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Cerebral malaria

MedGen UID:
44258
•Concept ID:
C0024534
•
Disease or Syndrome
Synonyms: Cerebral Malaria; Malaria, Cerebral
SNOMED CT: Cerebral malaria (53622003)
 
Monarch Initiative: MONDO:0005625

Definition

A sequestration of Plasmodium falciparum in the brain, which can cause coma and/or seizures. [from NCI]

Professional guidelines

PubMed

Pathogenetic mechanisms and treatment targets in cerebral malaria.
Hadjilaou A, Brandi J, Riehn M, Friese MA, Jacobs T
Nat Rev Neurol 2023 Nov;19(11):688-709. Epub 2023 Oct 19 doi: 10.1038/s41582-023-00881-4. PMID: 37857843
Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment.
Song X, Wei W, Cheng W, Zhu H, Wang W, Dong H, Li J
Front Cell Infect Microbiol 2022;12:939532. Epub 2022 Jul 25 doi: 10.3389/fcimb.2022.939532. PMID: 35959375Free PMC Article
The treatment of malaria.
White NJ
N Engl J Med 1996 Sep 12;335(11):800-6. doi: 10.1056/NEJM199609123351107. PMID: 8703186

Recent clinical studies

Etiology

Pathogenetic mechanisms and treatment targets in cerebral malaria.
Hadjilaou A, Brandi J, Riehn M, Friese MA, Jacobs T
Nat Rev Neurol 2023 Nov;19(11):688-709. Epub 2023 Oct 19 doi: 10.1038/s41582-023-00881-4. PMID: 37857843
Pathophysiology and neurologic sequelae of cerebral malaria.
Schiess N, Villabona-Rueda A, Cottier KE, Huether K, Chipeta J, Stins MF
Malar J 2020 Jul 23;19(1):266. doi: 10.1186/s12936-020-03336-z. PMID: 32703204Free PMC Article
Cerebral malaria.
Garg RK
J Assoc Physicians India 2000 Oct;48(10):1004-13. PMID: 11200901
Malaria--a neglected disease?
Marsh K
Parasitology 1992;104 Suppl:S53-69. doi: 10.1017/s0031182000075247. PMID: 1589300
Cerebral Malaria.
Marsden PD, Bruce-Chwatt LJ
Contemp Neurol Ser 1975;12:29-44. PMID: 1095294

Diagnosis

Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment.
Song X, Wei W, Cheng W, Zhu H, Wang W, Dong H, Li J
Front Cell Infect Microbiol 2022;12:939532. Epub 2022 Jul 25 doi: 10.3389/fcimb.2022.939532. PMID: 35959375Free PMC Article
Infectious Optic Neuropathies.
Eggenberger ER
Continuum (Minneap Minn) 2019 Oct;25(5):1422-1437. doi: 10.1212/CON.0000000000000777. PMID: 31584544
Cerebral malaria.
Luzolo AL, Ngoyi DM
Brain Res Bull 2019 Feb;145:53-58. Epub 2019 Jan 15 doi: 10.1016/j.brainresbull.2019.01.010. PMID: 30658131
Cerebral malaria: gamma-interferon redux.
Hunt NH, Ball HJ, Hansen AM, Khaw LT, Guo J, Bakmiwewa S, Mitchell AJ, Combes V, Grau GE
Front Cell Infect Microbiol 2014;4:113. Epub 2014 Aug 15 doi: 10.3389/fcimb.2014.00113. PMID: 25177551Free PMC Article
Cerebral malaria.
Warrell DA
Schweiz Med Wochenschr 1992 Jun 6;122(23):879-86. PMID: 1615297

Therapy

Blood-Brain Barrier in Cerebral Malaria: Pathogenesis and Therapeutic Intervention.
Nishanth G, Schlüter D
Trends Parasitol 2019 Jul;35(7):516-528. Epub 2019 May 27 doi: 10.1016/j.pt.2019.04.010. PMID: 31147271
Cerebral malaria.
Luzolo AL, Ngoyi DM
Brain Res Bull 2019 Feb;145:53-58. Epub 2019 Jan 15 doi: 10.1016/j.brainresbull.2019.01.010. PMID: 30658131
Cerebral malaria.
Postels DG, Birbeck GL
Handb Clin Neurol 2013;114:91-102. doi: 10.1016/B978-0-444-53490-3.00006-6. PMID: 23829902
Malaria: severe, life-threatening.
Omari AA, Garner P
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454095Free PMC Article
Cerebral malaria.
Warrell DA
Schweiz Med Wochenschr 1992 Jun 6;122(23):879-86. PMID: 1615297

Prognosis

Blood-Brain Barrier in Cerebral Malaria: Pathogenesis and Therapeutic Intervention.
Nishanth G, Schlüter D
Trends Parasitol 2019 Jul;35(7):516-528. Epub 2019 May 27 doi: 10.1016/j.pt.2019.04.010. PMID: 31147271
Plasmodium falciparum.
Maier AG, Matuschewski K, Zhang M, Rug M
Trends Parasitol 2019 Jun;35(6):481-482. Epub 2018 Dec 27 doi: 10.1016/j.pt.2018.11.010. PMID: 30595467
Cerebral malaria--clinical manifestations and pathogenesis.
Hora R, Kapoor P, Thind KK, Mishra PC
Metab Brain Dis 2016 Apr;31(2):225-37. Epub 2016 Jan 8 doi: 10.1007/s11011-015-9787-5. PMID: 26746434
Nodding syndrome.
Dowell SF, Sejvar JJ, Riek L, Vandemaele KA, Lamunu M, Kuesel AC, Schmutzhard E, Matuja W, Bunga S, Foltz J, Nutman TB, Winkler AS, Mbonye AK
Emerg Infect Dis 2013;19(9):1374-84. doi: 10.3201/eid1909.130401. PMID: 23965548Free PMC Article
Cerebral malaria.
Newton CR, Hien TT, White N
J Neurol Neurosurg Psychiatry 2000 Oct;69(4):433-41. doi: 10.1136/jnnp.69.4.433. PMID: 10990500Free PMC Article

Clinical prediction guides

Erythrocyte miRNA regulators and malarial pathophysiology.
Prabhu SR, Ware AP, Saadi AV
Infect Genet Evol 2021 Sep;93:105000. Epub 2021 Jul 10 doi: 10.1016/j.meegid.2021.105000. PMID: 34252617
Cerebral malaria--clinical manifestations and pathogenesis.
Hora R, Kapoor P, Thind KK, Mishra PC
Metab Brain Dis 2016 Apr;31(2):225-37. Epub 2016 Jan 8 doi: 10.1007/s11011-015-9787-5. PMID: 26746434
Contrasting pediatric and adult cerebral malaria: the role of the endothelial barrier.
Hawkes M, Elphinstone RE, Conroy AL, Kain KC
Virulence 2013 Aug 15;4(6):543-55. Epub 2013 Aug 2 doi: 10.4161/viru.25949. PMID: 23924893Free PMC Article
Malaria: severe, life-threatening.
Sheehy SH, Angus BJ
BMJ Clin Evid 2011 Mar 7;2011 PMID: 21375787Free PMC Article
Malaria: severe, life-threatening.
Omari AA, Garner P
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454095Free PMC Article

Recent systematic reviews

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Association of cerebral malaria and TNF-α levels: a systematic review.
Leão L, Puty B, Dolabela MF, Povoa MM, Né YGS, Eiró LG, Fagundes NCF, Maia LC, Lima RR
BMC Infect Dis 2020 Jun 23;20(1):442. doi: 10.1186/s12879-020-05107-2. PMID: 32576141Free PMC Article
Artemether for severe malaria.
Esu E, Effa EE, Opie ON, Uwaoma A, Meremikwu MM
Cochrane Database Syst Rev 2014 Sep 11;2014(9):CD010678. doi: 10.1002/14651858.CD010678.pub2. PMID: 25209020Free PMC Article
Malaria: severe, life-threatening.
Sheehy SH, Angus BJ
BMJ Clin Evid 2011 Mar 7;2011 PMID: 21375787Free PMC Article
Malaria: severe, life-threatening.
Omari AA, Garner P
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454095Free PMC Article

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