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Early Pregnancy Symptom

MedGen UID:
457515
•Concept ID:
C2985289
•
Sign or Symptom

Definition

A characteristic complaint in a fertile woman that is indicative of a pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly Pregnancy Symptom

Professional guidelines

PubMed

Hypothyroidism: Diagnosis and Treatment.
Wilson SA, Stem LA, Bruehlman RD
Am Fam Physician 2021 May 15;103(10):605-613. PMID: 33983002
ACOG Practice Bulletin No. 193: Tubal Ectopic Pregnancy.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Mar;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. PMID: 29470343
ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy.
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2018 Jan;131(1):e15-e30. doi: 10.1097/AOG.0000000000002456. PMID: 29266076

Recent clinical studies

Etiology

Anti-phospholipid antibodies and reproductive failures.
Beltagy A, Trespidi L, Gerosa M, Ossola MW, Meroni PL, Chighizola CB
Am J Reprod Immunol 2021 Apr;85(4):e13258. Epub 2020 May 15 doi: 10.1111/aji.13258. PMID: 32347616
Transforming growth factor-β1 in intrauterine adhesion.
Abudukeyoumu A, Li MQ, Xie F
Am J Reprod Immunol 2020 Aug;84(2):e13262. Epub 2020 Jun 3 doi: 10.1111/aji.13262. PMID: 32379911
Zika and pregnancy: A comprehensive review.
Hajra A, Bandyopadhyay D, Heise LR, Bhadra R, Ball S, Hajra SK
Am J Reprod Immunol 2017 Feb;77(2) Epub 2016 Nov 25 doi: 10.1111/aji.12607. PMID: 27885741
Management of pemphigus disease in pregnancy.
Tavakolpour S, Mirsafaei HS, Delshad S
Am J Reprod Immunol 2017 Jan;77(1) Epub 2016 Nov 8 doi: 10.1111/aji.12601. PMID: 27862562
Pregnancy and antiphospholipid syndrome.
Lockshin MD
Am J Reprod Immunol 2013 Jun;69(6):585-7. Epub 2012 Dec 28 doi: 10.1111/aji.12071. PMID: 23279134

Diagnosis

Zika and pregnancy: A comprehensive review.
Hajra A, Bandyopadhyay D, Heise LR, Bhadra R, Ball S, Hajra SK
Am J Reprod Immunol 2017 Feb;77(2) Epub 2016 Nov 25 doi: 10.1111/aji.12607. PMID: 27885741
Management of pemphigus disease in pregnancy.
Tavakolpour S, Mirsafaei HS, Delshad S
Am J Reprod Immunol 2017 Jan;77(1) Epub 2016 Nov 8 doi: 10.1111/aji.12601. PMID: 27862562
Early pregnancy bleeding.
Breeze C
Aust Fam Physician 2016 May;45(5):283-6. PMID: 27166462
Hyperemesis gravidarum: current aspect.
Tamay AG, Kuşçu NK
J Obstet Gynaecol 2011 Nov;31(8):708-12. doi: 10.3109/01443615.2011.611918. PMID: 22085059
Recurrent spontaneous abortion.
McIntyre JA, Coulam CB, Faulk WP
Am J Reprod Immunol 1989 Nov-Dec;21(3-4):100-4. doi: 10.1111/j.1600-0897.1989.tb01011.x. PMID: 2534830

Therapy

Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence.
Coomarasamy A, Devall AJ, Brosens JJ, Quenby S, Stephenson MD, Sierra S, Christiansen OB, Small R, Brewin J, Roberts TE, Dhillon-Smith R, Harb H, Noordali H, Papadopoulou A, Eapen A, Prior M, Di Renzo GC, Hinshaw K, Mol BW, Lumsden MA, Khalaf Y, Shennan A, Goddijn M, van Wely M, Al-Memar M, Bennett P, Bourne T, Rai R, Regan L, Gallos ID
Am J Obstet Gynecol 2020 Aug;223(2):167-176. Epub 2020 Jan 31 doi: 10.1016/j.ajog.2019.12.006. PMID: 32008730Free PMC Article
Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies.
Bartsch E, Medcalf KE, Park AL, Ray JG; High Risk of Pre-eclampsia Identification Group
BMJ 2016 Apr 19;353:i1753. doi: 10.1136/bmj.i1753. PMID: 27094586Free PMC Article
Cesarean scar pregnancy: a systematic review of treatment studies.
Birch Petersen K, Hoffmann E, Rifbjerg Larsen C, Svarre Nielsen H
Fertil Steril 2016 Apr;105(4):958-67. Epub 2016 Jan 18 doi: 10.1016/j.fertnstert.2015.12.130. PMID: 26794422
Interventions for nausea and vomiting in early pregnancy.
Matthews A, Haas DM, O'Mathúna DP, Dowswell T
Cochrane Database Syst Rev 2015 Sep 8;2015(9):CD007575. doi: 10.1002/14651858.CD007575.pub4. PMID: 26348534Free PMC Article

Prognosis

Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts.
Chavli EA, Klaasen SJ, Van Opstal D, Laven JS, Kops GJ, Baart EB
J Clin Invest 2024 Jan 4;134(6) doi: 10.1172/JCI174483. PMID: 38175717Free PMC Article
Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study.
Villar J, Ariff S, Gunier RB, Thiruvengadam R, Rauch S, Kholin A, Roggero P, Prefumo F, do Vale MS, Cardona-Perez JA, Maiz N, Cetin I, Savasi V, Deruelle P, Easter SR, Sichitiu J, Soto Conti CP, Ernawati E, Mhatre M, Teji JS, Liu B, Capelli C, Oberto M, Salazar L, Gravett MG, Cavoretto PI, Nachinab VB, Galadanci H, Oros D, Ayede AI, Sentilhes L, Bako B, Savorani M, Cena H, García-May PK, Etuk S, Casale R, Abd-Elsalam S, Ikenoue S, Aminu MB, Vecciarelli C, Duro EA, Usman MA, John-Akinola Y, Nieto R, Ferrazi E, Bhutta ZA, Langer A, Kennedy SH, Papageorghiou AT
JAMA Pediatr 2021 Aug 1;175(8):817-826. doi: 10.1001/jamapediatrics.2021.1050. PMID: 33885740Free PMC Article
Anti-phospholipid antibodies and reproductive failures.
Beltagy A, Trespidi L, Gerosa M, Ossola MW, Meroni PL, Chighizola CB
Am J Reprod Immunol 2021 Apr;85(4):e13258. Epub 2020 May 15 doi: 10.1111/aji.13258. PMID: 32347616
Pregnancy and antiphospholipid syndrome.
Lockshin MD
Am J Reprod Immunol 2013 Jun;69(6):585-7. Epub 2012 Dec 28 doi: 10.1111/aji.12071. PMID: 23279134
Tuberculosis in pregnancy.
Laibl VR, Sheffield JS
Clin Perinatol 2005 Sep;32(3):739-47. doi: 10.1016/j.clp.2005.04.010. PMID: 16085030

Clinical prediction guides

Chronic endometritis and reproductive failure: Role of syndecan-1.
Xu Y, Mei J, Diao L, Li Y, Ding L
Am J Reprod Immunol 2020 Sep;84(3):e13255. Epub 2020 Jun 26 doi: 10.1111/aji.13255. PMID: 32329146
Blood pressure measurement in pregnancy and in hypertensive disorders of pregnancy: devices, techniques and challenges.
Ngene NC, Moodley J
Cardiovasc J Afr 2019 Mar/Apr 23;30(2):120-129. Epub 2019 Jan 23 doi: 10.5830/CVJA-2018-067. PMID: 30720845
Zika virus and pregnancy: An overview.
de Carvalho NS, de Carvalho BF, Dóris B, Silverio Biscaia E, Arias Fugaça C, de Noronha L
Am J Reprod Immunol 2017 Feb;77(2) Epub 2017 Jan 3 doi: 10.1111/aji.12616. PMID: 28045216
Pregnancy and antiphospholipid syndrome.
Lockshin MD
Am J Reprod Immunol 2013 Jun;69(6):585-7. Epub 2012 Dec 28 doi: 10.1111/aji.12071. PMID: 23279134
The Hopkins Lupus Pregnancy Center: 1987-1991 update.
Petri M, Howard D, Repke J, Goldman DW
Am J Reprod Immunol 1992 Oct-Dec;28(3-4):188-91. doi: 10.1111/j.1600-0897.1992.tb00788.x. PMID: 1283682

Recent systematic reviews

Pregnancy in patients with systemic lupus erythematosus: a systematic review.
Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Cesarean scar defects and abnormal uterine bleeding: a systematic review and meta-analysis.
Murji A, Sanders AP, Monteiro I, Haiderbhai S, Matelski J, Walsh C, Abbott JA, Munro MG, Maheux-Lacroix S; International Federation of Gynecology and Obstetrics (FIGO) Committee on Menstrual Disorders and Related Health Impacts
Fertil Steril 2022 Oct;118(4):758-766. Epub 2022 Aug 17 doi: 10.1016/j.fertnstert.2022.06.031. PMID: 35985862
Headache and pregnancy: a systematic review.
Negro A, Delaruelle Z, Ivanova TA, Khan S, Ornello R, Raffaelli B, Terrin A, Reuter U, Mitsikostas DD; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2017 Oct 19;18(1):106. doi: 10.1186/s10194-017-0816-0. PMID: 29052046Free PMC Article
EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome.
Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, Doria A, Fischer-Betz R, Forger F, Moraes-Fontes MF, Khamashta M, King J, Lojacono A, Marchiori F, Meroni PL, Mosca M, Motta M, Ostensen M, Pamfil C, Raio L, Schneider M, Svenungsson E, Tektonidou M, Yavuz S, Boumpas D, Tincani A
Ann Rheum Dis 2017 Mar;76(3):476-485. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209770. PMID: 27457513Free PMC Article
Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies.
Bartsch E, Medcalf KE, Park AL, Ray JG; High Risk of Pre-eclampsia Identification Group
BMJ 2016 Apr 19;353:i1753. doi: 10.1136/bmj.i1753. PMID: 27094586Free PMC Article

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