U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Avian influenza

MedGen UID:
42091
Concept ID:
C0016627
Disease or Syndrome
Synonyms: Avian Flu; Avian Influenza; Avian Influenzas; Flu, Avian; Fowl Plague; Influenza in Bird; Influenza in Birds; Influenza, Avian; Influenzas, Avian; Plague, Fowl
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018695
Orphanet: ORPHA454836

Definition

A rare, infectious disease characterized by variable severity and outcome, ranging from mild upper respiratory tract infection with fever and cough, to influenza-like illness with rapid progression to severe pneumonia, sepsis with shock, acute respiratory distress syndrome and even death. Additional manifestations may include conjunctivitis, nausea, abdominal pain, diarrhea, vomiting, multiple organ dysfunction, and encephalopathy. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAvian influenza

Professional guidelines

PubMed

Bui CHT, Kuok DIT, Yeung HW, Ng KC, Chu DKW, Webby RJ, Nicholls JM, Peiris JSM, Hui KPY, Chan MCW
Emerg Infect Dis 2021 Oct;27(10):2619-2627. doi: 10.3201/eid2710.210297. PMID: 34545790Free PMC Article
Li H, Cao B
Clin Chest Med 2017 Mar;38(1):59-70. Epub 2016 Dec 10 doi: 10.1016/j.ccm.2016.11.005. PMID: 28159162
Kidd M
Curr Opin Pulm Med 2014 May;20(3):242-6. doi: 10.1097/MCP.0000000000000049. PMID: 24637227

Recent clinical studies

Etiology

Zhang J, Wang X, Chen Y, Ye H, Ding S, Zhang T, Liu Y, Li H, Huang L, Qi W, Liao M
Cell Rep 2023 Nov 28;42(11):113409. Epub 2023 Nov 10 doi: 10.1016/j.celrep.2023.113409. PMID: 37948179
Li YT, Linster M, Mendenhall IH, Su YCF, Smith GJD
Br Med Bull 2019 Dec 11;132(1):81-95. doi: 10.1093/bmb/ldz036. PMID: 31848585Free PMC Article
Uyeki TM, Peiris M
Infect Dis Clin North Am 2019 Dec;33(4):907-932. doi: 10.1016/j.idc.2019.07.003. PMID: 31668198
Suttie A, Deng YM, Greenhill AR, Dussart P, Horwood PF, Karlsson EA
Virus Genes 2019 Dec;55(6):739-768. Epub 2019 Aug 19 doi: 10.1007/s11262-019-01700-z. PMID: 31428925Free PMC Article
Lycett SJ, Duchatel F, Digard P
Philos Trans R Soc Lond B Biol Sci 2019 Jun 24;374(1775):20180257. doi: 10.1098/rstb.2018.0257. PMID: 31056053Free PMC Article

Diagnosis

Fu X, Wang Q, Ma B, Zhang B, Sun K, Yu X, Ye Z, Zhang M
Int J Mol Sci 2023 Dec 5;24(24) doi: 10.3390/ijms242417157. PMID: 38138987Free PMC Article
Yang R, Sun H, Gao F, Luo K, Huang Z, Tong Q, Song H, Han Q, Liu J, Lan Y, Qi J, Li H, Chen S, Xu M, Qiu J, Zeng G, Zhang X, Huang C, Pei R, Zhan Z, Ye B, Guo Y, Zhou Y, Ye W, Yao D, Ren M, Li B, Yang J, Wang Y, Pu J, Sun Y, Shi Y, Liu WJ, Ou X, Gao GF, Gao L, Liu J
Lancet Microbe 2022 Nov;3(11):e824-e834. Epub 2022 Sep 14 doi: 10.1016/S2666-5247(22)00192-6. PMID: 36115379
McArthur DB
Nurs Clin North Am 2019 Jun;54(2):297-311. Epub 2019 Mar 27 doi: 10.1016/j.cnur.2019.02.006. PMID: 31027668Free PMC Article
Rohde G, Straube E, Essig A, Reinhold P, Sachse K
Dtsch Arztebl Int 2010 Mar;107(10):174-80. Epub 2010 Mar 12 doi: 10.3238/arztebl.2010.0174. PMID: 20358033Free PMC Article
Zeitlin GA, Maslow MJ
Curr Allergy Asthma Rep 2006 Mar;6(2):163-70. doi: 10.1007/s11882-006-0055-y. PMID: 16566867Free PMC Article

Therapy

Cargnin Faccin F, Perez DR
Hum Vaccin Immunother 2024 Dec 31;20(1):2347019. Epub 2024 May 28 doi: 10.1080/21645515.2024.2347019. PMID: 38807261Free PMC Article
Whitaker JA, Sahly HME, Healy CM
Curr Opin Infect Dis 2023 Oct 1;36(5):385-393. Epub 2023 Jul 18 doi: 10.1097/QCO.0000000000000948. PMID: 37462930
Liang Y
Virulence 2023 Dec;14(1):2223057. doi: 10.1080/21505594.2023.2223057. PMID: 37339323Free PMC Article
Li YT, Linster M, Mendenhall IH, Su YCF, Smith GJD
Br Med Bull 2019 Dec 11;132(1):81-95. doi: 10.1093/bmb/ldz036. PMID: 31848585Free PMC Article
Saeed AA, Hussein MF
Saudi Med J 2006 May;27(5):585-95. PMID: 16680243

Prognosis

Morens DM, Park J, Taubenberger JK
Sci Transl Med 2023 Oct 18;15(718):eadj2379. doi: 10.1126/scitranslmed.adj2379. PMID: 37851826
Pinto RM, Bakshi S, Lytras S, Zakaria MK, Swingler S, Worrell JC, Herder V, Hargrave KE, Varjak M, Cameron-Ruiz N, Collados Rodriguez M, Varela M, Wickenhagen A, Loney C, Pei Y, Hughes J, Valette E, Turnbull ML, Furnon W, Gu Q, Orr L, Taggart A, Diebold O, Davis C, Boutell C, Grey F, Hutchinson E, Digard P, Monne I, Wootton SK, MacLeod MKL, Wilson SJ, Palmarini M
Nature 2023 Jul;619(7969):338-347. Epub 2023 Jun 28 doi: 10.1038/s41586-023-06261-8. PMID: 37380775
Bi Y, Chen Q, Wang Q, Chen J, Jin T, Wong G, Quan C, Liu J, Wu J, Yin R, Zhao L, Li M, Ding Z, Zou R, Xu W, Li H, Wang H, Tian K, Fu G, Huang Y, Shestopalov A, Li S, Xu B, Yu H, Luo T, Lu L, Xu X, Luo Y, Liu Y, Shi W, Liu D, Gao GF
Cell Host Microbe 2016 Dec 14;20(6):810-821. Epub 2016 Dec 1 doi: 10.1016/j.chom.2016.10.022. PMID: 27916476
El Zowalaty ME, Bustin SA, Husseiny MI, Ashour HM
Future Microbiol 2013 Sep;8(9):1209-27. doi: 10.2217/fmb.13.81. PMID: 24020746
Trajman A, Menzies D
Curr Opin Pulm Med 2010 May;16(3):226-34. doi: 10.1097/MCP.0b013e328338639b. PMID: 20375784

Clinical prediction guides

Morens DM, Park J, Taubenberger JK
Sci Transl Med 2023 Oct 18;15(718):eadj2379. doi: 10.1126/scitranslmed.adj2379. PMID: 37851826
Liu L, Chen G, Huang S, Wen F
Virulence 2023 Dec;14(1):2235459. doi: 10.1080/21505594.2023.2235459. PMID: 37469130Free PMC Article
Kessler S, Harder TC, Schwemmle M, Ciminski K
Viruses 2021 Nov 9;13(11) doi: 10.3390/v13112250. PMID: 34835056Free PMC Article
Li YT, Linster M, Mendenhall IH, Su YCF, Smith GJD
Br Med Bull 2019 Dec 11;132(1):81-95. doi: 10.1093/bmb/ldz036. PMID: 31848585Free PMC Article
El Zowalaty ME, Bustin SA, Husseiny MI, Ashour HM
Future Microbiol 2013 Sep;8(9):1209-27. doi: 10.2217/fmb.13.81. PMID: 24020746

Recent systematic reviews

Heidary F, Gharebaghi R
J Antibiot (Tokyo) 2020 Sep;73(9):593-602. Epub 2020 Jun 12 doi: 10.1038/s41429-020-0336-z. PMID: 32533071Free PMC Article
Shi N, Huang J, Zhang X, Bao C, Yue N, Wang Q, Cui T, Zheng M, Huo X, Jin H
J Infect Dis 2020 Feb 3;221(4):553-560. doi: 10.1093/infdis/jiz372. PMID: 31323094
Baudon E, Peyre M, Peiris M, Cowling BJ
PLoS One 2017;12(6):e0179044. Epub 2017 Jun 7 doi: 10.1371/journal.pone.0179044. PMID: 28591202Free PMC Article
Van Kerkhove MD, Mumford E, Mounts AW, Bresee J, Ly S, Bridges CB, Otte J
PLoS One 2011 Jan 24;6(1):e14582. doi: 10.1371/journal.pone.0014582. PMID: 21283678Free PMC Article
Brankston G, Gitterman L, Hirji Z, Lemieux C, Gardam M
Lancet Infect Dis 2007 Apr;7(4):257-65. doi: 10.1016/S1473-3099(07)70029-4. PMID: 17376383

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...