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Ectopic tissue

MedGen UID:
40280
•Concept ID:
C0008519
•
Pathologic Function
Synonym: Heterotopia
SNOMED CT: Heterotopic tissue (128490007); Heterotopia (128490007); Choristoma (417338002); Heterotopic structure, either congenital or acquired (128490007); Ectopic tissue (719446000); Aberrant tissue (719446000); Ectopia (719446000)

Definition

Proliferation of normal tissue in an anatomic site in which this particular type of tissue is not normally present. [from NCI]

Professional guidelines

PubMed

Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition.
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J
Cochrane Database Syst Rev 2019 Jan 30;1(1):CD009768. doi: 10.1002/14651858.CD009768.pub2. PMID: 30697701Free PMC Article
Safety of treatment with DLA-identical or unrelated mesenchymal stromal cells in DLA-identical canine bone marrow transplantation.
Kornblit B, Leisenring WM, Santos EB, Storb R, Sandmaier BM
Chimerism 2013 Jul-Sep;4(3):95-101. Epub 2013 May 29 doi: 10.4161/chim.25110. PMID: 23723082Free PMC Article
Mesenchymal stem cells for treatment of acute and chronic graft-versus-host disease, tissue toxicity and hemorrhages.
Ringden O, Le Blanc K
Best Pract Res Clin Haematol 2011 Mar;24(1):65-72. Epub 2011 Feb 25 doi: 10.1016/j.beha.2011.01.003. PMID: 21396594

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Complications Following Stem Cell Therapy in Inflammatory Bowel Disease.
Wei H, Liu X, Ouyang C, Zhang J, Chen S, Lu F, Chen L
Curr Stem Cell Res Ther 2017;12(6):471-475. doi: 10.2174/1574888X12666170315105556. PMID: 28302045
Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms.
Basu J, Assaf BT, Bertram TA, Rao M
Toxicol Pathol 2015 Jan;43(1):115-25. Epub 2014 Dec 4 doi: 10.1177/0192623314559104. PMID: 25476796
Pancreatic and gastric heterotopy in the gastrointestinal tract.
Wlaź J, Mądro A, Kaźmierak W, Celiński K, Słomka M
Postepy Hig Med Dosw (Online) 2014 Sep 3;68:1069-75. doi: 10.5604/17322693.1119720. PMID: 25228515
Unusual scrotal pathology: an overview.
Rosevear HM, Mishail A, Sheynkin Y, Wald M
Nat Rev Urol 2009 Sep;6(9):491-500. Epub 2009 Aug 11 doi: 10.1038/nrurol.2009.149. PMID: 19668251

Diagnosis

Biomarkers of endometriosis.
Pant A, Moar K, K Arora T, Maurya PK
Clin Chim Acta 2023 Sep 1;549:117563. Epub 2023 Sep 20 doi: 10.1016/j.cca.2023.117563. PMID: 37739024
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
The Origin and Pathogenesis of Endometriosis.
Wang Y, Nicholes K, Shih IM
Annu Rev Pathol 2020 Jan 24;15:71-95. Epub 2019 Sep 3 doi: 10.1146/annurev-pathmechdis-012419-032654. PMID: 31479615Free PMC Article
Meckel's diverticulum.
Martin JP, Connor PD, Charles K
Am Fam Physician 2000 Feb 15;61(4):1037-42, 1044. PMID: 10706156
Benign vulvar tumors.
Hood AF, Lumadue J
Dermatol Clin 1992 Apr;10(2):371-85. PMID: 1318812

Therapy

Immune Regulation of the Metastatic Process: Implications for Therapy.
de Mingo Pulido A, Ruffell B
Adv Cancer Res 2016;132:139-63. Epub 2016 Jun 17 doi: 10.1016/bs.acr.2016.05.004. PMID: 27613132Free PMC Article
Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms.
Basu J, Assaf BT, Bertram TA, Rao M
Toxicol Pathol 2015 Jan;43(1):115-25. Epub 2014 Dec 4 doi: 10.1177/0192623314559104. PMID: 25476796
Mesenchymal stem cells for treatment of acute and chronic graft-versus-host disease, tissue toxicity and hemorrhages.
Ringden O, Le Blanc K
Best Pract Res Clin Haematol 2011 Mar;24(1):65-72. Epub 2011 Feb 25 doi: 10.1016/j.beha.2011.01.003. PMID: 21396594
Medical treatments for endometriosis.
Kappou D, Matalliotakis M, Matalliotakis I
Minerva Ginecol 2010 Oct;62(5):415-32. PMID: 20938427
Vascular endothelial growth factor and endometriotic angiogenesis.
McLaren J
Hum Reprod Update 2000 Jan-Feb;6(1):45-55. doi: 10.1093/humupd/6.1.45. PMID: 10711829

Prognosis

Tertiary lymphoid structures in endometriosis.
Zutautas KB, Yolmo P, Xu M, Childs T, Koti M, Tayade C
F S Sci 2024 Nov;5(4):335-341. Epub 2024 Oct 5 doi: 10.1016/j.xfss.2024.10.001. PMID: 39370108
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Ectopic mammary tissue in vulva: case report and systematic literature review.
Buitrago-Flechas SM, Barrera-Latorre SJ, Morante-Caicedo C
Rev Colomb Obstet Ginecol 2021 Sep 30;72(3):271-290. doi: 10.18597/rcog.3593. PMID: 34851570Free PMC Article
Review of Endometriosis Diagnosis through Advances in Biomedical Engineering.
Shah R, Jagani RP
Crit Rev Biomed Eng 2018;46(3):277-288. doi: 10.1615/CritRevBiomedEng.2018027414. PMID: 30311558
Role of Epicardial Adipose Tissue in Health and Disease: A Matter of Fat?
Gaborit B, Sengenes C, Ancel P, Jacquier A, Dutour A
Compr Physiol 2017 Jun 18;7(3):1051-1082. doi: 10.1002/cphy.c160034. PMID: 28640452

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
INZ-701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1-Deficient Mice.
Cheng Z, O'Brien K, Howe J, Sullivan C, Schrier D, Lynch A, Jungles S, Sabbagh Y, Thompson D
J Bone Miner Res 2021 Aug;36(8):1594-1604. Epub 2021 May 5 doi: 10.1002/jbmr.4315. PMID: 33900645
Complications Following Stem Cell Therapy in Inflammatory Bowel Disease.
Wei H, Liu X, Ouyang C, Zhang J, Chen S, Lu F, Chen L
Curr Stem Cell Res Ther 2017;12(6):471-475. doi: 10.2174/1574888X12666170315105556. PMID: 28302045
The endometrium in adenomyosis.
Benagiano G, Brosens I
Womens Health (Lond) 2012 May;8(3):301-12. doi: 10.2217/whe.12.8. PMID: 22554177
Unusual scrotal pathology: an overview.
Rosevear HM, Mishail A, Sheynkin Y, Wald M
Nat Rev Urol 2009 Sep;6(9):491-500. Epub 2009 Aug 11 doi: 10.1038/nrurol.2009.149. PMID: 19668251

Recent systematic reviews

Ectopic mammary tissue in vulva: case report and systematic literature review.
Buitrago-Flechas SM, Barrera-Latorre SJ, Morante-Caicedo C
Rev Colomb Obstet Ginecol 2021 Sep 30;72(3):271-290. doi: 10.18597/rcog.3593. PMID: 34851570Free PMC Article
Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition.
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J
Cochrane Database Syst Rev 2019 Jan 30;1(1):CD009768. doi: 10.1002/14651858.CD009768.pub2. PMID: 30697701Free PMC Article
Systematic review of epidemiology, presentation, and management of Meckel's diverticulum in the 21st century.
Hansen CC, Søreide K
Medicine (Baltimore) 2018 Aug;97(35):e12154. doi: 10.1097/MD.0000000000012154. PMID: 30170459Free PMC Article
Abnormal peritoneal regulation of chemokine activation-The role of IL-8 in pathogenesis of endometriosis.
Sikora J, Smycz-Kubańska M, Mielczarek-Palacz A, Kondera-Anasz Z
Am J Reprod Immunol 2017 Apr;77(4) Epub 2017 Jan 25 doi: 10.1111/aji.12622. PMID: 28120482

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