U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vasogenic Edema

MedGen UID:
442997
•Concept ID:
C2825502
•
Finding

Definition

Edema that is characterized by increased permeability of capillary endothelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVasogenic Edema

Professional guidelines

PubMed

Detection and Management of Amyloid-Related Imaging Abnormalities in Patients with Alzheimer's Disease Treated with Anti-Amyloid Beta Therapy.
Barakos J, Purcell D, Suhy J, Chalkias S, Burkett P, Marsica Grassi C, Castrillo-Viguera C, Rubino I, Vijverberg E
J Prev Alzheimers Dis 2022;9(2):211-220. doi: 10.14283/jpad.2022.21. PMID: 35542992
The Medical Management of Cerebral Edema: Past, Present, and Future Therapies.
Halstead MR, Geocadin RG
Neurotherapeutics 2019 Oct;16(4):1133-1148. doi: 10.1007/s13311-019-00779-4. PMID: 31512062Free PMC Article
Pathophysiology and treatment of cerebral edema in traumatic brain injury.
Jha RM, Kochanek PM, Simard JM
Neuropharmacology 2019 Feb;145(Pt B):230-246. Epub 2018 Aug 4 doi: 10.1016/j.neuropharm.2018.08.004. PMID: 30086289Free PMC Article

Recent clinical studies

Etiology

Identifying Genetic Risk for Amyloid-Related Imaging Abnormalities.
Hardy J, Schott JM
Neurology 2024 Feb 13;102(3):e208096. Epub 2023 Dec 28 doi: 10.1212/WNL.0000000000208096. PMID: 38165303
Posterior Reversible Encephalopathy Syndrome: A Review of the Literature.
Ando Y, Ono Y, Sano A, Fujita N, Ono S
Intern Med 2022 Jan 15;61(2):135-141. Epub 2021 Jul 17 doi: 10.2169/internalmedicine.7520-21. PMID: 34275982Free PMC Article
Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome as Syndromes of Cerebrovascular Dysregulation.
Singhal AB
Continuum (Minneap Minn) 2021 Oct 1;27(5):1301-1320. doi: 10.1212/CON.0000000000001037. PMID: 34618761
Posterior Reversible Encephalopathy Syndrome.
Gewirtz AN, Gao V, Parauda SC, Robbins MS
Curr Pain Headache Rep 2021 Feb 25;25(3):19. doi: 10.1007/s11916-020-00932-1. PMID: 33630183Free PMC Article
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup.
Sperling RA, Jack CR Jr, Black SE, Frosch MP, Greenberg SM, Hyman BT, Scheltens P, Carrillo MC, Thies W, Bednar MM, Black RS, Brashear HR, Grundman M, Siemers ER, Feldman HH, Schindler RJ
Alzheimers Dement 2011 Jul;7(4):367-85. doi: 10.1016/j.jalz.2011.05.2351. PMID: 21784348Free PMC Article

Diagnosis

Posterior Reversible Encephalopathy Syndrome: A Review of the Literature.
Ando Y, Ono Y, Sano A, Fujita N, Ono S
Intern Med 2022 Jan 15;61(2):135-141. Epub 2021 Jul 17 doi: 10.2169/internalmedicine.7520-21. PMID: 34275982Free PMC Article
Posterior Reversible Encephalopathy Syndrome.
Gewirtz AN, Gao V, Parauda SC, Robbins MS
Curr Pain Headache Rep 2021 Feb 25;25(3):19. doi: 10.1007/s11916-020-00932-1. PMID: 33630183Free PMC Article
Comprehensive review of Wernicke encephalopathy: pathophysiology, clinical symptoms and imaging findings.
Ota Y, Capizzano AA, Moritani T, Naganawa S, Kurokawa R, Srinivasan A
Jpn J Radiol 2020 Sep;38(9):809-820. Epub 2020 May 10 doi: 10.1007/s11604-020-00989-3. PMID: 32390125
Posterior reversible encephalopathy syndrome.
Fischer M, Schmutzhard E
J Neurol 2017 Aug;264(8):1608-1616. Epub 2017 Jan 4 doi: 10.1007/s00415-016-8377-8. PMID: 28054130Free PMC Article
Metabolic encephalopathies.
Angel MJ, Young GB
Neurol Clin 2011 Nov;29(4):837-82. doi: 10.1016/j.ncl.2011.08.002. PMID: 22032664

Therapy

Aducanumab, gantenerumab, BAN2401, and ALZ-801-the first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval.
Tolar M, Abushakra S, Hey JA, Porsteinsson A, Sabbagh M
Alzheimers Res Ther 2020 Aug 12;12(1):95. doi: 10.1186/s13195-020-00663-w. PMID: 32787971Free PMC Article
The Medical Management of Cerebral Edema: Past, Present, and Future Therapies.
Halstead MR, Geocadin RG
Neurotherapeutics 2019 Oct;16(4):1133-1148. doi: 10.1007/s13311-019-00779-4. PMID: 31512062Free PMC Article
Pathophysiology and treatment of cerebral edema in traumatic brain injury.
Jha RM, Kochanek PM, Simard JM
Neuropharmacology 2019 Feb;145(Pt B):230-246. Epub 2018 Aug 4 doi: 10.1016/j.neuropharm.2018.08.004. PMID: 30086289Free PMC Article
Cerebral Edema and Elevated Intracranial Pressure.
Koenig MA
Continuum (Minneap Minn) 2018 Dec;24(6):1588-1602. doi: 10.1212/CON.0000000000000665. PMID: 30516597
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup.
Sperling RA, Jack CR Jr, Black SE, Frosch MP, Greenberg SM, Hyman BT, Scheltens P, Carrillo MC, Thies W, Bednar MM, Black RS, Brashear HR, Grundman M, Siemers ER, Feldman HH, Schindler RJ
Alzheimers Dement 2011 Jul;7(4):367-85. doi: 10.1016/j.jalz.2011.05.2351. PMID: 21784348Free PMC Article

Prognosis

Posterior Reversible Encephalopathy Syndrome: A Review of the Literature.
Ando Y, Ono Y, Sano A, Fujita N, Ono S
Intern Med 2022 Jan 15;61(2):135-141. Epub 2021 Jul 17 doi: 10.2169/internalmedicine.7520-21. PMID: 34275982Free PMC Article
Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome as Syndromes of Cerebrovascular Dysregulation.
Singhal AB
Continuum (Minneap Minn) 2021 Oct 1;27(5):1301-1320. doi: 10.1212/CON.0000000000001037. PMID: 34618761
Posterior Reversible Encephalopathy Syndrome.
Gewirtz AN, Gao V, Parauda SC, Robbins MS
Curr Pain Headache Rep 2021 Feb 25;25(3):19. doi: 10.1007/s11916-020-00932-1. PMID: 33630183Free PMC Article
Pathophysiology and treatment of cerebral edema in traumatic brain injury.
Jha RM, Kochanek PM, Simard JM
Neuropharmacology 2019 Feb;145(Pt B):230-246. Epub 2018 Aug 4 doi: 10.1016/j.neuropharm.2018.08.004. PMID: 30086289Free PMC Article
Posterior reversible encephalopathy syndrome.
Fischer M, Schmutzhard E
J Neurol 2017 Aug;264(8):1608-1616. Epub 2017 Jan 4 doi: 10.1007/s00415-016-8377-8. PMID: 28054130Free PMC Article

Clinical prediction guides

Posterior reversible encephalopathy syndrome.
Liman TG, Siebert E, Endres M
Curr Opin Neurol 2019 Feb;32(1):25-35. doi: 10.1097/WCO.0000000000000640. PMID: 30531559
How to monitor the brain in septic patients?
Oddo M, Taccone FS
Minerva Anestesiol 2015 Jul;81(7):776-88. Epub 2015 Mar 27 PMID: 25812488
Management of hypertension in the setting of acute ischemic stroke.
Heitsch L, Jauch EC
Curr Hypertens Rep 2007 Dec;9(6):506-11. doi: 10.1007/s11906-007-0092-5. PMID: 18367015
Pathophysiology of blood-spinal cord barrier in traumatic injury and repair.
Sharma HS
Curr Pharm Des 2005;11(11):1353-89. doi: 10.2174/1381612053507837. PMID: 15853669
Diabetic macular edema.
Cunha-Vaz J
Eur J Ophthalmol 1998 Jul-Sep;8(3):127-30. doi: 10.1177/112067219800800301. PMID: 9793763

Recent systematic reviews

Adjunctive cytoprotective therapies in acute ischemic stroke: a systematic review.
Mulder IA, van Bavel ET, de Vries HE, Coutinho JM
Fluids Barriers CNS 2021 Oct 19;18(1):46. doi: 10.1186/s12987-021-00280-1. PMID: 34666786Free PMC Article
Metabolic stroke or stroke-like lesion: Peculiarities of a phenomenon.
Finsterer J, Aliyev R
J Neurol Sci 2020 May 15;412:116726. Epub 2020 Feb 7 doi: 10.1016/j.jns.2020.116726. PMID: 32088469
Posterior reversible encephalopathy syndrome (PRES) and infection: a systematic review of the literature.
Racchiusa S, Mormina E, Ax A, Musumeci O, Longo M, Granata F
Neurol Sci 2019 May;40(5):915-922. Epub 2019 Jan 2 doi: 10.1007/s10072-018-3651-4. PMID: 30604335
Bapineuzumab for mild to moderate Alzheimer's disease: a meta-analysis of randomized controlled trials.
Abushouk AI, Elmaraezy A, Aglan A, Salama R, Fouda S, Fouda R, AlSafadi AM
BMC Neurol 2017 Apr 4;17(1):66. doi: 10.1186/s12883-017-0850-1. PMID: 28376794Free PMC Article
Matrix metalloproteinase-9 as a marker for acute ischemic stroke: a systematic review.
Ramos-Fernandez M, Bellolio MF, Stead LG
J Stroke Cerebrovasc Dis 2011 Jan-Feb;20(1):47-54. Epub 2010 Jun 17 doi: 10.1016/j.jstrokecerebrovasdis.2009.10.008. PMID: 21044610

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...