U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PDGFRB Gene Rearrangement

MedGen UID:
417665
•Concept ID:
C2827357
•
Cell or Molecular Dysfunction
Synonyms: CD140b Gene Rearrangement; JTK12 Gene Rearrangement; PDGFR1 Gene Rearrangement; Platelet Derived Growth Factor Receptor Beta Gene Rearrangement

Definition

Rearrangement of the PDGFRB gene, resulting in the formation of a fusion transcript and aberrant tyrosine kinase activity. It has been described in myeloid malignancies usually presenting as chronic myelomonocytic leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPDGFRB Gene Rearrangement

Professional guidelines

PubMed

World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management.
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850
Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic Syndromes.
Stella S, Massimino M, Manzella L, Pennisi MS, Tirrò E, Romano C, Vitale SR, Puma A, Tomarchio C, Gregorio SD, Palumbo GA, Vigneri P
Int J Mol Sci 2021 Jan 6;22(2) doi: 10.3390/ijms22020486. PMID: 33418988Free PMC Article
Molecularly targeted treatment for dermatofibrosarcoma protuberans.
McArthur G
Semin Oncol 2004 Apr;31(2 Suppl 6):30-6. doi: 10.1053/j.seminoncol.2004.03.038. PMID: 15176002

Recent clinical studies

Etiology

A novel subclonal rearrangement of the STRN3::PDGFRB gene in de novo acute myeloid leukemia with NPM1 mutation and its leukemogenic effects.
Wang Z, Liu T, Liu W, Gao X, Wan L, Qiu S, Song Y, Gu R, Tian Z, Wang M, Wang J, Mi Y, Wei S
Cancer Gene Ther 2023 Nov;30(11):1471-1484. Epub 2023 Aug 7 doi: 10.1038/s41417-023-00651-w. PMID: 37550570

Diagnosis

A novel subclonal rearrangement of the STRN3::PDGFRB gene in de novo acute myeloid leukemia with NPM1 mutation and its leukemogenic effects.
Wang Z, Liu T, Liu W, Gao X, Wan L, Qiu S, Song Y, Gu R, Tian Z, Wang M, Wang J, Mi Y, Wei S
Cancer Gene Ther 2023 Nov;30(11):1471-1484. Epub 2023 Aug 7 doi: 10.1038/s41417-023-00651-w. PMID: 37550570
Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.
Feldhahn N, Río P, Soh BN, Liedtke S, Sprangers M, Klein F, Wernet P, Jumaa H, Hofmann WK, Hanenberg H, Rowley JD, Müschen M
Proc Natl Acad Sci U S A 2005 Sep 13;102(37):13266-71. Epub 2005 Sep 2 doi: 10.1073/pnas.0505196102. PMID: 16141323Free PMC Article

Therapy

A novel subclonal rearrangement of the STRN3::PDGFRB gene in de novo acute myeloid leukemia with NPM1 mutation and its leukemogenic effects.
Wang Z, Liu T, Liu W, Gao X, Wan L, Qiu S, Song Y, Gu R, Tian Z, Wang M, Wang J, Mi Y, Wei S
Cancer Gene Ther 2023 Nov;30(11):1471-1484. Epub 2023 Aug 7 doi: 10.1038/s41417-023-00651-w. PMID: 37550570

Clinical prediction guides

Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.
Feldhahn N, Río P, Soh BN, Liedtke S, Sprangers M, Klein F, Wernet P, Jumaa H, Hofmann WK, Hanenberg H, Rowley JD, Müschen M
Proc Natl Acad Sci U S A 2005 Sep 13;102(37):13266-71. Epub 2005 Sep 2 doi: 10.1073/pnas.0505196102. PMID: 16141323Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...