
Auris Nasus Larynx 2024 Jun;51(3):501-506. Epub 2024 Mar 23 doi: 10.1016/j.anl.2024.01.007. PMID: 38522353
Long-Term Outcomes of Patients With Carotid and Aortic Body Tumors.
Verghis NM, Brown JA, Yousef S, Aranda-Michel E, Serna-Gallegos D, Levenson J, Ogami T, Diaz-Castrillon C, Thoma F, Singh M, Sultan I
Am J Cardiol 2023 Jul 15;199:78-84. Epub 2023 May 31 doi: 10.1016/j.amjcard.2023.05.003. PMID: 37262989
Surgical outcomes and factors associated with malignancy in carotid body tumors.
Zhang W, Liu F, Hou K, Shu X, Chen B, Wang L, Guo D, Fu W
J Vasc Surg 2021 Aug;74(2):586-591. Epub 2021 Feb 4 doi: 10.1016/j.jvs.2020.12.097. PMID: 33548423
Simple and complex carotid paragangliomas. Three decades of experience and literature review.
Lozano FS, Muñoz A, de Las Heras JA, González-Porras JR
Head Neck 2020 Dec;42(12):3538-3550. Epub 2020 Aug 19 doi: 10.1002/hed.26421. PMID: 32812684
Carotid Body Tumors: A Case Series and Review of the Literature.
Darouassi Y, Alaoui M, Mliha Touati M, Al Maghraoui O, En-Nouali A, Bouaity B, Ammar H
Ann Vasc Surg 2017 Aug;43:265-271. Epub 2017 May 3 doi: 10.1016/j.avsg.2017.03.167. PMID: 28478173

Diagnosis

High incidence of occult familial SDHD cases amongst Czech patients with head and neck paragangliomas.
Guha A, Vicha A, Zelinka T, Kana M, Musil Z, Pacak K, Betka J, Chovanec M, Plzak J, Boucek J
Front Endocrinol (Lausanne) 2023;14:1278175. Epub 2023 Dec 8 doi: 10.3389/fendo.2023.1278175. PMID: 38144572Free PMC Article
Simple and complex carotid paragangliomas. Three decades of experience and literature review.
Lozano FS, Muñoz A, de Las Heras JA, González-Porras JR
Head Neck 2020 Dec;42(12):3538-3550. Epub 2020 Aug 19 doi: 10.1002/hed.26421. PMID: 32812684
Carotid Body Tumors: A Case Series and Review of the Literature.
Darouassi Y, Alaoui M, Mliha Touati M, Al Maghraoui O, En-Nouali A, Bouaity B, Ammar H
Ann Vasc Surg 2017 Aug;43:265-271. Epub 2017 May 3 doi: 10.1016/j.avsg.2017.03.167. PMID: 28478173
The parapharyngeal space.
Maran AG, Mackenzie IJ, Murray JA
J Laryngol Otol 1984 Apr;98(4):371-80. doi: 10.1017/s0022215100146766. PMID: 6325567
Carotid body tumors, benign and malignant.
Staats EF, Brown RL, Smith RR
Laryngoscope 1966 May;76(5):907-16. doi: 10.1288/00005537-196605000-00008. PMID: 5937910

Therapy

Preoperative Embolization Of Carotid Body Tumours: Yes Or No?
Soares T, Dias P, Sampaio S, Teixeira J
Port J Card Thorac Vasc Surg 2023 Jan 14;29(4):27-30. doi: 10.48729/pjctvs.206. PMID: 36640293
Non-Functional Carotid Body Tumors in Patients Without Somatic Mutations May Be Considered for Non-Operative Management.
Reitz K, Ramos A, Speranza G, Chaer R, Singh M, Snyderman C, Hager E
Ann Vasc Surg 2022 Sep;85:57-67. Epub 2022 Apr 23 doi: 10.1016/j.avsg.2022.04.021. PMID: 35472500Free PMC Article
Surgical outcomes and factors associated with malignancy in carotid body tumors.
Zhang W, Liu F, Hou K, Shu X, Chen B, Wang L, Guo D, Fu W
J Vasc Surg 2021 Aug;74(2):586-591. Epub 2021 Feb 4 doi: 10.1016/j.jvs.2020.12.097. PMID: 33548423
Carotid body tumor: a 25-year experience.
Metheetrairut C, Chotikavanich C, Keskool P, Suphaphongs N
Eur Arch Otorhinolaryngol 2016 Aug;273(8):2171-9. Epub 2015 Aug 2 doi: 10.1007/s00405-015-3737-z. PMID: 26233244
Carotid body tumors.
Dent TL, Thompson NW, Fry WJ
Surgery 1976 Sep;80(3):365-72. PMID: 960003

Prognosis

Current management of carotid body tumors.
Ozawa H
Auris Nasus Larynx 2024 Jun;51(3):501-506. Epub 2024 Mar 23 doi: 10.1016/j.anl.2024.01.007. PMID: 38522353
High incidence of occult familial SDHD cases amongst Czech patients with head and neck paragangliomas.
Guha A, Vicha A, Zelinka T, Kana M, Musil Z, Pacak K, Betka J, Chovanec M, Plzak J, Boucek J
Front Endocrinol (Lausanne) 2023;14:1278175. Epub 2023 Dec 8 doi: 10.3389/fendo.2023.1278175. PMID: 38144572Free PMC Article
Treatment of relapses of benign latero-cervical pathology: a narrative literature review.
Meliante PG, Colizza A, Ralli M, Minni A, Angeletti D, Cambria F, de Vincentiis M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl 1):S76-S83. doi: 10.14639/0392-100X-suppl.1-43-2023-10. PMID: 37698104Free PMC Article
Carotid Body Tumors: A Case Series and Review of the Literature.
Darouassi Y, Alaoui M, Mliha Touati M, Al Maghraoui O, En-Nouali A, Bouaity B, Ammar H
Ann Vasc Surg 2017 Aug;43:265-271. Epub 2017 May 3 doi: 10.1016/j.avsg.2017.03.167. PMID: 28478173
The parapharyngeal space.
Maran AG, Mackenzie IJ, Murray JA
J Laryngol Otol 1984 Apr;98(4):371-80. doi: 10.1017/s0022215100146766. PMID: 6325567

Clinical prediction guides

Clinical management and outcome of head and neck paragangliomas (HNPGLs): A single centre retrospective study.
Darrat M, Lau L, Leonard C, Cooke S, Shahzad MA, McHenry C, McCance DR, Hunter SJ, Mullan K, Lindsay JR, Graham U, Bailie N, Hampton S, Rajendran S, Houghton F, Conkey D, Morrison PJ, Johnston PC
Clin Endocrinol (Oxf) 2024 Sep;101(3):243-248. Epub 2024 May 2 doi: 10.1111/cen.15070. PMID: 38696538
Current management of carotid body tumors.
Ozawa H
Auris Nasus Larynx 2024 Jun;51(3):501-506. Epub 2024 Mar 23 doi: 10.1016/j.anl.2024.01.007. PMID: 38522353
Treatment of relapses of benign latero-cervical pathology: a narrative literature review.
Meliante PG, Colizza A, Ralli M, Minni A, Angeletti D, Cambria F, de Vincentiis M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl 1):S76-S83. doi: 10.14639/0392-100X-suppl.1-43-2023-10. PMID: 37698104Free PMC Article
Carotid Body Tumors: A Case Series and Review of the Literature.
Darouassi Y, Alaoui M, Mliha Touati M, Al Maghraoui O, En-Nouali A, Bouaity B, Ammar H
Ann Vasc Surg 2017 Aug;43:265-271. Epub 2017 May 3 doi: 10.1016/j.avsg.2017.03.167. PMID: 28478173
Carotid body paragangliomas and matrix metalloproteinases.
Serra R, Grande R, Gallelli L, Rende P, Scarcello E, Buffone G, Caliò FG, Gasbarro V, Amato B, de Franciscis S
Ann Vasc Surg 2014 Oct;28(7):1665-70. Epub 2014 Apr 2 doi: 10.1016/j.avsg.2014.03.022. PMID: 24704048

Recent systematic reviews

Stereotactic radiosurgery for head and neck paragangliomas: a systematic review and meta-analysis.
Fatima N, Pollom E, Soltys S, Chang SD, Meola A
Neurosurg Rev 2021 Apr;44(2):741-752. Epub 2020 Apr 21 doi: 10.1007/s10143-020-01292-5. PMID: 32318920
Ancient schwannoma mimicking a carotid body tumor A case report and review of the literature.
Garbuglio R, Turchino D, Giribono AM, Viviani E, Ferrante L, Sodo M, Del Guercio L, Bracale UM
Ann Ital Chir 2020 Jan 20;9 PMID: 31957705

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