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ERG Gene Rearrangement

MedGen UID:
443151
•Concept ID:
C2826127
•
Cell or Molecular Dysfunction
Synonyms: ERG Rearrangement; Erg-3 Gene Rearrangement; ETS Transcription Factor ERG Gene Rearrangement; p55 Gene Rearrangement; v-Ets Erythroblastosis Virus E26 Oncogene Like Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the ERG gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVERG Gene Rearrangement

Professional guidelines

PubMed

Steroid receptor-associated and regulated protein is a biomarker in predicting the clinical outcome and treatment response in malignancies.
Naderi A
Cancer Rep (Hoboken) 2020 Oct;3(5):e1267. Epub 2020 Jul 24 doi: 10.1002/cnr2.1267. PMID: 32706923Free PMC Article
Genomics in acute lymphoblastic leukaemia: insights and treatment implications.
Roberts KG, Mullighan CG
Nat Rev Clin Oncol 2015 Jun;12(6):344-57. Epub 2015 Mar 17 doi: 10.1038/nrclinonc.2015.38. PMID: 25781572
Clinical applications of novel ERG immunohistochemistry in prostate cancer diagnosis and management.
Shah RB
Adv Anat Pathol 2013 Mar;20(2):117-24. doi: 10.1097/PAP.0b013e3182862ac5. PMID: 23399797

Recent clinical studies

Etiology

Correlation of ERG immunohistochemistry with molecular detection of TMPRSS2-ERG gene fusion.
Sung JY, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HY, Kang SY, Choi YL, Kwon GY
J Clin Pathol 2016 Jul;69(7):586-92. Epub 2015 Dec 15 doi: 10.1136/jclinpath-2015-203314. PMID: 26670747
Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas.
Tan HL, Haffner MC, Esopi DM, Vaghasia AM, Giannico GA, Ross HM, Ghosh S, Hicks JL, Zheng Q, Sangoi AR, Yegnasubramanian S, Osunkoya AO, De Marzo AM, Epstein JI, Lotan TL
Mod Pathol 2015 Mar;28(3):446-56. Epub 2014 Sep 12 doi: 10.1038/modpathol.2014.115. PMID: 25216229Free PMC Article
Heterogeneity of ERG expression in core needle biopsies of patients with early prostate cancer.
Mertz KD, Horcic M, Hailemariam S, D'Antonio A, Dirnhofer S, Hartmann A, Agaimy A, Eppenberger-Castori S, Obermann E, Cathomas G, Bubendorf L
Hum Pathol 2013 Dec;44(12):2727-35. Epub 2013 Sep 26 doi: 10.1016/j.humpath.2013.07.019. PMID: 24074533
TMPRSS2-ERG rearrangement in dominant anterior prostatic tumours: incidence and correlation with ERG immunohistochemistry.
Gopalan A, Leversha MA, Dudas ME, Maschino AC, Chang J, Al-Ahmadie HA, Chen YB, Tickoo SK, Reuter VE, Fine SW
Histopathology 2013 Aug;63(2):279-86. Epub 2013 May 23 doi: 10.1111/his.12153. PMID: 23701505Free PMC Article
Molecular biology underlying the clinical heterogeneity of prostate cancer: an update.
Mackinnon AC, Yan BC, Joseph LJ, Al-Ahmadie HA
Arch Pathol Lab Med 2009 Jul;133(7):1033-40. doi: 10.5858/133.7.1033. PMID: 19642730

Diagnosis

Primary spinal multifocal intradural-extramedullary Ewing sarcoma in children: presentation of a case and review of the literature.
Müngen E, Kurucu N, Kutluk T, Oğuz KK, Söylemezoğlu F, Yalçın B
Turk J Pediatr 2021;63(6):1084-1090. doi: 10.24953/turkjped.2021.06.018. PMID: 35023660
Ipsilateral breast metastasis after axillary dissection caused by epithelioid sarcoma: a case report and pathological investigation.
Chen L, Wang L, Zhang X, Yao M, Fu P
Diagn Pathol 2019 Oct 15;14(1):111. doi: 10.1186/s13000-019-0888-z. PMID: 31615564Free PMC Article
The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.
Klimstra DS, Beltran H, Lilenbaum R, Bergsland E
Am Soc Clin Oncol Educ Book 2015:92-103. doi: 10.14694/EdBook_AM.2015.35.92. PMID: 25993147
ERG expression and prostatic adenocarcinoma.
Verdu M, Trias I, Roman R, Rodon N, Garcia-Pelaez B, Calvo M, Dominguez A, Banus JM, Puig X
Virchows Arch 2013 Jun;462(6):639-44. Epub 2013 May 24 doi: 10.1007/s00428-013-1415-3. PMID: 23703293
ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy.
Minner S, Enodien M, Sirma H, Luebke AM, Krohn A, Mayer PS, Simon R, Tennstedt P, Müller J, Scholz L, Brase JC, Liu AY, Schlüter H, Pantel K, Schumacher U, Bokemeyer C, Steuber T, Graefen M, Sauter G, Schlomm T
Clin Cancer Res 2011 Sep 15;17(18):5878-88. Epub 2011 Jul 26 doi: 10.1158/1078-0432.CCR-11-1251. PMID: 21791629

Therapy

Primary spinal multifocal intradural-extramedullary Ewing sarcoma in children: presentation of a case and review of the literature.
Müngen E, Kurucu N, Kutluk T, Oğuz KK, Söylemezoğlu F, Yalçın B
Turk J Pediatr 2021;63(6):1084-1090. doi: 10.24953/turkjped.2021.06.018. PMID: 35023660
Clinicopathologic features of metastatic small cell carcinoma of the prostate to the liver: a series of four cases.
Bell PD, Huber AR, Agostini-Vulaj D
Diagn Pathol 2021 Apr 23;16(1):35. doi: 10.1186/s13000-021-01096-1. PMID: 33892760Free PMC Article
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.
Attard G, Swennenhuis JF, Olmos D, Reid AH, Vickers E, A'Hern R, Levink R, Coumans F, Moreira J, Riisnaes R, Oommen NB, Hawche G, Jameson C, Thompson E, Sipkema R, Carden CP, Parker C, Dearnaley D, Kaye SB, Cooper CS, Molina A, Cox ME, Terstappen LW, de Bono JS
Cancer Res 2009 Apr 1;69(7):2912-8. doi: 10.1158/0008-5472.CAN-08-3667. PMID: 19339269

Prognosis

Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer.
Dadhania V, Gonzalez D, Yousif M, Cheng J, Morgan TM, Spratt DE, Reichert ZR, Mannan R, Wang X, Chinnaiyan A, Cao X, Dhanasekaran SM, Chinnaiyan AM, Pantanowitz L, Mehra R
BMC Cancer 2022 May 5;22(1):494. doi: 10.1186/s12885-022-09559-4. PMID: 35513774Free PMC Article
Primary spinal multifocal intradural-extramedullary Ewing sarcoma in children: presentation of a case and review of the literature.
Müngen E, Kurucu N, Kutluk T, Oğuz KK, Söylemezoğlu F, Yalçın B
Turk J Pediatr 2021;63(6):1084-1090. doi: 10.24953/turkjped.2021.06.018. PMID: 35023660
Clinicopathologic features of metastatic small cell carcinoma of the prostate to the liver: a series of four cases.
Bell PD, Huber AR, Agostini-Vulaj D
Diagn Pathol 2021 Apr 23;16(1):35. doi: 10.1186/s13000-021-01096-1. PMID: 33892760Free PMC Article
The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.
Klimstra DS, Beltran H, Lilenbaum R, Bergsland E
Am Soc Clin Oncol Educ Book 2015:92-103. doi: 10.14694/EdBook_AM.2015.35.92. PMID: 25993147
ERG gene rearrangement status in prostate cancer detected by immunohistochemistry.
Falzarano SM, Zhou M, Carver P, Tsuzuki T, Simmerman K, He H, Magi-Galluzzi C
Virchows Arch 2011 Oct;459(4):441-7. Epub 2011 Jul 20 doi: 10.1007/s00428-011-1128-4. PMID: 21773753

Clinical prediction guides

Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer.
Dadhania V, Gonzalez D, Yousif M, Cheng J, Morgan TM, Spratt DE, Reichert ZR, Mannan R, Wang X, Chinnaiyan A, Cao X, Dhanasekaran SM, Chinnaiyan AM, Pantanowitz L, Mehra R
BMC Cancer 2022 May 5;22(1):494. doi: 10.1186/s12885-022-09559-4. PMID: 35513774Free PMC Article
Heterogeneity of ERG expression in core needle biopsies of patients with early prostate cancer.
Mertz KD, Horcic M, Hailemariam S, D'Antonio A, Dirnhofer S, Hartmann A, Agaimy A, Eppenberger-Castori S, Obermann E, Cathomas G, Bubendorf L
Hum Pathol 2013 Dec;44(12):2727-35. Epub 2013 Sep 26 doi: 10.1016/j.humpath.2013.07.019. PMID: 24074533
ERG expression in epithelioid sarcoma: a diagnostic pitfall.
Miettinen M, Wang Z, Sarlomo-Rikala M, Abdullaev Z, Pack SD, Fetsch JF
Am J Surg Pathol 2013 Oct;37(10):1580-5. doi: 10.1097/PAS.0b013e31828de23a. PMID: 23774169Free PMC Article
ERG expression and prostatic adenocarcinoma.
Verdu M, Trias I, Roman R, Rodon N, Garcia-Pelaez B, Calvo M, Dominguez A, Banus JM, Puig X
Virchows Arch 2013 Jun;462(6):639-44. Epub 2013 May 24 doi: 10.1007/s00428-013-1415-3. PMID: 23703293
ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy.
Minner S, Enodien M, Sirma H, Luebke AM, Krohn A, Mayer PS, Simon R, Tennstedt P, Müller J, Scholz L, Brase JC, Liu AY, Schlüter H, Pantel K, Schumacher U, Bokemeyer C, Steuber T, Graefen M, Sauter G, Schlomm T
Clin Cancer Res 2011 Sep 15;17(18):5878-88. Epub 2011 Jul 26 doi: 10.1158/1078-0432.CCR-11-1251. PMID: 21791629

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