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Childhood acute lymphoblastic leukemia

MedGen UID:
44122
•Concept ID:
C0023452
•
Neoplastic Process
Synonyms: ALL, Childhood; Childhood ALL; L1 Lymphocytic Leukemia; Leukemia, L1 Lymphocytic; Leukemia, Lymphoblastic, Acute, L1; Leukemia, Lymphocytic, Acute, L1; Lymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Leukemia, Acute, L1; Lymphocytic Leukemia, L1
 
Monarch Initiative: MONDO:0000870

Definition

An acute lymphoblastic leukemia (current term: precursor lymphoblastic leukemia) of B-or T-cell origin which according to the FAB classification is characterized by the presence of more mature-appearing lymphoblasts. [from NCI]

Professional guidelines

PubMed

Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients.
Hangai M, Kawaguchi T, Takagi M, Matsuo K, Jeon S, Chiang CWK, Dewan AT, De Smith AJ, Imamura T, Okamoto Y, Saito AM, Deguchi T, Kubo M, Tanaka Y, Ayukawa Y, Hori T, Ohki K, Kiyokawa N, Inukai T, Arakawa Y, Mori M, Hasegawa D, Tomizawa D, Fukushima H, Yuza Y, Noguchi Y, Taneyama Y, Ota S, Goto H, Yanagimachi M, Keino D, Koike K, Toyama D, Nakazawa Y, Nakamura K, Moriwaki K, Sekinaka Y, Morita D, Hirabayashi S, Hosoya Y, Yoshimoto Y, Yoshihara H, Ozawa M, Kobayashi S, Morisaki N, Gyeltshen T, Takahashi O, Okada Y, Matsuda M, Tanaka T, Inazawa J, Takita J, Ishida Y, Ohara A, Metayer C, Wiemels JL, Ma X, Mizutani S, Koh K, Momozawa Y, Horibe K, Matsuda F, Kato M, Manabe A, Urayama KY
Haematologica 2024 Apr 1;109(4):1247-1252. doi: 10.3324/haematol.2023.282914. PMID: 37881853Free PMC Article
Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response.
Lee SHR, Yang W, Gocho Y, John A, Rowland L, Smart B, Williams H, Maxwell D, Hunt J, Yang W, Crews KR, Roberts KG, Jeha S, Cheng C, Karol SE, Relling MV, Rosner GL, Inaba H, Mullighan CG, Pui CH, Evans WE, Yang JJ
Nat Med 2023 Jan;29(1):170-179. Epub 2023 Jan 5 doi: 10.1038/s41591-022-02112-7. PMID: 36604538Free PMC Article
Treatment of Childhood Acute Lymphoblastic Leukemia: Prognostic Factors and Clinical Advances.
Vrooman LM, Silverman LB
Curr Hematol Malig Rep 2016 Oct;11(5):385-94. doi: 10.1007/s11899-016-0337-y. PMID: 27502091

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Acute Lymphoblastic Leukemia, 2024

Recent clinical studies

Etiology

Naked antibodies and antibody-drug conjugates: targeted therapy for childhood acute lymphoblastic leukemia.
Brivio E, Bautista F, Zwaan CM
Haematologica 2024 Jun 1;109(6):1700-1712. doi: 10.3324/haematol.2023.283815. PMID: 38832425Free PMC Article
Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.
Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896Free PMC Article
Genetic susceptibility in childhood acute lymphoblastic leukemia.
Gutierrez-Camino A, Martin-Guerrero I, García-Orad A
Med Oncol 2017 Sep 13;34(10):179. doi: 10.1007/s12032-017-1038-7. PMID: 28905228
Biology of childhood acute lymphoblastic leukemia.
Bhojwani D, Yang JJ, Pui CH
Pediatr Clin North Am 2015 Feb;62(1):47-60. doi: 10.1016/j.pcl.2014.09.004. PMID: 25435111Free PMC Article

Diagnosis

Naked antibodies and antibody-drug conjugates: targeted therapy for childhood acute lymphoblastic leukemia.
Brivio E, Bautista F, Zwaan CM
Haematologica 2024 Jun 1;109(6):1700-1712. doi: 10.3324/haematol.2023.283815. PMID: 38832425Free PMC Article
Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.
Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896Free PMC Article
Metabolic reprogramming in childhood acute lymphoblastic leukemia.
Sbirkov Y, Burnusuzov H, Sarafian V
Pediatr Blood Cancer 2020 Jun;67(6):e28255. Epub 2020 Apr 15 doi: 10.1002/pbc.28255. PMID: 32293782
Predicting and Preventing Anthracycline-Related Cardiotoxicity.
Armenian S, Bhatia S
Am Soc Clin Oncol Educ Book 2018 May 23;38:3-12. doi: 10.1200/EDBK_100015. PMID: 30231396

Therapy

Naked antibodies and antibody-drug conjugates: targeted therapy for childhood acute lymphoblastic leukemia.
Brivio E, Bautista F, Zwaan CM
Haematologica 2024 Jun 1;109(6):1700-1712. doi: 10.3324/haematol.2023.283815. PMID: 38832425Free PMC Article
Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Bone health in glucocorticoid-treated childhood acute lymphoblastic leukemia.
Velentza L, Zaman F, Sävendahl L
Crit Rev Oncol Hematol 2021 Dec;168:103492. Epub 2021 Oct 13 doi: 10.1016/j.critrevonc.2021.103492. PMID: 34655742
Pharmacogenomics in acute lymphoblastic leukemia.
Lee SHR, Yang JJ
Best Pract Res Clin Haematol 2017 Sep;30(3):229-236. Epub 2017 Jul 27 doi: 10.1016/j.beha.2017.07.007. PMID: 29050696
Novel therapy for childhood acute lymphoblastic leukemia.
Santiago R, Vairy S, Sinnett D, Krajinovic M, Bittencourt H
Expert Opin Pharmacother 2017 Aug;18(11):1081-1099. Epub 2017 Jun 26 doi: 10.1080/14656566.2017.1340938. PMID: 28608730

Prognosis

Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001.
Vrooman LM, Blonquist TM, Stevenson KE, Supko JG, Hunt SK, Cronholm SM, Koch V, Kay-Green S, Athale UH, Clavell LA, Cole PD, Harris MH, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Place AE, Schorin MA, Welch JJG, Neuberg DS, Sallan SE, Silverman LB
J Clin Oncol 2021 Nov 1;39(31):3496-3505. Epub 2021 Jul 6 doi: 10.1200/JCO.20.03692. PMID: 34228505
TP53 alterations in relapsed childhood acute lymphoblastic leukemia.
Yu CH, Chang WT, Jou ST, Lin TK, Chang YH, Lin CY, Lin KH, Lu MY, Chen SH, Wu KH, Wang SC, Chang HH, Su YN, Hung CC, Lin DT, Chen HY, Yang YL
Cancer Sci 2020 Jan;111(1):229-238. Epub 2019 Dec 5 doi: 10.1111/cas.14238. PMID: 31729120Free PMC Article
Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16.
Jeha S, Pei D, Choi J, Cheng C, Sandlund JT, Coustan-Smith E, Campana D, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Khan RB, Yang JJ, Mullighan CG, Downing JR, Evans WE, Relling MV, Pui CH
J Clin Oncol 2019 Dec 10;37(35):3377-3391. Epub 2019 Oct 28 doi: 10.1200/JCO.19.01692. PMID: 31657981Free PMC Article
Role of miRNAs in treatment response and toxicity of childhood acute lymphoblastic leukemia.
Umerez M, Garcia-Obregon S, Martin-Guerrero I, Astigarraga I, Gutierrez-Camino A, Garcia-Orad A
Pharmacogenomics 2018 Mar;19(4):361-373. Epub 2018 Feb 22 doi: 10.2217/pgs-2017-0164. PMID: 29469670
Genomics of racial and ethnic disparities in childhood acute lymphoblastic leukemia.
Lim JY, Bhatia S, Robison LL, Yang JJ
Cancer 2014 Apr 1;120(7):955-62. Epub 2013 Dec 30 doi: 10.1002/cncr.28531. PMID: 24382716Free PMC Article

Clinical prediction guides

Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.
Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896Free PMC Article
Metabolic reprogramming in childhood acute lymphoblastic leukemia.
Sbirkov Y, Burnusuzov H, Sarafian V
Pediatr Blood Cancer 2020 Jun;67(6):e28255. Epub 2020 Apr 15 doi: 10.1002/pbc.28255. PMID: 32293782
Predicting and Preventing Anthracycline-Related Cardiotoxicity.
Armenian S, Bhatia S
Am Soc Clin Oncol Educ Book 2018 May 23;38:3-12. doi: 10.1200/EDBK_100015. PMID: 30231396
Novel therapy for childhood acute lymphoblastic leukemia.
Santiago R, Vairy S, Sinnett D, Krajinovic M, Bittencourt H
Expert Opin Pharmacother 2017 Aug;18(11):1081-1099. Epub 2017 Jun 26 doi: 10.1080/14656566.2017.1340938. PMID: 28608730
Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.
Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874Free PMC Article

Recent systematic reviews

lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review.
Illarregi U, Telleria J, Bilbao-Aldaiturriaga N, Lopez-Lopez E, Ballesteros J, Martin-Guerrero I, Gutierrez-Camino A
Int J Oncol 2022 May;60(5) Epub 2022 Apr 8 doi: 10.3892/ijo.2022.5348. PMID: 35419612
Maternal antibiotics exposure during pregnancy and the risk of acute lymphoblastic leukemia in childhood: a systematic review and meta-analysis.
Zhu X, Meng Y, Yang Y, Feng N
Eur J Pediatr 2022 Feb;181(2):471-478. Epub 2021 Sep 17 doi: 10.1007/s00431-021-04247-0. PMID: 34535829
Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
miRNA deregulation in childhood acute lymphoblastic leukemia: a systematic review.
Gutierrez-Camino A, Garcia-Obregon S, Lopez-Lopez E, Astigarraga I, Garcia-Orad A
Epigenomics 2020 Jan;12(1):69-80. Epub 2019 Dec 13 doi: 10.2217/epi-2019-0154. PMID: 31833405
Minimal Residual Disease Evaluation in Childhood Acute Lymphoblastic Leukemia: An Economic Analysis.
Health Quality Ontario
Ont Health Technol Assess Ser 2016;16(8):1-83. Epub 2016 Mar 8 PMID: 27099644Free PMC Article

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Acute Lymphoblastic Leukemia, 2024

    Reviews

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