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Marked delay in bone age

MedGen UID:
401468
•Concept ID:
C1868549
•
Finding
Synonyms: Marked retardation in skeletal maturation; Markedly retarded bone age
 
HPO: HP:0003799

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMarked delay in bone age

Conditions with this feature

Epiphyseal dysplasia, Baumann type
MedGen UID:
322764
•Concept ID:
C1835830
•
Disease or Syndrome
See: Condition Record
Short stature-pituitary and cerebellar defects-small sella turcica syndrome
MedGen UID:
394816
•Concept ID:
C2678408
•
Disease or Syndrome
Short stature-pituitary and cerebellar defects-small sella turcica syndrome is characterised by short stature, anterior pituitary hormone deficiency, small sella turcica, and a hypoplastic anterior hypophysis associated with pointed cerebellar tonsils. It has been described in three generations of a large French kindred. Ectopia of the posterior hypophysis was observed in some patients. The syndrome is transmitted as a dominantly inherited trait and is caused by a germline mutation within the LIM-homeobox transcription factor <i>LHX4</i> gene (1q25).
See: Condition Record
Epiphyseal dysplasia, Baumann type
Short stature-pituitary and cerebellar defects-small sella turcica syndrome

Professional guidelines

PubMed

Treatment of Adolescent Blount Disease Using Taylor Spatial Frame With and Without Fibular Osteotomy: Is There any Difference?
Sachs O, Katzman A, Abu-Johar E, Eidelman M
J Pediatr Orthop 2015 Jul-Aug;35(5):501-6. doi: 10.1097/BPO.0000000000000317. PMID: 25321881
Cancer treatment-induced bone loss: pathophysiology and clinical perspectives.
Brufsky AM
Oncologist 2008 Feb;13(2):187-95. doi: 10.1634/theoncologist.2007-0152. PMID: 18305064
Sotos syndrome: a study of the diagnostic criteria and natural history.
Cole TR, Hughes HE
J Med Genet 1994 Jan;31(1):20-32. doi: 10.1136/jmg.31.1.20. PMID: 7512144Free PMC Article

Recent clinical studies

Etiology

Skeletal and dental age discrepancy and occlusal traits in children with growth hormone deficiency and idiopathic short stature.
Torlińska-Walkowiak N, Majewska KA, Sowińska A, Kędzia A, Opydo-Szymaczek J
Clin Oral Investig 2022 Oct;26(10):6165-6175. Epub 2022 Jun 11 doi: 10.1007/s00784-022-04566-y. PMID: 35690690
Profile of paediatric tuberculosis mastoiditis - a case series.
Din TF, Fagan JJ, Peer S
S Afr J Surg 2022 Mar;60(1):62-66. PMID: 35451273
Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India.
Sharma A, Naidu G, Sharma V, Jha S, Dhooria A, Dhir V, Bhatia P, Sharma V, Bhattad S, Chengappa KG, Gupta V, Misra DP, Chavan PP, Malaviya S, Dudam R, Sharma B, Kumar S, Bhojwani R, Gupta P, Agarwal V, Sharma K, Singhal M, Rathi M, Nada R, Minz RW, Chaturvedi V, Aggarwal A, Handa R, Grossi A, Gattorno M, Huang Z, Wang J, Jois R, Negi VS, Khubchandani R, Jain S, Arostegui JI, Chambers EP, Hershfield MS, Aksentijevich I, Zhou Q, Lee PY
Arthritis Rheumatol 2021 Feb;73(2):276-285. Epub 2020 Dec 26 doi: 10.1002/art.41500. PMID: 32892503Free PMC Article
Cancer treatment-induced bone loss: pathophysiology and clinical perspectives.
Brufsky AM
Oncologist 2008 Feb;13(2):187-95. doi: 10.1634/theoncologist.2007-0152. PMID: 18305064
Growth abnormalities in children with juvenile rheumatoid arthritis.
White PH
Clin Orthop Relat Res 1990 Oct;(259):46-50. PMID: 2208873

Diagnosis

Skeletal and dental age discrepancy and occlusal traits in children with growth hormone deficiency and idiopathic short stature.
Torlińska-Walkowiak N, Majewska KA, Sowińska A, Kędzia A, Opydo-Szymaczek J
Clin Oral Investig 2022 Oct;26(10):6165-6175. Epub 2022 Jun 11 doi: 10.1007/s00784-022-04566-y. PMID: 35690690
Profile of paediatric tuberculosis mastoiditis - a case series.
Din TF, Fagan JJ, Peer S
S Afr J Surg 2022 Mar;60(1):62-66. PMID: 35451273
Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India.
Sharma A, Naidu G, Sharma V, Jha S, Dhooria A, Dhir V, Bhatia P, Sharma V, Bhattad S, Chengappa KG, Gupta V, Misra DP, Chavan PP, Malaviya S, Dudam R, Sharma B, Kumar S, Bhojwani R, Gupta P, Agarwal V, Sharma K, Singhal M, Rathi M, Nada R, Minz RW, Chaturvedi V, Aggarwal A, Handa R, Grossi A, Gattorno M, Huang Z, Wang J, Jois R, Negi VS, Khubchandani R, Jain S, Arostegui JI, Chambers EP, Hershfield MS, Aksentijevich I, Zhou Q, Lee PY
Arthritis Rheumatol 2021 Feb;73(2):276-285. Epub 2020 Dec 26 doi: 10.1002/art.41500. PMID: 32892503Free PMC Article
Trabecular bone score and bone mineral density reference data for women aged 20-70 years and the effect of local reference data on the prevalence of postmenopausal osteoporosis: a cross-sectional study from Sri Lanka.
Rathnayake H, Lekamwasam S, Wickramatilake C, Lenora J
Arch Osteoporos 2019 Aug 20;14(1):91. doi: 10.1007/s11657-019-0640-z. PMID: 31432256
Fibrosarcoma arising in the paranasal sinus: a clinicopathological and radiological analysis.
Zeng J, Liu H, Liu L, Liao W, Hu P, Wang X, Li X, Sun L, Zhang Y, Yi X
Dentomaxillofac Radiol 2018 Jul;47(6):20170459. Epub 2018 Apr 23 doi: 10.1259/dmfr.20170459. PMID: 29658783Free PMC Article

Therapy

Skeletal and dental age discrepancy and occlusal traits in children with growth hormone deficiency and idiopathic short stature.
Torlińska-Walkowiak N, Majewska KA, Sowińska A, Kędzia A, Opydo-Szymaczek J
Clin Oral Investig 2022 Oct;26(10):6165-6175. Epub 2022 Jun 11 doi: 10.1007/s00784-022-04566-y. PMID: 35690690
Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India.
Sharma A, Naidu G, Sharma V, Jha S, Dhooria A, Dhir V, Bhatia P, Sharma V, Bhattad S, Chengappa KG, Gupta V, Misra DP, Chavan PP, Malaviya S, Dudam R, Sharma B, Kumar S, Bhojwani R, Gupta P, Agarwal V, Sharma K, Singhal M, Rathi M, Nada R, Minz RW, Chaturvedi V, Aggarwal A, Handa R, Grossi A, Gattorno M, Huang Z, Wang J, Jois R, Negi VS, Khubchandani R, Jain S, Arostegui JI, Chambers EP, Hershfield MS, Aksentijevich I, Zhou Q, Lee PY
Arthritis Rheumatol 2021 Feb;73(2):276-285. Epub 2020 Dec 26 doi: 10.1002/art.41500. PMID: 32892503Free PMC Article
Common gynecological challenges in adolescents with sickle cell disease.
Stimpson SJ, Rebele EC, DeBaun MR
Expert Rev Hematol 2016;9(2):187-96. Epub 2015 Dec 29 doi: 10.1586/17474086.2016.1126177. PMID: 26613137
The use of bisphosphonates in women prior to or during pregnancy and lactation.
Stathopoulos IP, Liakou CG, Katsalira A, Trovas G, Lyritis GG, Papaioannou NA, Tournis S
Hormones (Athens) 2011 Oct-Dec;10(4):280-91. doi: 10.14310/horm.2002.1319. PMID: 22281884
Cancer treatment-induced bone loss: pathophysiology and clinical perspectives.
Brufsky AM
Oncologist 2008 Feb;13(2):187-95. doi: 10.1634/theoncologist.2007-0152. PMID: 18305064

Prognosis

Incidence and risk of surgical site infection/periprosthetic joint infection in tumor endoprosthesis-data from the nationwide bone tumor registry in Japan.
Morii T, Ogura K, Sato K, Kawai A
J Orthop Sci 2024 Jul;29(4):1112-1118. Epub 2023 Jul 6 doi: 10.1016/j.jos.2023.06.008. PMID: 37422424
Low-level lead exposure during development differentially affects neurobehavioral responses in male and female mouse offspring: A longitudinal study.
Dinçkol Ö, Fuentes B, Tartaglione AM, Pino A, Calamandrei G, Ricceri L
Neurotoxicology 2022 Jul;91:188-199. Epub 2022 May 13 doi: 10.1016/j.neuro.2022.05.007. PMID: 35577142
The surgical treatment of teratologic dislocation of the hip.
LeBel ME, Gallien R
J Pediatr Orthop B 2005 Sep;14(5):331-6. doi: 10.1097/01202412-200509000-00004. PMID: 16093943
Surgical correction of metopic synostosis.
Aryan HE, Jandial R, Ozgur BM, Hughes SA, Meltzer HS, Park MS, Levy ML
Childs Nerv Syst 2005 May;21(5):392-8. Epub 2005 Feb 16 doi: 10.1007/s00381-004-1108-y. PMID: 15714353
Bone mineral content and growth in very-low-birth-weight premature infants. Does bronchopulmonary dysplasia make a difference?
Greer FR, McCormick A
Am J Dis Child 1987 Feb;141(2):179-83. doi: 10.1001/archpedi.1987.04460020069029. PMID: 3812385

Clinical prediction guides

Low-level lead exposure during development differentially affects neurobehavioral responses in male and female mouse offspring: A longitudinal study.
Dinçkol Ö, Fuentes B, Tartaglione AM, Pino A, Calamandrei G, Ricceri L
Neurotoxicology 2022 Jul;91:188-199. Epub 2022 May 13 doi: 10.1016/j.neuro.2022.05.007. PMID: 35577142
Trabecular bone score and bone mineral density reference data for women aged 20-70 years and the effect of local reference data on the prevalence of postmenopausal osteoporosis: a cross-sectional study from Sri Lanka.
Rathnayake H, Lekamwasam S, Wickramatilake C, Lenora J
Arch Osteoporos 2019 Aug 20;14(1):91. doi: 10.1007/s11657-019-0640-z. PMID: 31432256
Fibrosarcoma arising in the paranasal sinus: a clinicopathological and radiological analysis.
Zeng J, Liu H, Liu L, Liao W, Hu P, Wang X, Li X, Sun L, Zhang Y, Yi X
Dentomaxillofac Radiol 2018 Jul;47(6):20170459. Epub 2018 Apr 23 doi: 10.1259/dmfr.20170459. PMID: 29658783Free PMC Article
The use of bisphosphonates in women prior to or during pregnancy and lactation.
Stathopoulos IP, Liakou CG, Katsalira A, Trovas G, Lyritis GG, Papaioannou NA, Tournis S
Hormones (Athens) 2011 Oct-Dec;10(4):280-91. doi: 10.14310/horm.2002.1319. PMID: 22281884
The surgical treatment of teratologic dislocation of the hip.
LeBel ME, Gallien R
J Pediatr Orthop B 2005 Sep;14(5):331-6. doi: 10.1097/01202412-200509000-00004. PMID: 16093943

Recent systematic reviews

Interventions for the prevention of nutritional rickets in term born children.
Lerch C, Meissner T
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD006164. doi: 10.1002/14651858.CD006164.pub2. PMID: 17943890Free PMC Article

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