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Focal onset aware motor onset Jacksonian epileptic seizure

MedGen UID:
43984
•Concept ID:
C0022333
•
Disease or Syndrome
Synonyms: Jacksonian Seizure; Seizure, Jacksonian
SNOMED CT: Focal onset aware motor onset Jacksonian epileptic seizure (246529004); Focal-onset aware motor-onset Jacksonian epileptic seizure (246529004); Focal aware motor Jacksonian seizure (246529004); Focal onset aware motor Jacksonian seizure (246529004)

Definition

An epileptic seizure originating within networks limited to one hemisphere and involving motor activity at the onset with spread of clonic movements through contiguous body parts unilaterally, and retained awareness (defined as knowledge of self and environment) throughout the entire duration of the seizure. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal onset aware motor onset Jacksonian epileptic seizure

Professional guidelines

PubMed

ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats.
Charalambous M, Muñana K, Patterson EE, Platt SR, Volk HA
J Vet Intern Med 2024 Jan-Feb;38(1):19-40. Epub 2023 Nov 3 doi: 10.1111/jvim.16928. PMID: 37921621Free PMC Article
ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions.
Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst JM, Specchio N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead OC, Wiebe S, Cross JH, Tinuper P, Scheffer IE, Perucca E, Moshé SL, Nabbout R
Epilepsia 2022 Jun;63(6):1349-1397. Epub 2022 May 3 doi: 10.1111/epi.17239. PMID: 35503712
Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management.
Abboud H, Probasco JC, Irani S, Ances B, Benavides DR, Bradshaw M, Christo PP, Dale RC, Fernandez-Fournier M, Flanagan EP, Gadoth A, George P, Grebenciucova E, Jammoul A, Lee ST, Li Y, Matiello M, Morse AM, Rae-Grant A, Rojas G, Rossman I, Schmitt S, Venkatesan A, Vernino S, Pittock SJ, Titulaer MJ; Autoimmune Encephalitis Alliance Clinicians Network
J Neurol Neurosurg Psychiatry 2021 Jul;92(7):757-768. Epub 2021 Mar 1 doi: 10.1136/jnnp-2020-325300. PMID: 33649022Free PMC Article

Recent clinical studies

Etiology

Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit.
Wang X, Yang F, Chen B, Jiang W
Acta Neurol Scand 2022 Dec;146(6):752-760. Epub 2022 Oct 26 doi: 10.1111/ane.13718. PMID: 36285875
Evaluation and Treatment of Psychogenic Nonepileptic Seizures.
Beimer NJ, LaFrance WC Jr
Neurol Clin 2022 Nov;40(4):799-820. Epub 2022 Sep 28 doi: 10.1016/j.ncl.2022.03.017. PMID: 36270692
Seizure classification, etiology, and management.
Shellhaas RA
Handb Clin Neurol 2019;162:347-361. doi: 10.1016/B978-0-444-64029-1.00017-5. PMID: 31324320
New-Onset Seizure in Adults and Adolescents: A Review.
Gavvala JR, Schuele SU
JAMA 2016 Dec 27;316(24):2657-2668. doi: 10.1001/jama.2016.18625. PMID: 28027373
Febrile seizures.
Patterson JL, Carapetian SA, Hageman JR, Kelley KR
Pediatr Ann 2013 Dec;42(12):249-54. doi: 10.3928/00904481-20131122-09. PMID: 24295158

Diagnosis

Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit.
Wang X, Yang F, Chen B, Jiang W
Acta Neurol Scand 2022 Dec;146(6):752-760. Epub 2022 Oct 26 doi: 10.1111/ane.13718. PMID: 36285875
Evaluation and Treatment of Psychogenic Nonepileptic Seizures.
Beimer NJ, LaFrance WC Jr
Neurol Clin 2022 Nov;40(4):799-820. Epub 2022 Sep 28 doi: 10.1016/j.ncl.2022.03.017. PMID: 36270692
Seizures, Status Epilepticus, and Continuous EEG in the Intensive Care Unit.
Rosenthal ES
Continuum (Minneap Minn) 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012. PMID: 34618762
Epilepsy-Definition, Classification, Pathophysiology, and Epidemiology.
Falco-Walter J
Semin Neurol 2020 Dec;40(6):617-623. Epub 2020 Nov 5 doi: 10.1055/s-0040-1718719. PMID: 33155183
How to diagnose and treat post-stroke seizures and epilepsy.
Zelano J, Holtkamp M, Agarwal N, Lattanzi S, Trinka E, Brigo F
Epileptic Disord 2020 Jun 1;22(3):252-263. doi: 10.1684/epd.2020.1159. PMID: 32597766

Therapy

Treatment of benzodiazepine-resistant status epilepticus: Systematic review and network meta-analyses.
Jain P, Aneja S, Cunningham J, Arya R, Sharma S
Seizure 2022 Nov;102:74-82. Epub 2022 Sep 26 doi: 10.1016/j.seizure.2022.09.017. PMID: 36209676
Seizures, Status Epilepticus, and Continuous EEG in the Intensive Care Unit.
Rosenthal ES
Continuum (Minneap Minn) 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012. PMID: 34618762
Novel Therapeutics for Neonatal Seizures.
Ziobro JM, Eschbach K, Shellhaas RA
Neurotherapeutics 2021 Jul;18(3):1564-1581. Epub 2021 Aug 12 doi: 10.1007/s13311-021-01085-8. PMID: 34386906Free PMC Article
Update on the management of status epilepticus.
Rossetti AO, Alvarez V
Curr Opin Neurol 2021 Apr 1;34(2):172-181. doi: 10.1097/WCO.0000000000000899. PMID: 33664203
Cannabidiol in the Treatment of Epilepsy.
von Wrede R, Helmstaedter C, Surges R
Clin Drug Investig 2021 Mar;41(3):211-220. Epub 2021 Feb 9 doi: 10.1007/s40261-021-01003-y. PMID: 33559102Free PMC Article

Prognosis

The SANTÉ study at 10 years of follow-up: Effectiveness, safety, and sudden unexpected death in epilepsy.
Salanova V, Sperling MR, Gross RE, Irwin CP, Vollhaber JA, Giftakis JE, Fisher RS; SANTÉ Study Group
Epilepsia 2021 Jun;62(6):1306-1317. Epub 2021 Apr 8 doi: 10.1111/epi.16895. PMID: 33830503
Incidence and Prevalence of Drug-Resistant Epilepsy: A Systematic Review and Meta-analysis.
Sultana B, Panzini MA, Veilleux Carpentier A, Comtois J, Rioux B, Gore G, Bauer PR, Kwon CS, Jetté N, Josephson CB, Keezer MR
Neurology 2021 Apr 27;96(17):805-817. Epub 2021 Mar 15 doi: 10.1212/WNL.0000000000011839. PMID: 33722992
Incidence, Implications, and Management of Seizures Following Ischemic and Hemorrhagic Stroke.
Doria JW, Forgacs PB
Curr Neurol Neurosci Rep 2019 May 27;19(7):37. doi: 10.1007/s11910-019-0957-4. PMID: 31134438Free PMC Article
First-ever convulsive seizures in children presenting to the emergency department: risk factors for seizure recurrence and diagnosis of epilepsy.
Sartori S, Nosadini M, Tessarin G, Boniver C, Frigo AC, Toldo I, Bressan S, Da Dalt L
Dev Med Child Neurol 2019 Jan;61(1):82-90. Epub 2018 Sep 7 doi: 10.1111/dmcn.14015. PMID: 30191957
Febrile seizures.
Patterson JL, Carapetian SA, Hageman JR, Kelley KR
Pediatr Ann 2013 Dec;42(12):249-54. doi: 10.3928/00904481-20131122-09. PMID: 24295158

Clinical prediction guides

Chance and risk in epilepsy.
Baud MO, Proix T, Rao VR, Schindler K
Curr Opin Neurol 2020 Apr;33(2):163-172. doi: 10.1097/WCO.0000000000000798. PMID: 32049738
Seizure prediction and intervention.
Meisel C, Loddenkemper T
Neuropharmacology 2020 Aug 1;172:107898. Epub 2019 Dec 5 doi: 10.1016/j.neuropharm.2019.107898. PMID: 31839204
Automated seizure prediction.
Acharya UR, Hagiwara Y, Adeli H
Epilepsy Behav 2018 Nov;88:251-261. Epub 2018 Oct 11 doi: 10.1016/j.yebeh.2018.09.030. PMID: 30317059
Computer modelling of epilepsy.
Lytton WW
Nat Rev Neurosci 2008 Aug;9(8):626-37. Epub 2008 Jul 2 doi: 10.1038/nrn2416. PMID: 18594562Free PMC Article
Controversies in febrile seizures.
Rajadhyaksha S, Shah KN
Indian J Pediatr 2000 Jan;67(1 Suppl):S71-9. PMID: 11129896

Recent systematic reviews

Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Deep brain stimulation targets in epilepsy: Systematic review and meta-analysis of anterior and centromedian thalamic nuclei and hippocampus.
Vetkas A, Fomenko A, Germann J, Sarica C, Iorio-Morin C, Samuel N, Yamamoto K, Milano V, Cheyuo C, Zemmar A, Elias G, Boutet A, Loh A, Santyr B, Gwun D, Tasserie J, Kalia SK, Lozano AM
Epilepsia 2022 Mar;63(3):513-524. Epub 2022 Jan 3 doi: 10.1111/epi.17157. PMID: 34981509
Use of antipyretics for preventing febrile seizure recurrence in children: a systematic review and meta-analysis.
Hashimoto R, Suto M, Tsuji M, Sasaki H, Takehara K, Ishiguro A, Kubota M
Eur J Pediatr 2021 Apr;180(4):987-997. Epub 2020 Oct 30 doi: 10.1007/s00431-020-03845-8. PMID: 33125519
Seizure cluster: Definition, prevalence, consequences, and management.
Jafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K
Seizure 2019 May;68:9-15. Epub 2018 May 21 doi: 10.1016/j.seizure.2018.05.013. PMID: 29871784
Recommendation for a definition of acute symptomatic seizure.
Beghi E, Carpio A, Forsgren L, Hesdorffer DC, Malmgren K, Sander JW, Tomson T, Hauser WA
Epilepsia 2010 Apr;51(4):671-5. Epub 2009 Sep 3 doi: 10.1111/j.1528-1167.2009.02285.x. PMID: 19732133

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