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Thymus Solitary Fibrous Tumor

MedGen UID:
459093
•Concept ID:
C2986867
•
Neoplastic Process
Synonym: Thymic Solitary Fibrous Tumor

Definition

A benign or malignant mesenchymal neoplasm that arises from the thymus gland. It is characterized by the presence of spindle cell fibroblasts and collagen tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymus Solitary Fibrous Tumor

Recent clinical studies

Etiology

Cytomorphology of monomorphic spindle epithelial tumor with thymus-like elements: A case with local recurrence after subtotal resection.
Arshia A, Balikani L, Booth CN
Diagn Cytopathol 2024 Jun;52(6):E134-E144. Epub 2024 Mar 23 doi: 10.1002/dc.25301. PMID: 38520309
Ectopic thymoma: Retrospective analysis of eight cases with clinical features and computed tomography findings.
Zhou Q, Han L, Ke X, Zhou J
Clin Imaging 2020 Apr;60(2):153-159. Epub 2019 Dec 6 doi: 10.1016/j.clinimag.2019.10.017. PMID: 31927170
Solitary fibrous tumor of the thyroid gland: report of seven cases.
Rodriguez I, Ayala E, Caballero C, De Miguel C, Matias-Guiu X, Cubilla AL, Rosai J
Am J Surg Pathol 2001 Nov;25(11):1424-8. doi: 10.1097/00000478-200111000-00011. PMID: 11684960
Solitary fibrous tumor of the mediastinum. A report of 14 cases.
Witkin GB, Rosai J
Am J Surg Pathol 1989 Jul;13(7):547-57. doi: 10.1097/00000478-198907000-00002. PMID: 2735490

Diagnosis

Solitary fibrous tumor of the thymus with variegated epithelial components.
Tsubochi H, Endo T, Sogabe M, Endo S, Morinaga S, Dobashi Y
Int J Clin Exp Pathol 2014;7(11):7477-84. Epub 2014 Oct 15 PMID: 25550783Free PMC Article
A solitary fibrous tumor arising from the thymus.
Eguchi T, Ito N, Makiuchi A, Yoshida K
Interact Cardiovasc Thorac Surg 2010 Sep;11(3):362-3. Epub 2010 Jun 4 doi: 10.1510/icvts.2010.237461. PMID: 20525760
Solitary fibrous tumor of the thymus with local invasiveness and pleural dissemination: report of a case.
Iwata T, Nishiyama N, Izumi N, Tsukioka T, Suehiro S
Ann Thorac Cardiovasc Surg 2007 Jun;13(3):198-202. PMID: 17592430
Solitary fibrous tumor of the thyroid gland: report of seven cases.
Rodriguez I, Ayala E, Caballero C, De Miguel C, Matias-Guiu X, Cubilla AL, Rosai J
Am J Surg Pathol 2001 Nov;25(11):1424-8. doi: 10.1097/00000478-200111000-00011. PMID: 11684960
Solitary fibrous tumor of the mediastinum. A report of 14 cases.
Witkin GB, Rosai J
Am J Surg Pathol 1989 Jul;13(7):547-57. doi: 10.1097/00000478-198907000-00002. PMID: 2735490

Prognosis

Ectopic pleural thymoma mimicking a giant solitary fibrous tumour of the pleura.
Filosso PL, Delsedime L, Cristofori RC, Sandri A
Interact Cardiovasc Thorac Surg 2012 Nov;15(5):930-2. Epub 2012 Aug 23 doi: 10.1093/icvts/ivs360. PMID: 22922387Free PMC Article
Primary spindle cell lesions of the thyroid gland; an overview.
Papi G, Corrado S, LiVolsi VA
Am J Clin Pathol 2006 Jun;125 Suppl:S95-123. doi: 10.1309/4DQW6RQX3C6KRX1J. PMID: 16830961
Solitary fibrous tumor of the thyroid gland: report of seven cases.
Rodriguez I, Ayala E, Caballero C, De Miguel C, Matias-Guiu X, Cubilla AL, Rosai J
Am J Surg Pathol 2001 Nov;25(11):1424-8. doi: 10.1097/00000478-200111000-00011. PMID: 11684960
Solitary fibrous tumor of the mediastinum. A report of 14 cases.
Witkin GB, Rosai J
Am J Surg Pathol 1989 Jul;13(7):547-57. doi: 10.1097/00000478-198907000-00002. PMID: 2735490

Clinical prediction guides

Ectopic pleural thymoma mimicking a giant solitary fibrous tumour of the pleura.
Filosso PL, Delsedime L, Cristofori RC, Sandri A
Interact Cardiovasc Thorac Surg 2012 Nov;15(5):930-2. Epub 2012 Aug 23 doi: 10.1093/icvts/ivs360. PMID: 22922387Free PMC Article
A solitary fibrous tumor arising from the thymus.
Eguchi T, Ito N, Makiuchi A, Yoshida K
Interact Cardiovasc Thorac Surg 2010 Sep;11(3):362-3. Epub 2010 Jun 4 doi: 10.1510/icvts.2010.237461. PMID: 20525760
Solitary fibrous tumor of the mediastinum. A report of 14 cases.
Witkin GB, Rosai J
Am J Surg Pathol 1989 Jul;13(7):547-57. doi: 10.1097/00000478-198907000-00002. PMID: 2735490

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